Fabry Disease: Cardiac Implications and Molecular Mechanisms DOI Creative Commons
David Weissman, Jan Dudek, Vasco Sequeira

et al.

Current Heart Failure Reports, Journal Year: 2024, Volume and Issue: 21(2), P. 81 - 100

Published: Jan. 30, 2024

Abstract Purpose of Review This review explores the interplay among metabolic dysfunction, oxidative stress, inflammation, and fibrosis in Fabry disease, focusing on their potential implications for cardiac involvement. We aim to discuss biochemical processes that operate parallel sphingolipid accumulation contribute disease pathogenesis, emphasizing importance a comprehensive understanding these processes. Recent Findings Beyond accumulation, emerging studies have revealed mitochondrial chronic inflammation could be significant contributors These factors promote remodeling may predispose patients conduction disturbances, ventricular arrhythmias, heart failure. While current treatments, such as enzyme replacement therapy pharmacological chaperones, address progression symptoms, effectiveness is limited. Summary Our uncovers relationships disease–related complications. Current findings suggest beyond other mechanisms significantly pathogenesis. prompts exploration innovative therapeutic strategies underscores holistic approach managing disease.

Language: Английский

The sirtuin family in health and disease DOI Creative Commons
Qi‐Jun Wu, Tie‐Ning Zhang,

Huanhuan Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 29, 2022

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, involved numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles members SIRT family health disease conditions. Notably, this protein plays a variety important cellular biology such as inflammation, metabolism, oxidative stress, apoptosis, etc., thus, it is considered potential therapeutic target for different kinds pathologies including cancer, cardiovascular disease, respiratory other Moreover, identification modulators exploring functions these prompted increased efforts discover new small molecules, which can modify activity. Furthermore, several randomized controlled trials indicated that interventions might affect expression human samples, supplementation diverse impact on physiological function participants. In review, we introduce history structure family, discuss molecular mechanisms elaborate regulatory SIRTs summarize inhibitors activators, review related clinical studies.

Language: Английский

Citations

398
A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids DOI Creative Commons
Chen Shen, Xiaojing Wang, Yu Cheng

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 4982 - 4982

Published: June 25, 2023

Flavonoids represent the main class of plant secondary metabolites and occur in tissues organs various species. In plants, flavonoids are involved many biological processes response to environmental stresses. The consumption has been known reduce risk chronic diseases due their antioxidant free radical scavenging properties. present review, we summarize classification, distribution, biosynthesis pathways, regulatory mechanisms flavonoids. Moreover, investigated activities discuss applications food processing cosmetics, as well pharmaceutical medical uses. Current trends flavonoid research also briefly described, including mining new functional genes through omics engineering using nanotechnology. This review provides a reference for basic applied on compounds.

Language: Английский

Citations

141
Mitochondrial quality control mechanisms as molecular targets in diabetic heart DOI
Xing Chang, Yukun Li, Chen Cai

et al.

Metabolism, Journal Year: 2022, Volume and Issue: 137, P. 155313 - 155313

Published: Sept. 17, 2022

Language: Английский

Citations

106
Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease DOI Creative Commons
Yan Qian, Shasha Liu, Yang Sun

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 2, 2023

Abstract Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS) plays crucial role in the pathogenesis advancement of CVDs, highlighting its significance as contributing factor. Maintaining an equilibrium between reactive oxygen species (ROS) antioxidant systems not only aids mitigating oxidative but also confers protective benefits cardiac health. Herbal monomers can inhibit OS CVDs by activating multiple signaling pathways, such increasing activity endogenous decreasing level ROS expression. Given actions herbal significantly protect normal function heart reduce damage caused organism. Hence, it is imperative recognize prospective therapeutic interventions for CVDs. This paper aims comprehensively review origins mechanisms underlying OS, elucidate intricate association explore potential treatment utilizing monomers. Furthermore, particular emphasis will be placed examining cardioprotective effects evaluating their pathways subsequent treatment. Graphical

Language: Английский

Citations

67
Quercetin inhibits necroptosis in cardiomyocytes after ischemia–reperfusion via DNA‐PKcs‐SIRT5‐orchestrated mitochondrial quality control DOI
Xing Chang, Qin Zhang, Yu Huang

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(5), P. 2496 - 2517

Published: March 6, 2024

Abstract We investigated the mechanism by which quercetin preserves mitochondrial quality control (MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked immunosorbent assay was employed vivo experiments assess myocardial injury markers, measure transcript levels of SIRT5/DNAPK‐cs/MLKL during various time intervals ischemia–reperfusion, and observe structural changes using transmission electron microscopy. In vitro investigations, adenovirus transfection establish a gene‐modified model DNA‐PKcs, primary were obtained from mouse with modified SIRT5 gene. Reverse transcription polymerase chain reaction, laser confocal microscopy, immunofluorescence localization, JC‐1 fluorescence assay, Seahorse energy analysis, other assays applied corroborate regulatory influence on MQC network after ischemia–reperfusion. demonstrated that caused structure myocardium. It seen had beneficial effect tissue, providing protection. As process continued, DNA‐PKcs/SIRT5/MLKL transcripts also found change. investigations revealed mitigated cardiomyocyte oxidative stress through regulated mitophagy kinetics sustain optimal metabolism levels. Quercetin, desuccinylation, modulated stability together they “mitophagy‐unfolded protein response.” This preserved integrity membrane genome, dynamics, metabolism. Quercetin may operate synergistically oversee regulation unfolded response DNA‐PKcs‐SIRT5 interaction.

Language: Английский

Citations

50
Zishen Tongyang Huoxue decoction (TYHX) alleviates sinoatrial node cell ischemia/reperfusion injury by directing mitochondrial quality control via the VDAC1–β-tubulin signaling axis DOI
Xing Chang, Siyuan Zhou, Jinfeng Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 320, P. 117371 - 117371

Published: Nov. 18, 2023

Language: Английский

Citations

44
Ginsenoside Rb1 ameliorates heart failure through DUSP-1-TMBIM-6-mediated mitochondrial quality control and gut flora interactions DOI

Xiangyi Pu,

Qin Zhang, Jinfeng Liu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155880 - 155880

Published: July 20, 2024

Language: Английский

Citations

20
Cardiac metabolism in HFpEF: from fuel to signalling DOI Open Access
Federico Capone, Cristian Sotomayor-Flores, David Bode

et al.

Cardiovascular Research, Journal Year: 2022, Volume and Issue: 118(18), P. 3556 - 3575

Published: Dec. 7, 2022

Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of energy substrates. Among the different types HF, HF with preserved ejection fraction (HFpEF) a highly prevalent, complex, heterogeneous condition for which metabolic derangements seem to dictate disease progression. Changes intermediate metabolism cardiometabolic HFpEF-among most prevalent forms HFpEF-have large impact both on provision number signalling pathways heart. This dual, vs. signalling, role played particular long-chain fatty acids (LCFAs) short-chain carbon sources [namely, (SCFAs) ketone bodies (KBs)]. LCFAs are key fuels heart, but their excess can be harmful, as case toxic accumulation lipid by-products (i.e. lipotoxicity). SCFAs KBs have been proposed potential major, alternative source HFpEF. At same time, substrate protein post-translational modifications other direct indirect pivotal importance HFpEF pathogenesis. An in-depth molecular understanding biological functions substrates will instrumental development novel therapeutic approaches Here, we summarize current evidence HFpEF, discuss metabolites through, at least part, fate modifications, highlight clinical translational challenges around therapy

Language: Английский

Citations

54
ß-tubulin contributes to Tongyang Huoxue decoction-induced protection against hypoxia/reoxygenation-induced injury of sinoatrial node cells through SIRT1-mediated regulation of mitochondrial quality surveillance DOI
Xing Chang, Yukun Li, Jinfeng Liu

et al.

Phytomedicine, Journal Year: 2022, Volume and Issue: 108, P. 154502 - 154502

Published: Oct. 13, 2022

Language: Английский

Citations

47
Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease DOI Creative Commons
Jianguo Lin, Jinlong Duan, Qingqing Wang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: June 17, 2022

Mitochondria play a key role in cellular metabolism. Mitochondrial dynamics (fusion and fission) mitophagy, are critical to mitochondrial function. Fusion allows organelles share metabolites, proteins, DNA, promoting complementarity between damaged mitochondria. Fission increases the number of mitochondria ensure that they passed on their offspring during mitosis. Mitophagy is process selective removal excess or helps improve energy Cardiometabolic disease characterized by dysfunction, high production reactive oxygen species, increased inflammatory response, low levels ATP. closely related mitophagy. This paper reviewed mechanisms mitophagy (focus MFN1, MFN2, OPA1, DRP1, PINK1 proteins) roles diabetic cardiomyopathy, myocardial infarction, cardiac hypertrophy, heart failure, atherosclerosis, obesity.

Language: Английский

Citations

46