Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 22
Published: Oct. 29, 2022
Increasing
evidence
suggests
that
disorders
of
inflammation,
oxidative
stress,
and
autophagy
contribute
to
the
pathogenesis
diabetic
kidney
disease
(DKD).
This
study
attempted
clarify
effect
allograft
inflammatory
factor-1
(AIF-1),
miR-34a,
ATG4B
on
in
DKD
both
vitro
vivo
experiments.
In
vivo,
it
was
found
levels
AIF-1,
factors
were
significantly
increased
blood
urine
samples
patients
mouse
models
correlated
with
level
urinary
protein.
vitro,
also
expressions
ROS,
increased,
while
other
related
proteins
decreased
human
renal
glomerular
endothelial
cells
(HRGECs)
cultured
high
concentration
glucose
medium
(30
mmol/L).
When
AIF-1
gene
overexpressed,
upregulated,
autophagy-related
such
as
downregulated,
downregulation
had
opposite
effect.
addition,
miR-34a
inhibited
expression
ROS
inflammation.
Furthermore,
result
luciferase
reporter
assay
suggested
target
miR-34a.
downregulated.
Conversely,
when
inhibited,
upregulated.
Then,
inducers
inflammation
whereas
inhibitors
function
HRGECs
induced
by
conclusion,
above
data
regulated
via
miR-34a/ATG4B
pathway
disease.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 114985 - 114985
Published: June 11, 2023
The
gut
microbiota
is
indispensable
for
maintaining
host
health
by
enhancing
the
host's
digestive
capacity,
safeguarding
intestinal
epithelial
barrier,
and
preventing
pathogen
invasion.
Additionally,
exhibits
a
bidirectional
interaction
with
immune
system
promotes
of
to
mature.
Dysbiosis
microbiota,
primarily
caused
factors
such
as
genetic
susceptibility,
age,
BMI,
diet,
drug
abuse,
significant
contributor
inflammatory
diseases.
However,
mechanisms
underlying
diseases
resulting
from
dysbiosis
lack
systematic
categorization.
In
this
study,
we
summarize
normal
physiological
functions
symbiotic
in
healthy
state
demonstrate
that
when
occurs
due
various
external
factors,
are
lost,
leading
pathological
damage
lining,
metabolic
disorders,
barrier
damage.
This,
turn,
triggers
disorders
eventually
causes
systems.
These
discoveries
provide
fresh
perspectives
on
how
diagnose
treat
unrecognized
variables
might
affect
link
between
illnesses
need
further
studies
extensive
basic
clinical
research
will
still
be
required
investigate
relationship
future.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 1314 - 1314
Published: Jan. 21, 2024
Mitochondria
are
critical
for
providing
energy
to
maintain
cell
viability.
Oxidative
phosphorylation
involves
the
transfer
of
electrons
from
substrates
oxygen
produce
adenosine
triphosphate.
also
regulate
proliferation,
metastasis,
and
deterioration.
The
flow
in
mitochondrial
respiratory
chain
generates
reactive
species
(ROS),
which
harmful
cells
at
high
levels.
stress
caused
by
ROS
accumulation
has
been
associated
with
an
increased
risk
cancer,
cardiovascular
liver
diseases.
Glutathione
(GSH)
is
abundant
cellular
antioxidant
that
primarily
synthesized
cytoplasm
delivered
mitochondria.
Mitochondrial
glutathione
(mGSH)
metabolizes
hydrogen
peroxide
within
A
long-term
imbalance
ratio
mGSH
can
cause
dysfunction,
apoptosis,
necroptosis,
ferroptosis,
may
lead
disease.
This
study
aimed
review
physiological
functions,
anabolism,
variations
organ
tissue
accumulation,
delivery
GSH
mitochondria
relationships
between
levels,
GSH/GSH
disulfide
(GSSG)
ratio,
programmed
death,
ferroptosis.
We
discuss
diseases
deficiency
related
therapeutics.
Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
185, P. 106520 - 106520
Published: Oct. 20, 2022
The
globally
escalating
diabetes
epidemic
is
responsible
for
significant
morbidity
and
mortality.
Microbiome-modulating
nutraceuticals
have
been
investigated
their
potential
to
restore
metabolic
floral
homeostasis
in
type
2
diabetic
patients
METHODS:
A
systematic
review,
meta-analyses
meta-regressions
were
conducted
investigate
the
effect
of
probiotics,
prebiotics,
synbiotics
on
various
biomarkers
glucose
based
a
multi-database
search
clinical
trials
published
through
April
10,
2022.
Data
was
pooled
using
random
effects
reported
as
mean
differences
with
95%
confidence
intervals
(CIs),
followed
by
univariate
linear
model
meta-regression.Data
from
68
trial
comparisons
across
58
studies
(n
=
3835)
revealed
that,
compared
placebo/control
group,
administration
pro/pre/synbiotics
associated
statistically
changes
fasting
plasma
(-12.41
mg/dl
[95%
CI:
-15.94;
-8.88],
p
0.0001),
glycated
hemoglobin
(-0.38%
-0.47;
-0.30],
insulin
(-1.49
µU/mL
-2.12;
-0.86],
HOMA-IR
(-0.69
-1.16;
-0.23],
0.0031)
QUICKI
(0.0148
0.0052;
0.0244],
0.0025),
but
not
C-peptide
(-0.0144
ng/mL
-0.2564;
-0.2275],
0.9069).
Age,
baseline
BMI,
biomarker
value,
pro/prebiotic
dosage,
duration,
nutraceutical
type,
recruitment
region
significantly
affected
use
personalized
adjunct
therapy.
Lastly,
we
discuss
unexplained
observations
directives
future
trials,
aim
maximizing
our
understanding
how
microbiome-modulating
can
treat
diseases
CONCLUSIONS:
Pro/pre/synbiotic
supplementation
improved
patients.
Our
results
support
therapy
improving
glycemia
insulinemia
alongside
pharmacological
therapeutics.
Current Nutrition Reports,
Journal Year:
2024,
Volume and Issue:
13(2), P. 251 - 263
Published: March 12, 2024
Abstract
Purpose
of
Review
Modulation
the
host
microbiota
through
probiotics
has
been
shown
to
have
beneficial
effects
on
health
in
growing
body
research.
Exercise
increases
amount
and
diversity
microorganisms
microbiome.
Although
low-
moderate-intensity
exercise
reduce
physiological
stress
improve
immune
function,
high-intensity
prolonged
can
suppress
function
microbial
due
intestinal
hypoperfusion.
The
effect
probiotic
supplementation
sports
performance
is
still
being
studied;
however,
questions
remain
regarding
mechanisms
action,
strain
used,
dose.
In
this
review,
aim
was
investigate
supplements
modulation
gut
alleviation
GI
symptoms,
promotion
system,
bioavailability
nutrients,
aerobic
metabolism.
Recent
Findings
Probiotic
may
by
reducing
adverse
exercise.
Summary
reported
positive
performance,
information
about
microbiome
nutrition
athletes
not
considered
most
current
studies.
This
limited
evaluation
performance.
Pharmaceutical Biology,
Journal Year:
2024,
Volume and Issue:
62(1), P. 423 - 435
Published: May 17, 2024
Context
Diabetic
kidney
disease
(DKD)
affects
nearly
40%
of
diabetic
patients,
often
leading
to
end-stage
renal
that
requires
replacement
therapies,
such
as
dialysis
and
transplantation.
The
gut
microbiota,
an
integral
aspect
human
evolution,
plays
a
crucial
role
in
this
condition.
Traditional
Chinese
medicine
(TCM)
has
shown
promising
outcomes
ameliorating
DKD
by
addressing
the
microbiota.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1773 - 1773
Published: Feb. 19, 2025
The
human
microbiota,
a
complex
ecosystem
of
microorganisms,
plays
pivotal
role
in
regulating
host
immunity
and
metabolism.
This
review
investigates
the
interplay
between
microbiota
inflammatory
markers,
emphasizing
their
impact
on
metabolic
autoimmune
disorders.
Key
biomarkers,
such
as
C-reactive
protein
(CRP),
interleukin-6
(IL-6),
lipopolysaccharides
(LPS),
zonulin
(ZO-1),
netrin-1
(Ntn1),
are
discussed
context
intestinal
barrier
integrity
chronic
inflammation.
Dysbiosis,
characterized
by
alterations
microbial
composition
function,
directly
modulates
levels
activity
these
exacerbating
responses
compromising
epithelial
barriers.
disruption
is
further
correlated
with
increased
permeability
inflammation,
serving
precursor
to
conditions
like
type
2
diabetes
(T2D),
obesity,
non-alcoholic
fatty
liver
disease.
Additionally,
this
examines
therapeutic
strategies,
including
probiotics
prebiotics,
designed
restore
balance,
mitigate
enhance
homeostasis.
Emerging
evidence
positions
microbiota-targeted
interventions
critical
components
advancement
precision
medicine,
offering
promising
avenues
for
diagnosing
treating
