Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(11), P. 6476 - 6529

Published: July 17, 2023

Language: Английский

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Characterization of Bioactive Metabolites and Antioxidant Activities in Solid and Liquid Fractions of Fresh Duckweed (Wolffia globosa) Subjected to Different Cell Wall Rupture Methods

ACS Omega, Journal Year: 2024, Volume and Issue: 9(18), P. 19940 - 19955

Published: April 23, 2024

Fresh

Language: Английский

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Natural drug delivery systems for the treatment of neurodegenerative diseases

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 10, 2025

Language: Английский

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Wild-Grown Romanian Eupatorium cannabinum: Advancing Phyto-Nanocarriers via Maltodextrin Micro-Spray Encapsulation—Metabolite Profiling, Antioxidant, Antimicrobial, and Cytotoxicity Insights

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 482 - 482

Published: Feb. 12, 2025

In Romanian ethnopharmacology, Eupatorium cannabinum species is known for its remarkable biological activity. We present an advanced approach to encapsulation using maltodextrin matrices enhance the stability and efficacy of phytoconstituents nanoparticles. Two distinct carrier systems were developed: (i) a direct micro-spray E. in produce maltodextrin-encapsulated (MEC), (ii) two-step process involving preparation new phytocarrier system based on gold nanoparticles (EC-AuNPs), followed by create AuNPs (MEC-AuNPs system). Comprehensive chemical profiling GC–MS ESI–QTOF–MS revealed 80 bioactive molecules, including terpenoids, alkaloids, flavonoids, phytoecdysteroids. Morpho-structural (XRD, FTIR, Raman spectroscopy, SEM) thermal analyses confirmed successful integration NPs within matrices. EC-AuNPs MEC-AuNPs exhibited superior antioxidant activity, significant antimicrobial against major bacterial pathogens (S. aureus, B. subtilis, cereus, P. aeruginosa, S. typhi, coli), enhanced cytotoxicity MCF-7 HT-29 cancer cell lines. This study highlights potential combining with develop multifunctional therapeutic systems. The findings underscore importance phytoconstituent stabilization nanotechnology addressing global resistance advancing innovative medical applications.

Language: Английский

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Jatrorrhizine, an alkaloid isolated from Phellodendron amurense, reduces melanogenesis in mouse B16F10 melanoma cells

NFS Journal, Journal Year: 2025, Volume and Issue: 38, P. 100221 - 100221

Published: March 1, 2025

Language: Английский

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Wild grown Portulaca oleracea as a novel magnetite based carrier with in vitro antioxidant and cytotoxicity potential

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 13, 2025

The latest research on nanotechnology through the new tailored scaffolds encompassed therapeutic effects of natural compounds, and unique properties metallic nanoparticles offer possibilities in emerging biomedical fields. Various strategies have been developed to address limitations existing agents concerning specificity, vectorization, bioavailability, drug resistance, adverse effects. In this study, medicinal plant Portulaca oleracea L. magnetite were used develop an innovative target carrier system, designed enhance cytotoxic effect overcome main drawbacks (permeability localization) phytoconstituents. low-metabolite profile Romanian wild-grown exhibits a diverse range hundred fifty-five compounds across various chemical categories (amino acids, peptides, fatty flavonoids, alkaloids, terpenoids, phenolic organic esters, sterols, coumarins, nucleosides, lignans, miscellaneous compounds). Morpho-structural magnetic phytocarrier investigated using variety methods, including XRD, FTIR, Raman, SEM, DLS), determinations. MTT assay was conducted evaluate vitro potential cytotoxicity normal human dermal fibroblasts (NHDF), as well two tumoral cell lines: osteosarcoma (HOS) cervical cancer (HeLa). Results indicated that significant inhibition both lines' viability exerted by compared herbal extract. Furthermore, results obtained for total content antioxidant screening performed FRAP DPPH assays superior system. These findings suggest applications system its promising implications future development field.

Language: Английский

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Berberine: A Multi-Target Natural PCSK9 Inhibitor with the Potential to Treat Diabetes, Alzheimer’s, Cancer and Cardiovascular Disease

Current Reviews in Clinical and Experimental Pharmacology, Journal Year: 2024, Volume and Issue: 19(4), P. 312 - 326

Published: Feb. 1, 2024

Berberine is a natural product with wide range of pharmacological effects. It has antimicrobial, anti-cancer, anti-inflammatory, anti-hyperlipidemic, neuroprotective, and cholesterollowering properties, among others. been used in traditional Chinese Ayurvedic medicine for 3000 years generally well-tolerated few side Its main drawback low oral bioavailability, which hindered widespread clinical use. However, recent interest surged the emergence evidence that berberine effective treating cancer, diabetes, Alzheimer's disease, cardiovascular disease via multiple mechanisms. enhances insulin sensitivity secretion by pancreatic β-cells Type 2 Diabetes Mellitus addition to reducing pro-inflammatory cytokines such as IL-6, IL-1β, TLR4 TNF-α. These are elevated diabetes. Reductions cytokine levels associated positive outcomes improved cognition, reduced events, glucose metabolism sensitivity. PCSK9 inhibitor, contributes its hypolipidemic also increases low-density lipoprotein receptor expression, reduces intestinal cholesterol absorption, promotes excretion from liver bile. This translates into notable decrease LDL levels. High increased risk. Novel synthetic derivatives currently being developed optimize reduction, other pharmacokinetic properties.

Language: Английский

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Biology of cyclooxygenase-2: An application in depression therapeutics

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 10, 2022

Depressive Disorder is a common mood disorder or affective that dominated by depressed mood. It characterized high incidence and recurrence. The onset of depression related to genetic, biological psychosocial factors. However, the pathogenesis still unclear. In recent years, there has been an increasing amount research on inflammatory hypothesis depression, in which cyclo-oxygen-ase 2 (COX-2), pro-inflammatory cytokine, closely associated with depression. A variety chemical drugs natural products have found exert therapeutic effects modulating COX-2 levels. This paper summarizes relationship between terms neuroinflammation, intestinal flora, neurotransmitters, HPA axis, mitochondrial dysfunction hippocampal neuronal damage, can provide reference for further preventive control, clinical treatment scientific

Language: Английский

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Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation and Evaluation

Plants, Journal Year: 2024, Volume and Issue: 13(5), P. 734 - 734

Published: March 5, 2024

Novel nanotechnology based on herbal products aspires to be a high-performing therapeutic platform. This study reports the development of an original engineering carrier system that jointly combines pharmacological action Chelidonium majus and AuNPs, with unique properties ensure limitations imposed by low stability, toxicity, absorption, targeted prolonged release can overcome. The metabolite profile Romanian wild-grown contains total seventy-four phytochemicals belonging eight secondary categories, including alkaloids, amino acids, phenolic flavonoids, carotenoids, fatty sterols, miscellaneous others. In this study, various techniques (XRD, FTIR, SEM, DLS, TG/DTG) were employed investigate his new system’s morpho-structural thermal properties. vitro assays conducted evaluate antioxidant potential profile. results indicate 99.9% 94.4% dissolution at different pH values for CG-AuNPs 93.5% 85.26% greater celandine 4 7, respectively. Additionally, three in indicated increase (flavonoid content 3.8%; FRAP assay 24.6%; DPPH 24.4%) compared herb sample. collective reflect promising perspective as efficient antimicrobial anti-inflammatory candidate versatile applications, ranging from target delivery systems, oral inflammation (periodontitis), anti-age cosmetics extending shelf lives food industry.

Language: Английский

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Production of specialized metabolites in plant cell and organo-cultures: the role of gamma radiation in eliciting secondary metabolism

International Journal of Radiation Biology, Journal Year: 2024, Volume and Issue: 100(5), P. 678 - 688

Published: March 7, 2024

Purpose To provide an updated summary of recent advances in the application gamma irradiation to elicit secondary metabolism and for induction mutations plant cell organ cultures production industrially important specialized metabolites (SMs).

Language: Английский

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