A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 18, 2023

Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer compounds that are widely used in the treatment hematologic malignancies and solid tumors. Unlike conventional chemotherapeutic drug-based therapies, mainly associated with modest specificity therapeutic benefit, three key components form ADC (a monoclonal antibody bound to a cytotoxic drug via chemical linker moiety) achieve remarkable improvement terms targeted killing cancer cells and, while sparing healthy tissues, reduction systemic side effects caused by off-tumor toxicity. Based on their beneficial mechanism action, 15 ADCs have been approved date market approval Food Drug Administration (FDA), European Medicines Agency (EMA) and/or other international governmental agencies for use clinical oncology, hundreds undergoing evaluation preclinical phases. Here, our aim is provide comprehensive overview features revolving around strategy including structural targeting properties, role tumor microenvironment review providing discussion regarding toxicity profile, manifestations novel combination therapies. Finally, we briefly pathological contexts information manufacturing analytical characterization.

Language: Английский

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A Questionnaire to Evaluate Undergraduate Students' Consumption and Awareness of Non-Steroidal Anti-Inflammatory Drugs in Syria

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2024, Volume and Issue: 4(4), P. 1 - 6

Published: June 22, 2024

This study aims to evaluate the level of awareness and consumption NSAIDs among college undergraduate students in Syria. 60.1% 309 participants were between 20 25 years old. 64.1% females. 27.6% medical students. NSAID was very high participating 94.9% have used these drugs. 65.9% admit taking medications 2 10 times per month. Most prefer take tablets capsules (93.8%), especially for relieving pain (84.6%). The first choice ibuprofen 36.6%, then diclofenac 25.3%. 69.1% not experienced any side effects as a result NSAIDs. findings showed that about good since 76% taken after food. However, most without consulting doctor or pharmacist every 8 hours. In addition, some them mentioned antibiotics an example who participated this survey general knowledge Medical are more aware effects, safety, dosage

Language: Английский

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A Survey of Knowledge About the Interaction Between Food and Drugs Among the Syrian Population

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2024, Volume and Issue: 4(4), P. 22 - 28

Published: June 22, 2024

This study aimed to evaluate the knowledge and awareness of food-drug interactions among general public in Syria. A questionnaire was distributed at Tishreen University published on social media between October November 2023. total 419 responses were collected. 83.3% know that food can affect effectiveness medications. 85.2% think increase or slow down effects 77.6% believe effect varies depending dose, age, health status. 68.5% may lead serious side effects. 45.8% death. 49.2% chose age group patients highest risk for should be over 60 years age. The results showed level participants about good because overall average number who answered correctly 63.34%.

Language: Английский

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A Survey of the Awareness and Practices of Antibiotic use Among College Undergraduates and Graduates in Latakia

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2024, Volume and Issue: 4(3), P. 1 - 5

Published: April 24, 2024

Antibiotic resistance has become a global health crisis, posing significant threat to our ability treat bacterial infections. Over the years, overuse and misuse of antibiotics in both humans animals have contributed development antibiotic-resistant bacteria. This leads longer more complicated treatment courses, increased healthcare costs, some cases untreatable In this study, survey was conducted on antibiotic use among college undergraduates graduates Latakia. The age 42.2% participants 20–25 years. More than half were male (55.9%). Most responses from 51%, either final-year students or graduates. them had used with prescriptions. highest rate for sore throat (47.1%). completed courses their symptoms improved (70.6%). Black red pills remained effective most patients (67.6%). 68.6% would consult doctor if did not improve after taking antibiotics. 62.7% didn’t give family member when they sick. 52.9% reserve necessary. Half take leftover case respiratory diseases. results show good level knowledge about study encourages improvement public attitudes towards appropriate

Language: Английский

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Overview of Analytical Methods for Characterizing the Charge Heterogeneity of Antibody-Drug Conjugates

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2024, Volume and Issue: 4(5), P. 16 - 22

Published: Aug. 26, 2024

Antibody-drug conjugates (ADCs) are ideal candidates for selective therapy. ADCs display considerable heterogeneity resulting from various modifications. One of the molecular characteristics is charge heterogeneity. Several analytical methods could be used to characterize ADC including ion exchange chromatography (IEC), isoelectric focusing (IEF), and capillary electrophoresis (CE). This work aimed give insights into different techniques determine pI distribution profile ADCs.

Language: Английский

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Overview of the Role of Chromatographic Modes in Pharmaceutical Peptide Analysis

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2025, Volume and Issue: 5(2), P. 22 - 29

Published: Feb. 21, 2025

Peptides represent promising candidates for medical treatments. They can be designed high specificity, which minimizes the adverse effects. Ensuring their purity, identity, and quality is crucial to therapeutic efficacity. exhibit different physical chemical properties (such as charge, pI, hydrophobic nature, size, etc.). These characteristics complicate separation of a mixture peptides. Various analytical techniques were used peptide purification, mapping, or identification. HPLC continues preferred method analyzing Different modes applied separate peptides from impurities related substances. Among these modes, ion exchange, reversed-phase, normal-phase, HILIC performed achieve separation. This review will discuss chromatographic role in analysis, including mixtures, creating isolating interest associated compounds.

Language: Английский

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Investigation of the Charge Variant Profile of Non-cleavable Conjugated Antibodies

Research Journal of Pharmacy and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 185 - 190

Published: Jan. 27, 2025

This research aimed to analyze the charge variant profiles of monoclonal antibodies (mAbs) conjugated maytansine derivatives or tomaymycin compounds via a non-cleavable linker, utilizing imaging capillary isoelectric focusing (icIEF) technique. Initially, for three mAbs were assessed, revealing both major and minor variants among samples. Specifically, mAB1 mAB2 displayed two distinct with points (pI) 9.00 8.95, respectively. In contrast, mAB3 showed predominant pI 8.50, along (pI values 8.30 8.60). The conjugation involved derivative using linkers, while linked molecules. resulting antibody conjugates exhibited greater heterogeneity acidity than their unconjugated forms. observed ranges 7.4 8.9 (∆pI: 1.4), 8.2 0.7), 8.4 1). icIEF method proved effective tracking antibody-drug (ADCs), showing excellent repeatability intra-day inter-day measurements ADCs.

Language: Английский

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Survey of Usage and Awareness of Ibuprofen Among the Syrian Population

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2024, Volume and Issue: 4(5), P. 23 - 28

Published: Aug. 27, 2024

Ibuprofen is a non-selective NSAID. This drug inhibits both COX-1 and COX-2. It commonly used to manage some conditions in Syria, especially pain. research aimed assess the awareness use of ibuprofen among Syrian population. A survey was conducted on social networking sites during January, February, March 2024 achieve this purpose. 217 responses were collected. Most participants female (65%) between 20 30 years old (83.9). had taken 80.9%. 45% as pain reliever. 74.4% responded that they can get from pharmacy without prescription. Half believe recommended dose relieve 400 mg every 8 hours for an adult. Only 23.5% experienced side effects when taking ibuprofen, mainly stomach (55%). The first alternative paracetamol 32%. treatment plan 69.8% includes combination with paracetamol. results demonstrated high consumption Syria. Indeed, surveyed Syrians good understanding medication.

Language: Английский

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Assessment of Knowledge About High Blood Pressure Among Syrians

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2024, Volume and Issue: 4(6), P. 28 - 32

Published: Oct. 28, 2024

Hypertension, often referred to the silent killer, is a prevalent health issue that impacts more than billion individuals worldwide. The purpose of this study was investigate understanding hypertension among Syrian individuals. 104 filled out surveys. Females made up 64.4% group surveyed. 28.8% participants in were between ages 46 and 60. More half had or work related medicinal field. showed good medication adherence where score accurate responses questions regarding compliance very high. Most familiar with normal values blood pressure levels optimistic about possibility treating condition. A percentage surveyed stated smoking obesity are contributing factors developing high pressure. believed consuming fatty foods raises plasma cholesterol levels. Participants overall However, they still need improvement medical information enhance treatments.

Language: Английский

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Assessment of use and Awareness of Diclofenac in Syria

International Journal of Advanced Pharmaceutical Sciences and Research, Journal Year: 2024, Volume and Issue: 4(6), P. 1 - 6

Published: Oct. 28, 2024

Diclofenac, known as diclone in Syria, is the most widely used drug multiple medical conditions. This research was conducted to assess use and awareness of diclofenac Syria through a survey. 601 responses were included this research.Most participants female (67.7%), between ages 18 30 years (82.9%), did not have chronic disease (86.3%). More than half university students (53.4%). A high proportion had education level (87.7%). The commonly dosage form for tablets among participants(70.9%). 43.8% chose 50mg dose diclofenac. Most improved after using (73.7%). Participants satisfied treatment (66.56%). no side effects with (79.5%). 81.3% who experienced suffered from stomach pain. Fortunately, 84.4% injection combining cortisone an antibiotic. 56.38% combination treat respiratory infections. minority allergic reactions taking medication (4%). two-thirds will continue pain management future (65.9%).77.9% without prescription. medicine meal (82%). 36.6% recorded hour onset reported action duration 6 hours (24.5%) 8 (31%). study confirmed Syrians. good observed surveyed participants.

Language: Английский

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