Pharmacomicrobiomics in Western Medicine and Traditional Chinese Medicine in Type 2 Diabetes DOI Creative Commons
Natural Chu, Juliana C.N. Chan, Elaine Chow

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: May 4, 2022

Pharmacomicrobiomics refers to the interactions between foreign compounds and gut microbiome resulting in heterogeneous efficacy, side effects, toxicity of compound concerned. Glucose lowering drugs reduce blood glucose by modulating insulin secretion its actions as well redistributing energy disposal. Apart from genetic, ecological, lifestyle factors, maintaining an equilibrium whole has been shown improve human health. Microbial fingerprinting using faecal samples indicated ‘invisible phenotype’ due different compositions microbiota which might orchestrate patients’ phenotypes their responses glucose-lowering drugs. In this article, we summarize current evidence on differences composition individuals with type 2 diabetes (T2D) healthy individuals, disruption balance beneficial pathogenic was patients T2D how Western Medicine (WM) Traditional Chinese (TCM) re-shape benefits host immunity metabolic We particularly highlighted effects both WM TCM increase relative abundance health promoting bacteria, such as, Akkermansia muciniphila , Blautia, Bifidobacterium adolescentis have implicated (T2D). Several lines suggested that complement efficacy through alteration warrants further investigation our pursuit prevention control T2D.

Language: Английский

Mulberry leaf polysaccharides ameliorate glucose and lipid metabolism disorders via the gut microbiota-bile acids metabolic pathway DOI

Hongyu Dai,

Ziyi Shan,

Lu Shi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136876 - 136876

Published: Oct. 30, 2024

Language: Английский

Citations

8
A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and regulating gut microbiota composition DOI
Wu Luo, Jiali Zhou, Xiao Yang

et al.

Food Research International, Journal Year: 2022, Volume and Issue: 161, P. 111744 - 111744

Published: July 28, 2022

Language: Английский

Citations

25
Intestinal microbiome diversity of diabetic and non-diabetic kidney disease: Current status and future perspective DOI
Soumik Das, Gnanasambandan Ramanathan

Life Sciences, Journal Year: 2023, Volume and Issue: 316, P. 121414 - 121414

Published: Jan. 19, 2023

Language: Английский

Citations

14
Enteric neuropathy in diabetes: Implications for gastrointestinal function DOI
Mona Mohamed Ibrahim Abdalla

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(22), P. 2852 - 2865

Published: June 5, 2024

Diabetes, commonly known for its metabolic effects, also critically affects the enteric nervous system (ENS), which is essential in regulating gastrointestinal (GI) motility, secretion, and absorption. The development of diabetes-induced neuropathy can lead to various GI dysfunctions, such as gastroparesis irregular bowel habits, primarily due disruptions function neuronal glial cells within ENS, well oxidative stress inflammation. This editorial explores pathophysiological mechanisms underlying diabetic patients. Additionally, it discusses latest advances diagnostic approaches, emphasizing need early detection intervention mitigate complications individuals. reviews current emerging therapeutic strategies, focusing on pharmacological treatments, dietary management, potential neuromodulatory interventions. Ultimately, this highlights necessity a multidisciplinary approach managing diabetes, aiming enhance patient quality life address frequently overlooked complication widespread disease.

Language: Английский

Citations

5
Exploring the interplay between antiretroviral therapy and the gut-oral microbiome axis in people living with HIV DOI Creative Commons
Aswathy Narayanan, Oscar Kieri,

Jan Vesterbacka

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 1, 2024

Abstract The gut and oral microbiome is altered in people living with HIV (PLWH). While antiretroviral treatment (ART) pivotal restoring immune function PLWH, several studies have identified an association between specific antiretrovirals, particularly integrase inhibitors (INSTI), weight gain. In our study, we explored the differences microbiota of PLWH under different ART regimens, its correlation to Body Mass Index (BMI). Fecal salivary samples were collected from (n = 69) healthy controls (HC, n 80). We performed taxonomy analysis determine microbial composition relationship abundance BMI, CD4 + T-cell count, CD4/CD8 ratio, duration. showed significantly lower richness compared HC both environment. INSTI-treated individuals was enriched Faecalibacterium Bifidobacterium , whereas non-nucleotide reverse transcriptase inhibitor (NNRTI)-treated Gordonibacter Megasphaera, Staphylococcus . microenvironment, Veillonella more abundant Fusobacterium Alloprevotella NNRTI-treated individuals. Furthermore, Dorea milieu high BMI. Collectively, findings identify distinct profiles, which are associated regimens BMI on successful ART, thereby highlighting significant effects antiretrovirals microbiome.

Language: Английский

Citations

5
Gut Microbiome Analysis Can Be Used as a Noninvasive Diagnostic Tool and Plays an Essential Role in the Onset of Membranous Nephropathy DOI Creative Commons
Jin Shang, Yiding Zhang, Ruixue Guo

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(28)

Published: Aug. 17, 2022

Abstract Membranous nephropathy (MN) is a common cause of nephrotic syndrome. The aim to establish non‐invasive diagnostic model MN using differential gut microbiome analysis, and explore the relationship between pathogenesis in vivo. 825 fecal samples from patients healthy participants are collected multiple medical centers across China. Key operational taxonomic units (OTUs) obtained through 16S rRNA sequencing used model. A rat developed MN. diversity richness significantly lower with than individuals. based on seven OTUs achieves an excellent efficiency 98.36% training group also high cross‐regional cohorts. In model, elimination prevents establishment, but transplantation restores phenotype protein urine. Gut analysis can be as tool for diagnosis. onset depends presence naturally colonized microbiome. Early intervention may help reduce urinary level

Language: Английский

Citations

20
Causal relationship between kidney stones and gut microbiota contributes to the gut-kidney axis: a two-sample Mendelian randomization study DOI Creative Commons
Minghui Liu, Youjie Zhang, Jian Wu

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 12, 2023

Background Gut microbiota, particularly Oxalobacter formigenes , has been previously reported to be associated with kidney stones. However, the conflicting results from both observational and intervention studies have created substantial uncertainty regarding contribution of formation stone. Methods We employed a two-sample MR analysis investigate causal relationship between gut microbiota stones using GWASs summary statistics obtained MiBioGen FinnGen consortia. Moreover, we conducted reserve assess direction associations The inverse variance weighted (IVW) approach represents primary method Mendelian Randomization (MR) analysis. Results Our analyses do not yield supportive evidence for link genus Oxalobacte r (OR = 0.99, 95% CI: 0.90–1.09, p 0.811) order Actinomycetales 0.79, 0.65–0.96, 0.020), family Actinomycetaceae 0.019), Clostridiaceae 1 0.80, 0.67–0.96, 0.015), Clostridiumsensustricto 0.81, 0.67–0.98, 0.030) Hungatella 0.86, 0.74–0.99, 0.040) had protective effects on stones, Haemophilus 1.16, 1.01–1.33, 0.032), Ruminococcaceae (UCG010) 1.38, 1.04–1.84, 0.028), Subdoligranulum 1.27, 1.06–1.52, 0.009) were risk factors Differential abundance provide no association showed Reverse did indicate any microbiota. No considerable heterogeneity instrumental variables or horizontal pleiotropy was observed. Conclusion study find does solely depend presence / . A more integrated multiple omics platforms is needed better understand pathogenesis in context complex gene–environment interactions over time.

Language: Английский

Citations

11
White common bean extract remodels the gut microbiota and ameliorates type 2 diabetes and its complications: A randomized double-blinded placebo-controlled trial DOI Creative Commons

Yuwei Feng,

Jie Zhu,

Qinyue Wang

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 11, 2022

Objective Excessive carbohydrate intake is a high risk factor for increased morbidity of type 2 diabetes (T2D). A novel regimen the dietary care that consists highly active α-amylase inhibitor derived from white common bean extract (WCBE) and sufficient carbohydrates was applied to attenuate T2D its complications. Furthermore, role gut microbiota in this remission also investigated. Methods We conducted 4-month randomized double-blinded placebo-controlled trial. During intense intervention period, ninety subjects were randomly assigned control group (Group C) WCBE W). Subjects Group C supplemented with 1.5 g maltodextrin as placebo. W took half an hour before meal. Fifty-five participants continued maintenance receiving previous whereas less frequent follow-up. The variation biochemical, vasculopathy neuropathy indicators structure fecal during analyzed. Result Glucose metabolism diabetic complications showed superior 0.721 ± 0.742% decline glycosylated hemoglobin after 4 months. proportion patients peripheral (Toronto Clinical Scoring System, TCSS ≥ 6) significantly lower than C. Both left right sural sensory nerve conduction velocity (SNCV-left SNCV-right sural) slightly decreased W. Additionally, abundances Bifidobacterium , Faecalibacterium Anaerostipes higher W, Weissella Klebsiella Cronobacter Enterobacteriaceae_unclassified those at month 2. At end 4, remained more abundant Conclusion To our knowledge, first report improvement by using supplement such short-term period. enrichment SCFA-producing bacteria might be responsible attenuation trial registration number http://www.chictr.org.cn/edit.aspx?pid=23309&htm=4 identifier ChiCTR-IOR-17013656

Language: Английский

Citations

18
A novel approach to finding the compositional differences and biomarkers in gut microbiota in type 2 diabetic patients via meta-analysis, data-mining, and multivariate analysis DOI
Faezeh Ebrahimi, Hadi Maleki, Mansour Ebrahimi

et al.

Endocrinología Diabetes y Nutrición, Journal Year: 2025, Volume and Issue: unknown, P. 501561 - 501561

Published: March 1, 2025

Language: Английский

Citations

0
The relationship between gut microbiome and human diseases: mechanisms, predisposing factors and potential intervention DOI Creative Commons
Mohammad Shabani,

Ali Ghoshehy,

Azadeh Mottaghi

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 6, 2025

The complex interrelation of gut microbiota with human health underlines the profound influence this microbial ecosystem has on mechanisms disease and wellness. microbiome profoundly impacts various diseases, encompassing gastrointestinal disorders, metabolic neurological immune-related diseases. Gastrointestinal disorders are closely linked to imbalances in gut. Metabolic including obesity type 2 diabetes, influenced by microbiota's role energy regulation glucose metabolism. Furthermore, gut-brain axis highlights correlation between conditions such as Alzheimer's Parkinson's. Moreover, assumes a pivotal function regulating immune system, whereby dysbiosis is implicated developing immunological-related ailments, allergies autoimmune disorders. Predisposing factors, diet, medicines, lifestyle, environmental influences, described having an important composition microbiome. By understanding these we can get valuable insights into how intervene reduce chances disease. Current interventions, probiotics, prebiotics, fecal transplants, lifestyle modification, show promise, but there still challenges unanswered questions evolving field that may lead improvements. This review interrelates complicated mechanisms, predisposing potential interventions.

Language: Английский

Citations

0