Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116363 - 116363
Published: March 12, 2024
Ferroptosis,
a
novel
form
of
regulated
cell
death
characterized
by
dependence
on
iron
and
lipid
peroxidation,
has
been
implicated
in
wide
range
clinical
conditions
including
neurological
diseases,
cardiovascular
disorders,
acute
kidney
failure,
various
types
cancer.
Therefore,
it
is
critical
to
suppress
cancer
progression
proliferation.
Ferroptosis
can
be
triggered
cells
some
normal
synthetic
substances,
such
as
erastin,
Ras-selective
lethal
small
molecule-3,
or
pharmaceuticals.
Natural
bioactive
compounds
are
traditional
drug
discovery
tools,
have
therapeutically
used
dietary
additives
pharmaceutical
agents
against
malignancies.
The
fact
that
natural
products
multiple
targets
minimal
side
effects
led
notable
advances
anticancer
research.
Research
indicated
ferroptosis
also
induced
during
treatment.
In
this
review,
we
focused
the
most
recent
developments
emerging
molecular
processes
significance
To
provide
new
perspectives
future
development
ferroptosis-related
medications,
summary
implications
phytochemicals
triggering
through
ROS
production
ferritinophagy
induction
variety
Cell,
Journal Year:
2024,
Volume and Issue:
187(15), P. 4043 - 4060.e30
Published: June 14, 2024
Inflammation-induced
neurodegeneration
is
a
defining
feature
of
multiple
sclerosis
(MS),
yet
the
underlying
mechanisms
remain
unclear.
By
dissecting
neuronal
inflammatory
stress
response,
we
discovered
that
neurons
in
MS
and
its
mouse
model
induce
stimulator
interferon
genes
(STING).
However,
activation
STING
requires
detachment
from
stromal
interaction
molecule
1
(STIM1),
process
triggered
by
glutamate
excitotoxicity.
This
initiates
non-canonical
signaling,
which
leads
to
autophagic
degradation
glutathione
peroxidase
4
(GPX4),
essential
for
redox
homeostasis
thereby
inducing
ferroptosis.
Both
genetic
pharmacological
interventions
target
protect
against
inflammation-induced
neurodegeneration.
Our
findings
position
as
central
regulator
detrimental
integrating
inflammation
with
signaling
cause
cell
death,
present
it
tractable
treating
MS.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 10, 2024
Abstract
Doxorubicin
(DOX)
is
an
effective
anticancer
agent,
but
its
clinical
utility
constrained
by
dose‐dependent
cardiotoxicity,
partly
due
to
cardiomyocyte
ferroptosis.
However,
the
progress
of
developing
cardioprotective
medications
counteract
ferroptosis
has
encountered
obstacles.
Protosappanin
A
(PrA),
anti‐inflammatory
compound
derived
from
hematoxylin,
shows
potential
against
DOX‐induced
cardiomyopathy
(DIC).
Here,
it
reported
that
PrA
alleviates
myocardial
damage
and
dysfunction
reducing
maintaining
mitochondrial
homeostasis.
Subsequently,
molecular
target
through
proteome
microarray,
docking,
dynamics
simulation
identified.
Mechanistically,
physically
binds
with
ferroptosis‐related
proteins
acyl‐CoA
synthetase
long‐chain
family
member
4
(ACSL4)
ferritin
heavy
chain
1
(FTH1),
ultimately
inhibiting
ACSL4
phosphorylation
subsequent
phospholipid
peroxidation,
while
also
preventing
FTH1
autophagic
degradation
release
ferrous
ions
(Fe
2+
)
release.
Given
critical
role
in
pathogenesis
ischemia‐reperfusion
(IR)
injury,
this
further
investigation
posits
can
confer
a
protective
effect
IR‐induced
cardiac
Overall,
novel
pharmacological
inhibitor
unveiled
targets
uncover
dual‐regulated
mechanism
for
DIC,
highlighting
additional
therapeutic
options
chemodrug‐induced
cardiotoxicity
ferroptosis‐triggered
disorders.
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 14, 2024
Abstract
Ferroptosis
is
a
new
form
of
regulated
cell
death
featuring
iron‐dependent
lipid
peroxides
accumulation
to
kill
tumor
cells.
A
growing
body
evidence
has
shown
the
potential
ferroptosis‐based
cancer
therapy
in
eradicating
refractory
malignancies
that
are
resistant
apoptosis‐based
conventional
therapies.
In
recent
years,
studies
have
reported
number
ferroptosis
inducers
can
increase
vulnerability
cells
by
regulating
ferroptosis‐related
signaling
pathways.
Encouraged
rapid
development
ferroptosis‐driven
therapies,
interdisciplinary
fields
combine
ferroptosis,
pharmaceutical
chemistry,
and
nanotechnology
focused.
First,
prerequisites
metabolic
pathways
for
briefly
introduced.
Then,
detail
emerging
designed
boost
ferroptosis‐induced
therapy,
including
metal
complexes,
metal‐based
nanoparticles,
metal‐free
nanoparticles
summarized.
Subsequently,
application
synergistic
strategies
with
apoptosis
other
emphasis
on
use
both
cuproptosis
induce
redox
dysregulation
intracellular
bimetallic
copper/iron
metabolism
disorders
during
treatment
discussed.
Finally,
challenges
associated
clinical
translation
future
directions
potentiating
therapies
highlighted.
Cell Biology and Toxicology,
Journal Year:
2024,
Volume and Issue:
40(1)
Published: March 21, 2024
Abstract
Cardiovascular
diseases
(CVDs)
are
the
main
that
endanger
human
health,
and
their
risk
factors
contribute
to
high
morbidity
a
rate
of
hospitalization.
Cell
death
is
most
important
pathophysiology
in
CVDs.
As
one
cell
mechanisms,
ferroptosis
new
form
regulated
(RCD)
broadly
participates
CVDs
(such
as
myocardial
infarction,
heart
transplantation,
atherosclerosis,
failure,
ischaemia/reperfusion
(I/R)
injury,
atrial
fibrillation,
cardiomyopathy
(radiation-induced
cardiomyopathy,
diabetes
sepsis-induced
cardiac
doxorubicin-induced
iron
overload
hypertrophic
cardiomyopathy),
pulmonary
arterial
hypertension),
involving
regulation,
metabolic
mechanism
lipid
peroxidation.
This
article
reviews
recent
research
on
regulation
its
relationship
with
occurrence
treatment
CVDs,
aiming
provide
ideas
targets
for
clinical
diagnosis
by
clarifying
latest
progress
research.
Graphical
•
The
identification,
development
history
characterization
ferroptosis.
role
different
subcellular
organelles
organelle-specific
regulators
includes
metabolism,
amino
acid
metabolism.
cardiovascular
cells
diseases.
efficacy
pathological
involved
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 23, 2024
Ferroptosis
is
a
non-apoptotic
mode
of
programmed
cell
death
characterized
by
iron
dependence
and
lipid
peroxidation.
Since
the
ferroptosis
was
proposed,
researchers
have
revealed
mechanisms
its
formation
continue
to
explore
effective
inhibitors
in
disease.
Recent
studies
shown
correlation
between
pathological
neurodegenerative
diseases,
as
well
diseases
involving
tissue
or
organ
damage.
Acting
on
ferroptosis-related
targets
may
provide
new
strategies
for
treatment
ferroptosis-mediated
diseases.
This
article
specifically
describes
metabolic
pathways
summarizes
reported
action
natural
synthetic
small
molecule
their
efficacy
The
paper
also
treatments
such
gene
therapy,
nanotechnology,
summarises
challenges
encountered
clinical
translation
inhibitors.
Finally,
relationship
other
modes
discussed,
hopefully
paving
way
future
drug
design
discovery.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(16), P. 12928 - 12928
Published: Aug. 18, 2023
Iron
is
essential
for
all
organisms
and
cells.
Diseases
of
iron
imbalance
affect
billions
patients,
including
those
with
overload
other
forms
toxicity.
Excess
load
an
adverse
prognostic
factor
diseases
can
cause
serious
organ
damage
fatalities
following
chronic
red
blood
cell
transfusions
in
patients
many
conditions,
hemoglobinopathies,
myelodyspasia,
hematopoietic
stem
transplantation.
Similar
toxicity
excess
body
but
at
a
slower
rate
disease
progression
found
idiopathic
haemochromatosis
patients.
deposition
different
regions
the
brain
suspected
has
been
identified
by
MRI
T2*
similar
methods
neurodegenerative
diseases,
Alzheimer’s
Parkinson’s
disease.
Based
on
its
role
as
major
biological
catalyst
free
radical
reactions
Fenton
reaction,
also
implicated
associated
pathology
tissue
damage.
Furthermore,
recent
discovery
ferroptosis,
which
death
program
based
generation
membrane
lipid
oxidation,
sparked
thousands
investigations
association
cardiac,
kidney,
liver,
cancer
infections.
The
implications
labile,
non-protein
bound
form
complexes
dietary
molecules
such
vitamin
C
drugs
doxorubicin
xenobiotic
relation
to
carcinogenesis
are
discussed.
In
each
case
toxicity,
mechanistic
insights,
diagnostic
criteria,
molecular
interactions
design
new
effective
therapeutic
interventions
future
targeted
strategies.
particular,
this
approach
successful
treatment
most
loading
conditions
especially
transition
thalassemia
from
fatal
due
protocols
resulting
complete
elimination
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 116057 - 116057
Published: Dec. 29, 2023
In
the
21st
century,
cardiovascular
disease
(CVD)
has
become
one
of
leading
causes
death
worldwide.
The
prevention
and
treatment
CVD
remain
pressing
scientific
issues.
Several
recent
studies
have
suggested
that
ferroptosis
may
play
a
key
role
in
CVD.
Most
conducted
thus
far
on
supported
link.
Ferroptosis
mediated
by
different
signaling
metabolic
pathways
can
lead
to
ischemic
heart
disease,
myocarditis,
failure,
ischemia-reperfusion
injury,
cardiomyopathy.
Still,
specific
mechanism
CVD,
particular
organ
areas
affected,
stage
involved
need
be
further
studied.
Therefore,
understanding
mechanisms
regulating
improve
management.
Throughout
this
review,
we
summarized
its
effect
pathogenesis
We
also
predicted
discussed
future
research
directions,
aiming
provide
new
ideas
strategies
for
preventing
treating
