Mechanism of sodium nitroprusside regulating ginseng quality

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 10, 2025

Language: Английский

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Beneficial Effects of In Vitro Reconstructed Human Gut Microbiota by Ginseng Extract Fermentation on Intestinal Cell Lines

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 192 - 192

Published: Jan. 17, 2025

Oxidative stress caused by reactive oxygen species (ROS) affects the aging process and increases likelihood of several diseases. A new frontier in its prevention includes bioactive foods natural extracts that can be introduced diet combination with specific probiotics. Among compounds we introduce diet, Panax ginseng extract is one most utilized since it contains a vast number molecules such as phenolic acids, flavonoids, polysaccharides have been shown to possess antioxidant, anti-ageing, anti-cancer, immunomodulatory activity. In this work, ability P. probiotic formulation was taken into consideration evaluate effects on modulation vitro reconstructed human gut microbiota (HGM). After evaluating growth individual strains extract, tested HGM setup (probiotics, minimal core, whole community) using 2% w/v only carbon energy source. The reached highest growth, while core community showed almost same growth. Specifically, presence favors L. plantarum B. animalis subsp. lactis among probiotics, cellulosilyticus prevails over other condition. both probiotics strains, plantarum, lactis, reach values. bacterial metabolites produced during fermentation three conditions were administered intestinal epithelial cells (HT-29) investigate potential antioxidant effect. Remarkably, our results highlighted significant reduction total ROS slightly cytosolic superoxide anion content HT-29 treated deriving from community.

Language: Английский

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Ginsenosides in cancer: Targeting cell cycle arrest and apoptosis

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 382, P. 110634 - 110634

Published: July 12, 2023

Language: Английский

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Comparative effects of dietary herbal mixture or guanidinoacetic acid supplementation on growth performance, cecal microbiota, blood profile, excreta gas emission, and meat quality in Hanhyup-3-ho chicken

Poultry Science, Journal Year: 2024, Volume and Issue: 103(4), P. 103553 - 103553

Published: Feb. 15, 2024

As the popularity of native chickens for meat production rises, coupled with their extended rearing duration, a phytogenic feed additive becomes essential to enhance while reducing disease susceptibility. The study aimed evaluate effect herbal mixture (mixture ginseng and artichoke) or guanidinoacetic acid (GAA) on growth performance, cecal microbiota, excretal gas emission, blood profile, quality in Hanhyup-3-ho chicken. A total 360 one-day-old (half males half females) were allocated into one three dietary treatments (12 replicate cages/treatment; 10 broilers / cage) 100 days age. Experimental diets CON: basal diet; TRT1: diet combined 0.05% mixture; TRT2: 0.06% GAA. All birds received during first 30 days, but from 31 100, an experimental was supplied. addition improved average body weight gain conversion ratio 31-100 as well overall period. Lactobacillus, Escherichia coli, Salmonella count remained consistent across all treatments. Blood albumin Superoxide Dismutase (SOD) levels increased supplemented diet. Additionally, there notable reduction NH3 H2S emissions group. Furthermore, group exhibited breast muscle weight, color, water holding capacity, decrease abdominal fat compared control supplementation GAA did not demonstrate any statistically significant impact evaluated parameter throughout experiment. results present investigation underscore potential together artichoke extract viable additive, conferring improvements efficiency, excreta parameters, defense mechanism against oxidative stress

Language: Английский

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Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(3), P. 2320 - 2342

Published: March 11, 2024

Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural abundance that primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns field of ginseng research and development, as well ginsenoside-related dietary supplements products. Ginsenosides Rb1, Rb2, Rc are generally used substrate generate via several bioconversion processes. Current shows wide range pharmacological actions, including boosting osteogenesis, lipid glucose metabolism, oxidation, insulin resistance, anti-inflammatory anti-apoptosis properties. Further on bioavailability toxicology can advance its medicinal application. The purpose this review lay groundwork for future clinical studies development therapy disorders. Furthermore, pharmacology investigated review. findings indicate modulates signaling pathways associated AMPK, SIRT1, PPARs, WNTs, NF-kB. It also demonstrates positive therapeutic effect non-alcoholic fatty liver disease (NAFLD), obesity, hyperlipidemia, diabetes, complications, osteoporosis. Additionally, analogues showed more bioavailability, less toxicity, efficacy against states. Enhancing regulating hazardous variables crucial use trials.

Language: Английский

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Gintonin-Enriched Panax ginseng Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 381 - 381

Published: Jan. 24, 2025

Gintonin, a non-saponin glycolipoprotein from Panax ginseng, acts as lysophosphatidic acid ligand. However, its anticancer effects, especially in melanoma, remain unclear. This study investigated the anti-proliferative effects and intracellular signaling mechanisms of gintonin-enriched fraction (GEF) ginseng human melanoma cell lines. In vitro, GEF treatment significantly inhibited proliferation, reduced clonogenic potential, delayed wound healing cells. Flow cytometry terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining showed that induced apoptosis, evidenced by increased apoptotic populations nuclear changes. also caused cycle arrest G1 phase for A375 cells G2/M A2058 It triggered via activation caspase-3, -9, poly (ADP-ribose) polymerase cleavage, downregulation B lymphoma-2 (Bcl-2). raised reactive oxygen species (ROS) levels mitochondrial stress, which were mitigated N-acetyl cysteine (NAC), an ROS inhibitor. vivo, suppressed tumor growth A375- A2058-xenografted mice without toxicity. These findings suggest has potential antitumor inducing apoptosis arrest, presenting promising therapeutic avenue.

Language: Английский

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Dietary supplementation with ginseng extract enhances testicular function, semen preservation, and fertility rate of mature and aging Thai native roosters

Theriogenology, Journal Year: 2024, Volume and Issue: 227, P. 31 - 40

Published: July 11, 2024

Language: Английский

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Efficacy and Safety of Panax ginseng Sprout Extract in Subjective Memory Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1952 - 1952

Published: June 19, 2024

Sprout ginseng extract (ThinkGIN™) manufactured through a smart farm system has been shown to improve memory in preclinical studies. This study conducted 12-week randomized, double-blind, placebo-controlled clinical trial evaluate the efficacy and safety of ThinkGIN™ for improving subjective impairment (SMI). Subjects aged 55 75 years with SMI participated this study. A total 80 subjects who met inclusion/exclusion criteria were assigned group (n = 40, 450 mg ThinkGIN™/day) or placebo 40). Efficacy evaluations before intervention at 12 weeks after intervention. As result intake, significant differences SVLT, RCFT, MoCA-K, PSQI-K, AChE observed between two groups. Safety evaluation (AEs, laboratory tests, vital signs, electrocardiogram) revealed that was safe no clinically changes. Therefore, potential be used as functional food memory.

Language: Английский

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A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity

BioMedical Engineering OnLine, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 21, 2024

Chemotherapy-induced cardiotoxicity is a significant concern in cancer treatment, as certain chemotherapeutic agents can have adverse effects on the cardiovascular system. This lead to range of cardiac complications, including heart failure, arrhythmias, myocardial dysfunction, pericardial and vascular toxicity. Strategies mitigate chemotherapy-induced may include use cardioprotective (e.g., dexrazoxane), dose adjustments, alternative treatment regimens, implementation preventive measures, such lifestyle modifications management risk factors. Ginsenosides, active compounds found ginseng (Panax ginseng), been studied for their potential context cardiotoxicity. In this review, we investigate effect ginsenosides Ginsenosides shown possess potent antioxidant properties, which help oxidative stress inflammation associated with injury. They modulate expression enzymes reduce production reactive oxygen species, thereby protecting cardiomyocytes from damage. also inhibit apoptosis (programmed cell death) cardiomyocytes, key mechanism underlying Modulation ion channels, improvement lipid profiles, anti-platelet anti-thrombotic effects, promotion angiogenesis neovascularization are another important mechanisms behind health. improve various parameters function, ejection fraction, fractional shortening, output, animal models The observed preclinical studies using agents, doxorubicin, cisplatin, 5-fluorouracil. However, more clinical needed fully elucidate therapeutic preventing managing patients.

Language: Английский

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Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Published: Feb. 2, 2024

Rare ginsenoside compound K (CK), is an intestinal microbial metabolite with a low natural abundance that primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns field of ginseng research and development as well ginsenosides-related dietary supplements products. Ginsenosides Rb1, Rb2, Rc are generally used substrate generate via several bio-conversion processes. Current shows wide range pharmacological actions including boosting osteogenesis, lipid glucose metabolism, oxidation, insulin resistance, anti-inflammatory, anti-apoptosis properties. Further on bioavailability toxicology can advance its medicinal application. The purpose this review lay groundwork for future clinical studies therapy disorders. Furthermore, pharmacology investigated review. findings indicate modulates signal-ing pathways associated AMPK, SIRT1, PPARs, WNTs, NF-kB. It also demonstrates positive therapeutic effect nonalcoholic fatty liver disease, obesity, hyperlipidemia, diabetes, complications, osteoporosis. Additionally, analogues showed more bioavailability, less toxicity, efficacy against disease states. Enhancing regulating hazardous variables crucial use trials.

Language: Английский

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