Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102747 - 102747
Published: April 7, 2025
Language: Английский
Foods, Journal Year: 2025, Volume and Issue: 14(1), P. 137 - 137
Published: Jan. 6, 2025
Background: Ulcerative colitis (UC) is a chronic intestinal disease of growing global concern. Bacteria associated with fermented food or probiotics regulate immune and inflammatory responses, playing key role in homeostasis. Results: Five relatively good antioxidant effects, namely Lactiplantibacillus plantarum H6, Latilactobacillus sakei QC9, Limosilactobacillus fermentum E7, Bacillus subtills D1, licheniformis Q13, were screened out from 30 strains through vitro assays. The five had varying degrees alleviating effects on UC mice improved various physiological indicators, such as oxidative stress parameters histopathological sections. Q13 more pronounced. Furthermore, E7 effectively regulated mouse microbiota composition, increased short-chain fatty acid concentration, promoted the expression anti-inflammatory factors, interleukin 10 (IL-10), while suppressing that pro-inflammatory 1β (IL-1β), 6 (IL-6), tumor necrosis factor α (TNF-α). Meanwhile, D1 only exhibited partial effects. Finally, tight junction proteins colon tissues. Conclusions: showed superior efficacy to other UC, offering novel therapeutic prospects for safer effective management UC.
Language: Английский
Citations
1
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189271 - 189271
Published: Jan. 1, 2025
Language: Английский
Citations
1
Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 22, 2025
Leuconostoc mesenteroides (L. mesenteroides) has known as an electrogenic probiotic bacterium. However, metabolites related to electro-fermentation in ferments of L. are not unveiled. Electrogenic fermentatively metabolized bovine milk dense with homogeneous particle-size distribution. A non-targeted metabolomics approach was performed on non-fermented and mesenteroides-fermented milk. total 917 were identified quantified by ultra-high performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS-MS). Thirteen prokaryotic metabolic pathways associated differentially expressed (DEMs) revealed through Koto Encyclopedia Genes Genomes (KEGG) enrichment analysis. Anthranilic acid (AA) 3-hydroxyanthranilin (3-HAA), potentially electron donors, quinolinic acid, donor precursor, the tryptophan kynurenine pathway significantly increased fermented Histidine, arginine, riboflavin involved bacterial survival or bioelectricity production elevated after fermentation. Results indicate that can mediate transform a new nutritional source which is rich donors reportedly acting antioxidants.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 508, P. 160962 - 160962
Published: Feb. 25, 2025
Language: Английский
Citations
1
Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103569 - 103569
Published: March 1, 2025
Nuclear factor erythroid 2-related 2 (NRF2) is a redox-activated transcription regulating cellular defense against oxidative stress, thereby playing pivotal role in maintaining homeostasis. Its dysregulation implicated the progression of wide array human diseases, making NRF2 compelling target for therapeutic interventions. However, challenges persist drug discovery and safe targeting NRF2, as unresolved questions remain especially regarding its context-specific diseases off-target effects. This comprehensive review discusses dualistic disease pathophysiology, covering protective and/or destructive roles autoimmune, respiratory, cardiovascular, metabolic well digestive system cancer. Additionally, we also development drugs that either activate or inhibit discuss main barriers translating NRF2-based therapies from bench to bedside, consider ways monitor activation vivo.
Language: Английский
Citations
1
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 19, 2025
Background Metformin, hypoglycemic medication, is recognized for its diverse properties and capacity to influence the inflammatory pathways. Medications with anti-inflammatory anti-oxidative characteristics have been demonstrated be able elicit sustain remission in ulcerative colitis (UC), chronic disorder of bowel. Studies both preclinical clinical settings looked into several metabolic pathways via which metformin protects against UC. Aim To assess efficacy as adjunctive therapy patients mild moderate Methods This research was double-blinded, randomized, controlled, involved 60 The participants were randomly assigned one two groups (n = 30). control group given 1 g mesalamine three times a day (t.i.d.) period 6 months (mesalamine group). 500 mg twice daily t. i.d. For months. Patients UC assessed by gastroenterologist using disease activity index (DAI) at beginning treatment thereafter. evaluate drug’s biological efficacy, measurements fecal calprotectin, serum C-reactive protein (CRP), interleukin 10 (IL-10), nitric oxide (NO) taken before after treatment. Study outcomes Decrease DAI change level measured markers. Results displayed statistical reduction ( p 0.0001), CRP 0.019), NO 0.04), calprotectin 0.027), well significant increase IL-10 0.04) when compared group. There direct correlation between (p < 0.0001, r 0.551), 0.794). negative 0.0003, 0.371). Conclusion Metformin may an effective adjunct drug management decreasing other markers that pathogenesis Clinical Trial Registration identifier NCT05553704.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148
Published: March 28, 2025
Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing
Language: Английский
Citations
1
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 547 - 547
Published: Jan. 31, 2025
Background: Ferroptosis is a regulated cell death process linked to various diseases. This study explored whether Epigallocatechin-3-gallate (EGCG), tea-derived antioxidant, could regulate ferroptosis alleviate dextran sulfate sodium (DSS)-induced colitis. Methods: A DSS-induced colitis model was used assess EGCG’s effects. markers, oxidative stress, and iron metabolism were evaluated, alongside Nrf2-GPX4 pathway activation ferritin (FTH/L) expression. Results: Iron dysregulation stress contributed by activating in colonic epithelial cells. EGCG supplementation inhibited ferroptosis, reducing damage. Mechanistically, activated the pathway, enhancing antioxidant defense, improved upregulating Conclusions: effectively suppressed colitis, highlighting its potential as inhibitor therapeutic agent.
Language: Английский
Citations
0
Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
Background In our previous research, we addressed the issues of poor stability and water solubility scutellarin by developing nanoparticles. Our findings indicated that these nanoparticles exhibited enhanced anti-colon cancer activity compared to alone. However, underlying mechanisms scutellarin’s effects require further investigation. Scutellarin is known suppress proliferation different tumor cells. this study, explored whether scutellarin, encapsulated in nanoparticles, could colon cells modulating ferroptosis. Purpose Methods SW480 HCT-116 were divided into (a) control group, group; (b) ferrostatin-1 + group. First, determined half-maximal inhibitory concentration Cell Counting Kit-8 (CCK-8) assay. Then, ferroptosis each group was detected, levels oxidative stress-related factors, superoxide dismutase (SOD) malondialdehyde (MDA), detected biochemical kits. death terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, cell invasion Transwell reactive oxygen species (ROS) flow cytometry. Western blotting used detect ferroptosis-related glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11), ferroportin 1 (FPN1) expression levels. Results We found cells, IC50 lower, apoptosis more obvious, stress level also higher, Fe 2+ content increased, GPX4, SLC7A11, FPN1 decreased. These results changed after addition ferrostatin-1. Conclusion have a better anti-tumor effect than same dose scutellarin. can inhibit proliferation, migration, promoting ferroptosis, as well apoptosis.
Language: Английский
Citations
0
Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102848 - 102848
Published: March 8, 2025
Language: Английский
Citations
0