Changes in menstrual cycles among Iranian women during the COVID-19 pandemic: A cross-sectional study DOI Creative Commons
Fahimeh Ranjbar, Shima Haghani,

Motahareh Aghashahi

et al.

International Journal of Reproductive BioMedicine (IJRM), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Some women experienced alterations in their menstrual cycles during the Coronavirus disease 2019 (COVID-19) pandemic.

Language: Английский

Association between COVID-19 vaccination and menstruation: a state of the science review DOI
Laura A. Payne, Lauren A. Wise, Amelia K. Wesselink

et al.

BMJ Sexual & Reproductive Health, Journal Year: 2024, Volume and Issue: 50(3), P. 212 - 225

Published: June 10, 2024

Menstrual health is a key patient-reported outcome beyond its importance as general indicator of and fertility. However, menstrual function was not measured in the clinical trials COVID-19 vaccines. The purpose this review to synthesise existing literature on relationship between vaccination outcomes.

Language: Английский

Citations

9

Messenger RNA Therapy for Female Reproductive Health DOI

Rachel VanKeulen‐Miller,

Owen S. Fenton

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(2), P. 393 - 409

Published: Jan. 8, 2024

Female reproductive health has traditionally been an underrepresented area of research in the drug delivery sciences. This disparity is also seen emerging field mRNA therapeutics, a class medicines that promises to treat and prevent disease by upregulating protein expression body. Here, we review advances therapies through lens improving female health. Specifically, begin our discussing fundamental structure biochemical modifications associated with mRNA-based drugs. Then, discuss various packaging technologies, including lipid nanoparticles, can be utilized protect transport drugs target cells Last, conclude usage therapy for addressing pregnancy-related vaccination against sexually transmitted diseases women. Of note, highlight relevant clinical trials using while providing their corresponding National Clinical Trial identifiers. In undertaking this review, aim provide background understanding its specifically address issues overarching goal information toward gender certain aspects research.

Language: Английский

Citations

7

Menstrual disorders following COVID-19 vaccination: a review using a systematic search DOI Creative Commons

Veerle R. Smaardijk,

Rana Jajou, A. Kant

et al.

Frontiers in Drug Safety and Regulation, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 31, 2024

Introduction: Menstrual disorders are commonly reported after COVID-19 vaccination and heavy menstrual bleeding was added to the product information of vaccines Moderna Pfizer. The aim this review, using a systematic search, is provide an overview available literature on risk vaccination. Methods: review conducted according Preferred Reporting Items for Systematic reviews Meta-Analysis (PRISMA) guidelines. A PubMed search performed 15 August 2023, including solely quantitative studies in English Dutch. Results: total 61 were included, which 40 cross-sectional studies, 18 cohort three self-controlled case series. Outcomes included wide variety disorders, changes cycle length ( n = 54), amount 44), menses 30), experience (pre)menstrual pain 21), breakthrough 18). All found higher percentage at least one disorder first different types doses. Discussion: In conclusion, evidence suggests that may cause women reproductive age. However, there need more longitudinal because important limitations study designs many studies. Although short-lived predominantly mild, it healthcare professionals be informed about these potential adverse reactions assess events clinical trials vaccines.

Language: Английский

Citations

7

Menstrual abnormalities after COVID‐19 vaccination in the Netherlands: A description of spontaneous and longitudinal patient‐reported data DOI Open Access
Janneke W. Duijster,

Mark E. Schoep,

Theodoor E. Nieboer

et al.

British Journal of Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 89(10), P. 3126 - 3138

Published: May 24, 2023

During the COVID-19 vaccination campaigns, number of reports menstrual abnormalities increased rapidly. Here, we describe nature and potential risk factors associated with based on spontaneously reporting data as well from a prospective cohort event monitoring (CEM) study these are poorly studied.Reports received by Netherlands Pharmacovigilance Centre Lareb in spontaneous system between February 2021 April 2022 were summarized. In addition, logistic regression analysis was performed reported CEM to assess association person characteristics, prior SARS-CoV-2 infection use hormonal contraceptives occurrence after vaccination.We analysed over 24 000 500 episodes (among 16 929 included women) study. The showed an incidence 41.4 per 1000 women aged ≤54 years. Amenorrhoea/oligomenorrhoea heavy bleeding collectively accounted for about half all reported. Significant associations observed age group 25-34 years (odds ratio 2.18; 95% confidence interval 1.45-3.41) Pfizer vaccine 3.04; 2.36-3.93). No body mass index presence most comorbidities assessed.The high disorders among years, this observation supported reports. This suggests that relation is plausible should be further investigated.

Language: Английский

Citations

12

The effect of COVID‐19 and COVID‐19 vaccination on serum anti‐Mullerian hormone: A systematic review and meta‐analysis DOI Creative Commons
Marjan Ghaemi, Sedigheh Hantoushzadeh, Arman Shafiee

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 1, 2024

The current study aims to evaluate the impact of COVID-19 infection and vaccination on ovarian reserve by detecting anti-Mullerian hormone (AMH) level.

Language: Английский

Citations

4

COVID-19 and persistent symptoms: implications for polycystic ovary syndrome and its management DOI Creative Commons
Shanshan Zhang,

Yanqun Wu,

Richard Mprah

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

The COVID-19 pandemic has left a profound mark on global health, leading to substantial morbidity and mortality worldwide. Beyond the immediate symptoms of infection, emergence “long COVID”, long-term effects SARS-CoV-2, become significant public health concern. Long COVID is multifaceted condition affecting various organs systems, including cardiovascular, digestive, nervous, endocrine systems. Individuals diagnosed with polycystic ovary syndrome (PCOS) may face an increased risk severe infection. It crucial comprehend how long affects PCOS patients devise effective treatment care strategies. Here, we review detrimental its reproductive function, inflammation, metabolism, cardiovascular body composition, lifestyle, mental in PCOS. We offer recommendations for post-covid-19 management PCOS, emphasizing necessity comprehensive, multidisciplinary approach patient care. Furthermore, discuss prospective research directions, highlighting significance continued investigations clinical trials evaluate approaches ramifications individuals

Language: Английский

Citations

4

Status of and perspectives on COVID-19 vaccination after lifting of the dynamic zero-COVID policy in China DOI Open Access
Mo Zhang, Yan Wang, Tao Zhang

et al.

Global Health & Medicine, Journal Year: 2023, Volume and Issue: 5(2), P. 112 - 117

Published: Feb. 10, 2023

On December 7, 2022, China's National Health Commission issued the Ten New Covid Rules lifting dynamic zero-COVID policy. In interim, vaccination campaigns continue to be promoted. We assessed potential impacts on status, perceptions, and attitudes toward COVID-19 vaccines via an online self-administered questionnaire. Among 1,170 participants, 1,142 (97.6%) participants were vaccinated against COVID-19, 51.8% (591/1,142) have already received booster. More than half of who ages 31 50 (51.8%). Participants believed following strategies could improve rate: timely feedback data (such as safety, efficacy, other issues public concern) from authoritative media (95.6%), increasing number sites availability using more convenient methods making appointment (95.2%), recommendations friends relatives (94.8%), presenting qualifications staff performing (89.1%). measures, including targeted measures for different age groups safety efficacy media, are likely help rates.

Language: Английский

Citations

9

Assessment of changes in menstrual pattern, menstrual volume, and sex hormones (FSH, LH, TSH, prolactin, and AMH) in women of childbearing age with COVID-19 in Semnan, Iran: a cross-sectional study DOI Creative Commons

Zahra Vafaeinezhad,

Sadra Sarandili, Safa Mousavi

et al.

Middle East Fertility Society Journal, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 28, 2025

Abstract Introduction and objectives Women’s reproductive fertility health may be influenced by COVID-19. However, data on whether SARS-CoV-2 infection affects menstrual pattern, volume, sex hormone levels remain limited. This study aimed to investigate changes in the pattern volume of menstruation as well FSH, LH, TSH, prolactin, AMH women age following Patients methods In this cross-sectional study, we enrolled 30 healthy (aged 18–36 years) who presented with male-factor infertility. Participants were included if they non-menopausal, had negative pregnancy test results, no history significant medical illness or drug treatment. Women using contraceptive treatments undergone specific therapeutic procedures medications for infertility excluded. Additionally, vaccinated against COVID-19 All participants a confirmed diagnosis (positive PCR test). To minimize acute-phase fluctuations, re-evaluated 5- 7-month post-infection. We compared pre- post-infection from their records, used screening checklist assess (e.g., oligomenorrhea, polymenorrhea) volume. Each participant effectively served her own control. Data analyzed at 95% confidence level P < 0.05 considered significant. Results The mean (± SD) was 29.23 ± 3.45 years. Nearly one-third (33%) reported new-onset after COVID-19, including oligomenorrhea (20%) polymenorrhea (13%). No experienced amenorrhea. Post-infection showed slight increase prolactin decrease AMH; however, only TSH exhibited statistically rise. Changes not associated treatment methods, hospitalization, pulmonary involvement. By contrast, those hospitalization more frequent alterations ( = 0.041 0.006, respectively). Pulmonary involvement did significantly impact pattern. Conclusion linked increases notable shifts among age, while other hormones remained largely unchanged. Further research larger sample sizes formal control group is needed clarify these observations.

Language: Английский

Citations

0

A Cross‐Sectional Study on Post‐COVID‐19 Menstrual Abnormalities in Women of Reproductive Age Group at a Tertiary Care Hospital DOI Creative Commons
S. Venkatesh,

T Malathi,

M. Gowda

et al.

Obstetrics and Gynecology International, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Purpose: This study aimed to evaluate the effect of COVID-19 infection and vaccination on all menstrual cycle parameters in women reproductive age group, 18-45 years, at a tertiary care hospital. Methods: A single-center, descriptive cross-sectional was done from January 2, 2023, June 24, 2023. Sampling nonprobabilistic purposeful. Participants were recruited via calls, in-person interviews, online surveys. total 931 participants recruited, which 141 eligible for study. Descriptive statistics performed variables. Pearson's chi-square test compare categorical variables among different groups, Wilcoxon matched pair signed-rank patterns before after vaccination. Simple linear regression multiple analysis wherever necessary. p < 0.05 considered statistically significant. Results: The median 29 years. Those who reported abnormalities mainly group 18-27 (n = 62, 44.0%), resided an urban locality 123, 87.2%), employed (full-time/part-time) 57, 40.4%). Of 42 with changes, 27 (64.3%) experienced changes post-COVID-19 their first dose 15 (35.7%) dose. In this continue experience cycles. Analysis showed that having severe symptoms more likely have earlier onset (beta -2.072, p=0.040). above-normal BMI increased pain/cramps during menses 0.236, p=0.0.013). students/employed -0.365, p=0.001) 0.182, p=0.024) mood swings/tension/irritability. On comparing duration postvaccination it found latter had late-onset short-term effect, while former early-onset long-term menses. Conclusion: Our shows there is evidence irregularities following revealed influence cycles, posing higher risk, but effects menstruation independent one another are be studied further.

Language: Английский

Citations

0

Changes in female cancer diagnostic billing rates over the COVID-19 period in the Ontario Health Insurance Plan DOI Creative Commons
Deanna McLeod, Ilidio Martins, Anna V. Tinker

et al.

Therapeutic Advances in Medical Oncology, Journal Year: 2025, Volume and Issue: 17

Published: May 1, 2025

Background: The initial response to coronavirus disease 2019 (COVID-19) in Ontario included suspension of cancer screening programs and deferral diagnostic procedures many treatments. Although the short-term impact these measures on female cancers is well documented, few studies have assessed mid- long-term impacts. Objectives: To compare annual billing prevalence incidence rates during COVID-19 period (2020–2022) pre-COVID-19 levels (2015–2019). Design: Retrospective analysis aggregated claims data for codes from Health Insurance Plan (OHIP). Methods: Linear regression was used fit (2015–2019) each OHIP code extrapolate counterfactual values years 2020–2022. Excess were calculated as difference between projected actual year. Results: In 2020, cervical, breast, uterine, ovarian decreased relative that year by −50.7/100k, −13.9/100k, −3.5/100k, −3.8/100k, respectively. reverse observed 2021 with rate increases 47.8/100k, 59.1/100k, 2.5/100k, 3.7/100k, 2022, excesses further amplified, especially cervical breast (111.2/100k 78.67/100k, respectively). net excess patient 2020–2022 largely positive all types (108.3/100k, 123.7/100k, 5.2/100k, 1.8/100k, Analysis showed similar trends. Conclusion: expected decreases 2020 followed large resulting a cumulative period. Further research required assess nature changes.

Language: Английский

Citations

0