Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 309, P. 116306 - 116306

Published: Feb. 27, 2023

Language: Английский

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Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 21, 2023

Diabetic nephropathy (DN) often leads to end-stage renal disease. Oxidative stress demonstrates a crucial act in the onset and progression of DN, which triggers various pathological processes while promoting activation inflammation forming vicious oxidative stress-inflammation cycle that induces podocyte injury, extracellular matrix accumulation, glomerulosclerosis, epithelial-mesenchymal transition, tubular atrophy, proteinuria. Conventional treatments for DN have limited efficacy. Polyphenols, as antioxidants, are widely used with multiple targets fewer adverse effects. This review reveals stress-associated led damage cells, including podocytes, endothelial mesangial epithelial cells. It potent antioxidant anti-inflammatory properties by targeting Nrf2, SIRT1, HMGB1, NF-κB, NLRP3 polyphenols, quercetin, resveratrol, curcumin, phenolic acid. However, there remains long way comprehensive understanding molecular mechanisms applications clinical therapy polyphenols.

Language: Английский

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Diabetic nephropathy: Focusing on pathological signals, clinical treatment, and dietary regulation

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114252 - 114252

Published: Jan. 13, 2023

Diabetic nephropathy (DN) is one of the most severe complications diabetes. However, due to its complex pathological mechanisms, no effective therapeutic methods (other than ACEIs and ARBs) have been applied, which used for many years in clinical practice. Recent studies shown that emerging therapeutics, including novel target-based pharmacotherapy, cell therapies, dietary regulation, are leading new hopes DN management. This review aims shed light on treatment by describing important mechanisms analysing recent advances treatment, drug therapy, regulation. In RAAS activation, AGE accumulation, EMT involved inflammation, cellular stress, apoptosis, pyroptosis, autophagy. several SGLT2 inhibitors, GLP-1 agonists, MRAs, receiving public attention. addition, stem therapies regulation also being emphasized. Herein, we highlight importance combining therapy anticipate more basic research or trials verify strategies.

Language: Английский

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Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives

Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1227 - 1227

Published: Sept. 2, 2022

Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with increased prevalence and incidence. In addition to its macrovascular damage, through microvascular complications, such as Diabetic Kidney Disease (DKD), DM further compounds quality life these patients. Considering DKD main cause end-stage renal disease (ESRD) in developed countries, extensive research currently investigating matrix pathophysiology. Hyperglycemia, inflammation oxidative stress (OS) are mechanisms behind this disease. By generating pro-inflammatory factors (e.g., IL-1,6,18, TNF-α, TGF-β, NF-κB, MCP-1, VCAM-1, ICAM-1) activation diverse pathways PKC, ROCK, AGE/RAGE, JAK-STAT), they promote a pro-oxidant state impairment antioxidant system (NRF2/KEAP1/ARE pathway) and, finally, alterations filtration unit. Hitherto, wide spectrum pre-clinical clinical studies shows beneficial use NRF2-inducing strategies, NRF2 activators Bardoxolone methyl, Curcumin, Sulforaphane their analogues), other natural properties treatment. However, limitations regarding lack larger trials, solubility or delivery hamper implementation for use. Therefore, review, we will discuss mechanisms, especially NRF2/KEAP1/ARE involvement, while highlighting potential therapeutic approaches that target via OS.

Language: Английский

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Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113953 - 113953

Published: Nov. 7, 2022

Diabetic nephropathy (DN) is the leading cause of end‑stage renal disease. Although Ginkgo biloba extract has a protective effect on DN, and mechanism its active ingredient Ginkgolide B (GB) DN remain unclear. The aim present study was to investigate whether GB improves via alleviating oxidative stress ferroptosis by inhibiting GPX4 ubiquitination in PA-G-induced mouse podocytes mice. vitro showed that effectively reduced serum total cholesterol, triglyceride concentrations lipid accumulation MPC5 cells. In addition, promoted expression markers FTH1, while inhibited TfR1, fibrosis α-SMA Collagen α1, as well intracellular iron content ROS levels. Interference with siRNA counteracted GB. And dose-dependent manner. vivo experimental results hyperglycemia, cholesterol concentrations, urinary albumin excretion number droplets, improved changes structure marker TfR1 FTH1. conclusion, suggested may improve protecting kidney from damage GPX4. These findings GB, natural medicine, be an effective therapeutic option for DN.

Language: Английский

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Quercetin Ameliorates Diabetic Kidney Injury by Inhibiting Ferroptosis via Activating Nrf2/HO-1 Signaling Pathway

The American Journal of Chinese Medicine, Journal Year: 2023, Volume and Issue: 51(04), P. 997 - 1018

Published: Jan. 1, 2023

Diabetic nephropathy (DN) is thought to be the major cause of end-stage renal disease. Due its complicated pathogenesis and low efficacy DN treatment, a deep understanding new etiological factors may useful. Ferroptosis, nonapoptotic form cell death, characterized by accumulation iron-dependent lipid peroxides lethal levels. Ferroptosis-triggered tubular injury reported participate in development DN, blocking ferroptosis might an effective strategy prevent DN. Quercetin (QCT), natural flavonoid that present variety fruits vegetables, has been ameliorate However, underlying nephroprotective mechanism unclear. Herein, we explored antiferroptosic effect QCT verified using mice high glucose (HG)-incubated epithelial models. We found HG-induced abnormal activation cells, treatment inhibited downregulating expression transferrin receptor 1 (TFR-1) upregulating glutathione peroxidase 4 (GPX4), ferritin heavy chain (FTH-1), cystine/glutamate reverse antiporter solute carrier family 7 member (SLC7A11) HG-incubated HK-2 cells. Subsequently, both vitro vivo results confirmed activated NFE2-related factor 2 (Nrf2)/Heme oxygenase-1(HO-1) signaling pathway increasing levels Nrf2 HO-1. Therefore, this study supports inhibits cells regulating Nrf2/HO-1 pathway, providing novel insight into protective treatment.

Language: Английский

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A natural products solution to diabetic nephropathy therapy

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 241, P. 108314 - 108314

Published: Nov. 22, 2022

Language: Английский

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Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis

Renal Failure, Journal Year: 2022, Volume and Issue: 44(1), P. 862 - 880

Published: May 24, 2022

Aims The role of probiotics in the management diabetic kidney disease (DKD) has been shown. Several current trials are investigating effect probiotics, which widely used to modulate biomarkers renal function, glucose, lipids, inflammation and oxidative stress patients with DKD. However, their findings controversial. This study aimed systematically evaluate impact on DKD via meta-analysis.Methods PubMed, Cochrane Library, Web Science, Scopus, Embase, China National Knowledge Infrastructure, Chinese Wanfang Database VIP were searched for relevant studies from establishment these databases September 2021. pooled results evaluated indicators Additionally, subgroup analysis was performed based intervention duration, probiotic dose consumption patterns, respectively.Results Ten that included 552 participants identified analysis. Compared controls, significantly decreased serum creatinine (Scr) [WMD = −0.17 mg/dL; 95%CI −0.29, −0.05; p 0.004], blood urea nitrogen (BUN) −1.36 −2.20, −0.52; 0.001], cystatin C (Cys C) −29.50 ng/mL; −32.82, −26.18; < 0.00001], urinary albumin/creatinine ratio (UACR) −16.05 mg/g; −27.12, −4.99; 0.004] natrium (Na) −0.94 mmol/L; −1.82, 0.04] Enhanced glycemic control observed receiving compared as demonstrated by reduced levels fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), homeostasis model assessment-estimated insulin resistance (HOMA-IR), increased quantitative sensitivity check index (QUICKI). Probiotics affected lipid metabolism parameters decreasing triglycerides (TG), total cholesterol (TC) low-density lipoprotein (LDL-c) could also improve high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), antioxidant capacity (TAC), glutathione (GSH) nitric oxide (NO). showed those who received multiple species had a statistically significant difference BUN, FPG, HOMA-IR, high-density (HDL-c), MDA, TAC, NO. Meanwhile, Scr, LDL-c, HDL-c, TAC ameliorated when duration more than eight weeks MDA improved greater four billion CFU/day.Conclusions Our revealed delay progression function injury, metabolism, reduce Subgroup patterns an outcomes.

Language: Английский

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Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12378 - 12378

Published: Aug. 3, 2023

Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates increases in prevalence. Diabetic nephropathy (DN) is a specific kind kidney damage that occurs 40% patients DM and considered serious complication DM. Most modern methods for treatments aimed at slowing down progression DN have side effects do not produce unambiguous positive results long term. This fact has encouraged researchers search additional or alternative treatment methods. Hyperglycemia negative effect on renal structures due number factors, including activation polyol hexosamine glucose metabolism pathways, renin-angiotensin-aldosterone sympathetic nervous systems, accumulation advanced glycation end products insulin resistance endothelial dysfunction tissues. The above mechanisms cause development oxidative stress (OS) reactions mitochondrial dysfunction, which turn contribute DN. Modern antioxidant therapies involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), are widely used only diabetes but also other systemic diseases. It been suggested therapeutic approaches target source reactive oxygen species may certain advantages terms nephroprotection from OS. review describes significance studies OS biomarkers pathogenesis analyzes reducing intensity prevention

Language: Английский

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Ginsenosides from Panax ginseng as Key Modulators of NF-κB Signaling Are Powerful Anti-Inflammatory and Anticancer Agents

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6119 - 6119

Published: March 24, 2023

Nuclear factor kappa B (NF-κB) signaling pathways progress inflammation and immune cell differentiation in the host response; however, uncontrollable stimulation of NF-κB is responsible for several inflammatory illnesses regardless whether conditions are acute or chronic. Innate cells, such as macrophages, microglia, Kupffer secrete pro-inflammatory cytokines, TNF-α, IL-6, IL-1β, via activation subunits, which may lead to damage normal including neurons, cardiomyocytes, hepatocytes, alveolar cells. This results occurrence neurodegenerative disorders, cardiac infarction, liver injury, eventually systemic cancer. Recently, ginsenosides from

Language: Английский

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