Lactic acid bacteria-derived exopolysaccharide: Formation, immunomodulatory ability, health effects, and structure-function relationship

Microbiological Research, Journal Year: 2023, Volume and Issue: 274, P. 127432 - 127432

Published: June 8, 2023

Language: Английский

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The emerging role of oxidative stress in inflammatory bowel disease

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: July 15, 2024

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition that affects the digestive system and includes Crohn’s (CD) ulcerative colitis (UC). Although exact etiology of IBD remains uncertain, dysfunctional immunoregulation gut believed to be main culprit. Amongst immunoregulatory factors, reactive oxygen species (ROS) nitrogen (RNS), components oxidative stress event, are produced at abnormally high levels in IBD. Their destructive effects may contribute disease’s initiation propagation, as they damage lining activate inflammatory signaling pathways, further exacerbating inflammation. Oxidative markers, such malondialdehyde (MDA), 8-hydroxy-2’-deoxyguanosine (8-OHdG), serum-free thiols (R-SH), can measured blood stool patients with These markers elevated IBD, their correlate severity disease. Thus, used not only diagnosis but also monitoring response treatment. It targeted treatment through use antioxidants, including vitamin C, E, glutathione, N-acetylcysteine. In this review, we summarize role pathophysiology its diagnostic targets, potential application antioxidant therapies manage treat

Language: Английский

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Chrysanthemum morifolium as a traditional herb: A review of historical development, classification, phytochemistry, pharmacology and application

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 330, P. 118198 - 118198

Published: April 14, 2024

Language: Английский

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Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis

Medical Science Monitor, Journal Year: 2022, Volume and Issue: 28

Published: Aug. 10, 2022

Diabetic nephropathy is a common complication of type I and II diabetes, in which renal glomeruli are destroyed, resulting damage, proteinuria, hypertension. Apoptosis, autophagy, necroptosis 3 forms programmed cell death that have been implicated the pathogenesis diabetic nephropathy. Apoptosis podocytes leads to glomerular injury podocyte depletion, associated with proteinuria structural damage Additionally, epithelial cells proximal convoluted tubules also undergo apoptosis nephropathy, leading tubular atrophy, causes depletion subsequent formation atubular association loss function. On other hand, insufficiency autophagy has correlated For instance, decreased autophagic activity shown kidney, causing variations function disruption filtration barrier. Furthermore, attenuated demonstrated buildup impaired molecules organelles, normally broken down by proteinuria. Moreover, might key role decline Thus, this article aims review mechanisms effects including roles apoptosis, necroptosis.

Language: Английский

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STAYGREEN‐mediated chlorophyll a catabolism is critical for photosystem stability during heat‐induced leaf senescence in perennial ryegrass

Plant Cell & Environment, Journal Year: 2022, Volume and Issue: 45(5), P. 1412 - 1427

Published: Feb. 22, 2022

Abstract Suppression of the chlorophyll a (Chl a) Mg‐dechelatase gene, SGR / NYE1 , blocks degradation Chl a, resulting in ‘stay‐green’ trait. In this study, we investigated effect catabolism on plant heat‐induced leaf senescence perennial ryegrass ( Lolium perenne L.). Under heat stress, LpSGR ‐RNAi lines not only lost stay‐green phenotype but also showed accelerated with increased chloroplast disruption, more loss photosystem (PS) proteins, lower PSⅡ quantum yields, higher levels energy dissipation, accumulation reactive oxygen species (ROS) and ROS‐scavenging enzyme activities. Transcriptome analysis revealed that suppression downregulated genes encoding PS proteins enzymes upregulated those ROS‐generation under stress. To account for possible side‐effects from constitutive growth tolerance, constructed an ethanol‐inducible RNAi vector to suppress functions. absence ethanol induction, these exhibited same tolerance as wildtype (WT). Upon transgenic compromised postharvest phenotype. Taken together, SGR‐mediated is required tolerance.

Language: Английский

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Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways

Journal of bone oncology, Journal Year: 2022, Volume and Issue: 33, P. 100415 - 100415

Published: Feb. 2, 2022

Language: Английский

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Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1349 - 1349

Published: July 11, 2022

Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration and cancer, which are closely associated with intracellular signal transducers such as reactive oxygen species (ROS). It has been suggested that ROS is the upstream regulator autophagy, it provides negative feedback regulation remove oxidative damage. Defects in ROS-autophagic redox homeostasis increased production accumulation damaged organelles turn promote metabolic reprogramming induce tumorigenesis. One significant characteristic pancreatic cancer cellular energy metabolism, facilitates rapid growth, invasiveness, survival cells. Thus, rectification dysfunction essential therapeutic targeting. Isoliquiritigenin (ISL) chalcone obtained from plant Glycyrrhiza glabra, powdered root licorice consumed for centuries different regions world. ISL known be natural antioxidant possesses diversified functions, This review contains discussions on herbal source, biological properties, anticancer potential ISL. first time activities elucidated, coverage involvement antioxidation, regulation, autophagy development. Furthermore, some remarks related compounds isoflavonoid biosynthetic pathway will also discussed.

Language: Английский

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Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 735 - 735

Published: March 16, 2023

Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways moderate the defects of these during their evolution. The company Kelch-like ECH-associated protein 1 (Keap1) as molecular sensing element oxidative and electrophilic stress nuclear erythroid 2 (NF-E2)-related (Nrf2) master transcriptional regulator antioxidant response makes cytoprotective pathway known Keap1/Nrf2 pathway. This is dual-edged sword with beneficial features for both normal cancer cells regulating gene expression array endogenous enzymes. Heme oxygenase-1 (HO-1), critical enzyme toxic heme removal, one clear state indicators duality this Therefore, Nrf2/HO-1 axis targeting novel strategy treatment. In review, mechanism action natural antioxidants on lung has investigated relying axis.

Language: Английский

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A 0D-2D Heterojunction Bismuth Molybdate-Anchored Multifunctional Hydrogel for Highly Efficient Eradication of Drug-Resistant Bacteria

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15568 - 15589

Published: Aug. 2, 2023

Due to the increasing antibiotic resistance and lack of broad-spectrum antibiotics, there is an urgent requirement develop fresh strategies combat multidrug-resistant pathogens. Herein, defect-rich bismuth molybdate heterojunctions [zero-dimensional (0D) Bi4MoO9/two-dimensional (2D) Bi2MoO6, MBO] were designed for rapid capture bacteria synergistic photocatalytic sterilization. The as-prepared MBO was experimentally theoretically demonstrated possess defects, heterojunctions, irradiation triple-enhanced activity efficient generation reactive oxygen species (ROS) due exposure more active sites separation effective electron-hole pairs. Meanwhile, dopamine-modified (pMBO) achieved a positively charged rough surface, which conferred strong bacterial adhesion physical penetration nanosheets, effectively trapping within damage range enhancing ROS damage. Based on this potent antibacterial ability pMBO, multifunctional hydrogel consisting poly(vinyl alcohol) cross-linked tannic acid-coated cellulose nanocrystals (CPTB) namely CPTB@pMBO, developed convincingly against methicillin-resistant Staphylococcus aureus in mouse skin infection model. In addition, strategy combining failed beta-lactam with CPTB@pMBO photoinactivation no observed developed, presented idea address issue explore facile anti-infection methods. can reduce excessive proteolysis tissue inflammatory response by regulating expression genes pro-inflammatory factors invivo, holding great potential treatment wound infections caused drug-resistant bacteria.

Language: Английский

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The crosstalk between Nrf2 and NF-κB pathways in coronary artery disease: Can it be regulated by SIRT6?

Life Sciences, Journal Year: 2023, Volume and Issue: 330, P. 122007 - 122007

Published: Aug. 5, 2023

Language: Английский

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