Neurofeedback with fMRI: A critical systematic review

NeuroImage, Journal Year: 2017, Volume and Issue: 172, P. 786 - 807

Published: Dec. 27, 2017

Language: Английский

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Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation

Frontiers in Human Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: March 29, 2018

This review focuses on the cognitive neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) based functional magnetic resonance imaging (fMRI) studies and recent clinically relevant applications such as fMRI-based diagnostic classification or neuromodulation therapies targeting fMRI deficits with neurofeedback (NF) brain stimulation. Meta-analyses executive functions (EFs) show that ADHD patients have cognitive-domain dissociated complex multisystem impairments in several right left hemispheric dorsal, ventral medial fronto-cingulo-striato-thalamic fronto-parieto-cerebellar networks mediate control, attention, timing working memory (WM). There is furthermore emerging evidence for abnormalities orbital ventromedial prefrontal limbic areas motivation emotion control. In addition, poor deactivation default mode network (DMN) suggests an abnormal interrelationship between hypo-engaged task-positive poorly "switched off" hyper-engaged task-negative networks, both which are related to impaired cognition. Translational still its infancy. Pattern recognition analyses attempted provide using data respectable accuracies over 80%. Necessary replication studies, however, outstanding. Brain stimulation has been tested heterogeneously designed, small numbered proof concept key frontal ADHD. Transcranial direct current (tDCS) appears be promising improve symptoms some but larger clinical trials repeated without training needed test efficacy potential costs non-targeted functions. Only three piloted NF dysfunctions near-infrared spectroscopy, two ones finding improvements cognition symptoms, which, were not superior active control conditions, suggesting placebo effects. Neurotherapeutics seems attractive due their safety longer-term neuroplastic effects, drugs cannot offer. However, they need thoroughly short- individualized treatment.

Language: Английский

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Current Psychosomatic Practice

Psychotherapy and Psychosomatics, Journal Year: 2016, Volume and Issue: 86(1), P. 13 - 30

Published: Nov. 24, 2016

Psychosomatic research has advanced over the past decades in dealing with complex biopsychosocial phenomena and may provide new effective modalities of patient care. Among psychosocial variables affecting individual vulnerability, course, outcome any medical disease, role chronic stress (allostatic load/overload) emerged as a crucial factor. Assessment strategies include Diagnostic Criteria for Research. They are presented here an updated version based on insights derived from studies carried out so far encompass allostatic overload, type A behavior, alexithymia, spectrum maladaptive illness demoralization, irritable mood, somatic symptoms secondary to psychiatric disorder. Macroanalysis is helpful tool identifying relationships between biological targets intervention. The personalized holistic approach includes integration psychological therapies all phases illness. In this respect, development psychotherapeutic modality, Well-Being Therapy, seems be promising. growth subspecialties, such psychooncology psychodermatology, drives towards multidisciplinary organization health care overcome artificial boundaries. There have been major transformations needs decades. From psychosomatic medicine, land innovative hypotheses trends, many indications changes current practice medicine now at hand. aim critical review outline potential clinical applications methods.

Language: Английский

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The self-regulating brain and neurofeedback: Experimental science and clinical promise

Cortex, Journal Year: 2015, Volume and Issue: 74, P. 247 - 261

Published: Nov. 18, 2015

Language: Английский

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Real‐time fMRI neurofeedback in adolescents with attention deficit hyperactivity disorder

Human Brain Mapping, Journal Year: 2017, Volume and Issue: 38(6), P. 3190 - 3209

Published: March 25, 2017

Abstract Attention Deficit Hyperactivity Disorder (ADHD) is associated with poor self‐control, underpinned by inferior fronto‐striatal deficits. Real‐time functional magnetic resonance neurofeedback (rtfMRI‐NF) allows participants to gain self‐control over dysregulated brain regions. Despite evidence for beneficial effects of electrophysiological‐NF on ADHD symptoms, no study has applied the spatially superior rtfMRI‐NF neurotherapy ADHD. A randomized controlled trial tested efficacy right prefrontal cortex (rIFG), a key region that compromised in and upregulated psychostimulants, improvement cognition, inhibitory fMRI activation. To control region‐specificity, an active group received left parahippocampal gyrus (lPHG). Thirty‐one boys were randomly allocated had learn upregulate their target average 11 runs 2 weeks. Feedback was provided through video‐clip rocket be moved up into space. transfer session without feedback learning retention as proximal measure everyday life. Both NF groups showed significant linear activation increases increasing number respective regions reduction symptoms after at 11‐month follow‐up. Only targeting rIFG, however, effect, which correlated symptom reductions, improved trend level sustained attention, increased IFG during task. This proof‐of‐concept demonstrates first time feasibility, safety, shorter‐ longer‐term rIFG adolescents Hum Brain Mapp 38:3190–3209, 2017 . © The Authors Human Mapping Published Wiley Periodicals, Inc.

Language: Английский

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Electrical fingerprint of the amygdala guides neurofeedback training for stress resilience

Nature Human Behaviour, Journal Year: 2018, Volume and Issue: 3(1), P. 63 - 73

Published: Dec. 7, 2018

Language: Английский

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Better than sham? A double-blind placebo-controlled neurofeedback study in primary insomnia

Brain, Journal Year: 2017, Volume and Issue: 140(4), P. 1041 - 1052

Published: Jan. 30, 2017

See Thibault et al. (doi:10.1093/awx033) for a scientific commentary on this article. Neurofeedback training builds upon the simple concept of instrumental conditioning, i.e. behaviour that is rewarded more likely to reoccur, an effect Thorndike referred as ‘law effect’. In case neurofeedback, information about specific electroencephalographic activity fed back participant who whenever desired electroencephalography pattern generated. If some kind hyperarousal needs be addressed, neurofeedback community considers sensorimotor rhythm gold standard. Earlier treatment approaches using sensorimotor-rhythm indicated increase 12–15 Hz over cortex during wakefulness could reduce attention-deficit/hyperactivity disorder and epilepsy symptoms even improve sleep quality by enhancing spindle (lying in same frequency range). present study we sought critically test whether earlier findings positive memory also replicated double-blind placebo-controlled 25 patients with insomnia. Patients spent nine polysomnography nights 12 sessions placebo-feedback (sham) our laboratory. Crucially, found both placebo feedback equally effective reflected subjective measures complaints suggesting observed improvements were due unspecific factors such experiencing trust receiving care empathy from experimenters. addition, these not objective electroencephalographic-derived quality. Furthermore, potentially mechanisms underlying efficacy spectral parameters remained unchanged following sessions. A stratification into ‘true’ insomnia ‘insomnia misperceivers’ (subjective, but no problems) did alter results. Based comprehensive well-controlled study, conclude primary insomnia, does have beyond effects. Importantly, do find advantage feedback, therefore it cannot recommended alternative cognitive behavioural therapy current (non-pharmacological) standard-of-care treatment. may foster critical discussion generally questions effectiveness emphasizes importance demonstrating other samples disorders truly controlled trials.

Language: Английский

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Computational neuroscience approach to biomarkers and treatments for mental disorders

Psychiatry and Clinical Neurosciences, Journal Year: 2016, Volume and Issue: 71(4), P. 215 - 237

Published: Dec. 29, 2016

Psychiatry research has long experienced a stagnation stemming from lack of understanding the neurobiological underpinnings phenomenologically defined mental disorders. Recently, application computational neuroscience to psychiatry shown great promise in establishing link between phenomenological and pathophysiological aspects disorders, thereby recasting current nosology more biologically meaningful dimensions. In this review, we highlight recent investigations into that have undertaken either theory- or data-driven approaches quantitatively delineate mechanisms The theory-driven approach, including reinforcement learning models, plays an integrative role process by enabling correspondence behavior disorder-specific alterations at multiple levels brain organization, ranging molecules cells circuits. Previous studies explicated plethora defining symptoms anhedonia, inattention, poor executive function. on other hand, is emerging field seeking identify features among high-dimensional big data. Remarkably, various machine-learning techniques been applied neuroimaging data, extracted used for automatic case-control classification. For many reported accuracies reached 90% more. However, note rigorous tests independent cohorts are critically required translate clinical applications. Finally, discuss utility found approach psychiatric therapies, neurofeedback. Such developments will allow simultaneous diagnosis treatment disorders using neuroimaging, 'theranostics' first time psychiatry.

Language: Английский

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Neurofeedback or neuroplacebo?

Brain, Journal Year: 2017, Volume and Issue: 140(4), P. 862 - 864

Published: Jan. 30, 2017

Language: Английский

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Functional connectivity changes associated with fMRI neurofeedback of right inferior frontal cortex in adolescents with ADHD

NeuroImage, Journal Year: 2018, Volume and Issue: 188, P. 43 - 58

Published: Dec. 1, 2018

Attention Deficit Hyperactivity Disorder (ADHD) is associated with poor self-control, underpinned by inferior fronto-striatal deficits. We showed previously that 18 ADHD adolescents over 11 runs of 8.5 min real-time functional magnetic resonance neurofeedback the right frontal cortex (rIFC) progressively increased activation in 2 regions rIFC which was clinical symptom improvement. In this study, we used connectivity analyses to investigate whether fMRI-Neurofeedback resulted dynamic changes underlying neural networks. Whole-brain seed-based were conducted using two clusters showing as seed test for before and after runs. Furthermore, tested resulting improvements they specific when compared a control group who had self-regulate another region. positive relative dorsal caudate anterior cingulate negative default mode network (DMN) such posterior precuneus. correlated correlation findings rIFC-Neurofeedback group. The show first time typically dysfunctional region leads strengthening within fronto-cingulo-striatal networks weakening DMN may be

Language: Английский

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