Neutralizing antibody test supports booster strategy for young individuals after SARS-CoV-2 Omicron breakthrough

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 6, 2025

The SARS-CoV-2 Omicron variant, since its initial detection, has rapidly spread across the globe, becoming dominant strain. It is important to study immune response of variant due remarkable ability escape majority existing neutralizing antibodies. surge in infections among most Chinese residents by end 2022 provides a unique opportunity understand system's populations with limited exposure prior variants. We tested levels IgG, IgA, and IgM specific prototype RBD (receptor-binding domain) blood samples from 636 individuals chemical luminescence assay, ELISA pseudovirus-based neutralization assay. Inoculation inactivated vaccines or recombinant protein showed higher IgG after infection than unvaccinated individuals. Moreover, age resulted different as level patients aged > 60 years was lower that < years. This indicates induced breakthrough between old young found booster dose vaccine led significant increase against helped induce antibodies BA.5 BF.7 variants an individuals, which previous report on older people. These data suggest vaccination helps high Trial registration: purely observational study.

Language: Английский

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Impact of COVID-19 on door-to-wire time in ST-segment elevation myocardial infarction treatment: the role of digital communication

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 12, 2025

Abstract Introduction ST-segment elevation myocardial infarction (STEMI) is a life-threatening cardiovascular emergency necessitating rapid reperfusion. During the COVID-19 pandemic, healthcare providers faced challenge of ensuring timely STEMI interventions while managing risk viral transmission in hospitals. This study aims to analyze changes door-to-wire (D-to-W) time for treatment across three pandemic phases—early pre-epidemic phase (Group C), initial lockdown A), and intermediate normalization B). It also examines impact digital communication tools, collectively referred as “InterNet + ” (e.g., Twitter, WeChat), on processes. Methods Based data 630 patients treated Chest Pain Center particular hospital China from 2019 2020, D-to-W different groups are measured. Time intervals process predicted by Bayesian statistics approach. The investigated influence InterNet utilization before after through questionnaire-based assessment. Results For transfer-non-emergency- treatment, first-electrocardiogram preliminary-diagnosis Group-A significantly longer than that Groups-B -C ( p = 0.004, 0.004); decision-on-intervention catheterization-room-activation -B Group-C 0.003, < 0.001). transfer-emergency- first-medical-contact arterial-puncture remarkably shorter 0.006). Meanwhile, method performs well forecasting intervals, so it can provide effective assistance treatment. findings questionnaire indicated physicians perceived significant association between optimal management an increased frequency tool usage following 0.019). Conclusions have been dilemmas various inevitably prolonged during pandemic. implementation tools proved essential minimizing delays FMC-to-W times, offering valuable strategy enhancing care amid ongoing challenges. Clinical trial number Not applicable.

Language: Английский

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Role and mechanisms of exercise therapy in enhancing drug treatment for glioma: a review

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Gliomas, particularly glioblastoma (GBM), are among the most aggressive and challenging brain tumors to treat. Although current therapies such as chemotherapy, radiotherapy, targeted treatments have extended patient survival some extent, their efficacy remains limited is often accompanied by severe side effects. In recent years, exercise therapy has gained increasing attention an adjunctive treatment in clinical research settings. Exercise not only improves patients’ physical function cognitive abilities but may also enhance of conventional drug modulating immune system, suppressing inflammatory responses, improving blood-brain barrier permeability. This review summarizes potential mechanisms glioma treatment, including enhancing surveillance through activation natural killer (NK) cells T cells, penetration function. Additionally, studies suggest that can synergize with chemotherapy immunotherapy, outcomes while reducing drug-related application patients still exploratory phase, existing evidence indicates its significant value approach, become a new standard future.

Language: Английский

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Predictive Factors and ACE-2 Gene Polymorphisms in Susceptibility to Long COVID-19 Syndrome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16717 - 16717

Published: Nov. 24, 2023

Long COVID-19 syndrome is present in 5-10% of patients infected with SARS-CoV-2, and there still little information on the predisposing factors that lead to its development. The purpose study was evaluate predictive early symptoms, clinical features role Angiotensin-Converting Enzyme-2 (ACE-2) c.513-1451G>A (rs2106806) c.15643279T>C (rs6629110) polymorphisms susceptibility developing subsequent infectionA total 29 who suffered were recruited a descriptive longitudinal two groups: (n = 16) non-Long 13). Early symptoms during classified by medical service. ACE-2 genotyped using Single Nucleotide Primer Extension (SNPE). Of fatigue, myalgia headache showed high risk increasing susceptibility. Clinical such as emergency care, SARS-CoV-2 reinfection, previous diseases, respiratory disease brain fog also had A allele rs2106806 variant associated an odds ratio (OR) 4.214 (95% CI 2.521-8.853; p < 0.001), T rs6629110 OR 3.754 1.785-6.105; 0.002) This shows polymorphisms, different infection COVID-19.

Language: Английский

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Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes

Infection Genetics and Evolution, Journal Year: 2024, Volume and Issue: 118, P. 105564 - 105564

Published: Feb. 1, 2024

This pilot study aimed to investigate genetic factors that may have contributed the milder clinical outcomes of COVID-19 in Brazilian indigenous populations. 263 Indigenous from Araweté, Kararaô, Parakanã, Xikrin do Bacajá, Kayapó and Munduruku peoples were analyzed, 55.2% women, ages ranging 10 95 years (average 49.5 ± 20.7). Variants genes involved entry SARS-CoV-2 into host cell (ACE1 rs1799752 I/D, ACE2 rs2285666 C/T, rs73635825 A/G TMPRSS2 rs123297605 C/T), genotyped Amazon, treated during pandemic between 2020 2021. The distribution genotypes did not show any association with presence or absence IgG antibodies. Additionally, influence variations on severity disease was examined extensively because a significant number individuals experienced either mild symptoms no symptoms. It is worth noting frequencies risk alleles found be lower populations compared both continental Brazilians. Amazon people exhibited an ethnic-specific profile associated disease, which could explain unexpected response they demonstrated COVID-19, being less impacted than

Language: Английский

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Associations of ACE I/D and AGTR1 rs5182 polymorphisms with diabetes and their effects on lipids in an elderly Chinese population

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 30, 2024

Abstract Background Diabetes mellitus is generally accompanied by dyslipidaemia, but inconsistent relationships between lipid profiles and diabetes are noted. Moreover, genetic variations in insertion/deletion (I/D) polymorphisms at angiotensin-converting enzyme gene ( ACE ) T/C the angiotensin type 1 receptor AGTR1 related to levels, associations controversial. Thus, current research aimed explore effects of I/D , rs5182 on serum 385 Chinese participants with an average age 75.01 years. Methods The variant was identified using polymerase chain reaction (PCR) method, whereas polymorphism PCR-based restriction fragment length (PCR-RFLP) method verified DNA sequencing. Total cholesterol (TC), triglyceride (TG), apolipoprotein A (ApoA), B (ApoB), high-density lipoprotein (HDL-C) low-density (LDL-C) levels were measured routine methods, ratios calculated. Results not rs5182, a predictor TG/HDL-C for whole study population. Both predictors HDL-C LDL-C females males. females, as TG TG/HDL-C, TG/HDL-C. combination exclusively females. Conclusions results demonstrated potential gender-dependent interactions profiles. These findings may serve additional explanation changes blood lipids individuals mellitus, thereby offering novel perspective clinical management diabetic patients.

Language: Английский

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Association of Renin-angiotensin pathway gene polymorphisms with COVID-19 susceptibility and severity in the Moroccan cohort

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

Infection by the recent SARS-Cov-2 virus causes COVID-19 disease with variable clinical manifestations ranging from asymptomatic or mild respiratory symptoms to severe distress and multiorgan failure. The renin-angiotensin system, responsible for maintaining homeostasis governing several critical processes, has been considered main system involved in pathogenesis progression of COVID-19. Here, we aimed assess possible association between variants RAS-related genes susceptibility severity a sample Moroccan population. A total 325 individuals were recruited this study, 105 outpatients, 107 hospitalized patients, 118 healthy controls negative SARS-CoV-2 infection, subjected NGS gene panel sequencing containing eleven RAS pathway genes. 65 functional identified including 63 missenses, 1 splice, INDEL. Most them rare, 47 (72%) found single individual. According common disease/common variant hypothesis, five candidate MAF > 10% (ACE2 rs2285666, TMPRSS2 rs12329760, AGT rs699 genes, ACE rs4341, rs4343). Statistical analysis showed that rs4343 AA genotype was associated 2.5-fold increased risk (p = 0.026), T ACE2 rs2285666 borderline males 0.092). In conclusion, our results are highly conserved among Moroccans, most rare. Among variants, polymorphism would lead genetic predisposition

Language: Английский

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Association of Renin–Angiotensin Pathway Gene Polymorphisms with COVID-19 Susceptibility and Severity in Moroccans: A Case–Control Study

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Language: Английский

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Clinical significance of post-COVID-19 in patients with hypertension, taking into account the polymorphism of genes encoding components of the renin-angiotensin system

Clinical Medicine (Russian Journal), Journal Year: 2024, Volume and Issue: 102(5-6), P. 433 - 440

Published: Nov. 8, 2024

To date, there has been no consensus on the impact of polymorphism components renin-angiotensin-aldosterone system (RAAS) course a new coronavirus infection or possible role in post-COVID syndrome. The objective is to study significance COVID-19 and gene encoding renin angiotensin patients with hypertension. Materials methods: A clinical examination was conducted 116 stage 2 hypertensive uncontrolled Of these, 96 underwent mild moderate COVID-19, 51 before 12 weeks 45 after 12. Results. Patients ongoing symptomatic phase COVID- 19 had higher systolic blood pressure than those post COVID syndrome (p1-2 = 0.03659, p1-3 ≤ 0,00001).The association polymorphisms genes AGT:704T>C, AGT521C>T, AGTR1:1166A>C, AGTR2:1675G>A, CYP1IB2:-344C>T gender, BMI transmission not identified. In carriage TT genotype for AGT704 less frequent (p=0.005) compared control group. Conclusions. effect an increase determined. An between instability established. During phase, increased C allele AGT (T704).

Language: Английский

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Effects of acute-phase COVID-19-related indicators on pulmonary fibrosis and follow-up evaluation

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 18, 2024

Post-COVID-19 pulmonary fibrosis is a significant long-term respiratory morbidity affecting patients' health. This exploratory study aims to investigate the incidence, clinical characteristics, and acute-phase risk factors for in COVID-19 patients. Additionally, it evaluates function chest CT outcomes provide evidence early identification of high-risk patients prevention post-COVID-19 fibrosis. We retrospectively analyzed 595 hospitalized from January 2022 July 2023. Patients were divided into nonfibrosis groups on basis imaging changes. Baseline data, including demographics, disease severity, laboratory indicators, collected. Univariate multivariate logistic regression analyses performed identify independent Pulmonary follow-ups conducted group. The data processed via SPSS 26.0, with P < 0.05 considered statistically significant. incidence was 4.37%, 2.08% moderate cases 8.22% severe cases. Significant differences found between sex; severity; NLR; ALB LDH levels; percentages lung reticular lesions, consolidations, GGOs (P 0.05). Multivariate analysis revealed (OR = 1.004, 95% CI 1.000–1.007, 0.035), 0.871, 0.778–0.974, 0.015), lesion volume 1.116, 1.040–1.199, 0.002), consolidation 1.131, 1.012–1.264, 0.030) as factors. follow-up results improvements function, specifically FVC%, FEV1%, DLCO%, but not FEV1/FVC. Quantitative consolidation, GGO volumes no difference honeycomb volume. increases severity. LDH, ALB, are

Language: Английский

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