Targeting Intrinsic and Extrinsic Pathways of Ferroptosis: A Novel Anticancer Strategy of Curcumin DOI Creative Commons
Wei Hao, Yuan Gao, Bangwei Cao

et al.

Pharmacognosy Magazine, Journal Year: 2024, Volume and Issue: 20(4), P. 1061 - 1070

Published: May 19, 2024

Background The turmeric rhizome yields a medicinal compound called curcumin. Curcumin’s anticancer methods mostly involve blocking cell invasion and proliferation, controlling gene expression, preventing angiogenesis, triggering apoptosis, inducing ferroptosis. A brand-new nonapoptotic kind of planned death is Ferroptosis can be initiated through two major pathways: the extrinsic or transporter-dependent pathway, intrinsic enzyme-regulated pathway. It unknown, therefore, how curcumin its derivatives prevent cancer by Purpose Through this review, we concentrate on possible mechanisms means effect ferroptosis; regulation iron metabolism, synthesis reactive oxygen species, targeting antioxidant pathways represent few these processes. Methodology Retrieve English literature in treatment tumor ferroptosis from databases such as Web Science, etc. Conclusion This review provides rationale for clinical use agents.

Language: Английский

Curcumin activates the JNK signaling pathway to promote ferroptosis in colon cancer cells DOI
Xin Wei, Yong Zhang

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(3)

Published: March 1, 2024

Abstract Recent evidence has proved that curcumin as a natural polyphenol have great anticancer and anti‐proliferative effects in cancer cells. Ferroptosis, new form of regulated cell death, plays vital role the pathogenesis therapy cancers. In this study, we aimed to examine ferroptosis human colorectal cells its underlying molecular mechanisms. SW‐480 were treated by with different concentrations. Cell viability was determined using MTT assay. The concentrations reactive oxygen species (ROS) intracellular iron measured specific related kits. Real‐time PCR Western blot analysis used determine expression ferroptosis‐related proteins including ACSL4, GPx4 FTH1 activation JNK protein. Curcumin suppressed dose‐dependent manner. treatment led accumulation ROS within increase levels lipid peroxidation. addition, modulated mRNA protein suppression signaling. may exhibit effect on downregulating signaling induce

Language: Английский

Citations

4
Multifaceted physiological and therapeutical impact of curcumin on hormone‐related endocrine dysfunctions: A comprehensive review DOI
Xiuying Wang, Wei Zhang, Shengxue Zhou

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3307 - 3336

Published: April 15, 2024

Over the past five decades, Curcumin (Cur), derived from turmeric (Curcuma longa), has gained considerable attention for its potential therapeutic applications. Synthesizing insights clinical trials conducted over last 25 years, this review delves into diseases where Cur demonstrated promise, offering a nuanced understanding of pharmacokinetics, safety, and effectiveness. Focusing on specific examples, impact various human is explored. Endocrine glands associated signaling pathways are highlighted, elucidating how influences cellular signaling. The article underscores molecular mechanisms such as hormone level alteration, receptor interaction, cytokine adipokine expression inhibition, antioxidant enzyme activity, modulation transcription factors. showcases diverse protective against inflammation oxidative damage by suppressing antiapoptotic genes impeding tumor promotion. This comprehensive overview emphasizes natural agent countering aging degenerative diseases, calling further dedicated research in realm.

Language: Английский

Citations

4
TCM targets ferroptosis: potential treatments for cancer DOI Creative Commons

Liwen Qin,

Yuhan Zhong,

Yi Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 22, 2024

Ferroptosis is caused by the accumulation of cellular reactive oxygen species that exceed antioxidant load glutathione (GSH) and phospholipid hydroperoxidases with GSH-based substrates can carry When capacity cells reduced, lipid accumulate, which cause oxidative death. Ferroptosis, an iron-dependent regulatory necrosis pathway, has emerged as a new modality cell death strongly associated cancer. Surgery, chemotherapy radiotherapy are main methods cancer treatment. However, resistance to these mainstream anticancer drugs strong toxic side effects have forced development alternative treatments high efficiency low toxicity. In recent years, increasing number studies shown traditional Chinese medicines (TCMs), especially herbs or herbal extracts, inhibit tumor growth metastasis inducing ferroptosis, suggesting they could be promising agents for This article reviews current research progress on antitumor TCMs through induction ferroptosis. The aim was elucidate potential mechanisms targeting ferroptosis in cancer, findings lead directions reference values developing better treatment strategies.

Language: Английский

Citations

4
Ferroptosis in thyroid cancer: mechanisms, current status, and treatment DOI Creative Commons
Wenzhi Tian, Xi Su,

Chenchen Hu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Thyroid cancer (TC) represents the most prevalent malignancy within endocrine system. In recent years, there has been a marked global increase in incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into pathogenesis TC have identified significant association with ferroptosis, newly characterized form cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is accumulation lipid peroxides reactive oxygen species, culminating cellular damage death.Recent research elucidated connection between initiation, progression, treatment cancer. These findings underscore significance offer valuable insights development novel therapeutic strategies precise predictive markers. The unique mechanisms present opportunities for targeting treatment-resistant cancers. Consequently, regulation may emerge as target, potentially addressing limitations current treatments. Moreover, elucidating molecular underpinning facilitate identification biomarkers early detection prognostication. This review endeavors to synthesize extant knowledge regarding role examine potential implications, propose future trajectories enhance understanding clinical application ferroptosis.

Language: Английский

Citations

0
Chondroitin sulfate nanoparticles based on co-delivery dual drug induced ferroptosis in lung cancer cells by disrupting mitochondrial oxidative homeostasis DOI Creative Commons

He Wang,

Shuimu Lin,

Jiacui Xie

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101632 - 101632

Published: March 5, 2025

Language: Английский

Citations

0
Hyperforin Enhances Heme Oxygenase-1 Expression Triggering Lipid Peroxidation in BRAF-Mutated Melanoma Cells and Hampers the Expression of Pro-Metastatic Markers DOI Creative Commons

Alessia Cardile,

Carlotta Passarini,

Valentina Zanrè

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1369 - 1369

Published: June 30, 2023

Hyperforin (HPF) is an acylphloroglucinol compound found abundantly in Hypericum perforatum extract which exhibits antidepressant, anti-inflammatory, antimicrobial, and antitumor activities. Our recent study revealed a potent antimelanoma effect of HPF, hinders melanoma cell proliferation, motility, colony formation, induces apoptosis. Furthermore, we have identified glutathione peroxidase-4 (GPX-4), key enzyme involved cellular protection against iron-induced lipid peroxidation, as one the molecular targets HPF. Thus, three BRAF-mutated lines, investigated whether iron unbalance peroxidation may be part mechanisms underlying activity Initially, focused on heme oxygenase-1 (HO-1), catalyzes group into CO, biliverdin, free iron, observed that HPF treatment triggered expression this inducible enzyme. In order to investigate mechanism HO-1 induction, verified downregulates BTB CNC homology 1 (BACH-1) transcription factor, inhibitor oxygenase (HMOX-1) gene transcription. Remarkably, partial recovery viability increase phosphorylated active form retinoblastoma protein when suppressed HMOX-1 using siRNA while was present. This suggests pathway cytostatic cells. To explore induced, conducted cytofluorimetric analysis significant fluorescence BODIPY C-11 probe 48 h after administration all tested lines. discover by triggers along with induction HO-1, examined additional proteins associated homeostasis peroxidation. After administration, confirmed downregulation GPX-4 low levels SLC7A11, cystine transporter crucial for production, ferritin, able sequester iron. A decreased level these can sensitize cells On other hand, resulted increased transferrin, facilitates uptake, LC3B proteins, marker autophagy induction. Indeed, ferritin been reported digested during autophagy. Altogether, findings suggest induced likely through overloading decreasing protect from Finally, invasion metastatic potential. We CD133, octamer-4, tyrosine-kinase receptor AXL, urokinase plasminogen activator receptor, metalloproteinase-2 following treatment. These provide further support our previous observations, demonstrating inhibitory effects motility formation soft agar, are both metastasis-related processes tumor

Language: Английский

Citations

9
Ferroptosis: Potential opportunities for natural products in cancer therapy DOI

Anzheng Nie,

Chaozan Shen,

Zheng Zhou

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(3), P. 1173 - 1190

Published: Dec. 20, 2023

Abstract Cancer cells often exhibit defects in the execution of cell death, resulting poor clinical outcomes for patients with many cancer types. Ferroptosis is a newly discovered form programmed death characterized by intracellular iron overload and lipid peroxidation membrane. Increasing evidence suggests that ferroptosis closely associated wide variety physiological pathological processes, particularly cancer. Notably, various bioactive natural products have been shown to induce initiation cells, thereby exerting anticancer effects. In this review, we summarize core regulatory mechanisms multifaceted roles Importantly, focus on regulate such as terpenoids, polyphenols, alkaloids, steroids, quinones, polysaccharides. The efficacy, adverse effects, drug–drug interactions these need be evaluated further high‐quality studies accelerate their application treatment.

Language: Английский

Citations

9
Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases DOI Creative Commons
Sri Jayanti, Libor Vı́tek, Camilla Dalla Verde

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(1), P. 63 - 63

Published: Jan. 2, 2024

The crucial physiological process of heme breakdown yields biliverdin (BV) and bilirubin (BR) as byproducts. BV, BR, the enzymes involved in their production (the “yellow players—YP”) are increasingly documented endogenous modulators human health. Mildly elevated serum concentration has been correlated with a reduced risk multiple chronic pro-oxidant pro-inflammatory diseases, especially elderly. BR BV per se have demonstrated to protect against neurodegenerative which oxygenase (HMOX), main enzyme pigments, is almost always altered. HMOX upregulation interpreted tentative defense ongoing pathologic mechanisms. With demonstration that cells possess YP, propensity be modulated, broad spectrum activity on signaling pathways, YP assumed role an adjustable system can promote health adults. Based that, there effort induce therapeutic option, natural compounds attractive alternative goal, possibly requiring only minimal changes life style. We review most recent evidence potential targeting context common condition adult elderly life.

Language: Английский

Citations

3
Anti-Ferroptosis: A Promising Therapeutic Method for Thyroid Cancer DOI Creative Commons

Rongyi Hu,

Zhi‐Zhou Shi, Jie Yang

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(2)

Published: Feb. 21, 2024

At present, many problems remain to be solved in studying the pathogenesis of thyroid cancer. Ferroptosis is a programmed cell death mode discovered recent years, and studies have found that ferroptosis plays significant role prognosis progression The researchers showed ferroptosis-related genes are essential diagnosing Therefore, this paper summarizes some pathological clinical characteristics cancer makes series combs on relationship between basis function cancer, thus providing specific ideas for diagnosis treatment

Language: Английский

Citations

3
Curcumin–polydopamine nanoparticles alleviate ferroptosis by iron chelation and inhibition of oxidative stress damage DOI Creative Commons
Lei Li, Jiali Yuan, Qingqing Yang

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(21), P. 14934 - 14941

Published: Jan. 1, 2024

A Cur–PDA NP based nanoregulator was developed for targeting ferroptosis to mitigate neuron degeneration by regulating iron and ROS homeostasis, suppressing lipid peroxidation oxidative stress, improving mitochondrial function.

Language: Английский

Citations

3