Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review

PeerJ, Journal Year: 2023, Volume and Issue: 11, P. e14952 - e14952

Published: March 13, 2023

Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease acute myocardial infarction. However, can lead ischemia injury (MIRI), which the prognosis of patients. Studying mechanisms MIRI help us improve treatment MIRI. The pathological process involves many ferroptosis mitophagy. Ferroptosis exacerbate MIRI, regulation mitophagy alleviate Both are closely related ROS, but there no clear understanding relationship between In this review, we analyzed according role mTOR, NLPR3 HIF. addition, simultaneous may be superior single for We summarized potential drugs that regulate and/or ferroptosis, hoping provide reference development methods treatment.

Language: Английский

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Prognostic model development and molecular subtypes identification in bladder urothelial cancer by oxidative stress signatures

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Aging | doi:10.18632/aging.205499. Ying Dong, Xiaoqing Wu, Chaojie Xu, Yasir Hameed, Mostafa A. Abdel-Maksoud, Taghreed N. Almanaa, Mohamed H. Kotob, Wahidah Al-Qahtani, Ayman M. Mahmoud, William C. Cho, Chen Li

Language: Английский

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Role of long non-coding RNA ELFN1-AS1 in carcinogenesis

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 13, 2024

Abstract As one of the leading causes death worldwide, cancer significantly burdens patients and healthcare system. The role long non-protein coding RNAs (lncRNAs) in carcinogenesis has been extensively studied. lncRNA ELFN1-AS1 was discovered recently, subsequent studies have revealed its aberrantly high expression various tissues. In vitro vivo experiments consistently demonstrated close association between increased malignant tumor characteristics, particularly gastrointestinal malignancies. Functional assays further mechanistic as a competitive endogenous RNA for microRNAs, inducing growth, invasive features, drug resistance. Additionally, investigation into clinical implication potential diagnostic, therapeutic, and, notably, prognostic marker. This review provides comprehensive summary evidence regarding involvement initiation development, highlighting significance.

Language: Английский

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The Predictive Value of Changes in the Absolute Counts of Peripheral Lymphocyte Subsets for Progression and Prognosis in Breast Cancer Patients

Contrast Media & Molecular Imaging, Journal Year: 2022, Volume and Issue: 2022(1)

Published: Jan. 1, 2022

As the number and proportion of lymphocyte subsets are an important indicator immune function, in depth understanding function patients with malignant tumor has clinical values for treatment, prognosis, evaluation disease. This retrospective study was to evaluate value absolute counts as potential blood biomarkers progression prognosis breast cancer patients.A total 237 BC 55 age-matched female normal healthy donors were included this study. Flow cytometry used determine percentages CD3+, CD4+, CD8+, B, NK cells. The receiver operating characteristic curve (ROC) accuracy count curative efficacy assessment. clinicopathological parameters influencing disease determined by Cox proportional hazards regression. Progression-free survival (PFS) estimated using Kaplan-Meier method log-rank test. Results: Compared donors, decreased significantly. ROC analysis showed that area under CD4+ 90% (95% confidence interval 0.859-0.940), sensitivity specificity 80.9% 85.3%, respectively. regression cutoff ≥451 cells/μL might be a favorable prognostic factor. Multivariate factors PFS CD8+ independent predicting PFS.The remarkably impaired cells can susceptible patient's status. higher level probably contributed longer outcome patients.

Language: Английский

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Screening and biomarker assessment of ferroptosis genes FLT3 and ALOX5 in lung adenocarcinoma

ONCOLOGIE, Journal Year: 2023, Volume and Issue: 25(3), P. 281 - 289

Published: March 29, 2023

Abstract Objectives Ferroptosis is a unique process of cell death that specifically requires iron. We investigated ferroptosis genes and their function in lung adenocarcinoma (LUAD) patients. Methods Data on the expression levels associated with were collected from FerrDb Cancer Genome Atlas database. Kaplan-Meier Plotter was employed to generate survival curves LUAD patients high vs low genes. The relationship between immune infiltration analyzed via TIMMER. Immunohistochemical staining quantitatively evaluate gene 43 Results A total 89 found have significant differential normal tissues (p<0.05), 23 which selected consistent prognostic trends observed based analysis RNA-Seq RNA microarray data (p<0.05). These assigned 10 high-abundance pathways 18 functional categories. Besides, ALOX5 FTL3 demonstrated positive correlation sets markers. exhibited dendritic cells, macrophages, neutrophils, CD4+ T while FLT3 correlated B cells. Furthermore, confirmed be downregulated tumor (p<0.01). Conclusions Our findings show play prominent roles during progression may serve as biomarkers for LUAD.

Language: Английский

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Potential prognostic value of a eight ferroptosis-related lncRNAs model and the correlative immune activity in oral squamous cell carcinoma

BMC Genomic Data, Journal Year: 2022, Volume and Issue: 23(1)

Published: Nov. 16, 2022

Abstract Background To investigate the prognostic value of ferroptosis-related long noncoding RNAs (lncRNAs) in oral squamous cell carcinoma (OSCC) and to construct a risk immune activity model. Methods We obtained clinical RNA-seq information on OSCC patient data The Cancer Genome Atlas (TCGA) Data Sharing (GDC) portal. Through combination differential analysis, Pearson correlation analysis Cox regression lncRNAs were identified, model was established based these lncRNAs. accuracy evaluated via analyses survival curves, receiver operating characteristic (ROC) decision curve (DCA). Univariate multivariate performed evaluate independent factors. Then, infiltration functional enrichment cells high- low-risk groups compared. Finally, certain small-molecule drugs that potentially target predicted use L1000FWD database. Results included 8 (FIRRE, LINC01305, AC099850.3, AL512274.1, AC090246.1, MIAT, AC079921.2 LINC00524). area under ROC (AUC) 0.726. DCA revealed score better indicator than other indicators. showed an factor for OSCC. There differences infiltration, functions, m6A-related gene expression levels, signal pathway between groups. Subsequently, several against differentially expressed genes Conclusions constructed new is valuable prediction evaluation, laying foundation study

Language: Английский

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Noncoding RNAs in cancer ferroptosis: From biology to clinical opportunity

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115053 - 115053

Published: June 28, 2023

Ferroptosis is a recently discovered pattern of programmed cell death that nonapoptotic and irondependent. It involved in lipid peroxidation dependent on reactive oxygen species. has been verified to play crucial regulatory role variety pathological courses disease, particularly cancer. Emerging research highlighted the potential ferroptosis tumorigenesis, cancer development resistance chemotherapy. However, mechanism remains unclear, which limits application treatment. Noncoding RNAs (ncRNAs) are noncoding transcripts regulate gene expression various ways affect malignant phenotypes cells. At present, biological function underlying ncRNAs have partially elucidated. Herein, we summarize current knowledge central network ferroptosis, with focus functions ferroptosis. The clinical prospects ferroptosis-related diagnosis, prognosis anticancer therapies also discussed. Elucidating along assessing significance ncRNAs, provides new perspectives for understanding biology treatment approaches, may benefit numerous patients future.

Language: Английский

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Costimulatory molecule‐related lncRNA model as a potential prognostic biomarker in non‐small cell lung cancer

Cancer Medicine, Journal Year: 2022, Volume and Issue: 12(5), P. 6419 - 6436

Published: Oct. 28, 2022

Abstract Objective Costimulatory molecules have been demonstrated to exert essential roles in multiple cancers. However, their role lung cancer remains elusive. Here, we sought identify costimulatory molecule‐related lncRNAs non‐small cell (NSCLC) and establish a prognostic signature predict the prognosis of patients with NSCLC. Methods A total 535 adenocarcinoma (LUAD) 502 squamous carcinoma (LUSC) from genome atlas (TCGA) database were recruited. novel molecule‐based lncRNA model was constructed using least absolute shrinkage selection operator (LASSO) algorithm overall survival. The Homo_sapiens.GRCh38 data set as reference file for probe annotation. Results 593 extracted. After analysis, six (AC084859.1, AC079949.2, HSPC324, LINC01150, AC090617.5) screened. based on established systematic bioinformatics analyses. had value NSCLC patients. Furthermore, nomogram clinical parameters risk‐score model. Patients different risk scores considerably tumor‐infiltrating immune cells, somatic mutational loading, outcomes, signaling pathways, immunotherapy efficacy. In addition, LINC01137 associated unfavorable disease outcomes fueled tumor progression Conclusion Taken together, our study that could be potential biomarker Moreover, facilitate proliferation invasion cancer.

Language: Английский

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PVT1/miR-16/CCND1 axis regulates gastric cancer progression

Open Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: Jan. 1, 2023

Abstract Long non-coding RNA plasmacytoma variant translocation 1 (PVT1) has been reported to be a vital modulator in tumorigenesis of gastric cancer (GC). However, the detailed regulatory mechanism PVT1 GC remains largely unclear. In this work, expressions and microRNA-16 (miR-16) were detected by quantitative real-time PCR (qRT-PCR) tissues cell lines. lines NCI-N87 MKN45 chosen for following assays. After was overexpressed or depleted, CCK-8 Transwell assays performed examine viability invasive capacity. Cell cycle analyzed flow cytometry. The expression cyclin D1 (CCND1) at mRNA protein levels measured qRT-PCR western blot. competitive endogenous molecular among PVT1, miR-16 CCND1 verified bioinformatics analysis, luciferase-reporter gene assay immunoprecipitation assay. present study, it revealed that remarkably evaluated than corresponding control group. positively regulated proliferation, migration progression cells. Besides, identified as target miR-16. depletion promoted suppressed expression. Moreover, either inhibitor overexpression plasmid could reverse promoting effects on malignant biological behaviors conclusion, negatively regulating enhance viability, invasion

Language: Английский

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Comparative analyses of the prognosis, tumor immune microenvironment, and drug treatment response between left-sided and right-sided colon cancer by integrating scRNA-seq and bulk RNA-seq data

Aging, Journal Year: 2023, Volume and Issue: 15(14), P. 7098 - 7123

Published: July 21, 2023

In this study, we compared the prognosis, tumor immune microenvironment (TIM), and drug treatment response between left-sided (LCC) right-sided (RCC) colon cancer to predict outcomes in patients with LCC RCC.Based on identified differentially expressed genes using single-cell RNA sequencing data, constructed validated a prognostic model for RCC TCGA-COAD cohort GSE103479 cohort. Moreover, differences of TIM characteristics patients.We five-gene four-gene patients, both showed excellent performance. The higher risk scores were significantly associated greater metastasis (P = 2.6×10-5), N stage 0.012), advanced pathological 1.4×10-4), more stable microsatellite status 0.007) but not T 0.200). For > 0.05). Additionally, infiltration by CD8 regulatory cells M0, M1, M2 macrophages differed < APC TP53 mutations common contrast, KRAS, SYNE1, MUC16 addition, mutation burden values than 5.9×10-8). expression checkpoint targets was 0.05), indicating that maybe sensitive immunotherapy. However, did differ their sensitivity eight selected chemicals or target drugs average half-maximal inhibitory concentrations camptothecin, teniposide, vinorelbine, mitoxantrone lower low-risk high-risk score they these four drugs.We investigated TIM, which may contribute accurate prognosis cancer.

Language: Английский

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