The uptake of extracellular vesicles: research progress in cancer drug resistance and beyond
Luomeng Qian,
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Pangzhou Chen,
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Shiwu Zhang
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et al.
Drug Resistance Updates,
Journal Year:
2025,
Volume and Issue:
79, P. 101209 - 101209
Published: Feb. 1, 2025
Language: Английский
Innovating cancer drug discovery with refined phenotypic screens
Trends in Pharmacological Sciences,
Journal Year:
2024,
Volume and Issue:
45(8), P. 723 - 738
Published: July 15, 2024
Before
molecular
pathways
in
cancer
were
known
to
a
depth
that
could
predict
targets,
drug
development
relied
on
phenotypic
screening,
where
the
effectiveness
of
candidate
chemicals
is
judged
from
functional
readouts
without
considering
mechanisms
action.
The
unraveling
tumor-specific
has
brought
targets
for
molecularly
driven
discovery,
but
precedents
field
have
shown
awareness
does
not
necessarily
therapeutic
efficacy,
and
many
cancers
still
lack
druggable
targets.
Phenotypic
screening
therefore
retains
niche
targeted
approach
informative.
We
analyze
unique
advantages
screens,
how
technological
advances
improved
their
discovery
power.
Notable
include
use
larger
biological
panels
refined
protocols
address
disease-relevance
increase
data
content
with
imaging
omic
approaches.
Language: Английский
Participation of suicide gene extracellular vesicles in metastasis prevention
Dajana Vanova,
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Michal Andrezal,
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Jana Jakubechova
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et al.
Neoplasma,
Journal Year:
2024,
Volume and Issue:
71(02), P. 117 - 122
Published: Jan. 1, 2024
The
incidence
of
distant
metastases
is
associated
with
most
cancer-related
mortalities.Extracellular
vesicles
(EVs),
secreted
from
tumors
and
cancer-associated
fibroblasts,
are
involved
in
the
metastatic
process
mediating
their
organotropism
through
involvement
pre-metastatic
niche
formation.We
have
been
developing
suicide
gene
therapy
mediated
by
EVs
mesenchymal
stem/
stromal
cells,
tumor
fibroblasts.Suicide
conjugated
prodrug
tropic,
penetrate
kill
them
intracellular
conversion
nontoxic
to
an
efficient
anti-cancer
drug.Here,
we
discuss
findings
regarding
possibility
using
as
a
novel
therapeutic
approach
for
metastases,
via
modification.The
provide
future
perspective
metastasis
prevention.
Language: Английский
Triple-Negative Breast Cancer EVs Modulate Growth and Migration of Normal Epithelial Lung Cells
Ilaria Leone,
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Jessie Santoro,
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Andrea Soricelli
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et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5864 - 5864
Published: May 28, 2024
Breast
cancer
is
the
most
common
amongst
women
worldwide.
Recently,
owing
to
screening
programs
and
new
technologies,
survival
rate
has
increased
significantly.
can
potentially
develop
metastases,
and,
despite
them,
lung
metastases
generally
occur
within
five
years
of
breast
diagnosis.
In
this
study,
objective
was
analyze
effect
cancer-derived
EVs
on
a
epithelial
cell
line.
BEAS-2B
cells
were
treated
with
extracellular
vesicles
(EVs)
derived
from
triple-negative
(TNBCs),
e.g.,
MDA-MB-231
HS578T,
separated
using
differential
ultracentrifugation.
We
observed
an
growth,
migration,
invasiveness
normal
over
time
in
presence
TNBC
compared
control.
Therefore,
these
data
suggest
that
released
by
tumor
contain
biological
molecules
capable
influencing
pro-tumorigenic
activity
cells.
Exploring
role
oncology
research
their
potential
cargo
may
be
novel
biomarkers
for
early
detection
further
Language: Английский