Fabry Disease: Cardiac Implications and Molecular Mechanisms DOI Creative Commons
David Weissman, Jan Dudek, Vasco Sequeira

et al.

Current Heart Failure Reports, Journal Year: 2024, Volume and Issue: 21(2), P. 81 - 100

Published: Jan. 30, 2024

Abstract Purpose of Review This review explores the interplay among metabolic dysfunction, oxidative stress, inflammation, and fibrosis in Fabry disease, focusing on their potential implications for cardiac involvement. We aim to discuss biochemical processes that operate parallel sphingolipid accumulation contribute disease pathogenesis, emphasizing importance a comprehensive understanding these processes. Recent Findings Beyond accumulation, emerging studies have revealed mitochondrial chronic inflammation could be significant contributors These factors promote remodeling may predispose patients conduction disturbances, ventricular arrhythmias, heart failure. While current treatments, such as enzyme replacement therapy pharmacological chaperones, address progression symptoms, effectiveness is limited. Summary Our uncovers relationships disease–related complications. Current findings suggest beyond other mechanisms significantly pathogenesis. prompts exploration innovative therapeutic strategies underscores holistic approach managing disease.

Language: Английский

Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review DOI Creative Commons
Roland Gál, Róbert Halmosi, Ferenc Gallyas

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2888 - 2888

Published: Oct. 25, 2023

Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality worldwide. Unhealthy dietary habits have clearly been shown to contribute development CVDs. Beyond primary nutrients, a healthy diet is also rich in plant-derived compounds. Natural polyphenols, found fruits, vegetables, red wine, clear role improving cardiovascular health. In this review, we strive summarize results relevant pre-clinical clinical trials that focused on some most important natural such as resveratrol flavonoids. addition, aim identify their common sources, biosynthesis, describe mechanism action including regulatory effect signal transduction pathways. Finally, provide scientific evidence regarding benefits moderate, long-term wine consumption.

Language: Английский

Citations

20
Impact of polyphenols on heart failure and cardiac hypertrophy: clinical effects and molecular mechanisms DOI Creative Commons
Neda Hedayati, Alireza Yaghoobi, Marziyeh Salami

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: May 24, 2023

Polyphenols are abundant in regular diets and possess antioxidant, anti-inflammatory, anti-cancer, neuroprotective, cardioprotective effects. Regarding the inadequacy of current treatments preventing cardiac remodeling following cardiovascular diseases, attention has been focused on improving function with potential alternatives such as polyphenols. The online databases were searched for relevant orginial published from 2000 to 2023: EMBASE, MEDLINE, Web Science databases. search strategy aimed assess effects polyphenols heart failure keywords "heart failure" "polyphenols" "cardiac hypertrophy" "molecular mechanisms". Our results indicated repeatedly regulate various failure-related vital molecules signaling pathways, inactivating fibrotic hypertrophic factors, mitochondrial dysfunction free radical production, underlying causes apoptosis, also lipid profile cellular metabolism. In study, we review most recent literature investigations mechanism actions different subclasses hypertrophy provide deep insight into novel mechanistic direct future studies this context. Moreover, due polyphenols' low bioavailability conventional oral intravenous administration routes, have investigated currently accessible nano-drug delivery methods optimize treatment outcomes by providing sufficient drug delivery, targeted therapy, less off-target effects, desired precision medicine standards.

Language: Английский

Citations

17
Activation of the sirtuin silent information regulator 1 pathway inhibits pathological myocardial remodeling DOI Creative Commons

Youheng Wang,

Rusheng Zhao,

Chengyan Wu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 10, 2023

Myocardial remodeling refers to structural and functional disorders of the heart caused by molecular biological changes in cardiac myocytes response neurological humoral factors. A variety diseases, such as hypertension, coronary artery disease, arrhythmia, valvular can cause myocardial eventually lead failure. Therefore, counteracting is essential for prevention treatment Sirt1 a nicotinamide adenine dinucleotide + -dependent deacetylase that plays wide range roles transcriptional regulation, energy metabolism cell survival, DNA repair, inflammation, circadian regulation. It positively or negatively regulates participating oxidative stress, apoptosis, autophagy, other processes. Taking into account close relationship between failure involvement SIRT1 development former, role via inhibition has received considerable attention. Recently, multiple studies have been conducted provide better understanding how these phenomena. This review presents progress research involving pathway pathophysiological mechanisms

Language: Английский

Citations

15
Cellular and molecular biology of sirtuins in cardiovascular disease DOI Creative Commons
Yongping Liu, Ri Wen, Chunfeng Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114931 - 114931

Published: May 30, 2023

Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+) -dependent histone deacetylase that regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified seven mammalian homologs of the yeast SIRT silencing message regulator 2, namely, SIRT1-SIRT7. Recent vivo vitro studies successfully demonstrated involvement SIRTs key for cell biological function physiological pathological processes cardiovascular system, including cellular senescence, oxidative stress, apoptosis, DNA damage, metabolism. Emerging evidence has stimulated significant evolution preventing treating disease (CVD). Here, we review important roles regulatory involved pathogenesis diseases their molecular targets, novel protein post-translational modifications succinylation. In addition, summarize agonists inhibitors currently to target specific small molecules SIRTs. A better understanding role biology CVD opens new avenues therapeutic intervention with great potential CVD.

Language: Английский

Citations

15
Fabry Disease: Cardiac Implications and Molecular Mechanisms DOI Creative Commons
David Weissman, Jan Dudek, Vasco Sequeira

et al.

Current Heart Failure Reports, Journal Year: 2024, Volume and Issue: 21(2), P. 81 - 100

Published: Jan. 30, 2024

Abstract Purpose of Review This review explores the interplay among metabolic dysfunction, oxidative stress, inflammation, and fibrosis in Fabry disease, focusing on their potential implications for cardiac involvement. We aim to discuss biochemical processes that operate parallel sphingolipid accumulation contribute disease pathogenesis, emphasizing importance a comprehensive understanding these processes. Recent Findings Beyond accumulation, emerging studies have revealed mitochondrial chronic inflammation could be significant contributors These factors promote remodeling may predispose patients conduction disturbances, ventricular arrhythmias, heart failure. While current treatments, such as enzyme replacement therapy pharmacological chaperones, address progression symptoms, effectiveness is limited. Summary Our uncovers relationships disease–related complications. Current findings suggest beyond other mechanisms significantly pathogenesis. prompts exploration innovative therapeutic strategies underscores holistic approach managing disease.

Language: Английский

Citations

5