Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 15, 2022
Nonalcoholic
steatohepatitis
(NASH)
is
the
progressive
form
of
nonalcoholic
fatty
liver
disease
(NAFLD),
and
dysregulation
lipid
metabolism
oxidative
stress
are
typical
features.
Subsequent
dyslipidemia
oxygen
radical
production
may
render
formation
modified
lipids.
Macrophage
scavenger
receptor
1
(MSR1)
responsible
for
uptake
lipoprotein
one
key
molecules
in
atherosclerosis.
However,
unrestricted
lipoproteins
by
MSR1
cholesterol-rich
foamy
macrophages
also
can
be
observed
NASH
patients
mouse
models.
In
this
review,
we
highlight
NASH,
alteration
expression
physiological
pathological
conditions,
lipoproteins,
role
on
macrophage
foaming
development
progression.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 821 - 821
Published: Jan. 9, 2024
Diabetes
is
a
chronic
disease
that
induces
many
comorbidities,
including
cardiovascular
disease,
nephropathy,
and
liver
damage.
Many
mechanisms
have
been
suggested
as
to
how
diabetes
leads
these
of
which
increased
oxidative
stress
in
diabetic
patients
has
strongly
implicated.
Limited
knowledge
antioxidative
antidiabetic
drugs
substances
can
address
comorbidities
through
the
nuclear
factor
erythroid
2-related
2
(Nrf2)
pathway
calls
for
detailed
investigation.
This
review
will
describe
increases
stress,
general
impact
primarily
contributes
comorbidities.
It
also
treatments
diabetes,
especially
focusing
on
their
effects
Nrf2
pathway,
shown
similarly
affect
heart,
kidney,
systems.
demonstrates
common
pathogenic
component
its
associated
potentially
identifying
this
target
guide
future
treatments.
Journal of Gastroenterology and Hepatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
ABSTRACT
Background
Resmetirom,
the
first
FDA‐approved
drug
for
nonalcoholic
steatohepatitis
(NASH)
with
fibrosis
in
obese
patients,
when
combined
lifestyle
modifications,
improves
NASH
resolution
and
reduces
by
at
least
one
stage.
Low
thyroid
hormone
(T
3
)
levels
are
linked
to
a
higher
risk
of
developing
metabolic
dysfunction‐associated
steatotic
liver
disease
(MASLD).
Epidemiological
studies
have
confirmed
positive
correlation
between
hypothyroidism
MASLD.
Unraveling
molecular
mechanisms
T
signaling
pathways
MASLD
will
enhance
prospects
identifying
effective
specific
targets.
Therefore,
this
review
discusses
significant
role
hormones
homeostasis
fat
metabolism
describes
possible
thyromimetics
treatment
Methods
A
comprehensive
search
PubMed
EMBASE
was
conducted
using
keywords
“thyromimetics
diseases,”
“thyroid
“hypothyroidism
“T
,
4
disease,”
“resmetirom
disease.”
Relevant
papers
published
before
October
2024
were
included.
Results
enhances
mitochondrial
respiration,
biogenesis,
β‐oxidation,
mitophagy,
reducing
lipid
accumulation.
However,
causes
cardiotoxicity
through
receptor
(THR)α
agonistic
activity.
To
address
this,
molecules
high
THRβ
but
lower
THRα
activity
been
developed.
Besides
resmetirom,
other
agonists
like
TG68,
CS27109,
MB07811,
KB‐141
show
promising
results
experimental
studies.
These
upregulate
target
genes,
activate
genes
fatty
acid
β‐oxidation
mitochondria
breakdown
peroxisomes,
downregulate
involved
de
novo
lipogenesis,
reduce
inflammation
downregulating
NF‐κB/JNK/STAT3
pathways,
accelerate
expressions
marker
tissue.
Conclusion
Future
clinical
should
thoroughly
investigate
agonists,
including
KB‐141.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4162 - 4162
Published: April 9, 2024
Metabolic
disorders
(MDs),
including
dyslipidemia,
non-alcoholic
fatty
liver
disease,
diabetes
mellitus,
obesity
and
cardiovascular
diseases
are
a
significant
threat
to
human
health,
despite
the
many
therapies
developed
for
their
treatment.
Different
classes
of
bioactive
compounds,
such
as
polyphenols,
flavonoids,
alkaloids,
triterpenes
have
shown
therapeutic
potential
in
ameliorating
various
disorders.
Most
these
compounds
present
low
bioavailability
when
administered
orally,
being
rapidly
metabolized
digestive
tract
which
makes
metabolites
less
effective.
Moreover,
some
cannot
fully
exert
beneficial
properties
due
solubility
complex
chemical
structure
impede
passive
diffusion
through
intestinal
cell
membranes.
To
overcome
limitations,
an
innovative
delivery
system
phytosomes
was
developed.
This
review
aims
highlight
scientific
evidence
proving
enhanced
benefits
formulated
compared
free
compounds.
The
existing
knowledge
concerning
phytosomes’
preparation,
characterization
well
commercially
available
with
alleviate
MDs
concisely
depicted.
brings
arguments
encourage
use
phytosome
formulation
diminish
risk
factors
inducing
MDs,
or
treat
already
installed
complementary
therapy
allopathic
medication.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4666 - 4666
Published: Feb. 28, 2023
Inflammation
is
the
primary
response
to
infection
and
injury.
Its
beneficial
effect
an
immediate
resolution
of
pathophysiological
event.
However,
sustained
production
inflammatory
mediators
such
as
reactive
oxygen
species
cytokines
may
cause
alterations
in
DNA
integrity
lead
malignant
cell
transformation
cancer.
More
attention
has
recently
been
paid
pyroptosis,
which
necrosis
that
activates
inflammasomes
secretion
cytokines.
Taking
into
consideration
phenolic
compounds
are
widely
available
diet
medicinal
plants,
their
role
prevention
support
treatment
chronic
diseases
apparent.
Recently,
much
explaining
significance
isolated
molecular
pathways
related
inflammation.
Therefore,
this
review
aimed
screen
reports
concerning
mode
action
assigned
compounds.
The
most
representative
from
classes
flavonoids,
tannins,
acids,
glycosides
were
selected
for
review.
Our
was
focused
mainly
on
nuclear
factor-κB
(NF-κB),
factor
erythroid
2-related
2
(Nrf2),
mitogen-activated
protein
kinase
(MAPK)
signaling
pathways.
Literature
searching
performed
using
Scopus,
PubMed,
Medline
databases.
In
conclusion,
based
literature,
regulate
NF-κB,
Nrf2,
MAPK
signaling,
supports
potential
disorders,
including
osteoarthritis,
neurodegenerative
diseases,
cardiovascular,
pulmonary
disorders.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 12, 2023
Background:
Resveratrol,
a
polyphenol
found
in
various
plants,
is
known
for
its
diverse
bioactivities
and
has
been
explored
relation
to
nonalcoholic
fatty
liver
disease
(NAFLD).
However,
no
high-quality
evidence
exists
regarding
efficacy.
Objective:
meta-analysis
was
conducted
evaluate
the
potential
efficacy
of
resveratrol
treating
by
analyzing
both
preclinical
studies
clinical
trials.
Method:
PubMed,
Embase
Web
Science
were
searched
included
literature
with
criteria
screening.
Quantitative
synthesis
meta-analyses
performed
STATA
16.0.
Results:
Twenty-seven
included,
results
indicated
that
effectively
improved
function,
reduced
indicators,
affected
other
indices
studies.
The
effective
dosage
ranged
from
50
mg/kg-200
mg/kg,
administered
over
period
4–8
weeks.
While
there
inconsistencies
between
trials
research,
study
types
revealed
significantly
tumor
necrosis
factor-α
levels,
further
supporting
protective
effect
against
disease.
Additionally,
alleviated
primarily
via
AMPK/Sirt1
anti-inflammatory
signaling
pathways.
Conclusion:
Current
could
not
consistently
verify
disease,
but
demonstrated
liver-protective
effects
on
large-sample
scale
single
region
RCTs
needed
investigate
