Molecular Mechanism of Fasting-Mimicking Diet in Inhibiting Colorectal Cancer Progression: Implications for Immune Therapy and Metabolic Regulation DOI
C. Bush, Rachel J. Perry

Cancer Research, Journal Year: 2023, Volume and Issue: 83(21), P. 3493 - 3494

Published: Nov. 1, 2023

Abstract Recently, fasting-mimicking diet and caloric restriction have been shown to improve antitumor immunity. In this issue of Cancer Research, Zhong colleagues provide insights into the molecular mechanism diet–mediated metabolic reprogramming in colorectal cancer progression. The authors performed comprehensive mechanistic experiments mouse models show that prevents progression by lowering intratumoral IgA+ B cells accelerating fatty acid oxidation inhibit B-cell IgA class switching. addition, they found oxidation–dependent acetylation switching interfere with anticancer effects cancer. Overall, their study establishes has potential activate immunity induce tumor regression See related article et al., p. 3529

Language: Английский

Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence DOI
Claudio Vernieri, Francesca Ligorio,

Debu Tripathy

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(8), P. 1644 - 1667

Published: July 25, 2024

Language: Английский

Citations

7
Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression DOI Creative Commons
Man Luo, Qingyi Wang,

Yong Sun

et al.

npj Biofilms and Microbiomes, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 25, 2024

Abstract The progression of colorectal cancer is closely associated with diet. Fasting-mimicking diet (FMD) a promising type dietary intervention that have beneficial effects in the prevention and treatment various cancers. We investigated therapeutic effect 4-day FMD against mice through immune cell analysis, microbiota composition analysis anti-PD-1 treatment. These cycles effectively suppressed growth, reduced proliferation angiogenesis, increased tumor-infiltration lymphocytes especially CD8 + T cells. stimulated protective gut microbiota, Lactobacillus . Supplementation johnsonii induced similar results as intervention, which also tumor growth CD45 Additionally, synthesizing therapy inhibited CRC progression. findings suggest Lactobacillus. necessary for anticancer process CRC. its on both system, mouse model.

Language: Английский

Citations

6
A bibliometric analysis of the Fasting-Mimicking Diet DOI Creative Commons
Xiaoxiao Lin, Yue Gao

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 23, 2024

The Fasting-Mimicking Diet (FMD) is a nutritional strategy that involves significantly reducing calorie intake for specific period to mimic the physiological effects of fasting while still providing body with nutrition. Our study aimed conduct bibliometric explore latest publishing trends and areas intense activity within sphere FMD. We extracted data on FMD publications from Web Science Core Collection (WOSCC) database. analysis was conducted by WOSCC Online Analysis Platform VOSviewer 1.6.16. In total, there were 169 945 authors 342 organizations 25 countries/regions, published in 111 journals. most productive country, organization, author, journal United States, University Southern California, Valter D. Longo, Nutrients, respectively. first high-cited document Ageing Research Reviews authored Mattson et al. this study, they discuss various health benefits including improved metabolic health, weight management, even potential delaying aging processes risk chronic diseases. conclusion, our main research hotspots frontiers cancer, metabolic-related diseases, cognitive improvement. may have some multiple diseases which should be further investigated.

Language: Английский

Citations

5
Causal effects and metabolites mediators between immune cell and risk of colorectal cancer: a Mendelian randomization study DOI Creative Commons
Qian Yang,

Bixia Duan,

Jian Yue

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 12, 2024

The involvement of immune cells in colorectal cancer (CRC) and their interplay with metabolic disorders are yet to be fully elucidated. This study examines how peripheral cells, inferred genetically, affect CRC investigates the intermediary roles metabolites.

Language: Английский

Citations

4
Emerging insights into the impact of systemic metabolic changes on tumor-immune interactions DOI
Andrea L Cote, Chad J. Munger, Alison E. Ringel

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115234 - 115234

Published: Jan. 23, 2025

Language: Английский

Citations

0
Fasting-mimicking diet-enrichedBifidobacterium pseudolongumsuppresses colorectal cancer by inducing memory CD8+T cells DOI
Ke Nan, Ziwen Zhong, Ying Yue

et al.

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 333020

Published: Jan. 27, 2025

Background Fasting-mimicking diet (FMD) boosts the antitumour immune response in patients with colorectal cancer (CRC). The gut microbiota is a key host immunity regulator, affecting physiological homeostasis and disease pathogenesis. Objective We aimed to investigate how FMD protects against CRC via modulation. Design assessed probiotic species enrichment FMD-treated mice using faecal metagenomic sequencing. candidate were verified antibiotic-treated conventional germ-free mouse models. Immune landscape alterations evaluated single-cell RNA sequencing multicolour flow cytometry. microbiota-derived metabolites identified metabolomic profiling. Results Faecal profiling revealed Bifidobacterium pseudolongum mice. B. mediates effects by increasing tissue-resident memory CD8 + T-cell (TRM) population level of L-arginine, functional metabolite, increased mice; furthermore, L-arginine induced TRM phenotype vivo vitro. Mechanistically, transported solute carrier family 7-member 1 (SLC7A1) receptor T cells. Both improved anti-CTLA-4 efficacy orthotopic model. In CRC, cell number as accumulated. abundance cells was associated better prognosis CRC. Conclusion contributes producing L-arginine. This promotes differentiation into administration potential therapeutic strategy.

Language: Английский

Citations

0
Tumor-Intrinsic Cgas-Sting Pathway Activation Contributes to Fasting-Sensitized Immunotherapy in Colorectal Cancer DOI
Weichen Song, Zhaohui Tang, Donglin Zeng

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Impact of fasting and refeeding on immune markers, hepatic gene expression, and gut microbiota in geese: insights into metabolic regulation and gut-liver interactions DOI Creative Commons
Yi Liu, Guangquan Li, Xianze Wang

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 18, 2025

Fasting and refeeding protocols, which induce short-term fluctuations in nutrient energy levels, elicit adaptive physiological responses animals. In this study, biochemical, transcriptome 16S rRNA sequencing techniques were used to investigate the effects of fasting on immune responses, liver gene expression, gut microbiota composition geese. led a significant reduction circulating levels IgA IFN-γ, while IgG, TNF-α, IL-6, IL-10 remained stable. Upon refeeding, IFN-γlevels rapidly returned baseline. RNA-Seq analysis identified 858 differentially expressed genes (DEGs) between control fasted groups, 732 DEGs refed groups. Key regulatory involved metabolism lipid biosynthesis, such as CPT1A, HMGCS1, PCK1, upregulated during fasting, reflecting an increase fatty acid oxidation gluconeogenesis. Conversely, lipogenic genes, including FASN, ACSS2, ACCα, SCD, downregulated indicating metabolic shift from catabolic anabolic processes. Gene Ontology (GO) KEGG pathway enrichment analyses revealed involvement PPAR signaling, glycolysis/gluconeogenesis, insulin signaling pathways. Additionally, indicated that increased abundance Bacteroidetes Proteobacteria, decreasing Firmicutes. Both alpha beta diversity significantly reduced fasting. Functional suggested toward Correlation further demonstrated relative Barnesiella was positively correlated with gluconeogenesis negatively ELOVL6 PHGDH. This underscores role gut-liver axis regulating adaptations. These findings offer critical insights into how availability influence function, regulation, research also provides potential strategies for optimizing poultry nutrition health management.

Language: Английский

Citations

0
Age- and diet-instructed metabolic rewiring of the tumor–immune microenvironment DOI
Ana Belén Plata-Gómez, Ping‐Chih Ho

The Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 222(6)

Published: April 11, 2025

The tumor–immune microenvironment (TIME) plays a critical role in tumor development and metastasis, as it influences the evolution of cells fosters an immunosuppressive state by intervening metabolic reprogramming infiltrating immune cells. Aging diet significantly impact TIME, contributing to cancer progression evasion. With aging, cell function declines, leading proinflammatory alterations such increased oxidative stress mitochondrial dysfunction, which compromise antitumor immunity. Similarly, dietary factors, particularly high-fat high-sugar diets, promote shifts, creating permissive TIME fostering tumor-supportive phenotypes while impairing tumoricidal activity In contrast, restrictions have been shown restore modulating metabolism enhancing responses. Here, we discuss intricate interplay between diet, shaping with particular focus on T cells, highlight therapeutic strategies targeting these pathways empower

Language: Английский

Citations

0
Biomimetic Nanovesicles Synergize with Short-Term Fasting for Enhanced Chemotherapy of Triple-Negative Breast Cancer DOI

Seok Theng Chiang,

Qi Chen,

Tianzhen Han

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype of among women. Chemotherapy acts as standard regimen for TNBC treatment but suffers from limited drug accumulation in tumor regions undesired side effects. Herein, we developed a synergistic strategy by combining red blood cell (RBC) membrane-liposome hybrid nanovesicle with short-term fasting (STF) improved chemotherapy TNBC. The biomimetic nanovesicles exhibited reduced phagocytosis macrophages while displaying significant increase uptake through caveolae/raft-mediated endocytosis under nutrient-deprivation conditions. Importantly, drug-loaded STF synergistically increased cytotoxicity cells inhibiting their cycles aerobic glycolysis well amplifying reactive oxygen species (ROS) autophagosomes generation. In STF-treated mice, greatly antitumor efficacy at lower dosage inhibited metastasis Overall, demonstrated that synergizing therapy serve promising therapeutic enhanced malignant

Language: Английский

Citations

3