Diosgenin-Conjugated Zinc Oxide Nanoparticles: A Sustainable Approach to Counter Antibiotic-Induced Oxidative Stress in the Aquatic Environment Using the in vivo Zebrafish Larvae Model (Danio rerio)

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(2), P. 903 - 918

Published: April 10, 2024

Language: Английский

---

Santalum Genus: phytochemical constituents, biological activities and health promoting-effects

Zeitschrift für Naturforschung C, Journal Year: 2022, Volume and Issue: 78(1-2), P. 9 - 25

Published: Sept. 7, 2022

Santalum genus belongs to the family of Santalaceae, widespread in India, Australia, Hawaii, Sri Lanka, and Indonesia, valued as traditional medicine, rituals modern bioactivities. Sandalwood is reported possess a plethora bioactive compounds such essential oil its components (α-santalol β-santalol), phenolic fatty acids. These bioactives play important role contributing towards biological activities health-promoting effects humans. Pre-clinical clinical studies have shown sandalwood extract antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroleptic, antihyperglycemic, antihyperlipidemic, anticancer activities. Safety on (EO) extracts proven them safe ingredient be utilized health promotion. Phytoconstituents, bioactivities uses established one innovative materials for application pharma, food, biomedical industry.

Language: Английский

---

Natural essential oils as a new therapeutic tool in colorectal cancer

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: Dec. 13, 2022

Colorectal cancer (CRC) is the third most revalent type of in world and second common cause death (about 1 million per year). Historically, natural compounds their structural analogues have contributed to development new drugs useful treatment various diseases, including cancer. Essential oils are odorous products made up a complex mixture low molecular weight with recognized biological pharmacological properties investigated also for prevention The aim this paper highlight possible role essential CRC, composition preclinical studies involving them. It has been reviewed determine experimental models used anticancer potential mechanisms action CRC. Searches were performed following databases PubMed/Medline, Web science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. results analyzed showed that EOs exhibited wide range bioactive effects like cytotoxicity, antiproliferative, antimetastatic on cells through action. This updated review provides better quality scientific evidence efficacy as chemotherapeutic/chemopreventive agents Future translational clinical needed establish effective dose humans well suitable route administration maximum bioavailability efficacy. Given positive obtained from studies, can be considered efficient complementary therapies chemotherapy

Language: Английский

---

Therapeutic Approaches in Pancreatic Cancer: Recent Updates

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1611 - 1611

Published: June 1, 2023

Cancer is a significant challenge for effective treatment due to its complex mechanism, different progressing stages, and lack of adequate procedures screening identification. Pancreatic cancer typically identified in advanced progression phase with low survival ~5 years. Among cancers, pancreatic also considered high mortality-causing casualty over other accidental or disease-based mortality, it ranked seventh among all mortality-associated cancers globally. Henceforth, developing diagnostic early detection, understanding cancer-linked mechanisms, various therapeutic strategies are crucial. This review describes the recent development progression, approaches, including molecular techniques biomedicines effectively treating cancer.

Language: Английский

---

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: March 2, 2023

Abstract Paeonia emodi Wall. ex Royle is commonly known as Himalayan paeony has great importance a food and medicine. The practice of very ancient it conventionally used for wide range illnesses in the folk system medicine because its beneficial phytochemical profile. main purpose current review was synthesis recent data on botany, ethnopharmacology, phytochemistry potential pharmacological mechanisms action Royle, thus offering new prospects development adjuvant natural therapies. Using scientific databases such PubMed/MedLine, Scopus, Web Science, ScienceDirect, Google Scholar, Springer, Wiley, comprehensive literature search performed Royle. For searching, we next MeSH terms: “Biological Product/isolation purification”, Products/pharmacology”, “Drug Discovery/methods”, “Ethnopharmacology, Medicine”, “Traditional/methods”, “Paeonia/chemistry”, “Plant Extracts/pharmacology”, “Phytochemicals/chemistry”, “Phytochemicals/pharmacology”, “Plants, Medicinal”. results most studies were analyzed important summarized tables figures. Phytochemical research led to isolation triterpenes, monoterpenes, phenolic acids, fatty organic compounds, steroids, free radicals some other classes primary metabolites. In addition, diverse activities like antibacterial, antifungal, anticoagulant, airway relaxant lipoxygenase beta-glucuronidase inhibiting activity, radical scavenging phytotoxic insecticidal have been reported Different bioactive compounds proven their therapeutic modern biomedical cure numerous gastrointestinal nervous disorders. future, further vitro vivo are required identify action, pharmacokinetics studies, pharmaceutical formulations target transport possible interaction with allopathic drugs. Also, regarding quality evaluation, toxicity safety humans needed.

Language: Английский

---