Potentials of Natural Antioxidants in Reducing Inflammation and Oxidative Stress in Chronic Kidney Disease DOI Creative Commons

On Ying Angela Lee,

Alex Ngai Nick Wong,

Ching Yan Ho

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 751 - 751

Published: June 20, 2024

Chronic kidney disease (CKD) presents a substantial global public health challenge, with high morbidity and mortality. CKD patients often experience dyslipidaemia poor glycaemic control, further exacerbating inflammation oxidative stress in the kidney. If left untreated, these metabolic symptoms can progress to end-stage renal disease, necessitating long-term dialysis or transplantation. Alleviating responses has become standard approach management. Medications such as statins, metformin, GLP-1 agonists, initially developed for treating dysregulation, demonstrate promising therapeutic benefits. The rising popularity of herbal remedies supplements, perceived natural antioxidants, spurred investigations into their potential efficacy. Notably, lactoferrin, Boerhaavia diffusa, Amauroderma rugosum, Ganoderma lucidum are known anti-inflammatory antioxidant properties may support function preservation. However, mechanisms underlying effectiveness Western medications alleviating occurring dysfunction not completely known. This review aims provide comprehensive overview treatment strategies preservation critically discusses existing literature’s limitations whilst offering insight effects interventions. could useful guide future clinical trials facilitate development effective functions.

Language: Английский

Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress DOI Creative Commons

Hasna Tirichen,

Hasnaa Yaigoub, Weiwei Xu

et al.

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: April 23, 2021

Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial (mtROS) production and removal due overproduction ROS and/or decreased antioxidants defense activity results in oxidative stress (OS), which leads damage that affects several components such as lipids, DNA, proteins. Since the kidney is a highly energetic organ, it more vulnerable caused by OS thus its contribution development progression chronic disease (CKD). This article aims review mtROS CKD function deterioration.

Language: Английский

Citations

272
Healthful aging mediated by inhibition of oxidative stress DOI
Stephen F. Vatner, Jie Zhang, Marko Oydanich

et al.

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 64, P. 101194 - 101194

Published: Oct. 19, 2020

Language: Английский

Citations

187
Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation DOI Creative Commons
Muthu Thiruvengadam, Baskar Venkidasamy, Umadevi Subramanian

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(12), P. 1859 - 1859

Published: Nov. 23, 2021

Oxidative stress is a pathological condition occurring due to an imbalance between the oxidants and antioxidant defense systems in body. Nuclear factor E2-related 2 (NRF2), encoded by gene NFE2L2, master regulator of phase II enzymes that protect against oxidative inflammation. NRF2/ARE signaling has been considered as promising target stress-mediated diseases like diabetes, fibrosis, neurotoxicity, cancer. The consumption dietary phytochemicals acts effective modulator various acute chronic diseases. In present review, we discussed role NRF2 Alzheimer’s disease (AD), Parkinson’s (PD), cancer, atherosclerosis. Additionally, curcumin, quercetin, resveratrol, epigallocatechin gallate, apigenin, sulforaphane, ursolic acid have effectively modified prevented both vitro vivo models. Based on literature, it clear can prevent (1) blocking stress-inhibiting inflammatory mediators through inhibiting Keap1 or activating Nrf2 expression its downstream targets nucleus, including HO-1, SOD, CAT; (2) regulating kinases GSK3beta, PI3/AKT, MAPK; (3) modifying epigenetic modulation, such methylation, at promoter region; however, further investigation into other upstream molecules effect them still need be investigated near future.

Language: Английский

Citations

153
Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases DOI Creative Commons
Ana Karina Aranda‐Rivera, Alfredo Cruz‐Gregorio, Omar Emiliano Aparicio‐Trejo

et al.

Biomolecules, Journal Year: 2021, Volume and Issue: 11(8), P. 1144 - 1144

Published: Aug. 3, 2021

Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) produced. ROS function as secondary messengers, inducing redox-sensitive post-translational modifications (PTM) proteins activating or deactivating different cell signaling pathways. However, overproduction causes oxidative stress (OS), dysfunction altering its metabolism dynamics. The latter processes closely related changes the pathways, causing inflammation apoptosis death. Although production, OS have been studied role of redox pathways mitochondria has not addressed. This review focuses on dynamics through dysregulation diseases.

Language: Английский

Citations

134
Interplay of oxidative stress, cellular communication and signaling pathways in cancer DOI Creative Commons
Muhammad Javed Iqbal,

Ayesha Kabeer,

Zaighum Abbas

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 2, 2024

Abstract Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays critical role in development cancer affecting genomic stability signaling pathways cellular microenvironment. Elevated levels ROS disrupt homeostasis contribute to loss normal functions, which are associated initiation progression various types cancer. In this review, we have focused on elucidating downstream that influenced oxidative stress carcinogenesis. These include p53, Keap1-NRF2, RB1, p21, APC, tumor suppressor genes, cell type transitions. Dysregulation these can lead uncontrolled growth, impaired DNA repair mechanisms, evasion death, all hallmark features development. Therapeutic strategies aimed at targeting emerged as area investigation for molecular biologists. The objective is limit response time cancer, including liver, breast, prostate, ovarian, lung cancers. By modulating redox balance restoring homeostasis, it may be possible mitigate damaging effects enhance efficacy treatments. targeted therapies interventions specifically address impact holds great promise improving patient outcomes. approaches antioxidant-based treatments, redox-modulating agents, restore function affected stress. summary, understanding carcinogenesis process through therapeutic utmost importance combating Further research needed unravel complex mechanisms underlying stress-related develop effective translated into clinical applications management treatment

Language: Английский

Citations

115
Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease DOI Creative Commons
Hsin‐Jung Ho, Hitoshi Shirakawa

Cells, Journal Year: 2022, Volume and Issue: 12(1), P. 88 - 88

Published: Dec. 25, 2022

The kidney contains many mitochondria that generate ATP to provide energy for cellular processes. Oxidative stress injury can be caused by impaired with excessive levels of reactive oxygen species. Accumulating evidence has indicated a relationship between oxidative and diseases, revealed new insights into mitochondria-targeted therapeutics renal injury. Improving mitochondrial homeostasis, increasing biogenesis, balancing turnover the potential protect function against stress. Although there are some reviews addressed this issue, articles summarizing effects risk factors failure still few. In review, we integrate recent studies on in especially chronic disease. We organized causes kidneys based their effects. This review also listed possible candidates clinical diseases modulating function.

Language: Английский

Citations

113
NADPH oxidase family proteins: signaling dynamics to disease management DOI

Rizwana Begum,

Shilpa Thota,

Abubakar Abdulkadir

et al.

Cellular and Molecular Immunology, Journal Year: 2022, Volume and Issue: 19(6), P. 660 - 686

Published: May 18, 2022

Language: Английский

Citations

80
Oxidative stress and antioxidants in health and disease DOI Creative Commons
Tuğba Raika Kıran, Önder Otlu, Aysun Bay Karabulut

et al.

Journal of Laboratory Medicine, Journal Year: 2023, Volume and Issue: 47(1), P. 1 - 11

Published: Feb. 1, 2023

Abstract The increase in the formation of reactive oxygen and nitrogen species endogenous or exogenous origin causes oxidative stress due to pro-oxidant antioxidant imbalance that cellular damage metabolism. This can inflammation cells, apoptosis necrosis, DNA base damage, protein cross-links, lipid membrane peroxidation, mitochondrial dysfunction. Antioxidants be described as a system protects biomolecules organism against harmful effects free radicals, reduces repairs done by (ROS) target molecule, this is called defense. It known mechanisms caused ROS resulting from are positively related pathology many diseases such cancer, metabolic syndrome, atherosclerosis, malaria, Alzheimer’s disease, rheumatoid arthritis, neurodegenerative preeclampsia.

Language: Английский

Citations

73
Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies DOI Open Access
M. A. Darenskaya, С. И. Колесников, Н. В. Семенова

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12378 - 12378

Published: Aug. 3, 2023

Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates increases in prevalence. Diabetic nephropathy (DN) is a specific kind kidney damage that occurs 40% patients DM and considered serious complication DM. Most modern methods for treatments aimed at slowing down progression DN have side effects do not produce unambiguous positive results long term. This fact has encouraged researchers search additional or alternative treatment methods. Hyperglycemia negative effect on renal structures due number factors, including activation polyol hexosamine glucose metabolism pathways, renin-angiotensin-aldosterone sympathetic nervous systems, accumulation advanced glycation end products insulin resistance endothelial dysfunction tissues. The above mechanisms cause development oxidative stress (OS) reactions mitochondrial dysfunction, which turn contribute DN. Modern antioxidant therapies involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), are widely used only diabetes but also other systemic diseases. It been suggested therapeutic approaches target source reactive oxygen species may certain advantages terms nephroprotection from OS. review describes significance studies OS biomarkers pathogenesis analyzes reducing intensity prevention

Language: Английский

Citations

45
Antioxidant activities of reissantia indica willd. (mopane paddle-pod) and nephroprotective effect on paracetamol-induced nephrotoxicity in male wistar rats DOI
Great Iruoghene Edo, Ufuoma Ugbune, Favour Ogheneoruese Onoharigho

et al.

Nutrire, Journal Year: 2023, Volume and Issue: 48(1)

Published: May 15, 2023

Language: Английский

Citations

41