Omaveloxolone ameliorates isoproterenol-induced pathological cardiac hypertrophy in mice DOI

Xianchao Li,

Yang Wu,

Yunzhao Yang

et al.

Free Radical Research, Journal Year: 2023, Volume and Issue: 58(1), P. 57 - 68

Published: Dec. 25, 2023

Nuclear factor erythroid 2-related 2 (Nrf2) is an important transcriptional regulator that plays a protective role against various cardiovascular diseases. Omaveloxolone newly discovered potent activator of Nrf2 has variety cytoprotective functions. However, the potential omaveloxolone in process pathological cardiac hypertrophy and heart failure are still unknown. In this study, isoproterenol (ISO)-induced model was established to investigate effect vivo vitro. Our study first confirmed administration improved ISO-induced mice neonatal cardiomyocytes. also diminished oxidative stress, inflammation cardiomyocyte apoptosis. addition, activated signaling pathway, knockdown almost completely abolished cardioprotective omaveloxolone, indicated directly related activation signaling. summary, our identified may be promising therapeutic agent mitigate hypertrophy.

Language: Английский

SIRT1/SREBPs-mediated regulation of lipid metabolism DOI Creative Commons
Shan Shen, Mingyang Shen,

Lirun Kuang

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 107037 - 107037

Published: Dec. 7, 2023

Sirtuins, also called silent information regulator 2, are enzymes that rely on nicotinamide adenine dinucleotide (NAD+) to function as histone deacetylases. Further investigation is warranted explore the advantageous impacts of Sirtuin 1 (SIRT1), a constituent sirtuin group, lipid metabolism, in addition its well-researched involvement extending lifespan. The regulation gene expression has been extensively linked SIRT1. Sterol regulatory element-binding protein (SREBP) substrate SIRT1 attracted significant interest due role multiple cellular processes including cell cycle regulation, DNA damage repair, and metabolic functions. Hence, objective this analysis was investigate elucidate correlation between SREBPs, well assess contribution SIRT1/SREBPs mitigating metabolism dysfunction. research whether SREBPs could be utilized viable targets for therapeutic intervention managing complications associated with diabetes.

Language: Английский

Citations

38
Taxifolin Protects Against 5-Fluorouracil-Induced Cardiotoxicity in Mice Through Mitigating Oxidative Stress, Inflammation, and Apoptosis: Possible Involvement of Sirt1/Nrf2/HO-1 Signaling DOI
Mohammad H. Abukhalil, Zina M. Al‐Alami, Manal A. Alfwuaires

et al.

Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Language: Английский

Citations

1
SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism DOI Creative Commons

Benluvankar Varghese,

Ugo Chianese, Lucia Capasso

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 15, 2023

Cancer cells are characterized by uncontrolled cell proliferation and impaired bioenergetics. Sirtuins a family of highly conserved enzymes that play fundamental role in energy metabolism regulation. SIRT1, particular, drives many physiological stress responses metabolic pathways following nutrient deprivation. We previously showed SIRT1 activation using SCIC2.1 was able to attenuate genotoxic response senescence. Here, we report hepatocellular carcinoma (HCC) under glucose-deprived conditions, treatment induced overexpression SIRT3, SIRT6, modulating response.Flow cytometry used analyze the cycle. The MTT assay xCELLigence system were measure viability proliferation. In vitro enzymatic assays carried out as directed manufacturer, absorbance measured with an automated Infinite M1000 reader. Western blotting immunoprecipitation evaluate expression various proteins described this study. relative genes studied real-time PCR. employed Seahorse XF24 Analyzer determine state cells. Oil Red O staining lipid accumulation.SCIC2.1 significantly promoted mitochondrial biogenesis via AMPK-p53-PGC1α pathway enhanced ATP production glucose inhibition Ex-527 further supported our hypothesis effects dependent on activation. Interestingly, reprogrammed fatty acid oxidation for bioenergetic circuits repressing de novo lipogenesis. addition, SCIC2.1-mediated strongly modulated antioxidant through SIRT3 activation, p53-dependent indirect recruitment SIRT6.Our results show is promote homeostasis, attenuating deprivation SIRT1. These findings shed light action pathogenesis HCC may help future therapies and, possibly, other diseases.

Language: Английский

Citations

17
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1–NF-κB–p65 signaling pathway DOI
Yitong Yang,

Nisha Wang,

Zhenyi Wang

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 392, P. 110953 - 110953

Published: March 11, 2024

Language: Английский

Citations

7
Research progress on the role and mechanism of Sirtuin family in doxorubicin cardiotoxicity DOI
Xuan Zhang, Chaoming Huang,

Yanhong Hou

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155673 - 155673

Published: April 22, 2024

Language: Английский

Citations

5
Panax ginseng exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways DOI Creative Commons
Honglin Xu, Mingjie Pang,

Changlei Hu

et al.

Journal of Ginseng Research, Journal Year: 2025, Volume and Issue: 49(2), P. 197 - 207

Published: Jan. 11, 2025

Myocardial fibrosis and inflammation induce adverse cardiac remodeling post-myocardial infarction (MI). Panax ginseng (P. ginseng) is beneficial for diverse cardiovascular diseases. However, the therapeutic effect molecular mechanism underlying are largely unclear. A MI mouse model was constructed through permanent left anterior descending (LAD) coronary artery ligation. Transforming growth factor-β1 (TGF-β1) or lipopolysaccharide (LPS) used stimulating fibroblasts (CFs) RAW264.7 macrophages to construct collagen synthesis in vitro. The structure function were detected hematoxylin-eosin staining, Masson echocardiography, while myocardial markers determined by Western-blot, immunohistochemistry, RT-PCR, ELISA. Additionally, Silent information regulator 1 (SIRT1)/nuclear factor-κB (NF-κB) mediated NOD like receptor 3 (NLRP3) inflammasome TGF-β I (TGFBR1) signaling pathways also evaluated. SIRT1 selective inhibitor (EX-527) confirming pharmacological of P. ginseng. In vivo, alleviated ventricular remodeling, enhanced heart function, ameliorated I, III, IL-1β, IL-18 levels dose-dependently. Moreover, significantly suppressed NLRP3-caspase1 TGFBR1/Smads mice. vitro, markers, NLRP3 TGF-β1-induced CFs LPS-stimulated cells. Mechanistically, NF-κB activity promoting expression. suppression EX-527 partially abolished protective effects CFs. protects from attenuating post-MI regulation its downstream pathways.

Language: Английский

Citations

0
Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review) DOI Open Access

Shijie Zheng,

Linlin Yang,

Qiuting Dai

et al.

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(3)

Published: Jan. 14, 2025

Depression and coronary heart disease (CHD) are two interconnected diseases that profoundly impact global health. is both a complex psychiatric disorder an established risk factor for CHD. Sirtuin 1 (SIRT1) enzyme requires the cofactor nicotinamide adenine dinucleotide (NAD+) to perform its deacetylation function, involvement crucial in reducing cardiovascular risks associated with depression. SIRT1 exerts cardioprotective effects via modulating oxidative stress, inflammation metabolic processes, all of which central pathogenesis CHD individuals Through influencing these pathways, helps reduce endothelial dysfunction, prevent formation atherosclerotic plaques stabilize existing plaques, thereby decreasing overall The present review underscores important role serving as therapeutic intervention molecule tackling complications stemming from Furthermore, it highlights need further studies clarify how influences depression at molecular level. ultimate goal this research will be translate findings into practical clinical strategies.

Language: Английский

Citations

0
Metrnl and Cardiomyopathies: From Molecular Mechanisms to Therapeutic Insights DOI Creative Commons

Miaomiao Xu,

Xiaoguang Liu, Liming Lu

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(2)

Published: Jan. 1, 2025

ABSTRACT Cardiomyopathies, a diverse group of diseases affecting the heart muscle, continue to pose significant clinical challenges due their complex aetiologies and limited treatment options targeting underlying genetic molecular dysregulations. Emerging evidence indicates that Metrnl, myokine, adipokine cardiokine, plays role in pathogenesis various cardiomyopathies. Therefore, objective this review is examine mechanism Metrnl cardiomyopathies, with expectation providing new insights for these diseases.

Language: Английский

Citations

0
SRT1720 attenuates UVA-induced corneal endothelial damage via inhibition of oxidative stress and cellular apoptosis DOI

Chunxiao Dong,

Zongyi Li, Xin Wang

et al.

Experimental Eye Research, Journal Year: 2023, Volume and Issue: 231, P. 109464 - 109464

Published: April 2, 2023

Language: Английский

Citations

5
The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases DOI Creative Commons
Yuqin Wang, Yongnan Li, Hong Ding

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2023, Volume and Issue: 10(9), P. 382 - 382

Published: Sept. 6, 2023

Sirtuins belong to the class III histone deacetylases and possess nicotinamide adenine dinucleotide-dependent deacetylase activity. They are involved in regulation of multiple signaling pathways implicated cardiovascular diseases. Autophagy is a crucial adaptive cellular response stress stimuli. Mounting evidence suggests strong correlation between autophagy, potentially involving cross-regulation crosstalk. Sirtuin-mediated autophagy plays regulatory role some diseases, including atherosclerosis, ischemia/reperfusion injury, hypertension, heart failure, diabetic cardiomyopathy, drug-induced myocardial damage. In this context, we summarize research advancements pertaining various molecular mechanisms regulating autophagy. We also elucidate biological function across diverse diseases further discuss development novel drugs that regulate

Language: Английский

Citations

5