Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

Frontiers in Physiology, Journal Year: 2020, Volume and Issue: 11

Published: July 2, 2020

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative and cancer. Long term exposure to increased levels pro-oxidant factors can cause structural defects at a mitochondrial DNA level, well functional alteration several enzymes cellular structures leading aberrations gene expression. The modern lifestyle associated with processed food, wide range chemicals lack exercise important oxidative induction. However, use medicinal plants antioxidant properties has been exploited for their ability treat or prevent human pathologies which seems be one causes. In this review we discuss is triggers plant-derived compounds mechanisms defenses that help prevention these diseases. Finally, both beneficial detrimental effects molecules are used reduce conditions discussed.

Language: Английский

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Extraction of phenolic compounds: A review

Current Research in Food Science, Journal Year: 2021, Volume and Issue: 4, P. 200 - 214

Published: Jan. 1, 2021

Phenolic compounds are parts of secondary metabolites mostly found in plant species with enormous structural diversities. They can exist as glycosides or aglycones; matrix free-bound compounds; and comprising polymerized monomer structures. Additionally, these not universally dispensed within plants varied stability. This has contributed to challenging extraction processes; implying that employing a single step inappropriate technique might change the recovery phenolic components from samples. Hence, it is important select an appropriate method so recover targeted compounds. will helps substantial yields sample matrix. Therefore, this review mainly focuses on several methods used obtaining them materials. These includes both conventional unconventional techniques.

Language: Английский

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Influence of the extraction method on the recovery of bioactive phenolic compounds from food industry by-products

Food Chemistry, Journal Year: 2021, Volume and Issue: 378, P. 131918 - 131918

Published: Dec. 23, 2021

Agro-foodindustries generate colossal amounts of non-edible waste and by-products, easily accessible as raw materials for up-cycling active phytochemicals. Phenolic compounds are particularly relevant in this field given their abundance plant residues the market interest functionalities (e.g. natural antioxidant activity) part nutraceutical, cosmetological biomedical formulations. In "bench-to-bedside" achievements, sample extraction is essential because valorization benefits from matrix desorption solubilization targeted phytocompounds. Specifically, composition polarity extractant, optimal particle size sample:solvent ratio, well pH, pressure temperature strategic release stability mobilized species. On other hand, current green chemistry environmental rules require approaches that eliminate polluting consumables reduce energy needs. Thus, following pages provide an update on advanced technologies sustainable efficient recovery phenolics matrices.

Language: Английский

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Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development

Journal of Biomolecular Structure and Dynamics, Journal Year: 2020, Volume and Issue: 39(16), P. 6306 - 6316

Published: July 22, 2020

Spike glycoprotein, a class I fusion protein harboring the surface of SARS-CoV-2 (SARS-CoV-2S), plays seminal role in viral infection starting from recognition host cell receptor, attachment to envelope with cells. glycoprotein engages Angiotensin-converting enzyme 2 (ACE2) receptors for entry into cells, where receptor and spike ACE2 is prerequisite step key determinant tissue tropism. Binding triggers cascade structural transitions, including transition metastable pre-fusion post-fusion form, thereby allowing membrane internalization virus. From ancient times people have relied on naturally occurring substances like phytochemicals fight against diseases infection. Among these phytochemicals, flavonoids non-flavonoids been active sources different anti-microbial agents. We performed molecular docking studies using 10 potential compounds (flavonoids/non-flavonoids) compared their affinity an FDA approved repurposed drug hydroxychloroquine (HCQ). Further, our dynamics (MD) simulation energy landscape fisetin, quercetin, kamferol revealed that molecules bind hACE2-S complex low binding free energy. The study provided indication might perturb complex. In addition, ADME analysis also suggested consist drug-likeness property, which may be further explored as anti-SARS-CoV-2

Language: Английский

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Focus on the Contribution of Oxidative Stress in Skin Aging

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1121 - 1121

Published: June 6, 2022

Skin aging is one of the most evident signs human aging. Modification skin during life span characterized by fine lines and wrinkling, loss elasticity volume, laxity, rough-textured appearance, pallor. In contrast, photoaged associated with uneven pigmentation (age spot) markedly wrinkled. At cellular molecular level, it consists multiple interconnected processes based on biochemical reactions, genetic programs, occurrence external stimulation. The principal perturbation in driving senescence alteration oxidative balance. chronological aging, reactive oxygen species (ROS) are produced mainly through metabolism adenosine triphosphate (ATP) generation from glucose mitochondrial dysfunction, whereas extrinsic redox equilibrium caused environmental factors, such as ultraviolet radiation, pollution, cigarette smoking, inadequate nutrition. During process, stress attributed to both augmented ROS production reduced levels enzymatic non-enzymatic protectors. Apart appearance structural change, throughout gradually loses its natural functional characteristics regenerative potential. With immune system also undergoes manifested a ability counteract infections frequency autoimmune neoplastic diseases. This review proposes an update role clinical manifestation well mechanisms that underline this phenomenon sometimes accelerated factors.

Language: Английский

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Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Frontiers in Bioengineering and Biotechnology, Journal Year: 2020, Volume and Issue: 7

Published: Jan. 9, 2020

The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation regarded as a promising strategy combat pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such curcumin, resveratrol, catechins, quercetin among commonly applied natural used potential modulators free radical-induced cellular damages. therapeutic is, however, restricted by their low bioavailability poor solubility, stability absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for delivery improved and, consequently, efficacy clinical practice. Such have provided many benefits preclinical research over conventional preparations, including superior solubility stability, extended half-life, epithelium permeability bioavailability, enhanced tissue targeting minimized side effects. present review summarizes recent developments nanodelivery its application conditions stress.

Language: Английский

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Citrus peel as a renewable bioresource: Transforming waste to food additives

Journal of Functional Foods, Journal Year: 2022, Volume and Issue: 95, P. 105163 - 105163

Published: June 29, 2022

This review summarizes the potential use of citrus peels in food industry. The present work is an overview different compounds extracted from various species peel and functional properties compounds, along with their applications as valuable ingredients food-based products. Citrus a natural source diverse bioactive including polyphenols, pectins, proteins, pigments, dietary fibers, essential oils. These exhibit many biological activities, antioxidant, antimicrobial, anticancer, anti-inflammatory, antidiabetic activities. Thus, can be considered promising foods. It also utilized food-coloring, flavoring, thickening agent. waste generated processing industry form exhibits economic benefits by reentering line additive while providing sustainable innovative solutions to utilization.

Language: Английский

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Biochemical and nutritional characterization of dragon fruit (Hylocereus species)

Food Chemistry, Journal Year: 2021, Volume and Issue: 353, P. 129426 - 129426

Published: March 3, 2021

Language: Английский

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The Effect of Dietary Polyphenols on Vascular Health and Hypertension: Current Evidence and Mechanisms of Action

Nutrients, Journal Year: 2022, Volume and Issue: 14(3), P. 545 - 545

Published: Jan. 27, 2022

The aim of this review was to explore existing evidence from studies conducted on humans and summarize the mechanisms action dietary polyphenols vascular health, blood pressure hypertension. There is that some polyphenol-rich foods, including berry fruits rich in anthocyanins, cocoa green tea flavan-3-ols, almonds pistachios hydroxycinnamic acids, soy products isoflavones, are able improve levels. A variety can elucidate observed effects. Some limitations evidence, variability polyphenol content plant-derived foods human absorption, difficulty disentangling effects other compounds, discrepancy doses between animal should be taken into account. While no single food counteracts hypertension, adopting a plant-based pattern an advisable practice pressure.

Language: Английский

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Nutritional and bioactive characteristics of buckwheat, and its potential for developing gluten‐free products: An updated overview

Food Science & Nutrition, Journal Year: 2022, Volume and Issue: 11(5), P. 2256 - 2276

Published: Dec. 22, 2022

Abstract In the present era, food scientists are concerned about exploiting functional crops with nutraceutical properties. Buckwheat is one of pseudocereals components used in treatment health‐related diseases, malnutrition, and celiac diseases. As a preferred diet as gluten‐free product for buckwheat good source nutrients, bioactive components, phytochemicals, antioxidants. The general characteristics better nutritional profile than other cereal family were highlighted by previous investigations. buckwheats, like peptides, flavonoids, phenolic acids, d ‐fagomine, fagopyritols, fagopyrins posing significant health benefits. This study highlights current knowledge its characteristics, constituents, their potential developing products to target people (1.4% world population)

Language: Английский

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