Macrophage plasticity: signaling pathways, tissue repair, and regeneration

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: Aug. 1, 2024

Abstract Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) alternatively (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay signaling pathways, transcriptional regulators, epigenetic modifications orchestrates polarization, allowing respond stimuli dynamically. Here, we provide comprehensive overview the cascades governing focusing on roles Toll‐like receptors, signal transducer activator transcription proteins, nuclear microRNAs. We also discuss emerging concepts metabolic reprogramming trained immunity, contributing their functional adaptability. Macrophage plasticity plays pivotal role in repair regeneration, macrophages coordinating inflammation, angiogenesis, matrix remodeling restore homeostasis. By harnessing potential novel therapeutic strategies targeting polarization could be developed for diseases, including chronic wounds, fibrotic disorders, inflammatory conditions. Ultimately, deeper understanding molecular mechanisms underpinning will pave way innovative regenerative medicine engineering approaches.

Language: Английский

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Polystyrene nanoplastics of different particle sizes regulate the polarization of pro-inflammatory macrophages

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 15, 2024

Abstract Microplastics (MPs) are defined as plastic particles smaller than 5 mm in size, and nanoplastics (NPs) those MPs with a particle size of less 1000 nm or 100 nm. The prevalence the environment human tissues has raised concerns about their potential negative effects on health. Macrophages major defence against foreign substances intestine, can be polarized into two types: M1 phenotype M2 phenotype. However, effect NPs polarization macrophages remains unclear. Herein, we selected polystyrene, one most plastics controlled sizes at 50 500 respectively to study macrophages. We used mouse RAW264.7 cell line models this macrophage-associated study. Experiments absorption showed that could quickly ingest polystyrene both diameters time-dependent uptake. Compared untreated group 10 μg/mL treatment group, exposed groups (50 nm) had considerably higher levels CD86, iNOS, TNF-α, but decreased aCD206, IL-10, Arg-1. According these findings, macrophage induced inhibited by nanoplastics. This work provided first evidence possible mode action appropriate concentration through production M1, providing dietary environmental recommendations for people, particularly autoimmune autoinflammatory illnesses.

Language: Английский

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Inhibition of peptidyl arginine deiminase-4 ameliorated pulmonary fibrosis via modulating M1/M2 polarisation of macrophages

Life Sciences, Journal Year: 2025, Volume and Issue: 362, P. 123354 - 123354

Published: Jan. 2, 2025

Language: Английский

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Cellular aspects of immunity involved in the development of atherosclerosis

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Atherosclerosis, previously regarded as a lipid storage disease, has now been classified chronic inflammatory disease. The hardening of arterial vessels characterizes atherosclerosis due to the accumulation lipids in walls, eliciting an response. development occurs various stages and is facilitated by many clinical factors, such hypertension, hyperlipidemia, status. A large arsenal cells implicated its development. This review will summarize phases atherosclerotic formation all involved either promoting or inhibiting

Language: Английский

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Omega-3 Lipid Mediators: Modulation of the M1/M2 Macrophage Phenotype and Its Protective Role in Chronic Liver Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15528 - 15528

Published: Oct. 24, 2023

The complex interplay between dietary factors, inflammation, and macrophage polarization is pivotal in the pathogenesis progression of chronic liver diseases (CLDs). Omega-3 fatty acids (FAs) have brought attention due to their potential modulate inflammation exert protective effects various pathological conditions. eicosapentaenoic acid (EPA) docosahexaenoic (DHA) shown promise mitigating enhancing resolution inflammatory responses. They influence M1/M2 phenotype balance, promoting a shift towards M2 anti-inflammatory phenotype. Specialized pro-resolving mediators (SPMs), such as resolvins (Rvs), protectins (PDs), maresins (MaRs), emerged potent regulators polarization. show properties, by modulating expression cytokines, facilitate phagocytosis apoptotic cells, promote tissue repair. MaR1, particular, has demonstrated significant hepatoprotective polarization, reducing oxidative stress, inhibiting key pathways NF-κB. In context CLDs, nonalcoholic disease (NAFLD) cirrhosis, omega-3s SPMs attenuating injury, regeneration, phenotypes. aim this article was analyze emerging role omega-3 FAs with special interest mechanisms underlying interactions other cell types within microenvironment, focused on CLDs development novel therapeutic strategies.

Language: Английский

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Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms–Macrophage Interface

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: April 19, 2024

Abstract Macrophages play an essential role in immunotherapy and tissue regeneration owing to their remarkable plasticity diverse functions. Recent bioengineering developments have focused on using external physical stimuli such as electric magnetic fields, temperature, compressive stress, among others, micro/nanostructures induce macrophage polarization, thereby increasing therapeutic potential. However, it is difficult find a concise review of the interaction between stimuli, advanced micro/nanostructures, polarization. This examines present research stimuli‐induced polarization micro/nanoplatforms, emphasizing synergistic fabricated structure stimulation for regeneration. A overview advancements investigating impact including forces, fluid shear photothermal multiple stimulations macrophages within complex engineered structures, provided. The prospective implications these strategies regenerative medicine immunotherapeutic approaches are highlighted. will aid creating stimuli‐responsive platforms immunomodulation

Language: Английский

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The role of M1/M2 macrophage polarization in primary Sjogren’s syndrome

Arthritis Research & Therapy, Journal Year: 2024, Volume and Issue: 26(1)

Published: May 14, 2024

The purpose of this study was to investigate the role macrophage polarization in pathogenesis primary Sjogren's syndrome (pSS).

Language: Английский

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Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti‐inflammatory profile of macrophages‐derived monocytes of newly diagnosed patients with systemic lupus erythematosus

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)

Published: March 1, 2024

Abstract Systemic lupus erythematosus (SLE) is known as an autoimmune disorder that characterized by the breakdown of self‐tolerance, resulting in disease onset and progression. Macrophages have been implicated a factor development SLE through faulty phagocytosis dead cells or imbalanced M1/M2 ratio. The study aimed to investigate immunomodulatory effects Lactobacillus delbrueckii rhamnosus on M1 M2 macrophages new case patients. For this purpose, blood monocytes were collected from patients healthy people cultured for 5 days produce macrophages. 48 h, then cocultured with either probiotics lipopolysaccharides (LPS). Flow cytometry real‐time polymerase chain reaction used analyze expression cluster differentiation (CD) 14, CD80, human leukocyte antigen – DR (HLADR) markers, well cytokine (interleukin [IL]1‐β, IL‐12, tumor necrosis α [TNF‐α], IL‐10, transforming growth beta [TGF‐β]). results indicated three distinct macrophage populations, M0, M1, M2. In both control patient‐derived macrophage‐derived (MDMs), probiotic groups showed decrease CD14, HLADR compared LPS group. This was particularly evident M0 subjects. addition, increased levels IL‐10 TGF‐β decreased IL1‐β, TNF‐α MDMs subjects groups. Although there higher pro‐inflammatory cytokines patients, anti‐inflammatory general, L. could induce

Language: Английский

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Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management

Immune Network, Journal Year: 2024, Volume and Issue: 24(3)

Published: Jan. 1, 2024

Recent advancements in various technologies have shed light on the critical role of metabolism immune cells, paving way for innovative disease treatment strategies through immunometabolism modulation. This review emphasizes glucose myeloid-derived suppressor cells (MDSCs), an emerging pivotal immunosuppressive factor especially within tumor microenvironment. MDSCs, immature and heterogeneous myeloid cell population, act as a double-edged sword by exacerbating tumors or mitigating inflammatory diseases their immune-suppressive functions. Numerous recent studies centered glycolysis MDSC, investigating regulation altered glycolytic pathways to manage diseases. However, specific changes MDSC exact functions continue be areas ongoing discussion yet. In this paper, we range current findings, including latest research alteration consequential functional alterations these outcomes attempts modulate regulating glycolysis. Ultimately, will provide insights into whether efforts could translated clinical applications.

Language: Английский

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Macrophage-based cancer immunotherapy: Challenges and opportunities

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 442(1), P. 114198 - 114198

Published: Aug. 3, 2024

Language: Английский

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