Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 9, 2025
Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and crucial determinant progression. Research indicates that various metabolic regulators form network in TME interact with immune cells, coordinating response. dysregulation creates an immunosuppressive TME, impairing antitumor In this review, we discuss how affect cell crosstalk TME. We also summarize recent clinical trials involving challenges metabolism-based therapies translation. word, our review distills key regulatory factors their mechanisms action from complex metabolism, identified as regulators. These provide theoretical basis research direction for development new strategies targets therapy based on reprogramming. Refining Depicting between stromal cells during Emphasizing unresolved translation advantages personalized treatment. Providing support therapies.
Language: Английский
Citations
2
Nature Cancer, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(16), P. 2871 - 2871
Published: Aug. 18, 2024
Glutamine (Gln) is a non-essential amino acid that involved in the development and progression of several malignancies, including prostate cancer (PCa). While Gln for non-malignant epithelial cells, PCa cells become highly dependent on an exogenous source Gln. The metabolism tightly controlled by well-described oncogenes such as MYC, AR, mTOR. These contribute to therapy resistance aggressive castration-resistant PCa. Inhibition catabolism impedes growth, survival, tumor-initiating potential while sensitizing radiotherapy. Therefore, given its significant role tumor targeting promising approach developing new therapeutic strategies. Ongoing clinical trials evaluate safety efficacy inhibitors combination with conventional targeted therapies patients various solid tumors, Further understanding how metabolically interact their microenvironment will facilitate translation help improve outcomes. This review focuses provides insights into current trials.
Language: Английский
Citations
6
OncoImmunology, Journal Year: 2024, Volume and Issue: 13(1)
Published: Aug. 21, 2024
The inflammatory tumor microenvironment (TME) is a key driver for tumor-promoting processes. Tumor-associated macrophages are one of the main immune cell types in TME and their increased density related to poor prognosis prostate cancer. Here, we investigated influence pro-inflammatory (M1) immunosuppressive (M2) on cancer lineage plasticity. Our findings reveal that M1 macrophage secreted factors upregulate genes stemness while downregulating associated with androgen response cells. expression stem (CSC) plasticity markers NANOG, KLF4, SOX2, OCT4, CD44 was stimulated by from macrophages. Moreover, AR its target gene PSA were observed be suppressed LNCaP cells treated Inhibition NFκB signaling using IKK16 inhibitor resulted downregulation CSC study highlights drive upregulating through pathway.
Language: Английский
Citations
6
Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 498 - 498
Published: Feb. 2, 2025
Although immune checkpoint inhibitor (ICI) therapy is currently the standard of care in microsatellite-unstable (MSI) metastatic colorectal cancer (CRC), ICI therapy, alone or combination with other therapies, not a treatment approach microsatellite-stable (MSS) CRC, which present 95% patients. In this review, we focus on metabolic singularities—at transcriptomic (either bulk single cell), proteomic, and post-translational modification levels—that induce immunosuppression specifically MSS CRC. First, evaluate current efficacy ICIs limited disease Second, discuss latest findings potential biomarkers for evaluating CRC using strict REMARK criteria. Third, review evidence patterns tumors cell metabolism to advance our understanding crosstalk pave way development strategies enhance efficacy.
Language: Английский
Citations
0
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: Feb. 4, 2025
Abstract Amino acids are pivotal regulators of immune cell metabolism, signaling pathways, and gene expression. In myeloid cells, these processes underlie their functional plasticity, enabling shifts between pro-inflammatory, anti-inflammatory, pro-tumor, anti-tumor activities. Within the tumor microenvironment, amino acid metabolism plays a crucial role in mediating immunosuppressive functions contributing to progression. This review delves into mechanisms by which specific acids—glutamine, serine, arginine, tryptophan—regulate function polarization. Furthermore, we explore therapeutic potential targeting enhance immunity, offering insights novel strategies for cancer treatment.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 723 - 723
Published: Feb. 20, 2025
Background/Objectives: Tumour-associated macrophages (TAMs) are critical components of the tumour microenvironment (TME), significantly influencing cancer progression and treatment resistance. This review aims to explore innovative use engineered bacteria reprogram TAMs, enhancing their anti-tumour functions improving therapeutic outcomes. Methods: We conducted a systematic following predefined protocol. Multiple databases were searched identify relevant studies on phenotypic plasticity, for reprogramming. Inclusion exclusion criteria applied select studies, data extracted using standardised forms. Data synthesis was performed summarise findings, focusing mechanisms benefits non-pathogenic modify TAMs. Results: The summarises findings that can selectively target promoting shift from tumour-promoting M2 phenotype tumour-fighting M1 phenotype. reprogramming enhances pro-inflammatory responses activity within TME. Evidence various indicates significant regression improved immune bacterial therapy. Conclusions: Reprogramming TAMs presents promising strategy approach leverages natural targeting abilities directly tumour, potentially patient outcomes offering new insights into immune-based treatments. Further research is needed optimise these methods assess clinical applicability.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 10, 2025
Tumor metabolic reprogramming is a highly complex process that enables tumor survival in the presence of limited nutrients, involving multiple signaling pathways, non-coding RNAs (ncRNAs), and transcription factors. Lately, glutamine has been found to enhance growth, spread, drug resistance cancer cells, while also fostering an immunosuppressive microenvironment aids development. However, some tumors, such as pancreatic melanoma, additional can inhibit proliferation this mechanism closely related regulation immune microenvironment. Therefore, further exploration metabolism tumors essential for understanding pathogenesis developing new metabolically targeted therapies. We systematically review latest research on its role system regulation. Additionally, we clinical progress therapies their application combination with current anti-tumor treatments. Ultimately, address challenges prospects involved anti-cancer strategies aimed at metabolism.
Language: Английский
Citations
0
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(12), P. 1997 - 2014
Published: Dec. 1, 2024
Language: Английский
Citations
3
Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)
Published: Aug. 12, 2024
The influenza virus (IFV) imposes a considerable health and economic burden globally, requiring comprehensive understanding of its pathogenic mechanisms. Ferroptosis, an iron-dependent lipid peroxidation cell death pathway, holds unique implications for the antioxidant defense system, with possible contributions to inflammation. This exploration focuses on dynamic interplay between ferroptosis host against viruses, emphasizing influence IFV infections activation pathway. causes different types death, including apoptosis, necrosis, ferroptosis. IFV-induced ferroptotic is mediated by alterations in iron homeostasis, intensifying accumulation reactive oxygen species promoting peroxidation. A investigation into mechanism viral infections, specifically IFV, has great potential identify therapeutic strategies. may pave way development drugs using inhibitors, presenting effective approach suppress infections.
Language: Английский
Citations
2