Nutrients,
Journal Year:
2024,
Volume and Issue:
16(6), P. 809 - 809
Published: March 12, 2024
The
purpose
of
this
work
was
to
examine
the
effects
potassium
poly-γ-glutamate
(PGA-K)
on
mice
fed
a
high-fat
diet
consisting
60%
total
calories
for
12
weeks.
PGA-K
administration
reduced
increase
in
body
weight,
epididymal
fat,
and
liver
weight
caused
by
compared
obese
group.
triglyceride,
low-density
lipoprotein
cholesterol
high-density
levels,
which
are
blood
lipid
indicators,
were
significantly
increased
group
but
decreased
PGA-K-treated
resulted
significant
inhibition
pro-inflammatory
cytokines,
including
tumor
necrosis
factor
α
interleukin
6.
Moreover,
levels
leptin
insulin,
insulin
resistance
These
results
suggest
that
exhibits
protective
effect
against
obesity
induced
diet,
underscoring
its
potential
as
candidate
treatment.
Food Frontiers,
Journal Year:
2024,
Volume and Issue:
5(3), P. 1188 - 1211
Published: Feb. 19, 2024
Abstract
Owing
to
concerns
about
animal
proteins,
resource
limitations,
and
population
growth,
there
is
growing
interest
in
exploring
soybeans
as
protein
alternatives
fulfill
consumption
requirements.
Black
soybean
(BS)
has
superior
nutritional
health
benefits,
compared
yellow
(YS).
However,
BS
been
explored
less
often
than
YS.
While
previous
reviews
have
individually
focused
on
the
composition,
bioactive
compounds,
or
benefits
of
BS,
they
not
delved
into
intricate
mechanisms
underlying
these
interactions,
especially
distinct
roles
individual
components.
This
comprehensive
review
aims
bridge
this
gap
by
providing
an
overview
key
composition
compounds
associated
with
well
possible
changes.
Various
processing
technologies
(physical,
biological,
thermal)
applied
BS.
Additionally,
bioavailability,
biotransformation,
safety
were
studied,
factors
are
crucial
for
its
potential
application,
such
natto,
films,
microcapsules.
some
gaps
application
In
future,
it
will
be
worth
effects
meat
analogs,
3D
printing
constituents,
amyloid
fibrils,
lipids
oleogels
seed
coats
ingredients
pharmaceutical
products.
Frontiers in Bioscience-Elite,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: March 11, 2024
Food
is
an
integral
part
of
our
civilization.
It
a
cultural
phenomenon
that,
while
having
evolved,
associated
with
societal
traditions
and
identity.
This
work
analyzes
studies
conducted
to
highlight
the
health
properties
most
common
ethnic
foods.
Although
these
foods
were
originally
created
from
need
preserve
perishable
produce,
presently,
we
know
that
fermentation
process
makes
them
nutritionally
more
complete.
The
basis
transformations
lies
in
vast
range
prokaryotic
eukaryotic
microorganisms
similar
small
biochemical
factories,
can
transform
initial
nutrients
into
metabolically
active
biomolecules
through
fermentation.
naturally
occurring
microbes
together
for
mutual
benefit,
environmental
conditions
enhance
or
inhibit
their
development.
Starting
selection
present
on
substrate,
attempt
select
suitable
species
obtain
fermented
food
best
nutritional
qualities
richest
nutraceuticals.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 7, 2024
Abstract
Nattokinase,
from
the
Japanese
fermented
food
natto,
is
a
protease
with
fibrinolytic
activity
that
can
thus
degrade
conventional
blood
clots.
In
some
cases,
however,
including
in
Long
COVID,
fibrinogen
polymerise
into
an
anomalous
amyloid
form
to
create
clots
are
resistant
normal
fibrinolysis
and
we
refer
as
fibrinaloid
microclots.
These
be
detected
fluorogenic
stain
thioflavin
T.
We
describe
automated
microscopic
technique
for
quantification
of
microclot
formation,
which
also
allows
kinetics
their
formation
aggregation
recorded.
here
show
recombinant
nattokinase
effective
at
degrading
microclots
vitro
.
This
adds
otherwise
largely
anecdotal
evidence,
review,
might
anticipated
have
value
part
therapeutic
treatments
individuals
COVID
related
disorders
involve
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2024,
Volume and Issue:
23(4)
Published: June 25, 2024
Abstract
Lipopeptides
are
a
class
of
lipid–peptide‐conjugated
compounds
with
differing
structural
features.
This
diversity
is
responsible
for
their
diverse
range
biological
properties,
including
antimicrobial,
antioxidant,
and
anti‐inflammatory
activities.
have
been
attracting
the
attention
food
scientists
due
to
potential
as
additives
preservatives.
review
provides
comprehensive
overview
lipopeptides,
production,
characteristics,
functional
properties.
First,
classes,
chemical
features,
structure–activity
relationships,
sources
lipopeptides
summarized.
Then,
gene
expression
biosynthesis
in
microbial
cell
factories
strategies
optimize
lipopeptide
production
discussed.
In
addition,
main
methods
purification
characterization
described.
Finally,
some
activities
especially
those
relevant
systems
along
mechanism
action,
critically
examined.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(7), P. 7001 - 7031
Published: July 4, 2024
Vitamin
K
(VK)
is
an
essential
micronutrient
impacting
many
systems
in
the
body.
This
lipid-soluble
vitamin
found
various
plant
and
animal
products
absorbed
via
lymphatic
system.
biomolecule's
importance
to
human
health
includes
but
not
limited
its
promotion
of
brain,
cardiovascular,
bone,
immune
functions.
These
biological
properties
are
also
necessary
for
maintaining
domesticated
health.
The
synergistic
impact
both
VK
D
(VD)
maximizes
these
benefits,
specifically
circulatory
skeletal
systems.
manuscript
reviews
VK's
properties,
molecular
structures,
nutrikinetics,
mechanisms
action,
daily
requirements,
safety
supplemental
form,
biomarkers
used
detection,
impacts
on
organs.
purpose
synthesizing
this
information
evaluate
potential
uses
treatment
or
prevention
diseases.
Probiotics
serve
as
promising
candidates
in
type
2
diabetes
mellitus
(T2DM)
therapy.
Not
only
they
presumably
reduce
the
T2DM
prevalence,
but
also
keep
down
its
complications.
In
present
study,
we
explored
beneficial
impact
of
ZBiotics,
an
engineered
probiotic,
on
Wistar
rats.
silico
analysis
was
performed
to
construct
a
genetic-epigenetic
network
linked
STING-NOD
pathway
and
autophagy
signaling.
Then,
30
rats
were
divided
into
5
groups
(each
n
=
6);
normal
group,
diabetic
model,
B.
subtilis,
ZBiotics
treated
at
high
low
doses.
Experimental
procedures
carried
out
including
biochemical
histopathologic
analyses.
Samples
extracted
from
rats'
blood,
liver,
kidney
adipose
tissues.
At
molecular
aspect,
players,
chosen
by
analysis,
assessed
using
2-ΔΔCt
estimate
their
relative
quantification.
With
immunohistochemistry,
TNF-alpha
LC3B
reflectors
for
inflammation
respectively.
reported
ameliorate
T2DM-induced
histological
damage.
Besides,
it
downregulated
upregulated
expression
levels.
corrected
LDL-c
improved
serum
creatinine
CK-MB
Inflammation
relevant
genes
have
been
regarding
CHUK,
NFKB1
miR-611.
Therefore,
is
speculated
operate
modulating
inflammatory
cGAS-STING
recommended
clinical
trials
separate
candidate
or
adjuvant
conventional
Molecules,
Journal Year:
2025,
Volume and Issue:
30(5), P. 1027 - 1027
Published: Feb. 24, 2025
Vitamin
K
is
essential
for
many
physiological
processes,
including
coagulation,
bone
metabolism,
tissue
calcification,
and
antioxidant
activity.
vitamers
are
represented
by
lipophilic
compounds
with
similar
chemical
structure
(i.e.,
phylloquinone
(vitamin
K1)
menaquinone
K2)).
deficiency
can
affect
coagulation
vascular
increasing
the
risk
of
hemorrhages,
atherosclerosis,
cerebrovascular
diseases,
neurodegeneration.
Recently,
several
studies
have
hypothesized
a
possible
dual
role
vitamin
in
benefiting
both
cerebral
health,
e.g.,
sphingolipids
biosynthesis
or
ferroptosis
inhibition.
The
aim
this
narrative
review
to
deepen
understanding
biological
activities
its
protective/preventive
actions
neurovascular
degenerative
conditions,
stroke
dementia.
Given
difficulties
related
hemorrhagic
entailed
prevention
strokes,
function
antagonists
also
investigated.
Finally,
we
track
development
clinical
concept
future
preventive
strategy
innovative
use
as
supplement
counteract
pathological
focusing
particular
on
