Preventive Medicine Reports, Journal Year: 2024, Volume and Issue: 42, P. 102741 - 102741
Published: April 24, 2024
The purpose of this study was to examine the relationship between sleep duration and risk sarcopenia in general U.S. population.
Language: Английский
Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 4821 - 4832
Published: Oct. 1, 2023
Objective: This study aimed to evaluate the relationship between systemic inflammation response index (SIRI) and risk of stroke its subtypes in elderly patients with hypertension explore predictive accuracy any potential effect modifiers. Methods: The included 4749 participants no history at baseline. Cox regression was used estimate adjusted hazard ratios (HR) 95% confidence intervals (CIs). Interaction tests subgroup analyses were conducted. performance various inflammatory indicators for compared using area under curve (AUC), continuous net reclassification improvement (NRI), integrated discrimination (IDI). Results: During a median follow-up period 3.2 years, 640 strokes recorded, which 526 ischemic remainder hemorrhagic. After adjustment confounders, reference group, HRs (95% CI) 1.28 CI, 1.01– 1.64) 1.46 1.14– 1.88) second third tertiles, respectively. We observed interactions SIRI homocysteine levels (< 15 vs. ≥ μmol/L) (p interaction = 0.014) on risk. Furthermore, AUC, NRI, IDI demonstrated that exhibited better value when other indicators. Similar results both hemorrhagic strokes. Conclusion: Elevated significantly associated hypertension, suggesting as promising indicator this population. However, larger prospective studies are needed confirm these findings. Keywords: index, stroke, elderly, inflammation, cohort
Language: Английский
Citations
30
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(13), P. 3941 - 3941
Published: July 5, 2024
Background/Objectives: Insulin resistance is crucial in the pathogenesis of Metabolic Syndrome (MetS), type 2 diabetes mellitus (T2DM) and premature atherosclerotic cardiovascular disease (ASCVD). The triglyceride-glucose index (TyG index), a validated measure insulin resistance, also predicts MetS, T2DM, severity albuminuria ASCVD. There are scant data providing mechanistic insights into these sequalae. Accordingly, we investigated relationship between TyG biomarkers inflammation, oxidative stress, free fatty acid (FFA) levels adipokine dysregulation cohort comprising both controls patients with nascent MetS. Methods: Participants (n = 102) included 59 MetS 43 controls. People diabetes, ASCVD, smoking macro-inflammation were excluded. Fasting blood was obtained for plasma monocyte isolation. Results: Receiver Operating Characteristic (ROC) curve analysis revealed that an excellent predictor area under 0.87, it correlated hepatic adipose tissue resistance. Both serum RBP-4 non-HDL cholesterol increased significantly over tertiles index. Based on and/or correlations, oxidized LDL, nitrotyrosine, C-reactive protein, endotoxin, chemerin, interleukin-6 toll-like receptor (TLR)-4 TLR-2 their cellular signaling associated Conclusions: Increased non-HDL-C and, most importantly, pro-inflammatory pro-oxidant state could be advanced as potential mechanisms explaining risk T2DM ASCVD increasing
Language: Английский
Citations
9
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: Jan. 9, 2025
Various measures of arterial stiffness have been linked to the risk cardiovascular disease. However, relationship between estimated pulse wave velocity (ePWV), a novel indicator stiffness, and cardio-cerebrovascular disease remains unclear. This study investigated ePWV diseases. A total 17,708 participants aged 45 years older enrolled in China Health Retirement Longitudinal Study (CHARLS), conducted 2011 2012, with 7-year follow-up were included. Ultimately, 8242 respondents included study. The was calculated using age mean blood pressure. Cardio-cerebrovascular diseases, including myocardial infarction, cerebral intracerebral haemorrhage, categorised as cerebrovascular Clinical demographic characteristics collected. Cox proportional hazards model used explore During follow-up, 21.7% (1791/8242) developed After adjusting for potential confounding factors, positively associated (adjusted hazard ratio: 1.16, 95% CI 1.11–1.22, P < 0.001). divided into quartiles, regression analysis performed. Participants highest quartile had 128% higher than those lowest quartile. subgroup showed that positive association remained consistent among middle-aged adults across different Chinese communities. In adults, significantly disease, making it reliable innovative predictor these conditions.
Language: Английский
Citations
1
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: March 6, 2025
Frailty is a multifactorial syndrome associated with adverse health outcomes. The metabolic underpinnings of frailty, particularly lipid metabolism, are not fully understood. Unlike isolated fractions or inflammatory markers, atherogenic index plasma (AIP) integrates profiles and systemic inflammation. However, its association frailty has been extensively studied. Six thousand four hundred participants from the National Health Nutrition Examination Survey (NHANES) were enrolled. was calculated (FI), scores ≥ 0.21 indicating frailty. Logistic regression adjusted for demographic, socioeconomic, lifestyle factors evaluated between AIP Restricted cubic splines (RCS) explored nonlinear associations, subgroup analyses assessed interactions across age, sex, race, poverty income ratio, smoking status, drinking marital status. This study demonstrated strong dose-response relationship After full adjustment, Individuals in quartile 3 4 showed higher odds than those lowest quartile, ORs (95% CI) 1.26(1.01,1.57) 1.73(1.34,2.23), respectively. Continuous measures also exhibited significant associations (OR: 1.82, 95% CI: 1.34-2.47). RCS analysis that risk Subgroup more pronounced females. sensitivity substantiated stability strength results. Our findings suggest elevated levels independently risk, females, highlighting potential as cost-effective biomarker stratification. Future longitudinal studies needed to validate AIP's predictive utility uncover underlying mechanisms.
Language: Английский
Citations
1
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 356, P. 239 - 247
Published: April 10, 2024
Language: Английский
Citations
8
Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e38273 - e38273
Published: Sept. 1, 2024
Language: Английский
Citations
6
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: June 21, 2024
Abstract Background The anti-aging protein Klotho has diverse functions in antioxidative stress and energy metabolism through several pathways. While it been reported that α-Klotho is downregulated patients with insulin resistance (IR), the association between IR complex controversial. triglyceride-glucose (TyG) index provided a practical method for assessing IR. With this mind, our study aimed to investigate relationship TyG soluble levels US populations, both without diabetes mellitus. Methods This cross-sectional analyzed data from middle-aged older participants National Health Nutrition Examination Survey (NHANES) conducted 2007 2016. were divided into two groups based on their mellitus status: those diabetes. To evaluate concentration of each group, series survey-weighted multivariable linear regression models employed. Furthermore, examine these variables, multivariable-adjusted restricted cubic spline curves subgroup analysis generated. Results involved 6,439 adults aged 40 years or older, mean age 57.8 ± 10.9 years. Among them, 1577 (24.5%) had A indicated presence significantly affected level. After considering all covariables, revealed decreased by 32.35 pg/ml (95% CI: -50.07, -14.64) one unit increase ( p < 0.001). decline elevated was more pronounced female population. In mellitus, non-linear observed. There no significant correlation observed when below 9.7. However, there an klotho 106.44 above 9.7 28.13, 184.74) = 0.008). Conclusion Our findings suggested may influence α-Klotho. seem be sex differences individuals Further studies are necessary validate findings.
Language: Английский
Citations
5
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: June 22, 2024
The triglyceride-glucose (TyG) index is a risk marker for arterial stiffness; however, the extent to which TyG associated with stiffness via lipids and inflammation remains unknown. first aim was probe relationship between in two surveys. second clarify whether mediate this relationship.
Language: Английский
Citations
5
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 4, 2024
Systemic immune-inflammation index (SII), a novel inflammatory marker, has been reported to be associated with diabetic kidney disease (DKD) in the U.S., however, such close relationship DKD other countries, including China, not never determined. We aimed explore association between SII and Chinese population. A total of 1922 hospitalized patients type 2 diabetes mellitus (T2DM) included this cross-sectional study were divided into three groups based on estimated glomerular filtration rate (eGFR) urinary albumin-to-creatinine ratio (ACR): non-DKD group, stages 1-2 Alb DKD-non-Alb+DKD stage 3 group. The possible was investigated by correlation multivariate logistic regression analysis, receiver-operating characteristic (ROC) curves analysis. Moving from group level gradually increased (P for trend <0.01). Partial analysis revealed that positively ACR prevalence DKD, negatively eGFR (all P<0.01). Multivariate showed remained independently significantly presence after adjustment all confounding factors [(odds (OR), 2.735; 95% confidence interval (CI), 1.840-4.063; P < 0.01)]. Moreover, compared subjects lowest quartile (Q1), fully adjusted OR 1.060 (95% CI 0.773-1.455) Q2, 1.167 0.995-1.368) Q3, 1.266 1.129-1.420) highest (Q4) Similar results observed or DKD-non- Alb+DKD among quartiles. Last, ROC best cutoff values predict 1- 2, DKD-non-Alb+ 609.85 (sensitivity: 48.3%; specificity: 72.8%), 601.71 43.9%; 72.3%), 589.27 61.1%; 71.1%), respectively. Higher is an risk severity might promising biomarker its distinct phenotypes
Language: Английский
Citations
4
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: July 30, 2024
Abstract Background Despite the known association between chronic inflammation and reduced muscle mass, there is a gap in research regarding systemic immune-inflammation index (SII) sarcopenic obesity (SO). This study aims to assess relationship SII SO middle-aged elderly adults mediating role of triglyceride-glucose (TyG). Methods cross-sectional involved 2,719 participants aged 45–90 years who underwent health check-ups. was evaluated by combining sarcopenia [assessed handgrip strength appendicular skeletal (ASMI)] with (determined body fat percentage). Association SO, sarcopenia, individuals examined using multivariable logistic regression, restricted cubic spline analysis, subgroup analysis. Bidirectional mediation analysis conducted determine direct indirect effects through TyG. Results The included participants, which 228 had (8.4%). prevalence increased as quartiles rose ( P for trend <0.001). (per SD increase) significantly positive both (OR = 1.69, 95% CI: 1.43 ~ 1.99) older 2.52, 1.68 3.77). found be non-linear nonlinear <0.05). In addition, showed strong negative ASMI across all participants. still shown increase risk subgroups gender, mass index, waist circumference, smoking, drinking, hypertension, diabetes, dyslipidemia. TyG mediate 21.36%, 11.78%, 9.94% associations obesity, respectively. no effect on >0.05). Conclusions Elevated levels were associated an adults, especially population, elevated played this relationship.
Language: Английский
Citations
4