Bee Pollen as a Source of Biopharmaceuticals for Neurodegeneration and Cancer Research: A Scoping Review and Translational Prospects DOI Creative Commons

Rachid Kacemi,

María G. Campos

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5893 - 5893

Published: Dec. 13, 2024

Bee Pollen (BP) has many advantageous properties relying on its multitargeting potential, a new tendency in managing challenging illnesses. In cancer and neurodegeneration, the multiple effects of BP could be unequaled importance need further investigation. Although still limited, available data interestingly spotlights some floral sources with promising activities line this Adopting scoping review methodology, we have identified crucial bioactivities that are widely recognized to individual compounds but remain completely untapped valuable bee cocktail. A wide range these been recently found endowed great potential modulating pivotal processes neurodegeneration pathophysiology. addition, ubiquitous only isolated, while number studied BPs remains extremely limited compared endless pool plant species worldwide. We also elucidated clinical profits from perspectives impeded by hurdles such as bioavailability phytocompounds, diversity lack phytochemical standardization BP, difficulty selective targeting pathophysiological mechanisms. finally present interesting insights guide future research pave way for urgently needed simplified investigations.

Language: Английский

Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

Citations

3
Editorial: World digestive health day: investigating the link between neurodegenerative disease and gut microbiota DOI Creative Commons
Shampa Ghosh, Sunil Dhungel, Mohd. Farooq Shaikh

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 3, 2024

EDITORIAL article Front. Aging Neurosci., 03 January 2024Sec. Cellular and Molecular Mechanisms of Brain-aging Volume 15 - 2023 | https://doi.org/10.3389/fnagi.2023.1351855

Language: Английский

Citations

7
Role of nutraceutical against exposure to pesticide residues: power of bioactive compounds DOI Creative Commons

Mabil Sajad,

Shabnam Shabir, Sandeep Kumar Singh

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 17, 2024

Pesticides play a crucial role in modern agriculture, aiding the protection of crops from pests and diseases. However, their indiscriminate use has raised concerns about potential adverse effects on human health environment. Pesticide residues food water supplies are serious hazards to general public since long-term exposure can cause cancer, endocrine disruption, neurotoxicity, among other problems. In response these concerns, researchers professionals have been exploring alternative approaches mitigate toxic pesticide residues. Bioactive substances called nutraceuticals that come whole foods including fruits, vegetables, herbs, spices drawn interest because ability negative These substances, which include minerals, vitamins, antioxidants, polyphenols, variety biological actions may assist body's detoxification healing harm exposure. this context, review aims explore nutraceutical interventions as promising strategy

Language: Английский

Citations

5
Synthesis of Green Engineered Silver Nanoparticles through Urtica dioica: An Inhibition of Microbes and Alleviation of Cellular and Organismal Toxicity in Drosophila melanogaster DOI Creative Commons
Mahendra Pratap Singh, Shabnam Shabir,

Aman Singh Deopa

et al.

Antibiotics, Journal Year: 2022, Volume and Issue: 11(12), P. 1690 - 1690

Published: Nov. 23, 2022

Plant fractions have a diversity of biomolecules that can be used to make complicated reactions for the bioactive fabrication metal nanoparticles (NPs), in addition being beneficial as antioxidant medications or dietary supplements. The current study shows Urtica dioica (UD) and biologically synthesized silver (AgNPs) UD antibacterial properties against bacteria (Escherichia coli Pseudomonas putida) Drosophila melanogaster (Oregon R+). According their ability scavenge free radicals, DPPH, ABTS, TFC, TPC initially estimated potential AgNPs. fabricated AgNPs were analyzed (UV–Vis, FTIR, EDS, SEM) determine functional groups (alcohol, carboxylic acids, phenol, proteins, aldehydes) observe shape (agglomerated crystalline rod-shaped structure). disc diffusion method was test antimicrobial Ag-NPs E. P. putida. For 24 120 h, newly enclosed flies third instar larvae treated with After exposure, tests biochemical effects (acetylcholinesterase inhibition protein estimation assays), cytotoxicity (dye exclusion), behavioral (jumping climbing assays) conducted. results showed found potent activity all microbial strains tested at various concentrations. In this regard, ethno-medicinal characteristics exhibit similar impact D. melanogaster, showing (p < 0.05) significantly decreased cellular toxicity (trypan blue dye), enhanced markers (AChE efficacy proteotoxicity), improved patterns organism AgNPs, especially comparison extract. may help utilization specific plants reliable sources natural antioxidants been synthesis metallic NPs, which aids production nanomedicine other therapeutic applications.

Language: Английский

Citations

17
Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease DOI Creative Commons
Huaxiong Zhang,

Dilmurat Hamit,

Qing Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 4, 2025

Background: Melatonin (MLT) can improve mitophagy, thereby ameliorating cognitive deficits in Alzheimer's disease (AD) patients. Hence, our research focused on the potential value of MLT-related genes (MRGs) AD through bioinformatic analysis. Methods: First, key cells single-cell dataset GSE138852 were screened out based proportion annotated and Fisher's test between control groups. The differentially expressed (DEGs) cell GSE5281 datasets identified, MRGs selected via weighted gene coexpression network After intersecting two sets DEGs MRGs, we performed Mendelian randomization analysis to identify causally related AD. Biomarkers further ascertained receiver operating characteristic curve (ROC) expression GSE48350. Furthermore, set enrichment analysis, immune infiltration correlation with metabolic pathways conducted, as well construction a regulator molecular docking. Results: According Fisher test, oligodendrocytes regarded due their excellent abundance dataset, which there 281 overlapping 3,490 550 GSE5281, four found be AD, namely, G protein-coupled receptor, family C, group 5, member B (GPRC5B), Methyltransferase-like protein 7 A (METTL7A), NF-κB inhibitor alpha (NFKBIA) RAS association domain 4(RASSF4). Moreover, GPRC5B, NFKBIA RASSF4 deemed biomarkers, except for METTL7A, because indistinctive might involved oxidative phosphorylation, adipogenesis heme metabolism. T helper type 17 cells, natural killer CD56dim significantly correlated biomarkers. Transcription factors (GATA2, POU2F2, NFKB1, etc.) regulate Finally, discovered that all biomarkers could bind MLT strong binding energy. Conclusion: Our study identified three novel RASSF4, providing approach investigation treatment

Language: Английский

Citations

0
Therapeutic Potential of Green-Engineered ZnO Nanoparticles on Rotenone-Exposed D. melanogaster (Oregon R+): Unveiling Ameliorated Biochemical, Cellular, and Behavioral Parameters DOI Creative Commons
Shabnam Shabir, Amit Sehgal, Joydeep Dutta

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1679 - 1679

Published: Aug. 28, 2023

Nanotechnology holds significant ameliorative potential against neurodegenerative diseases, as it can protect the therapeutic substance and allow for its sustained release. In this study, reducing capping agents of Urtica dioica (UD), Matricaria chamomilla (MC), Murraya koenigii (MK) extracts were used to synthesize bio-mediated zinc oxide nanoparticles (ZnO-NPs) bacteria (Staphylococcus aureus Escherichia coli) rotenone-induced toxicities in D. melanogaster first time. Their optical structural properties analyzed via FT-IR, DLS, XRD, EDS, SEM, UV–Vis, zeta potential. The antioxidant antimicrobial fabricated ZnO-NPs evaluated employing cell-free models (DPPH ABTS) well diffusion method, respectively. Rotenone (500 µM) was administered Drosophila third instar larvae freshly emerged flies 24–120 h, either alone or combination with plant (UD, MC, an MK) their biogenic ZnO-NPs. A comparative study on protective effects synthesized NPs undertaken neurotoxic, cytotoxic, behavioral alterations using acetylcholinesterase inhibition assay, dye exclusion test, locomotor parameters. findings revealed that among plant-derived ZnO-NPs, MK-ZnO exhibit strong activities, followed by UD-ZnO MC-ZnO NPs. regard, ethno-nano medicinal uses mimic similar suppressing oxidative stress restoring biochemical parameters (AchE proteotoxicity activity) lower cellular toxicity. These suggest green-engineered have significantly enhance outcomes, promise effective therapies neurodegeneration, could be a great alternative clinical development.

Language: Английский

Citations

3
Mind Over Microbes: Investigating the Interplay Between Lifestyle Factors, Gut Microbiota, and Brain Health DOI
Parul Bali,

Parth Lal,

Madhava Sai Sivapuram

et al.

Neuroepidemiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: March 26, 2024

<b><i>Background:</i></b> The gut microbiota (GM) of the human body comprises several species microorganisms. This microorganism plays a significant role in physiological and pathophysiological processes various diseases. <b><i>Methods:</i></b> literature review includes studies that describe causative factors influence GM. GM is sensitive to like circadian rhythms, environmental agents, physical activity, nutrition, hygiene together impact functioning composition microbiome. affects health host, including psycho-neural aspects, due interconnectivity between brain gut. Hence, this paper examines relationship with neurodegenerative disorders context these aforesaid factors. <b><i>Conclusion:</i></b> Future identify regulatory pathways associated microbes can provide causal link degeneration at molecular level. Together, could be helpful designing preventive treatment strategies aimed GM, so diseases treated.

Language: Английский

Citations

0
Melatonin-Related Genes as Key Players in Alzheimer's Disease: Discovery of Promising Biomarkers for Treatment Targets for Alzheimer's Disease DOI Creative Commons
Huaxiong Zhang,

Dilmurat Hamit,

Qing Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Background Melatonin can improve mitophagy, thereby ameliorating cognitive deficits in Alzheimer’s disease (AD) patients. Hence, our research focused on the potential value of melatonin-related genes (MRGs) AD through bioinformatic analysis. Methods First, key cells single-cell dataset GSE138852 were screened out based proportion annotated and Fisher’s test between control groups. The differentially expressed (DEGs) cell GSE5281 datasets identified, MRGs selected via weighted gene coexpression network After intersecting two sets DEGs MRGs, we performed Mendelian randomization analysis to identify causally related AD. biomarkers GSE48350 identified receiver operating characteristic (ROC) curve expression analyses. Furthermore, set enrichment analysis, immune infiltration correlation with metabolic pathways conducted, as well construction a regulator molecular docking. Results According Fisher test, oligodendrocytes regarded due their excellent abundance dataset, which there 281 overlapping 3,490 550 GSE5281, four found be AD, namely, GPRC5B, METTL7A, NFKBIA RASSF4. Moreover, RASSF4 deemed biomarkers, except for because indistinctive Biomarkers might involved oxidative phosphorylation, adipogenesis heme metabolism. T helper type 17 cells, natural killer CD56dim significantly correlated biomarkers. Transcription factors (GATA2, POU2F2, NFKB1, etc.) regulate Finally, discovered that all could bind melatonin strong binding energy. Conclusion Our study three novel RASSF4, providing approach investigation treatment

Language: Английский

Citations

0
Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management DOI Creative Commons
Adil Hassan, Yin Huang,

Mahjabina

et al.

iMetaOmics., Journal Year: 2024, Volume and Issue: 1(2)

Published: Oct. 25, 2024

Abstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown dynamic relationship between microbiota central nervous system (CNS). Dysbiosis key establishing progressing diseases, including neurodegenerative disorders. Recently, extracellular vesicles (GMEVs) have been suggested as brain‐gut communication carriers. Vesicle components contact immune receptors, initiating neuroinflammatory responses causing diseases. This study seeks explain how its cause or worsen We also highlighted recent advances our understanding these GMEVs' cargo's routes, which could used drug delivery treatments. examines current state potential therapeutic effects GMEVs on illnesses.

Language: Английский

Citations

0
Unveiling the complexity of Alzheimer's disease: Introduction and its pathophysiology DOI
Shabnam Shabir, Mahendra Pratap Singh

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Oct. 25, 2024

Language: Английский

Citations

0