Flavonoids and Their Role in Preventing the Development and Progression of MAFLD by Modifying the Microbiota DOI Open Access
Aneta Sokal, Sara Jarmakiewicz-Czaja, Rafał Filip

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11187 - 11187

Published: Oct. 17, 2024

With the increasing prevalence and serious health consequences of metabolic-associated fatty liver disease (MAFLD), early diagnosis intervention are key to effective treatment. Recent studies highlight important role dietary factors, including use flavonoids, in improving health. These compounds possess anti-inflammatory, antioxidant, liver-protective properties. Flavonoids have been shown affect gut microbiota, which plays a function progression. Therefore, their preventing development progression MAFLD through modulation microbiome seems be interest. This narrative review aims consolidate current evidence on effects selected flavonoids progression, potential mechanisms action, implications for personalized interventions management disease.

Language: Английский

Updated mechanisms of MASLD pathogenesis DOI Creative Commons
Yuxuan Li,

Peipei Yang,

Jialu Ye

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 22, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity have promoted its development. MASLD is typically accompanied by obesity strongly linked to metabolic syndromes. Given that prevalence on the rise, there an urgent need elucidate pathogenesis. Hepatic lipid accumulation generally triggers lipotoxicity induces or progress steatohepatitis (MASH) mediating endoplasmic reticulum stress, oxidative organelle dysfunction, ferroptosis. Recently, significant been directed towards exploring role of gut microbial dysbiosis in development MASLD, offering a novel therapeutic target for MASLD. Considering are no recognized pharmacological therapies due diversity mechanisms involved difficulty associated with undertaking clinical trials, potential targets remain elusive. Thus, this article aimed summarize evaluate prominent roles lipotoxicity, ferroptosis, microbes underlying their effects. Furthermore, existing advances challenges treatment were outlined.

Language: Английский

Citations

47
Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs DOI Creative Commons
Xing Wan, Jingyuan Ma,

He Bai

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 140 - 140

Published: Jan. 17, 2025

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.

Language: Английский

Citations

2
Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a Systematic Scoping Review DOI Open Access
Deepa Handu,

Kim S. Stote,

Tami A. Piemonte

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 453 - 453

Published: Jan. 26, 2025

Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition affecting broad population. This review aimed to identify and summarize the current evidence on bioactive-substance-based interventions for adults with MASLD, formerly known as nonalcoholic fatty (NAFLD), covering publications from 2000 2023. Methods: A search was conducted across six databases (MEDLINE, CINAHL, Cochrane CENTRAL, Database of Systematic Reviews, Food Science Source, SPORTDiscus) randomized controlled trials other study types (e.g., prospective cohort studies systematic reviews), reflecting scoping nature this review. The limited in (>18 years old), an intervention interest at least one comparator group. Results: total 4572 articles were retrieved, 201 full-text screened eligibility. Of these, 131 primary 49 reviews included most studied bioactive substances Curcumin (Turmeric) (n = 25), Silymarin (Milk Thistle) 17), Resveratrol 10), Coffee 7), Green Tea 5), Berberine 5 each). Moreover, 46 reported 36 2 or fewer each. Among reviews, 13 focused Curcumin, 12 Tea, 10 substance combinations, 6 Resveratrol, each Artichoke Leaf. showed substantial heterogeneity outcomes, which primarily hepatic health, body weight, adverse events, glycemic control, blood lipids, composition. Conclusions: highlights range used treatment MASLD. While abundant like Silymarin, further research synthesis findings necessary establish clinical efficacy all substances.

Language: Английский

Citations

2
Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity DOI Open Access
Hong‐Tai Tzeng, Wei‐Chia Lee

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1388 - 1388

Published: May 3, 2024

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent pediatric disorder, primarily attributed to dietary shifts in recent years. NAFLD is characterized by accumulation of lipid species hepatocytes, leading inflammation that can progress steatohepatitis, fibrosis, and cirrhosis. Risk factors contributing encompass genetic variations metabolic disorders such obesity, diabetes, insulin resistance. Moreover, transgenerational influences, resulting an imbalance gut microbial composition, epigenetic modifications, dysregulated hepatic immune responses offspring, play a pivotal role development. Maternal nutrition shapes profile microbiota-derived metabolites exerting significant influence on system regulation development syndrome offspring. In this review, we summarize evidence elucidating intricate interplay between microbiota, epigenetics, immunity fetuses exposed maternal nutrition, its impact onset Furthermore, potential therapeutic strategies targeting network are also discussed.

Language: Английский

Citations

6
Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway DOI

Decheng Meng,

Guoliang Yin,

Suwen Chen

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 977, P. 176737 - 176737

Published: June 10, 2024

Language: Английский

Citations

4
A Literature Review of Glutathione Therapy in Ameliorating Hepatic Dysfunction in Non-Alcoholic Fatty Liver Disease DOI Creative Commons

M. Hong Nguyen,

Andrew Lian,

Frederick T. Guilford

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 644 - 644

Published: March 6, 2025

Non-alcoholic fatty liver disease (NAFLD) is a global cause of dysfunction. This spectrum hepatic disorders can progress to severe conditions, such as non-alcoholic steatohepatitis (NASH) and cirrhosis, due oxidative stress sustained cellular injury. With limited pharmacological options, glutathione (GSH), key antioxidant, has shown promising potential in reducing stress, maintaining redox balance, improving function. literature review examines studies from 2014–2024 exploring GSH therapy NAFLD patients. Eligible assessed the primary intervention for human subjects, reporting outcomes function or markers. Randomized clinical trials (RCTs) were eligible, while combination included if GSH’s effect could be isolated. Exclusions applied non-NAFLD studies, animal/in vitro models, non-GSH antioxidant interventions. Analysis three (totaling 109 participants) demonstrated consistent improvements alanine transaminase (ALT) levels reductions markers like 8-hydroxy-2-deoxyguanosine (8-OHdG). However, small sample sizes inconsistent protocols limit generalizability. Further large-scale RCTs are required confirm efficacy, determine optimal dosing, assess long-term effects. highlights novel therapeutic strategy emphasizing need further refine its application.

Language: Английский

Citations

0
Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma DOI Creative Commons
Mahmoud Zhra, Muhammad Affan Elahi, Aamira Tariq

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 466 - 466

Published: March 20, 2025

Metabolic dysfunction leading to non-alcoholic fatty liver disease (NAFLD) exhibits distinct molecular and immune signatures that are influenced by factors like gut microbiota. The microbiome interacts with the via a bidirectional relationship gut–liver axis. Microbial metabolites, sirtuins, responses pivotal in different metabolic diseases. This extensive review explores complex multifaceted interrelationship between sirtuins microbiota, highlighting their importance health disease, particularly hepatocellular carcinoma (HCC). Sirtuins (SIRTs), classified as group of NAD+-dependent deacetylases, serve crucial modulators wide spectrum cellular functions, including pathways, inflammatory response, process senescence. Their subcellular localization diverse functions link them various conditions, NAFLD cancer. Concurrently, comprising microorganisms, significantly influences host metabolism responses. Recent findings indicate modulate microbiota composition function, while can affect sirtuin activity. is relevant disorders, where dysbiosis contributes progression. highlights recent on roles specific maintaining implications HCC development. Understanding these interactions offers potential therapeutic avenues for managing diseases linked dysregulation pathology.

Language: Английский

Citations

0
Mitochondria at the Crossroads: Linking the Mediterranean Diet to Metabolic Health and Non-Pharmacological Approaches to NAFLD DOI Open Access
Giovanna Mercurio, Antonia Giacco,

Nicla Scopigno

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1214 - 1214

Published: March 30, 2025

Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern that closely linked to metabolic syndrome, yet no approved pharmacological treatment exists. The Mediterranean diet (MD) emerged as first-line dietary intervention for NAFLD, offering and hepatoprotective benefits. Now conceptualized complex chemical matrix rich in bioactive compounds, the MD exerts antioxidant anti-inflammatory effects, improving insulin sensitivity lipid metabolism. Mitochondria play central role NAFLD pathophysiology, influencing energy metabolism, oxidative stress, homeostasis. Emerging evidence suggests MD's compounds enhance mitochondrial function by modulating phosphorylation, biogenesis, mitophagy. However, most research has focused on individual rather than whole, leaving gaps understanding its collective impact pattern. This narrative review explores how influence highlighting key pathways such substrate control, dynamics, efficiency. A literature search was conducted identify relevant studies MD, mitochondria, NAFLD. While promising, our remains incomplete, particularly when current knowledge limited lack of mechanistic comprehensive holistic impact. Future integrating cutting-edge experimental approaches needed elucidate intricate diet-mitochondria interactions. deeper influences essential developing precision-targeted nutritional strategies can effectively prevent manage disease.

Language: Английский

Citations

0
figure captionsEfficacy of resveratrol supplementation on lipid profile parameters: An umbrella of meta-analysis DOI

Zhe Li,

Sha Liu, Qian Liu

et al.

Prostaglandins & Other Lipid Mediators, Journal Year: 2024, Volume and Issue: 175, P. 106903 - 106903

Published: Sept. 8, 2024

Language: Английский

Citations

2
Construction of a mitochondrial-targeting near-infrared fluorescent probe for detection of viscosity changes in type 2 diabetes mellitus and nonalcoholic steatohepatitis DOI

Xiaowen Ren,

Zahid Nasim Sayed,

Suntao Shi

et al.

Talanta, Journal Year: 2024, Volume and Issue: 286, P. 127470 - 127470

Published: Dec. 26, 2024

Language: Английский

Citations

2