Effect of Mo doping in NiO nanoparticles for structural modification and its efficiency for antioxidant, antibacterial applications

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 24, 2023

Novel molybdenum (Mo)-doped nickel oxide (NiO) Nanoparticles (NPs) were synthesized by using a simple sonochemical methodology and the NPs investigated for antioxidant, antibacterial applications. The X-ray diffraction (XRD) analysis revealed that crystal systems of rhombohedral (21.34 nm) monoclinic (17.76 observed pure NiO Mo-doped respectively. scanning electron microscopy (SEM) results show possess irregular spherical shape with an average particle size 93.89 nm while exhibit morphology 85.48 nm. ultraviolet-visible (UV-Vis) spectrum further indicated exhibited strong absorption band at wavelengths 365 349 nm, free radical scavenging activity was also utilizing several biochemical assays. showed better antioxidant (84.2%) towards ABTS. + 200 µg/mL in comparison to their counterpart which confirmed not only potency doped than but this efficacy concentration dependant as well. evaluated against gram-positive (Staphylococcus aureus Bacillus subtilis) gram-negative (Pseudomonas aeruginosa Escherichia coli) bacterial strains. displayed (25 mm) E. coli NPs. excellent aptitude multi-dimensional

Language: Английский

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Carbon nanomaterials-based electrochemical aptasensor for point-of-care diagnostics of cancer biomarkers

Materials Today Chemistry, Journal Year: 2023, Volume and Issue: 30, P. 101499 - 101499

Published: April 18, 2023

Language: Английский

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Green synthesis of metal nanoparticles and study their anti-pathogenic properties against pathogens effect on plants and animals

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 18, 2024

According to an estimate, 30% 40%, of global fruit are wasted, leading post harvest losses and contributing economic ranging from $10 $100 billion worldwide. Among, all fruits the discarded portion oranges is around 20%. A novel value addition approach utilize orange peels in nanoscience. In present study, a synthesis was conducted prepare metallic nanoparticles (copper silver); by utilizing food waste (Citrus plant peels) as bioactive reductants. addition, Citrus sinensis extracts showed reducing activity against salts copper chloride silver nitrate form Cu-NPs nanoparticles) Ag-NPs (Silver nanoparticles). The vitro potential both types prepared examined pathogenic bacteria Erwinia carotovora (Pectobacterium carotovorum) pathogens effect on human health Escherichia coli (E. coli) Staphylococcus aureus (S. aureus). Moreover, vivo antagonistic their interaction with (potato slices). Furthermore, additional antipathogenic (antiviral antifungal) properties were also examined. statistical analysis done explain level significance effectiveness among synthesized Cu-NPs. surface morphology, elemental description size particles analyzed scanning electron microscopy, transmission energy-dispersive spectroscopy zeta sizer (in polydispersity index potential). justification for preparation UV-Vis Spectroscopy (excitation peaks at 339 nm 415 silver) crystalline nature observed X-ray diffraction. Hence, quite effective soft rot plants can be used effectively some other multifunctional applications such sport wear, surgical gowns, bandages wrist or knee compression bandages, etc.

Language: Английский

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Iron oxide nanoparticles: The versatility of the magnetic and functionalized nanomaterials in targeting drugs, and gene deliveries with effectual magnetofection

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105838 - 105838

Published: June 3, 2024

Language: Английский

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Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway

Nanotechnology Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 1, 2025

Abstract The green synthesis approach has drawn a lot of interest as an environmentally friendly and sustainable acceptable means producing diverse range nanoparticles (NPs). This piece described rapid for synthesizing selenium (SeNPs) with grape seed extract. A biologically active composition selenium-chitosan (Se-chitosan NPs) been prepared characterized using, ultraviolet–visible, scanning electron microscopy, transmission zeta potential size distribution experiments. To study the anticancer activity NP cytotoxicity (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay chitosan (Chito-NPs), SeNPs were tested on two cancer cell lines: A549 normal line (HK-2). In addition to series morphological changes, induction apoptosis, reactive oxygen species (ROS) generation, mitochondrial membrane potential. results showed that synthesized NPs spherical 55.285 30.9 nm, Se-chitosan NPs, respectively. line, exhibited dose-dependent cytotoxicity, IC 50 Chito-NPs 24.09 µg/mL, whereas it was 18.56 µg/mL. Conversely, lines (MCF-10) not significantly cytotoxically affected by NPs. Additionally, SeNP treatment resulted in increased ROS generation caused dysfunction. Based ROS-mediated pathways, demonstrated Chito-NPs, SeNPs, cause apoptosis death cells. As nanotherapeutics, appear offer great deal unrealized based these findings. Further investigation is warranted clinically significant elucidate specific therapeutic safety when applied vivo . this work, we show exposure alters human lung A549’s route signaling, thereby causing apoptosis.

Language: Английский

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Functionalized SWCNTs@Ag–TiO₂ nanocomposites induce ROS-mediated apoptosis and autophagy in liver cancer cells

Nanotechnology Reviews, Journal Year: 2023, Volume and Issue: 12(1)

Published: Jan. 1, 2023

Abstract Hybrid nanomaterials with unique physiochemical properties have received a lot of attention, making them attractive for application in different fields like cancer treatment. This study was designed to investigate the combined effects single-walled carbon nanotubes (SWCNTs) hybridized silver titanium dioxide composite (SWCNTs@Ag–TiO 2 ). Transmission electron microscopy and field emission scanning images demonstrated accumulation SWCNTs Ag–TiO due an increased main grain size functionalization 40 nm. The D G bands @Ag–TiO shifted 1,366 1,534 cm −1 , respectively. SWCNTs@Ag-TiO were assessed their cytotoxicity autophagy induction liver cells (Hep-G2) using lactate dehydrogenase assay, MTT flow cytometry methods. results showed that SWCNTs@Ag–TiO exhibited strong anti-cancer activity vitro against Hep-G2 by inducing apoptosis via controlling AKT JNK mitogen-activated protein kinase pathways. show coated silver/titanium ) reduce cells’ viability proliferation. It shown excessive amount reactive oxygen species crucial mediator both cell death caused . Based on these findings, it appears potential be developed as nanotherapeutics treatment cells.

Language: Английский

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Fabrication of pure Bi2WO6 and Bi2WO6/MWCNTs nanocomposite as potential antibacterial and anticancer agents

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 25, 2024

Abstract An essential research area for scientists is the development of high-performing, inexpensive, non-toxic antibacterial materials that prevent transfer bacteria. In this study, pure Bi 2 WO 6 and /MWCNTs nanocomposite were prepared by hydrothermal method. A series characterization results using XRD FTIR, Raman, FESEM, TEM, EDS analyses, reveal formation orthorhombic nanoflakes addition NaOH pH adjustment to 7. Compared , exhibited CNTs are efficiently embedded into structure which in charge between metal ion electrons conduction or valence band MWCNTs result shifting longer wavelength as shown UV–visible PL. The confirmed stuck surface microflowers, some them inside without affecting demonstrated TEM. addition, Pure tested against P. mirabilis S. mutans., confirming effect had better activity opposition both bacterial strains than . Besides, cytotoxicity lung MTT test on Hep-G2 liver cancer cells, flow-cytometry. Results indicated have significant anti-cancer efficacy cells vitro. findings triggered cell death via increasing ROS. Based these findings, it appears potential be developed nanotherapeutics treatment infections, cancer.

Language: Английский

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Exploitation of cantaloupe peels for bacterial cellulose production and functionalization with green synthesized Copper oxide nanoparticles for diverse biological applications

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 10, 2022

Abstract The promising features of most bacterial celluloses (BC) promote the continuous mining for a cost-effective production approach toward wide and sustainable applications. Herein, cantaloupe peels (CP) were successfully implemented BC production. Results indicated that enzymatically hydrolyzed CP supported maximum approximately 3.49 g/L when used as sole fermentation media. produced was fabricated with polyvinyl alcohol (PVA) chitosan (Ch), loaded green synthesized copper oxide nanoparticles (CuO-NPs) to improve its biological activity. novel composite showed an antimicrobial activity against several human pathogens such Staphylococcus aureus, Streptococcus mutans, Salmonella typhimurium, Escherichia coli, Pseudomonas fluorescens . Furthermore, new revealed significant in vitro anticancer colon (Caco-2), hepatocellular (HepG-2), breast (MDA) cancer cells, low IC 50 0.48, 0.27, 0.33 mg/mL three cell lines, respectively. On other hand, remarkably safe skin fibroblast (HSF) 1.08 mg/mL. Interestingly, membranes exhibited lethal effects all stages larval instar pupal stage compared control. In this study, we first report diverse potential applications BC/PVA/Ch/CuO-NPs composites based on CuO-NPs sustainably membrane.

Language: Английский

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Green synthesis and characterization of copper nanoparticles for investigating their effect on germination and growth of wheat

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(6), P. e0269987 - e0269987

Published: June 21, 2022

Today, different types of nanoparticles (NPs) are being synthesized and used for medical agricultural applications. In this study, copper (CuNPs) were using the aqueous extract mint (Mentha longifolia L.). For characterization CuNPs, UV-visible spectroscopy, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry used. The UV-Visible absorption peak at 558 nm confirmed formation CuNPs. XRD pattern phase-centered crystalline nature FTIR analysis showed O-H, Cu-H C-C bonds, indicating active role these functional groups as reducing agents Cu ions to CuNPS. NPs found have an almost spherical shape with average size 23 nm. When applied wheat, a condition dependent effect CuNPs was found. Variety 18-Elite Line 1, Elite 3, 6 maximum germination growth rate 50 mg CuNPs/L, while variety 5 that increase 25 CuNPs/L. Beyond concentrations, seed wheat declined. conclusion, application beneficial in improving certain concentration.

Language: Английский

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A comparative study of smart nanoformulations of diethyldithiocarbamate with Cu4O3 nanoparticles or zinc oxide nanoparticles for efficient eradication of metastatic breast cancer

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: March 2, 2023

Abstract Metastatic tumor is initiated by metastatic seeds (cancer stem cells “CSCs”) in a controlled redox microenvironment. Hence, an effective therapy that disrupts balance with eliminating CSCs critical. Diethyldithiocarbamate (DE) potent inhibitor of radical detoxifying enzyme (aldehyde dehydrogenase “ALDH”1A) causing eradication CSCs. This DE effect was augmented and more selective its nanoformulating green synthesized copper oxide (Cu 4 O 3 ) nanoparticles (NPs) zinc NPs, forming novel nanocomplexes CD NPs ZD respectively. These exhibited the highest apoptotic, anti-migration, ALDH1A inhibition potentials M.D. Anderson-metastatic breast (MDA-MB) 231 cells. Importantly, these revealed oxidant activity than fluorouracil elevating reactive oxygen species depleting glutathione only tissues (mammary liver) using mammary liver metastasis animal model. Due to higher tumoral uptake stronger had potential induce apoptosis, suppress hypoxia-inducing factor gene, eliminate CD44 + downregulating their stemness, chemoresistance, genes diminishing hepatic marker (α-fetoprotein). interpreted size reduction complete eradicating NPs. Consequently, nanocomplex therapeutic representing safe promising nanomedicine against stage cancer.

Language: Английский

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