Autophagy mediates an amplification loop during ferroptosis

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(7)

Published: July 25, 2023

Ferroptosis, a programmed cell death, has been identified and associated with cancer various other diseases. Ferroptosis is defined as reactive oxygen species (ROS)-dependent death related to iron accumulation lipid peroxidation, which different from apoptosis, necrosis, autophagy, forms of death. However, accumulating evidence revealed link between autophagy ferroptosis at the molecular level suggested that involved in regulating iron-dependent peroxidation ROS during ferroptosis. Understanding roles pathophysiological processes may provide effective strategies for treatment ferroptosis-related In this review, we summarize current knowledge regarding regulatory mechanisms underlying ferroptosis, including metabolism, its association pathway. addition, discuss contribution elucidate role enhancer ROS-dependent

Language: Английский

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Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 10, 2023

Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt

Language: Английский

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Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance

Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)

Published: July 12, 2023

In recent years, the incidence of gastrointestinal cancers is increasing, particularly in younger population. Effective treatment crucial for improving patients' survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role growth and development organisms. It also critical maintaining tissue organ homeostasis takes part multiple pathological processes. addition to apoptosis, there are other types programmed such as ferroptosis, necroptosis, pyroptosis, which can induce severe inflammatory responses. Notably, besides pyroptosis contribute occurrence cancers. This review aims provide comprehensive summary on biological roles molecular mechanisms well their regulators hope open up new paths tumor targeted therapy near future.

Language: Английский

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Ferroptosis in gastrointestinal cancer: from mechanisms to implications

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216147 - 216147

Published: March 24, 2023

Language: Английский

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Current Progress of Ferroptosis Study in Hepatocellular Carcinoma

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(9), P. 3621 - 3637

Published: Jan. 1, 2024

Ferroptosis, an emerging type of programmed cell death, is initiated by iron-dependent and excessive ROS-mediated lipid peroxidation, which eventually leads to plasma membrane rupture death. Many canonical signalling pathways biological processes are involved in ferroptosis. Furthermore, cancer cells more susceptible ferroptosis due the high load ROS unique metabolic characteristics, including iron requirements. Recent investigations have revealed that plays a crucial role progression tumours, especially HCC. Specifically, induction can not only inhibit growth hepatoma cells, thereby reversing tumorigenesis, but also improves efficacy immunotherapy enhances antitumour immune response. Therefore, triggering has become new therapeutic strategy for therapy. In this review, we summarize characteristics based on its underlying mechanism HCC provide possible applications.

Language: Английский

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Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-κB Pathway

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2157 - 2157

Published: April 30, 2023

Licorice is a traditional and versatile herbal medicine food. Glabridin (Gla) kind of isoflavone extracted from the licorice root, which has anti-obesity, anti-atherosclerotic, antioxidative effects. Alcoholic liver disease (ALD) widespread induced by chronic alcohol consumption. However, studies demonstrating effect Gla on ALD are rare. The research explored positive in C57BL/6J mice fed Lieber–DeCarli ethanol diet HepG2 cells treated with ethanol. alleviated ethanol-induced injury, including reducing vacuolation lipid accumulation. serum levels inflammatory cytokines were decreased Gla-treated mice. reactive oxygen species apoptosis attenuated antioxidant enzyme activity restored treatment. In vitro, reduced cytotoxicity, nuclear factor kappa B (NF-κB) translocation, enhanced (erythroid-derived 2)-like 2 (Nrf2) translocation. Anisomycin (an agonist p38 MAPK) eliminated role ethanol-caused oxidative stress inflammation. On whole, can alleviate alcoholic damage via MAPK/Nrf2/NF-κB pathway may be used as novel health product or drug to potentially ALD.

Language: Английский

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Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156417 - 156417

Published: Jan. 1, 2025

Language: Английский

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Epigenetic Modifications in HBV‐Related Hepatocellular Carcinoma

Journal of Viral Hepatitis, Journal Year: 2025, Volume and Issue: 32(2)

Published: Jan. 27, 2025

ABSTRACT Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Hepatitis B virus (HBV) main pathogen for HCC development. HBV covalently closed circular DNA (cccDNA) forms extra‐host chromatin‐like minichromosomes in nucleus of hepatocytes with host histones, non‐histones, X protein (HBx) and core (HBc). Epigenetic alterations are dynamic reversible, which regulate gene expression without altering sequence play a pivotal role regulation onset progression. The aim this review to elucidate deregulation epigenetic mechanisms involved pathogenesis HBV‐related (HBV‐HCC), including post‐translational histone non‐histone modifications, hypermethylation hypomethylation, non‐coding RNA modification on cccDNA factors, effecting replication/transcription transcription/translation genes, thus HBV‐HCC It expected that perspective provides new ways more in‐depth development therapeutic control HBV‐HCC.

Language: Английский

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Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0318450 - e0318450

Published: Jan. 29, 2025

Hepatocellular carcinoma(HCC) has a high mortality and morbidity rate seriously jeopardizes human life. Chemicals chemotherapeutic agents have been experiencing problems such as side effects drug resistance in the treatment of HCC, which cannot meet needs clinical treatment. Therefore, finding novel low-toxicity high-efficiency anti-hepatocellular carcinoma drugs exploring their mechanisms action become current to be solved HCC. Several studies reported anticancer inotodiol. This study focuses on effect inotodiol HCC cells its molecular mechanism, aiming explore depth. The CCK8 assay was utilized assess cell viability, scratch detect migration ability, clone formation clonogenic flow cytometry analyze apoptosis cycle. Animal experiments verify inhibitory Meanwhile, western blotting proteins associated with apoptosis, cycle MAPK/ERK pathway. These results showed that ability promote well inhibit proliferation, migration, ability. arrested G1 phase, when expression CDK2, CDK4, CDK6 Cyclin D were inhibited. In addition, induce characterized by an increase Bax expression, decrease Bcl-2, Bcl-XL MCL1 initiation cleaved PARP1 caspase 3, inhibition demonstrated possessed suppress tumor growth nude mice models, at same time, there no significant impact body weight organs mice. conclusion, findings presented herein compellingly suggest may serve promising candidate for hepatocellular (HCC).

Language: Английский

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Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

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