Progress in investigating the relationship between Schlafen5 genes and malignant tumors DOI Creative Commons

Teng Tu,

Ye Yuan,

Xiaoxue Liu

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Sept. 11, 2023

The Schlafen5(SLFN5)gene belongs to the third group of Schlafen protein family. As a tumor suppressor gene, SLFN5 plays pivotal role in inhibiting growth, orchestrating cell cycle regulation, and modulating extent cancer infiltration metastasis various malignancies. However, high expression SLFN 5 some tumors was positively correlated with lymph node metastasis, stage, grade. This article endeavors elucidate reciprocal relationship between gene malignant tumors, thereby enhancing our comprehension intricate mechanisms underlying its implications for progression, invasive potential, metastatic behavior tumors. At same time, this paper summarizes basis as new biomarker diagnosis prognosis, provides ideas target treatment tumor.

Language: Английский

The complex role of MEG3: An emerging long non-coding RNA in breast cancer DOI Open Access
Md Sadique Hussain,

Abdullah A. Majami,

Ali Haider

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 251, P. 154850 - 154850

Published: Oct. 5, 2023

Language: Английский

Citations

46
LncRNAs in oncogenic microenvironment: from threat to therapy DOI Creative Commons
Dipanjan Roy, B. Bhattacharya,

Rudra Chakravarti

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: March 13, 2025

LncRNAs are RNA molecules of more than 200 nucleotides in length and participate cellular metabolism responses through their diverse interactomedespite having no protein-coding capabilities. Such significant interactions also implicate the presence lncRNAs complex pathobiological pathways various diseases, affecting survival by modulating autophagy, inflammation apoptosis. Proliferating cells harbour a microenvironment that mainly stimulate growth-specific activities such as DNA replication, repair, protein synthesis. They recognise damages at macromolecular level, preventing them from reaching next-generation. have shown association with events occurring towards proliferation, regulating key dividing cells, dysregulation lncRNA transcriptome affects normal life-cycle, promoting development cancer. Furthermore, demonstrated an cancer growth progression governing cell growth, epithelial-mesenchymal transition metastasis. This makes attractive target for treatment can be used marker diagnosis prognosis diseases due to differential expression diseased samples. review delves into correlation fundamental signalling how this crosstalk shapes complexity oncogenic microhabitat.

Language: Английский

Citations

0
Long non-coding RNA MEG3 acts as a suppressor in breast cancer by regulating miR-330/CNN1 DOI Creative Commons
Dandan Yi, Zetian Wang, Haojie Yang

et al.

Aging, Journal Year: 2024, Volume and Issue: 16(2), P. 1318 - 1335

Published: Jan. 17, 2024

Background: The current study aimed to investigate the molecular mechanism of long non-coding RNA (lncRNA) MEG3 in development breast cancer. Methods: regulating relationships among lncRNA MEG3, miRNA-330 and CNN1 were predicted by bioinformatics analysis cancer samples Cancer Genome Atlas database. differential expression was first validated tissues cells. effects on malignant properties evaluated manipulating its MCF-7 BT-474 Rescue experiments, dual-luciferase assays, immunoprecipitation (RIP) experiments further used validate CNN1. Results: Bioinformatics showed that MEGs significantly downregulated tissues, while miR-330 upregulated. These expressions our cohort samples. High levels as well low associated with favorable overall survival. Overexpression inhibited cell viability, migration invasion, decreased cells S stage promoted apoptosis. Dual-luciferase reporter gene assay RIP could directly bind miR-330. Moreover, mimics basis overexpression ameliorated tumor-suppressing decreasing expression. Conclusion: Our indicated is a suppressor miR-330/CNN1 axis.

Language: Английский

Citations

2
New insights of LncRNAs fingerprints in breast cancer progression: Tumorigenesis, drug resistance, and therapeutic opportunities DOI Creative Commons
Bashdar Mahmud Hussen,

Diyar Idris Othman,

Snur Rasool Abdullah

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138589 - 138589

Published: Dec. 9, 2024

Breast cancer (BC) is one of the common female cancers and it characterized by considerable problems regarding its development therapy. Long non-coding RNAs (lncRNAs) have been identified as significant modulators in BC development, especially, tumorigenicity chemoresistance. We therefore endeavor to present an up-to-date understanding lncRNAs their impact on progression treatment, concerning molecular processes, treatment options, use a therapeutic opportunity. LncRNAs are novel regulators genes that cause resistance directly functioning both coding patients, but little known about mechanisms actions. Thus, additional study required deeper modes action possible roles disease. This aims investigate functions BC, with particular attention role tumorigenesis, drug mechanisms, targets. will help identify targets improve effectiveness treatment.

Language: Английский

Citations

1
Progress in investigating the relationship between Schlafen5 genes and malignant tumors DOI Creative Commons

Teng Tu,

Ye Yuan,

Xiaoxue Liu

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Sept. 11, 2023

The Schlafen5(SLFN5)gene belongs to the third group of Schlafen protein family. As a tumor suppressor gene, SLFN5 plays pivotal role in inhibiting growth, orchestrating cell cycle regulation, and modulating extent cancer infiltration metastasis various malignancies. However, high expression SLFN 5 some tumors was positively correlated with lymph node metastasis, stage, grade. This article endeavors elucidate reciprocal relationship between gene malignant tumors, thereby enhancing our comprehension intricate mechanisms underlying its implications for progression, invasive potential, metastatic behavior tumors. At same time, this paper summarizes basis as new biomarker diagnosis prognosis, provides ideas target treatment tumor.

Language: Английский

Citations

1