Polyherbal renal tea extract shows anti-inflammatory and antioxidant effects against gentamicin-induced nephrotoxicity in guinea pigs DOI Open Access

Joshua Asante,

Aliu Moomin, Michael Ofori

et al.

Egyptian Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 12(1), P. 1 - 15

Published: Dec. 31, 2024

Renal diseases pose a tremendous economic burden worldwide, and the only treatment options are renal transplantation dialysis, which remain unaffordable to low-income people. This study evaluated potential of polyherbal tea extract (RTE) as remedy for kidney disease using gentamicin-induced damage model in guinea pigs. Polyherbal was purchased from market extracted with 70% ethanol. RTE phytochemicals were screened qualitatively chemoprofiled by High-performance liquid chromatography. Acute sub-acute toxicity studies on carried out. To investigate possible effects RTE, groups animals received either gentamicin intraperitoneally alone or combination oral administration (200, 600 1000 mg/kg/day) 14 days. On day 15, biochemical markers inflammation assessed. The caused no significant changes blood biochemistry histomorphology, LD50 >5000 mg/kg. Significantly (p<0.001) reduced serum creatinine urea levels observed when compared gentamicin-treated group. also showed significantly increased superoxide dismutase catalase activities malondialdehyde, IL-6 TNF-α protects against nephrotoxicity pigs through its antioxidant anti-inflammatory effects.

Language: Английский

Ultrasound-assisted extraction and antioxidant activity of triterpenoid saponins from Platycodon grandiflorum roots: Optimization, purification, and molecular insights DOI Creative Commons
Wei Li,

Yanqing Zhang,

Yinghao Wei

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 223, P. 119877 - 119877

Published: Oct. 23, 2024

Language: Английский

Citations

8
Polyphenol extract ameliorates diabetes-related atherosclerosis through HIF-1 signaling pathway in APOE−/- mice: possible synergism with atorvastatin DOI
Yang Yang,

Shengxiang Chen,

Gu Shi

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156572 - 156572

Published: Feb. 25, 2025

Language: Английский

Citations

1
Huanglian Jiedu Decoction enhances the stability of atherosclerotic plaques through SLC2A1-mediated efferocytosis DOI Creative Commons
Guiting Zhou, Liwen Lin, Shushu Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112834 - 112834

Published: Aug. 7, 2024

Atherosclerotic (AS) plaques require a dense necrotic core and robust fibrous cap to maintain stability. While previous studies have indicated that the traditional Chinese medicine Huang Lian Jie Du Decoction (HLJDD) possesses capability stabilize AS plaques, underlying mechanisms remain obscure. This study aims delve deeper into potential by which HLJDD improves through an integrated research strategy.

Language: Английский

Citations

5
Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms DOI
Md. Shimul Bhuia, Raihan Chowdhury, Manik Chandra Shill

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(7)

Published: May 17, 2024

Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate hepatoprotective effect of FA and its derivatives (methyl ferulic trans-ferulic acid) against oxidative stress inflammation-related hepatotoxicity due toxicants based on results different non-clinical preclinical tests. For this, data was collected from reliable electronic databases such as PubMed, Google Scholar, ScienceDirect, etc. The this investigation demonstrated that have potent effects damage. findings also revealed these protective are antioxidant anti-inflammatory chemical compound. analogues significantly inhibit free radical generation hinder proinflammatory markers inflammatory enzymes, resulting diminished cytotoxic apoptotic hepatocyte death. compounds prevent intracellular lipid accumulation provide effects.

Language: Английский

Citations

4
Gynura procumbens leaf extract-loaded self-microemulsifying drug delivery system offers enhanced protective effects in the hepatorenal organs of the experimental rats DOI Creative Commons
Manik Chandra Shill,

Md. Faisal Bin Jalal,

Madhabi Lata Shuma

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0304435 - e0304435

Published: Feb. 24, 2025

Gynura procumbens , known as longevity spinach, is a plant traditionally used in tropical Asian countries for its anti-inflammatory, hepatoprotective, anti-hypertensive, and anti-hyperglycemic properties. The current study aimed to enhance the hepatorenal protective activity of leaf extract (GLE) by developing self-microemulsifying drug delivery system (SMEDDS). SMEDDS-GLE exhibited formation small micelles with mean droplet size 231 nm. This resulted significant enhancement dispersion GLE water, evidenced dispersibility that was at least 4.8 times greater than alone. In rat model hepatic injury induced cisplatin (7.5 mg/kg, i.p. ), administration (75 mg-GLE/kg, p.o. ) significantly reduced liver damage, observed histological examination levels plasma biomarkers associated injury. Furthermore, according findings assessment, enhanced nephroprotective benefits acute kidney Based on these findings, strategic application SMEDDS-based approach could be viable choice GLE’s nutraceutical

Language: Английский

Citations

0
Harnessing traditional medicine: A dual-action antimicrobial combination against pathogens DOI Creative Commons
Li Chen,

Mengwei Cheng,

Kunping Song

et al.

iScience, Journal Year: 2025, Volume and Issue: unknown, P. 111910 - 111910

Published: March 1, 2025

The persistent threat of bacterial infections and escalating antibiotic resistance necessitates antimicrobial solutions. MAC4, a Malic Acid Combination inspired by Traditional Chinese Medicine, exhibits potent dual antibacterial immunomodulatory effects. MAC4 demonstrates significant activity, with minimum inhibitory concentrations (MIC) 0.1C for E. coli S. aureus, 0.2C P. aeruginosa marcescens. It effectively disrupts biofilm formation, reducing mass decreasing metabolic activity over 94.97% at 2MIC 4MIC concentrations. Transcriptomic analysis reveals reprograms gene expression, 1,150 differentially expressed genes affecting membrane, energy metabolism, DNA replication. In an lung infection mouse model, reduces load modulates inflammation, downregulating IL-6, IL-1β, TNF-α, preserving architecture. MAC4's dual-action capability, targeting both pathogen host positions it as promising candidate inflammatory diseases, especially when conventional antibiotics are insufficient.

Language: Английский

Citations

0
Targeting diabetes with flavonoids from Indonesian medicinal plants: a review on mechanisms and drug discovery DOI

Tubagus Rayyan Fitra Sinuhaji,

Sintiami Ramadhani,

Volta Kellik Setiawan

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Bergenin inhibits hepatic fat deposition by activating the AMPK signaling pathway, thereby attenuating alcoholic liver disease DOI

Fengyue Guo,

Huaping Zheng, Houkang Cao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113169 - 113169

Published: Sept. 19, 2024

Language: Английский

Citations

2
Evaluation of Antidiabetic Potential of Mangifera indica Leaf in Streptozotocin-Induced Type 2 Diabetic Rats: Focus on Glycemic Control and Cholesterol Regulation DOI Creative Commons
Joyeeta T. Khan,

Anika E. Richi,

Sanjida Akter Riju

et al.

Endocrines, Journal Year: 2024, Volume and Issue: 5(2), P. 137 - 152

Published: April 8, 2024

Mangifera indica (Anacardiaceae family) is renowned for its diverse pharmacological properties, encompassing antidiabetic, antioxidant, and anti-inflammatory effects. The present study delves into the insulin-releasing glucose-lowering potential of ethanolic extract (EEMI) leaves in streptozotocin-induced type 2 diabetic (STZ-T2D) rats, concurrently investigating phytoconstituents. EEMI’s effects on insulin secretion were measured using BRIN BD11 β-cells isolated mouse islets. Its enzymatic inhibitory properties carbohydrate digestion, absorption, free radicals investigated vitro methods. In vivo parameters including lipid profile liver glycogen content assessed STZ-T2D rats. EEMI exhibited a dose-dependent increase from clonal pancreatic inhibited starch glucose diffusion over time, DPPH activity vitro. acute studies, improved food intake oral tolerance. Moreover, following 28 days treatment with EEMI, remarkable amelioration body weight, fasting blood glucose, plasma insulin, content, total cholesterol, triglyceride, LDL, VLDL, HDL levels was observed. Further phytochemical analysis identified presence alkaloids, tannins, saponins, steroids, flavonoids. synergistic potentially attributable to naturally occurring phytoconstituents, hold promise development enriched antidiabetic therapies, offering promising avenue management diabetes.

Language: Английский

Citations

1
Synthesis and molecular docking of novel biguanide-NSAIDs hybrid with dual Anti-diabetic and Anti-inflammatory activity DOI
Rajesh A. Rane,

Bharat Satpute,

Ratndeep Patil

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1320, P. 139512 - 139512

Published: Aug. 3, 2024

Language: Английский

Citations

1