Different Targeting Ligands-Mediated Drug Delivery Systems for Tumor Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 248 - 248

Published: Feb. 7, 2024

Traditional tumor treatments have the drawback of harming both cells and normal cells, leading to significant systemic toxic side effects. As a result, there is pressing need for targeted drug delivery methods that can specifically target or tissues. Currently, researchers made progress in developing systems therapy using various targeting ligands. This review aims summarize recent advancements therapy, focusing on different ligands such as folic acid, carbohydrates, peptides, aptamers, antibodies. The also discusses advantages, challenges, future prospects these systems.

Language: Английский

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A Review: Surface Engineering of Lipid‐Based Drug Delivery Systems

Small, Journal Year: 2024, Volume and Issue: 20(43)

Published: July 14, 2024

This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.

Language: Английский

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Targeting triple negative breast cancer stem cells using nanocarriers

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: March 7, 2024

Abstract Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, treatment responses. Categorization of based on the presence or absence estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2), leading to such as luminal A, B, HER2-positive, triple-negative breast (TNBC). TNBC, comprising around 20% all cancers, lacks expression ER, PR, HER2 receptors, rendering it unresponsive targeted therapies presenting significant challenges in treatment. TNBC associated with aggressive behavior, high rates recurrence, resistance chemotherapy. Tumor initiation, progression, are attributed stem cells (BCSCs), which possess self-renewal, differentiation, tumorigenic potential. Surface markers, self-renewal pathways (Notch, Wnt, Hedgehog signaling), apoptotic protein (Bcl-2), angiogenesis inhibition (VEGF inhibitors), immune modulation (cytokines, checkpoint inhibitors) among key targets discussed this review. However, targeting BCSC subpopulation presents challenges, including off-target effects, low solubility, bioavailability anti-BCSC agents. Nanoparticle-based offer promising approach target cellular processes implicated survival BSCS TNBC. In review, we explore nanocarrier-based approaches for BCSCs aiming overcome these improve outcomes patients. These nanoparticle-based therapeutic strategies hold promise addressing gap delivering while minimizing systemic toxicity enhancing efficacy. Graphical abstract

Language: Английский

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Surface Functionalization of Nanocarriers with Anti-EGFR Ligands for Cancer Active Targeting

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(3), P. 158 - 158

Published: Jan. 21, 2025

Active cancer targeting consists of the selective recognition overexpressed biomarkers on cell surfaces or within tumor microenvironment, enabled by ligands conjugated to drug carriers. Nanoparticle (NP)-based systems are highly relevant for such an approach due their large surface area which is amenable a variety chemical modifications. Over past decades, several studies have debated efficiency passive targeting, highlighting active as more specific and approach. The choice conjugation chemistry attaching nanocarriers critical ensure stable robust system. Among panel biomarkers, epidermal growth factor receptor (EGFR) stands one most frequently receptors in different types. design development with surface-bound anti-EGFR vital targeted therapy, relying facilitated capture EGFR-overexpressing cells enabling receptor-mediated endocytosis improve accumulation microenvironment. In this review, we examine examples recent significant explore various strategies NP functionalization biomolecules small molecular ligands. addition, also describe some common characterization techniques confirm analyze patterns.

Language: Английский

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Receptor-Targeted Nanomedicine for Cancer Therapy

Receptors, Journal Year: 2024, Volume and Issue: 3(3), P. 323 - 361

Published: July 3, 2024

Receptor-targeted drug delivery has been extensively explored for active targeting of therapeutic moiety in cancer treatment. In this review, we discuss the receptors that are overexpressed on tumor cells and have potential to be targeted by nanocarrier systems We also highlight different types ligands researchers explored. Our discussion covers various modalities, including small molecules, aptamers, peptides, antibodies, cell-based strategies, focuses clinical developments. Additionally, article highlights challenges arise during translation nanocarrier-based strategies. It provides future directions improving research area clinically translatable cancer-targeted therapy improve treatment efficacy while minimizing toxicity.

Language: Английский

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Single-atom nanozymes: From bench to bedside

Nano Research, Journal Year: 2022, Volume and Issue: 16(2), P. 1992 - 2002

Published: Nov. 8, 2022

Language: Английский

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Functional Materials for Subcellular Targeting Strategies in Cancer Therapy: Progress and Prospects

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 4, 2023

Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment. However, tumor therapy still faces challenges due to the intrinsic heterogeneity of cancer, genomic instability, formation an immunosuppressive microenvironment. Functional materials possess unique biological properties such as long circulation times, tumor-specific targeting, immunomodulation. The combination functional with natural substances nanotechnology has led development smart biomaterials multiple functions, high biocompatibilities, negligible immunogenicities, which can be used for precise Recently, subcellular structure-targeting received particular attention various biomedical applications including diagnosis, sensing, imaging tumors drug delivery. Subcellular organelle-targeting precisely accumulate therapeutic agents organelles, considerably reduce threshold dosages agents, minimize drug-related side effects. This review provides a systematic comprehensive overview research organelle-targeted based on nanomaterials. Moreover, it explains prospects precision oncology. will serve excellent cutting-edge guide researchers field therapy.

Language: Английский

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Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology

Cancers, Journal Year: 2023, Volume and Issue: 15(9), P. 2661 - 2661

Published: May 8, 2023

Breast cancer is a heterogeneous disease which accounts globally for approximately 1 million new cases annually, wherein more than 200,000 of these turn out to be triple-negative breast (TNBC). TNBC an aggressive and rare subtype that 10–15% all cases. Chemotherapy remains the only therapy regimen against TNBC. However, emergence innate or acquired chemoresistance has hindered chemotherapy used treat The data obtained from molecular technologies have recognized with various gene profiling mutation settings helped establish develop targeted therapies. New therapeutic strategies based on delivery therapeutics relied application biomarkers derived patients. Several been found are targets precision in TNBC, such as EGFR, VGFR, TP53, interleukins, insulin-like growth factor binding proteins, c-MET, androgen receptor, BRCA1, glucocorticoid, PTEN, ALDH1, etc. This review discusses candidate identified treatment along evidence supporting their use. It was established nanoparticles had considered multifunctional system delivering target sites increased precision. Here, we also discuss role nanotechnology translation management.

Language: Английский

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DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors

Cancers, Journal Year: 2023, Volume and Issue: 15(7), P. 2151 - 2151

Published: April 5, 2023

DNA nanotechnology has significantly advanced and might be used in biomedical applications, drug delivery, cancer treatment during the past few decades. nanomaterials are widely research involving biosensing, bioimaging, delivery since they remarkably addressable biocompatible. Gradually, modified nucleic acids have begun to employed construct multifunctional nanostructures with a variety of architectural designs. Aptamers single-stranded (both DNAs RNAs) capable self-pairing acquire secondary structure specifically binding target. Diagnosis tumor therapy prospective fields which aptamers can applied. Many three-dimensional structures been studied as systems for different anticancer medications or gene agents. Different chemical alterations wide range nanostructures. Chemically altered DNA-based useful because their improved stability inclusion functional groups. In this work, most common oligonucleotide were reviewed modern cells.

Language: Английский

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Solid Lipid Nanoparticles, an Alternative for the Treatment of Triple-Negative Breast Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10712 - 10712

Published: Oct. 5, 2024

Within the field of nanomedicine, which is revolutionizing cancer treatment, solid lipid nanoparticles (SLNs) have shown advantages over conventional chemotherapy when tested on cells in preclinical studies. SLNs proven to be an innovative strategy for treatment triple-negative breast cells, providing greater efficiency than existing treatments various The encapsulation antineoplastic drugs has facilitated a sustained, controlled, and targeted release, enhances therapeutic reduces adverse effects. Moreover, surface can modified increase efficiency. For instance, coating these particles with polyethylene glycol (PEG) decreases their opsonization, resulting longer life circulatory system. creation positively charged cationic (cSLNs), achieved by utilization surfactants or ionic lipids structural groups, increases affinity cell membranes plasma proteins. Hyaluronic acid been added so that distinct pH tumor would stimulate release drug and/or genetic material. current review summarizes recent research SLNs, focusing transport agents cytotoxic effect cancer.

Language: Английский

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