The EPMA Journal,
Journal Year:
2024,
Volume and Issue:
15(2), P. 163 - 205
Published: April 18, 2024
Despite
their
subordination
in
humans,
to
a
great
extent,
mitochondria
maintain
independent
status
but
tightly
cooperate
with
the
"host"
on
protecting
joint
life
quality
and
minimizing
health
risks.
Under
oxidative
stress
conditions,
healthy
promptly
increase
mitophagy
level
remove
damaged
"fellows"
rejuvenating
mitochondrial
population
sending
fragments
of
mtDNA
as
SOS
signals
all
systems
human
body.
As
long
metabolic
pathways
are
under
systemic
control
well-concerted
together,
adaptive
mechanisms
become
triggered
increasing
protection,
activating
antioxidant
defense
repair
machinery.
Contextually,
attributes
patho-/physiology
instrumental
for
predictive
medical
approach
cost-effective
treatments
tailored
individualized
patient
profiles
primary
(to
protect
vulnerable
individuals
again
health-to-disease
transition)
secondary
affected
disease
progression)
care.
Nutraceuticals
naturally
occurring
bioactive
compounds
demonstrating
health-promoting,
illness-preventing,
other
health-related
benefits.
Keeping
mind
health-promoting
properties
nutraceuticals
along
therapeutic
potential
safety
profile,
there
is
permanently
growing
demand
application
mitochondria-relevant
nutraceuticals.
Application
beneficial
only
if
meeting
needs
at
individual
level.
Therefore,
risk
assessment
creation
pivotal
importance
followed
by
adapted
nutraceutical
sets
needs.
Based
scientific
evidence
available
nutraceuticals,
this
article
presents
examples
frequent
which
require
protective
measures
targeted
holistic
following
advanced
concepts
predictive,
preventive,
personalized
medicine
(PPPM/3PM)
Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(4), P. 105650 - 105650
Published: Jan. 24, 2024
Gold
nanoparticles
(AuNPs)
exhibit
promising
potential
as
medical
materials
due
to
their
high
biocompatibility,
tunable
size
and
shape,
excellent
drug
delivery
capabilities,
among
other
unique
physicochemical
properties.
Previous
studies
have
indicated
the
remarkable
anti-inflammatory
activity
of
ginsenoside
compound
K
(CK).
However,
relatively
low
bioavailability
CK
restricts
its
effective
action
within
biological
system.
Hence,
exploring
novel
methods
based
on
gold
emerges
a
strategy
overcome
these
challenges
in
application,
thereby
enhancing
therapeutic
effectiveness
CK.
Probiotic-mediated
AuNPs
were
synthesized
using
salt
lysates
Bifidobacterium
animalis
subsp.
lactis.
Then,
was
loaded
with
form
(Bifi-CKAuNPs).
The
Bifi-CKAuNPs
evaluated
vitro
RAW
264.7
cells
vivo
mice.
NF-κB/
mitogen-activated
protein
kinases
(MAPK)
pathway
investigated
mechanism
action.
In
experiments
showed
that
inhibited
activation
reactive
oxygen
species
reduced
expression
iNOS,
COX-2,
pro-inflammatory
cytokines
(IL-1β,
IL-6,
TNF-α)
cells.
significantly
inflammation
lung,
kidney,
liver
tissues
mice
without
toxicity.
mediated
through
inhibition
NF-κB/MAPK
signal
transduction,
which
is
well-known
critical
pathogenesis
inflammation.
We
successfully
characterized
Bifi-AuNPs,
demonstrating
potent
both
vivo.
Our
results
might
play
key
role
Bifi-CKAuNPs.
These
findings
underscored
significant
platform
for
therapy.
observed
efficacy
cellular
animal
models,
along
insights
into
underlying
molecular
pathways,
positions
valuable
candidate
advancing
strategies
realm
management.
Oxygen,
Journal Year:
2022,
Volume and Issue:
2(3), P. 246 - 268
Published: July 2, 2022
The
rising
prevalence
of
chronic
metabolic
disorders,
such
as
obesity
and
type
2
diabetes,
most
notably
associated
with
cardiovascular
diseases,
has
emerged
a
major
global
health
concern.
Reactive
oxygen
species
(ROS)
play
physiological
functions
by
maintaining
normal
cellular
redox
signaling.
By
contrast,
disturbed
balance
occurring
between
ROS
production
detoxification
reactive
intermediates
results
in
excessive
oxidative
stress.
Oxidative
stress
is
critical
mediator
endothelial
dysfunction
diabetes.
Under
hyperglycemic
condition,
the
antioxidant
enzymes
are
downregulated,
resulting
an
increased
generation
ROS.
Increases
lead
to
impairment
endothelium-dependent
vasodilatations
reducing
NO
bioavailability.
Chronic
treatments
antioxidants
were
reported
prevent
development
diabetic
patients
animals;
however,
beneficial
effects
treatment
combating
vascular
complications
diabetes
remain
controversial
do
not
always
reverse
clinical
settings.
In
this
review,
we
summarize
latest
progress
research
focused
on
role
properties
bioactive
compounds
from
medicinal
plants
food
animal
experiments
studies
provide
insights
for
therapeutic
strategies.
Applied Sciences,
Journal Year:
2023,
Volume and Issue:
13(5), P. 2893 - 2893
Published: Feb. 23, 2023
Reactive
oxygen
species
(ROS)-the
byproduct
of
regular
cell
activity
formed
by
various
cellular
components—play
a
significant
role
in
pathological
and
physiological
conditions.
Alternatively,
antioxidants
are
compounds
that
reduce
or
scavenge
reactive
cells.
An
asymmetry
between
the
antioxidant
defense
system
ROS
from
intracellular
extracellular
sources
cause
chronic
diseases
such
as
cancer,
inflammation,
tumorigenesis,
cardiovascular
neurogenerative
diseases.
However,
Panax
ginseng
its
secondary
metabolites
(known
ginsenosides,
phenolic
compounds,
peptides,
acid
polysaccharides,
polyacetylene,
alkaloids)
well-recognized
many
vitro
vivo
experiments
which
show
beneficial
regulating
these
There
extensive
evidences
P.
can
destroy
cancer
cells
specifically
increasing
oxidative
stress
through
generation
without
significantly
harming
normal
Additionally,
numerous
studies
have
examined
derivatives
on
ROS-mediated
signaling
pathways
discussed
herein.
This
review
summarizes
potential
several
diseases,
gives
updated
research
evidence
with
related
mechanisms
future
possibilities
nano-formulated
other
polyphenols.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(15), P. 3286 - 3286
Published: July 25, 2023
Aging
is
a
cellular
state
characterized
by
permanent
cessation
of
cell
division
and
evasion
apoptosis.
DNA
damage,
metabolic
dysfunction,
telomere
mitochondrial
dysfunction
are
the
main
factors
associated
with
senescence.
increases
β-galactosidase
activity,
enhances
spreading,
induces
Lamin
B1
loss,
which
further
accelerate
aging
process.
It
variety
diseases,
such
as
Alzheimer’s
disease,
Parkinson’s,
type
2
diabetes,
chronic
inflammation.
Ginseng
traditional
Chinese
medicine
anti-aging
effects.
The
active
components
ginseng,
including
saponins,
polysaccharides,
peptides,
have
antioxidant,
anti-apoptotic,
neuroprotective,
age-delaying
damage
factor
aging,
mechanism
through
ingredients
ginseng
reduce
delay
has
not
been
comprehensively
described.
This
review
focuses
on
mechanisms
ginseng.
Furthermore,
it
broadens
scope
ideas
for
research
natural
products
aging.
