Correlation between the Closure Time of Patent Ductus Arteriosus in Preterm Infants and Long-Term Neurodevelopmental Outcome

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(1), P. 26 - 26

Published: Jan. 16, 2024

In patent ductus arteriosus (PDA) in preterm infants, the relationship between treatment timing and long-term developmental prognosis remains unclear. The purpose of this study was to clarify age days when closure occurred development. Preterm infants with a birth weight less than 1500 g who were admitted our NICU over period 9 years (2011–2019) diagnosed PDA included. A new version K-type test for corrected ages 1.5 3 used as an index duration evaluated using Pearson’s correlation coefficient, multiple regression analysis performed. Development quotient (DQ) at showed date standard deviation (SD) value term weight. Multiple positive DQ SD negative date. addition, stronger found “posture/motor” sub-item years. On other hand, including without that on 6th day or later after had significantly lower 3-year-old exposure within 5 days. conclusion, it is suggested decrease cerebral blood flow due has adverse effect neurodevelopment. Appropriate interventions, surgical delay, ideally birth, may be effective improving prognosis.

Language: Английский

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Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseases

Redox Biology, Journal Year: 2023, Volume and Issue: 66, P. 102865 - 102865

Published: Aug. 29, 2023

Oxygen therapy is common during the neonatal period to improve survival, but it can increase risk of oxygen toxicity. Hyperoxia damage multiple organs and systems in newborns, commonly causing lung conditions such as bronchopulmonary dysplasia pulmonary hypertension, well other organs, including brain, gut, eyes. These are collectively referred newborn radical disease indicate multi-system caused by hyperoxia. also lead changes metabolic pathways production abnormal metabolites through a process called reprogramming. Currently, some studies have analyzed mechanism reprogramming induced The focus has been on mitochondrial oxidative stress, dynamics, multi-organ interactions, lung–gut, lung–brain, brain–gut axes. In this article, we provide an overview major pathway reported hyperoxia-associated diseases explore potential mechanisms Metabolic hyperoxia cause disorders glucose, lipid, amino acid metabolism. Moreover, may predict occurrence disease, suggesting their therapeutic targets. Although requires further elucidation, mitochondria gut–lung–brain axis play key role

Language: Английский

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The emerging role of extracellular vesicles in bronchopulmonary dysplasia

AJP Lung Cellular and Molecular Physiology, Journal Year: 2024, Volume and Issue: 326(5), P. L517 - L523

Published: March 12, 2024

Extracellular vesicle (EV) biology in neonatal lung development and disease is a rapidly growing area of investigation. Although EV research the population lags behind adult diseases, recent discoveries demonstrate promise furthering our understanding pathophysiology bronchopulmonary dysplasia potential use EVs clinical setting, as both biomarkers therapeutic agents. This review article explores some advances this field evolving knowledge role dysplasia.

Language: Английский

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Neonatal Oxidative Stress Impairs Cortical Synapse Formation and GABA Homeostasis in Parvalbumin-Expressing Interneurons

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 12

Published: May 25, 2022

Neonatal brain injury is often caused by preterm birth. Brain development vulnerable to increased environmental stress, including oxidative stress challenges. Due a premature change of the fetal living environment from low oxygen in utero into postnatal high-oxygen room air conditions ex utero, immature exposed relative hyperoxia, which can induce and impair neuronal cell development. To simulate drastic increase exposure brain, 5-day-old C57BL/6 mice were hyperoxia (80% oxygen) for 48 hours or kept (normoxia, 21% analyzed maturational alterations cortical GABAergic interneurons. As result, was indicated elevated tyrosine nitration proteins. We found perturbation perineuronal net formation line with decreased density parvalbumin-expressing (PVALB) interneurons hyperoxic mice. Moreover, deficits PVALB+ obtained glutamate decarboxylase 67 (GAD67) protein expression Western blot analysis lower gamma-aminobutyric acid (GABA) fluorescence intensity immunostaining. Hyperoxia-induced affected synaptogenesis decreasing synapsin 1, 2, synaptophysin expression. Developmental delay synaptic marker demonstrated together PI3K-signaling as pathway being involved synaptogenesis. These results elucidate that neonatal lead interneuron damage may serve an explanation high incidence psychiatric behavioral infants.

Language: Английский

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Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 24, 2025

Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature neonates, yet without an established pharmacological treatment. The BPD rabbit model exposed to 95% oxygen has been used in recent years for drug testing. However, the toxicity strong hyperoxic hit precludes longer-term follow-up due high mortality after first week life. This study aimed extend preterm postnatal day (PND) 14 mimic evolving phase and enable investigation therapeutic interventions at later more relevant time points. Preterm pups delivered on 28th gestation were either room air or different degrees hyperoxia (50% 70% O2) days. Single (immediately birth) double (at birth PND5) intratracheal lipopolysaccharide (LPS) administrations also tested combination with 50% O2. Age-matched rabbits vaginally term as controls. Survival, weight gain, function, pulmonary artery micro-ultrasound Doppler analysis, histology (alveolarization, injury score, design-based stereology), longitudinal micro-CT imaging compare outcomes PND14. Premature itself, any other hit, was associated function deficits, delayed development, cardiovascular abnormalities. BPD-like phenotype enhanced by O2 but not hyperoxia. Intratracheal LPS immediately significantly higher scores PND14 increased tissue damping, marker parenchymal resistance. Several strategies are feasible saccular even absence hits, abnormalities compared age-matched pups. Enhanced phenotypes can be further achieved continued exposure moderate (70% administration LPS.

Language: Английский

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Association of preoperative cerebral oxygenation with concurrent neurobehavioral scores in term neonates with congenital heart disease compared to healthy controls

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 14, 2025

Objective 1st: To determine the association of cerebral oxygenation (rcSO 2 ) and concurrent neurodevelopmental outcomes between neonates with congenital heart disease (CHD) healthy controls. 2nd: examine fractional tissue oxygen extraction (FTOE) in two groups. 3rd: evaluate how type severity CHD influenced associations our primary secondary objectives. Study design Our analysis included 137 (74 63 controls). We used linear regression models to predictors (i.e., oxygenation, FTOE, CHD) percentage abnormal neurobehavioral scores (outcome). The main effects group, rcSO , a -by-group interaction (examined differences groups) covariates postconceptional age at exam, sex, ethnicity, preductal peripheral saturation on scores. also performed separate separately each group. these for 2nd 3rd objectives, replacing FTOE as predictors. Results Neonates had lower values (67% vs. 79%; p < 0.001) higher (0.27 0.19; compared significantly differed groups ( = 0.004). In increased showed trend toward better outcomes. However, associated poorer Additionally, 0.012). group towards Conversely, Conclusions different both findings suggest that decreased may negatively affect neonates. imply critical range values, where extreme either side be harmful. controls exhibit responses due differing metabolic demands.

Language: Английский

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Severity of bronchopulmonary dysplasia and characteristics of neuro-motor development prior to acquisition of independent walking in very preterm and/or very low-birth-weight infants: A retrospective cohort study in a children's medical centre in Japan

Early Human Development, Journal Year: 2025, Volume and Issue: 203, P. 106225 - 106225

Published: Feb. 20, 2025

Language: Английский

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Prenatal inflammation exacerbates hyperoxia-induced neonatal brain injury

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 28, 2025

Abstract Background Premature born infants are at high risk to develop white matter injury (WMI). Hyperoxia and perinatal inflammation main factors for preterm birth associated brain injury. To date the majority of experimental studies have focused on isolated insults. However, clinically, WMI is a multifactorial disorder caused by variety triggers. establish clinically relevant rodent model WMI, we combined prenatal with postnatal hyperoxia investigate individual, additive or synergistic effects inflammatory processes, myelination grey development. Methods At embryonic day 20, pregnant Wistar rat dams received either single intraperitoneal injection 100 µg/ kg lipopolysaccharide (LPS) sodium chloride. Offspring were exposed (80% O 2 ) normoxia (21% from 3 5. Animals sacrificed immediately after 6 days later, corresponding term-equivalent age. White development neuroinflammatory responses investigated cellular molecular levels applying immunohistochemistry, western blotting, real time PCR in tissues multiplex protein expression analysis serum samples. Results Prenatal resulted reduced body weight length offspring, accompanied increased leptin term equivalent The altered parameters, like weight, decreased volume, thinning deep cortical layers hypomyelination. As potential underlying mechanisms, identified severe deficits an microglia activation elevated cytokine tissues, while peripheral reduced. Interestingly, size mainly mediated LPS, independent hyperoxia, oligodendrocyte degeneration was induced inflammation. pathological changes, including size, deficits, expression, detected. Conclusion results aggravated compared insults, making it ideal improve our understanding complex pathophysiology evaluate urgently needed therapies.

Language: Английский

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SIRT2 Regulates Apoptosis Signaling in Hyperoxic Acute Lung Injury

Lung, Journal Year: 2025, Volume and Issue: 203(1)

Published: March 11, 2025

Language: Английский

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A Novel Model for Simultaneous Evaluation of Hyperoxia-Mediated Brain and Lung Injury in Neonatal Rats

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 443 - 443

Published: March 16, 2025

Despite improved neonatal intensive care, the risk of premature-born infants developing bronchopulmonary dysplasia (BPD) and encephalopathy prematurity (EoP) remains high. With hyperoxia being a major underlying factor, both preterm-birth-related complications are suggested to be closely interrelated. However, experimental models lacking for assessment potentially close interplay between organs. To establish model, suitable affected organs, Wistar rats were exposed 80% oxygen from postnatal day 2 (P2) seven days. Brain lung tissues analysed via histomorphometry, immunohistochemistry, real-time PCR, western blot at term P11. In brain, induced significant hypomyelination accompanied by reduction in oligodendrocytes CD68 expression on microglia cells. These changes correlate with arrested alveolarisation an increased number macrophages lung. Interestingly, contrast reduced formation pulmonary microvessels, vascular density was detected brain. Seven days induces typical characteristics BPD EoP rats, thereby linking impaired disturbed myelination brain providing model understanding pathophysiological mechanisms identifying organ-spanning novel therapeutic interventions targeting diseases.

Language: Английский

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