AIMS Materials Science,
Journal Year:
2023,
Volume and Issue:
10(6), P. 1004 - 1033
Published: Jan. 1, 2023
<abstract>
<p>In
the
past
few
decades,
many
researchers
have
focused
their
research
interests
on
nanocomposite
hydrogel
fibers
(NHFs).
These
practitioners
developed
and
optimized
techniques
for
preparing
nanofiber
membranes
such
as
template
method,
microfluidic
spinning,
electrospinning,
wet
spinning
three-dimensional
printing
(3D
printing).
NHFs
important
applications
in
wearable
monitoring,
diagnosis
nursing
due
to
various
excellent
properties
(such
high-water
content,
porous
morphology,
flexibility,
braiding
rich
active
functional
groups).
In
this
paper,
latest
progress
of
pose
continuous
monitoring
physiological
indicators,
diagnosis,
wearables,
nursing,
drug
delivery
dressings
are
reviewed.
This
paper
also
aims
review
key
operational
parameters,
advantages
disadvantages
above
fields,
including
sensitivity,
working
range
other
special
properties.
Specifically,
can
be
used
biological
postures
gestures)
or
indicators
blood
sugar)
<italic>in
vitro</italic>
vivo</italic>.
long-term
related
field.
tissue
engineering
delivery.
Finally,
we
look
forward
development
prospects,
challenges
opportunities
next
generation
NHFs.
We
confirm
that
emergence
field
treatment
has
opened
up
a
new
vision
human
health.
Researchers
3D
printing.</p>
</abstract>
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 123 - 123
Published: Feb. 7, 2025
Recent
advancements
in
wound
dressing
materials
have
significantly
improved
acute
and
chronic
management
by
addressing
challenges
such
as
infection
control,
moisture
balance,
enhanced
healing.
Important
progress
has
been
made,
especially
with
hydrogels,
foams,
antimicrobial
for
creating
optimized
dressings.
Hydrogels
are
known
maintaining
optimal
levels,
while
foam
dressings
excellent
exudate
absorbents.
Meanwhile,
incorporates
various
agents
to
reduce
risks.
These
options
healing
time
focusing
on
customized
patient
needs.
Therefore,
this
review
highlights
the
newest
research
prototypes
applications,
emphasizing
their
particular
benefits
clinical
importance.
Innovations
stimuli-responsive
hydrogels
hybrid
bioengineered
composites
discussed
relation
properties,
including
responsiveness
pH,
temperature,
glucose,
or
enzymes
drug
delivery
precision.
Moreover,
ongoing
trials
included,
demonstrating
potential
of
emerging
solutions
be
soon
translated
from
laboratory
settings.
By
discussing
interdisciplinary
approaches
that
integrate
advanced
materials,
nanotechnology,
biological
insights,
work
provides
a
contemporary
framework
patient-centric,
efficient
care
strategies.
Abstract
With
the
aging
and
obesity
era,
increasing
incidence
of
diabetes
diabetic
complications,
especially
non‐healing
wounds,
imposes
a
serious
economic
burden
on
both
patients
society.
The
complex
microenvironments,
including
hyperglycemia,
bacterial
infection,
ischemia,
nerve
damage,
lead
to
prolonged
inflammation
proliferation
phase
wounds.
Mesenchymal
stem
cell‐derived
small
extracellular
vesicles
(MSC‐sEVs),
which
contain
rich
variety
therapeutic
molecules,
have
been
chased
for
decades
because
their
potential
roles
in
cellular
communication,
tissue
regeneration,
drug
delivery.
As
powerful
tools
controlled‐sustained
release
sEVs,
biocompatible
hydrogels
applied
wide
range
biomedical
applications.
Herein,
we
first
summarize
pathological
features
such
as
angiopathy,
neuropathy,
immune
cell
dysfunction.
Then,
discuss
biological
properties,
performance,
stability
pure
MSC‐sEVs.
After
that,
components,
application
patterns,
responsiveness
hydrogels.
Next,
loading
avenues
MSC‐sEVs
into
hydrogel,
behaviors
sEVs
from
hydrogels,
influence
crosslinking
method
hydrogel‐sEV
composites.
Finally,
provide
an
overview
current
applications
loaded
with
novel
cell‐free
engineering
system
managing
wounds
propose
critical
unsolved
issues.
This
review
is
expected
meaningful
guidance
developing
wound
management.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 27, 2024
Abstract
Chronic
wounds,
resulting
from
persistent
inflammation,
can
trigger
a
cascade
of
detrimental
effects
including
exacerbating
inflammatory
cytokines,
compromised
blood
circulation
at
the
wound
site,
elevation
white
cell
count,
increased
reactive
oxygen
species,
and
potential
risk
bacterial
infection.
The
interleukin-17
(IL-17)
signaling
pathway,
which
plays
crucial
role
in
regulating
immune
responses,
has
been
identified
as
promising
target
for
treating
skin
diseases.
This
review
aims
to
delve
deeper
into
pathological
molecular
mechanisms
IL-17
family
its
pathways
repair.
intricate
interactions
between
other
cytokines
will
be
discussed
detail,
along
with
activation
various
pathways,
provide
comprehensive
understanding
IL-17’s
involvement
chronic
inflammation
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 2, 2025
Diabetic
wounds
are
notoriously
difficult
to
heal
due
impaired
cell
repair
mechanisms,
reduced
angiogenesis,
and
a
heightened
risk
of
infection.
Fibroblasts
play
vital
role
in
wound
healing
by
producing
extracellular
matrix
(ECM)
components
various
growth
factors,
but
their
function
is
inhibited
diabetic
wounds.
Chitooligosaccharides
(COS),
intermediate
products
chitosan
degradation,
have
shown
efficacy
promoting
tissue
repair,
yet
remains
underexplored.
In
mouse
model
wounds,
COS
treatment
demonstrated
substantial
bioactivity
accelerating
enhancing
fibroblast
proliferation
migration.
Additionally,
increased
collagen
III
deposition
angiogenesis
at
the
sites.
The
also
mitigated
inflammatory
responses
controlling
leukocyte
infiltration
bacterial
Mechanistically,
regulated
activity
via
PI3K/Akt
signaling
pathway,
providing
novel
bioactive
material
for
chronic
healing.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(15), P. 3745 - 3764
Published: Jan. 1, 2024
Hydrogels,
as
an
emerging
biomaterial,
have
found
extensive
use
in
the
healing
of
wounds
due
to
their
distinctive
physicochemical
structure
and
functional
properties.
Moreover,
hydrogels
can
be
made
match
a
range
therapeutic
requirements
for
materials
used
wound
through
specific
modifications.
This
review
provides
step-by-step
explanation
processes
involved
cutaneous
healing,
including
hemostasis,
inflammation,
proliferation,
reconstitution,
along
with
investigation
factors
that
impact
these
processes.
Furthermore,
thorough
analysis
is
conducted
on
various
stages
process
at
which
are
implemented,
anti-infection
measures,
encouraging
regeneration,
scar
reduction,
monitoring.
Next,
latest
progress
multifunctional
methods
achieve
functions
discussed
depth
categorized
elucidation.
Finally,
perspectives
challenges
associated
clinical
applications
discussed.
International Wound Journal,
Journal Year:
2024,
Volume and Issue:
21(8)
Published: Aug. 1, 2024
Abstract
The
disturbance
of
the
inflammatory
microenvironment
is
a
frequent
pathological
trait
diabetic
wounds,
contributing
to
emergence
numerous
chronic
illnesses.
This
crucial
in
both
development
and
recovery
wounds
caused
by
diabetes.
study
aims
perform
bibliometric
analysis
research
on
within
domain
(DW)
over
past
10
years.
objective
map
out
current
global
landscape,
pinpoint
most
significant
areas
offer
guidance
for
future
avenues.
Our
involved
querying
Web
Science
Core
Collection
(WoSCC)
database
all
pertinent
studies
(DW).
We
utilized
tools
such
as
CiteSpace,
VOSviewer
R
(version
4.3.1)
identify
highlight
impactful
field.
encompassed
review
1454
articles
published
from
2014
2023,
highlighting
China
United
States
pivotal
nations
Within
this
sphere,
University
Michigan
Harvard
States,
along
with
Shanghai
Jiaotong
China,
emerged
prolific
institutions.
WANG
Y
was
identified
productive
author,
while
KUNKEL
SL
received
citations.
primarily
focuses
topics
wound
healing,
repair
processes,
angiogenesis,
oxidative
stress
macrophage
activity.
Additionally,
“macrophage”
“delivery”
were
pinpointed
leading
subjects
promising
potential
area.
Research
rapidly
advancing
through
active
international
collaboration.
new
mechanisms
related
novel
materials
based
represent
emerging
fields
research,
particularly
terms
translational
applications.
may
perspectives
further
area
microenvironment.
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 104 - 104
Published: Feb. 2, 2025
Diabetic
wound
healing
presents
significant
challenges
due
to
impaired
angiogenesis,
chronic
inflammation,
and
cellular
dysfunction.
Building
on
previous
research,
this
study
further
explores
the
potential
of
a
plant-derived
glucosyloxybenzyl
2-isobutylmalates
(B-CGT)
hydrogel
in
promoting
diabetic
healing.
Network
pharmacology
molecular
docking
analyses
suggest
that
B-CGT
may
regulate
key
mechanisms,
such
as
apoptosis,
matrix
remodeling,
through
core
targets
including
SIRT1,
CASP8,
MMP8.
In
vivo
studies
demonstrated
significantly
accelerated
closure
mice,
enhanced
promoted
collagen
deposition,
achieved
immune
balance
by
modulating
macrophage
polarization,
thereby
shifting
inflammatory
environment
toward
repair
state.
Moreover,
improved
microenvironment
upregulating
VEGF
expression
exerting
antioxidant
effects.
By
combining
theoretical
predictions
with
experimental
validation,
elucidates
multi-target
synergistic
regulatory
mechanisms
hydrogel.
These
findings
provide
new
research
directions
for
addressing
imbalance
angiogenesis
defects
lay
scientific
foundation
optimization
application
treatment
strategies.
