International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13086 - 13086
Published: Dec. 5, 2024
Alzheimer's
disease
imposes
an
increasing
burden
on
aging
Western
societies.
The
disorder
most
frequently
appears
in
its
sporadic
form,
which
can
be
caused
by
environmental
and
polygenic
factors
or
monogenic
conditions
of
incomplete
penetrance.
According
to
the
authors,
majority
cases,
represents
aggravated
form
natural
central
nervous
system.
It
characterized
decreased
elimination
amyloid
β
Food Science & Nutrition,
Journal Year:
2023,
Volume and Issue:
12(2), P. 694 - 706
Published: Dec. 7, 2023
Modulatory
effects
of
serotonin
(5-Hydroxytryptamine
[5-HT])
have
been
seen
in
hepatic,
neurological/psychiatric,
and
gastrointestinal
(GI)
disorders.
Probiotics
are
live
microorganisms
that
confer
health
benefits
to
their
host.
Recent
research
has
suggested
probiotics
can
promote
signaling,
a
crucial
pathway
the
regulation
mood,
cognition,
other
physiological
processes.
Reviewing
literature,
we
find
peripheral
increases
nutrient
uptake
storage,
regulates
composition
gut
microbiota,
is
involved
mediating
neuronal
This
review
explores
mechanisms
underlying
probiotic-mediated
increase
highlighting
role
microbiota
production
modulation
neurotransmitter
receptors.
Additionally,
this
discusses
potential
clinical
implications
as
therapeutic
strategy
for
disorders
associated
with
altered
such
GI
neurological
Overall,
demonstrates
promising
avenue
treatment
serotonin-related
signaling
serotonin.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 2, 2024
The
P2X7
receptor
(P2X7R),
a
non-selective
cation
channel
modulated
by
adenosine
triphosphate
(ATP),
localizes
to
microglia,
astrocytes,
oligodendrocytes,
and
neurons
in
the
central
nervous
system,
with
most
incredible
abundance
microglia.
P2X7R
partake
various
signaling
pathways,
engaging
immune
response,
release
of
neurotransmitters,
oxidative
stress,
cell
division,
programmed
death.
When
neurodegenerative
diseases
result
neuronal
apoptosis
necrosis,
ATP
activates
P2X7R.
This
activation
induces
biologically
active
molecules
such
as
pro-inflammatory
cytokines,
chemokines,
proteases,
reactive
oxygen
species,
excitotoxic
glutamate/ATP.
Subsequently,
this
leads
neuroinflammation,
which
exacerbates
involvement.
is
essential
development
diseases.
implies
that
it
has
potential
drug
target
could
be
treated
using
antagonists
are
able
cross
blood-brain
barrier.
review
will
comprehensively
objectively
discuss
recent
research
breakthroughs
on
genes,
their
structural
features,
functional
properties,
roles
possible
therapies.
Frontiers in Behavioral Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Feb. 6, 2024
Background
Neurexins,
essential
synaptic
proteins,
are
linked
to
neurodevelopmental
and
neuropsychiatric
disorders
like
autism
spectrum
disorder
(ASD)
schizophrenia.
Objective
Through
this
systematic
review,
we
aimed
shed
light
on
the
relationship
between
neurexin
dysfunction
its
implications
in
manifestations.
Both
animal
human-induced
pluripotent
stem
cell
(hiPSC)
models
served
as
our
primary
investigative
platforms.
Methods
Utilizing
PRISMA
2020
guidelines,
search
strategy
involved
scouring
articles
from
PubMed
Google
Scholar
databases
covering
a
span
of
two
decades
(2003–2023).
Of
initial
collection,
27
rigorously
evaluated
studies
formed
essence
review.
Results
Our
review
suggested
significant
ties
anomalies
outcomes,
most
notably
ASD.
Rodent-based
investigations
delineated
pronounced
ASD-associated
behaviors,
hiPSC
derived
ASD-diagnosed
patients
revealed
disruptions
calcium
dynamics
activities.
Additionally,
underlined
integral
role
specific
variants,
primarily
NRXN1,
pathology
It
was
also
evident
observation
that
malfunctions
were
implicated
broader
array
these
disorders,
including
ADHD,
intellectual
challenges,
seizure
disorders.
Conclusion
This
accentuates
cardinal
neurexins
play
pathological
process
The
findings
underscore
critical
need
for
standardized
methodologies
developing
future
studies,
aiming
minimize
heterogeneity.
Moreover,
highlight
expand
research
into
less
studied
variants
(i.e.,
NRXN2
NRXN3),
broadening
scope
understanding
field.
projects
potent
tools
bridging
gaps,
promoting
translational
research,
fostering
development
patient-specific
therapeutic
interventions.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1735 - 1735
Published: Aug. 22, 2024
Evidence
shows
that
neurodegenerative
and
neuropsychiatric
disorders
are
influenced
by
alterations
in
the
gut
microbiome.
Various
diseases
have
been
linked
to
microbiome
dysbiosis,
yet
there
inconclusive
data
regarding
which
microorganisms
associated
with
each
disorder.
The
aim
of
our
study
is
systematically
review
recent
literature
past
decade
clarify
whether
contributes
understanding
pathogenesis
progression
disorders.
Most
included
studies
showed
a
strong
correlation
between
relative
abundance
certain
microorganisms,
mainly
species
phyla
Firmicutes
Bacteroidetes,
such
as
Parkinson’s
disease
(PD)
Alzheimer’s
(AD).
It
speculated
their
byproducts
significant
role
brain
protein
accumulation,
neuro-inflammation,
permeability.
estimation
microbial
populations
could
potentially
improve
clinical
outcomes
hinder
disease.
However,
further
research
needed
include
more
larger
patient
samples
identify
specific
subspecies
these
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7221 - 7221
Published: June 29, 2024
Decades
of
research
have
identified
genetic
and
environmental
factors
involved
in
age-related
neurodegenerative
diseases
and,
to
a
lesser
extent,
neuropsychiatric
disorders.
Genomic
instability,
i.e.,
the
loss
genome
integrity,
is
common
feature
among
both
(mayo-trophic
lateral
sclerosis,
Parkinson's
disease,
Alzheimer's
disease)
psychiatric
(schizophrenia,
autism,
bipolar
depression)
instability
associated
with
accumulation
persistent
DNA
damage
activation
response
(DDR)
pathways,
as
well
pathologic
neuronal
cell
or
senescence.
Typically,
DDR
signaling
ensures
that
genomic
proteomic
homeostasis
are
maintained
dividing
cells,
including
neural
progenitors,
post-mitotic
neurons.
However,
dysregulation
these
protective
responses,
part
due
aging
insults,
contributes
progressive
development
and/or
In
this
Special
Issue,
we
introduce
highlight
overlap
between
disorders,
emerging
clinical,
genomic,
molecular
evidence
for
contributions
aberrant
repair.
Our
goal
illuminate
importance
subject
uncover
possible
treatment
prevention
strategies
relevant
devastating
brain
diseases.
Frontiers in Human Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: Feb. 3, 2025
As
life
becomes
more
stressful,
neurological
disorders,
psychiatric
and
comorbidities
of
the
two
are
becoming
a
concern.
Multiple
neuropsychiatric
disorders
share
same
mental
somatic
dysfunction
may
involve
common
brain
circuits
mechanistic
targets.
Music
therapy,
as
an
art
form
with
proven
efficacy,
low
cost
few
side
effects,
is
promoted
for
use
in
interventions
disorders.
This
be
closely
related
to
release
signaling
molecules
such
monoamine
neurotransmitters,
glutamatergic
system,
gut-microbiota-brain
axis,
pro-inflammatory
cytokines
endogenous
opioid
peptide
system.
However,
fewer
studies
have
mentioned
main
targets
music
promote
functional
changes
regions.
Therefore,
this
paper
review
mechanisms
by
which
therapy
interacts
prefrontal
cortex-hippocampus-amygdala
circuit
through
aforementioned
molecules.
It
also
hypothesized
that
glial
cells,
mitochondria
microRNAs
microscopic
musical
intervention
The
aim
give
new
ideas
future
research
into
biological
