Exploring the role of lncrna neat1 knockdown in regulating apoptosis across multiple cancer types: A review

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 252, P. 154908 - 154908

Published: Oct. 31, 2023

Language: Английский

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Kaempferol: Paving the path for advanced treatments in aging-related diseases

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 188, P. 112389 - 112389

Published: March 8, 2024

Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, flavonoid found in several plants, has emerged as promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, pharmacokinetics, highlights its potential therapeutic utility against underpinned by distinctive structure, which confers antioxidative anti-inflammatory properties. Kaempferol counteracts reactive oxygen species (ROS) modulates crucial cellular pathways, thereby combating oxidative stress inflammation, hallmarks low toxicity wide margins, demonstrated preclinical clinical studies, further substantiate potential. Compelling evidence supports substantial addressing ARDs through mechanisms, notably anti-inflammatory, antioxidant, anti-apoptotic actions. exhibits versatile neuroprotective effect modulating various proinflammatory signaling including NF-kB, p38MAPK, AKT, β-catenin cascade. Additionally, it hinders formation aggregation beta-amyloid protein regulates brain-derived neurotrophic factors. In terms anticancer potential, kaempferol acts diverse inducing apoptosis, arresting cell cycle at G2/M phase, suppressing epithelial-mesenchymal transition (EMT)-related markers, affecting phosphoinositide 3-kinase/protein kinase B pathways. Subsequent studies should focus on refining dosage regimens, exploring innovative delivery systems, conducting trials to translate these findings into applications.

Language: Английский

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MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155091 - 155091

Published: Jan. 3, 2024

Language: Английский

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Osteomyelitis and non-coding RNAS: A new dimension in disease understanding

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155186 - 155186

Published: Feb. 2, 2024

Language: Английский

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GAS5 lncRNA: A biomarker and therapeutic target in breast cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155424 - 155424

Published: June 20, 2024

Language: Английский

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Connecting the Dots: LncRNAs in the KRAS Pathway and Cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155570 - 155570

Published: Aug. 29, 2024

Language: Английский

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Exploring the oncogenic and tumor-suppressive roles of Circ-ADAM9 in cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155257 - 155257

Published: March 13, 2024

Language: Английский

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The emerging role of noncoding RNAs in the PI3K/AKT/mTOR signalling pathway in breast cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155180 - 155180

Published: Jan. 30, 2024

Language: Английский

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Non-Coding RNA: A Key Regulator in the Glutathione-GPX4 Pathway of Ferroptosis

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1222 - 1234

Published: May 20, 2024

Ferroptosis, a form of regulated cell death, has emerged as crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by peroxidase 4 (GPX4), assumes an essential part driving ferroptosis. GPX4, the principal orchestrator ferroptosis, garnered significant attention across cardiovascular, neuroscience domains over past decade. Noteworthy investigations have elucidated indispensable functions ferroptosis numerous diseases, including tumorigenesis, wherein robust within cells can impede tumor advancement. Recent research underscored complex regulatory role non-coding RNAs (ncRNAs) regulating GSH-GPX4 network, thus influencing cellular susceptibility to This exhaustive review endeavors probe into multifaceted processes which ncRNAs control network Specifically, we delve miRNAs, lncRNAs, circRNAs GPX4 expression impacting Moreover, discuss clinical implications dysregulated interactions between several conditions, underscoring their capacity viable targets for therapeutic intervention. Additionally, explores emerging strategies aimed at targeting modulate pathway manipulate advantage. A comprehensive understanding these intricate networks furnishes insights innovative avenues diseases associated with perturbed thereby laying groundwork interventions ferroptosis-related pathological conditions.

Language: Английский

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Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155224 - 155224

Published: Feb. 23, 2024

Language: Английский

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