Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment DOI Creative Commons
Daniek A. M. Meijs, Bas C. T. van Bussel, Björn Stessel

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Jan. 14, 2022

Although male Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) patients have higher Intensive Care Unit (ICU) admission rates and a worse disease course, comprehensive analysis of female ICU survival underlying factors such as comorbidities, risk factors, and/or anti-infection/inflammatory therapy administration is currently lacking. Therefore, we investigated the association between sex survival, adjusting for these other variables. In this multicenter observational cohort study, all with SARS-CoV-2 pneumonia admitted to seven ICUs in one region across Belgium, The Netherlands, Germany, requiring vital organ support during first pandemic wave were included. With random intercept center, mixed-effects logistic regression was used investigate survival. Models adjusted age, Physiology Chronic Health Evaluation II (APACHE II) score, therapy. Interaction terms added effect modifications by country obesity. A total 551 (29% females) Mean age 65.4 ± 11.2 years. Females more often obese smoked less frequently than males (p-value 0.001 0.042, respectively). APACHE scores females comparable. Overall, mortality 12% lower (27% vs 39% respectively, p-value < 0.01) an odds ratio (OR) 0.62 (95%CI 0.39-0.96, 0.032) after adjustment 0.63 0.40-0.99, 0.044) additional 0.39-0.99, 0.047) No obesity found (p-values interaction > 0.23 0.84, patients, independent severity, smoking, obesity, therapy, country. Sex-specific biological mechanisms may play role, emphasizing need address diversity, sex-specific prediction, prognostic, therapeutic approach strategies.

Language: Английский

Neurological manifestations of long-COVID syndrome: a narrative review DOI Creative Commons
Maria‐Ioanna Stefanou, Lina Palaiodimou, Eleni Bakola

et al.

Therapeutic Advances in Chronic Disease, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 1, 2022

Accumulating evidence points toward a very high prevalence of prolonged neurological symptoms among coronavirus disease 2019 (COVID-19) survivors. To date, there are no solidified criteria for 'long-COVID' diagnosis. Nevertheless, is conceptualized as multi-organ disorder with wide spectrum clinical manifestations that may be indicative underlying pulmonary, cardiovascular, endocrine, hematologic, renal, gastrointestinal, dermatologic, immunological, psychiatric, or disease. Involvement the central peripheral nervous system noted in more than one-third patients antecedent severe acute respiratory syndrome 2 (SARS-CoV-2) infection, while an approximately threefold higher incidence recorded observational studies including patient-reported data. The most frequent encompass fatigue; 'brain fog'; headache; cognitive impairment; sleep, mood, smell, taste disorders; myalgias; sensorimotor deficits; and dysautonomia. Although limited exists to date on pathophysiological mechanisms implicated manifestation 'long-COVID', neuroinflammatory oxidative stress processes thought prevail propagating sequelae. In this narrative review, we sought present comprehensive overview our current understanding features, risk factors, Moreover, propose diagnostic therapeutic algorithms aid prompt recognition management causes persist beyond resolution COVID-19. Furthermore, causal treatments currently unavailable, approaches symptom-oriented symptoms. addition, emphasize collaborative research initiatives urgently needed expedite development preventive strategies

Language: Английский

Citations

223
Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis DOI Creative Commons
Giovanni Corona, Alessandro Pizzocaro, Walter Vena

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2021, Volume and Issue: 22(2), P. 275 - 296

Published: Feb. 22, 2021

Language: Английский

Citations

217
Sex disparities in COVID-19 outcomes in the United States: Quantifying and contextualizing variation DOI Creative Commons
Ann Caroline Danielsen, Katharine M. N. Lee, Marion Boulicault

et al.

Social Science & Medicine, Journal Year: 2022, Volume and Issue: 294, P. 114716 - 114716

Published: Jan. 10, 2022

Language: Английский

Citations

94
Animal models for COVID-19: advances, gaps and perspectives DOI Creative Commons
Changfa Fan, Yong Wu,

Rui Xiong

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 7, 2022

Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this century. Since outbreak in late 2019, animal models have been playing crucial roles aiding rapid development vaccines/drugs for prevention and therapy, as well understanding pathogenesis SARS-CoV-2 infection immune responses hosts. However, current some deficits there an urgent need novel to evaluate virulence variants concerns (VOC), antibody-dependent enhancement (ADE), various comorbidities COVID-19. This review summarizes clinical features COVID-19 different populations, characteristics major including those naturally susceptible animals, such non-human primates, Syrian hamster, ferret, minks, poultry, livestock, mouse sensitized genetically modified, AAV/adenoviral transduced, mouse-adapted strain engraftment human tissues or cells. host receptors proteases essential designing advanced modified models, successful studies on are also reviewed. Several improved alternatives future proposed, reselection alternative receptor genes multiple gene combinations, use transgenic knock-in method, strains establishing next generation mice.

Language: Английский

Citations

82
Adult- and late-onset male hypogonadism: the clinical practice guidelines of the Italian Society of Andrology and Sexual Medicine (SIAMS) and the Italian Society of Endocrinology (SIE) DOI Open Access
Andrea M. Isidori, Antônio Aversa, Aldo E. Calogero

et al.

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 45(12), P. 2385 - 2403

Published: Aug. 26, 2022

Language: Английский

Citations

76
Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors DOI Creative Commons
Levente Zsichla, Viktor Müller

Viruses, Journal Year: 2023, Volume and Issue: 15(1), P. 175 - 175

Published: Jan. 7, 2023

The clinical course and outcome of COVID-19 are highly variable, ranging from asymptomatic infections to severe disease death. Understanding the risk factors is relevant both in setting at epidemiological level. Here, we provide an overview host, viral environmental that have been shown or (in some cases) hypothesized be associated with outcomes. considered detail include age frailty, genetic polymorphisms, biological sex (and pregnancy), co- superinfections, non-communicable comorbidities, immunological history, microbiota, lifestyle patient; variation infecting dose; socioeconomic factors; air pollution. For each category, compile (sometimes conflicting) evidence for association factor outcomes (including strength effect) outline possible action mechanisms. We also discuss complex interactions between various factors.

Language: Английский

Citations

71
Case fatality rates of COVID‐19 during epidemic periods of variants of concern: A meta-analysis by continents DOI Creative Commons
Qianhang Xia, Yujie Yang, Fengling Wang

et al.

International Journal of Infectious Diseases, Journal Year: 2024, Volume and Issue: 141, P. 106950 - 106950

Published: Feb. 2, 2024

To calculate the case fatality rates (CFR) of COVID-19 during epidemic periods different variants concern (VOC) by continents.

Language: Английский

Citations

20
6-month mortality and readmissions of hospitalized COVID-19 patients: A nationwide cohort study of 8,679 patients in Germany DOI Creative Commons
Christian Günster, Reinhard Busse, Melissa Spoden

et al.

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(8), P. e0255427 - e0255427

Published: Aug. 5, 2021

Background COVID-19 frequently necessitates in-patient treatment and mortality is high. Less known about the long-term outcomes in terms of readmissions following treatment. Aim The aim this paper to provide a detailed account hospitalized patients up 180 days after their initial hospital admission. Methods An observational study with claims data from German Local Health Care Funds adult Germany between February 1 April 30, 2020, PCR-confirmed related principal diagnosis, for whom 6-month all-cause readmission rates admission or until death were available. A multivariable logistic regression model identified independent risk factors 180-day cohort. Results Of 8,679 median age 72 years, 2,161 (24.9%) died during index hospitalization. 30-day rate was 23.9% (2,073/8,679), 90-day 27.9% (2,425/8,679), rate, 29.6% (2,566/8,679). latter 52.3% (1,472/2,817) aged ≥80 years 23.6% (1,621/6,865) if not ventilated hospitalization, but 53.0% case those invasively (853/1,608). Risk included coagulopathy, BMI ≥ 40, age, while female sex protective factor beyond fewer prevalence comorbidities. 6,235 discharged alive, 1,668 readmitted total 2,551 times within days, resulting an overall 26.8%. Conclusions follow-up nationwide cohort representing almost one-third population show significant long-term, rates, especially among whereas women have profoundly better long-lasting clinical outcome compared men.

Language: Английский

Citations

98
COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue DOI Creative Commons
Yongzhi Xi

Emerging Microbes & Infections, Journal Year: 2021, Volume and Issue: 10(1), P. 266 - 276

Published: Jan. 1, 2021

SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19 patients experience sudden and rapid deterioration with the onset of fatal cytokine storm syndrome (CSS), which have increased interest CSS's mechanisms, diagnosis therapy. Although prototypic concept CSS was first proposed 116 years ago, we only begun to study understand for less 30 years. Actually, diseases under umbrella include familial/primary secondary hemophagocytic lymphohistiocytosis (HLH), macrophage activation (MAS), infection-associated syndrome, release (CRS), (CS). Hematologic malignancies autoimmune that cause are named malignancy-associated (MAHS) MAS, respectively. In-depth research on pathogenesis HLH/CSS greatly number were able be definitively diagnosed HLH/CSS. However, it should emphasized is difficult at early stages due non-specific clinical signs symptoms, tends result missed incorrect diagnoses. Therefore, clinicians not possess extensive ensure high sensitivity characteristics but must also familiar HLH-2004/2009 diagnostic criteria, HScore methods. The paper concisely comment evolution classifications, cytokines associated CSS, criteria importance correct identification hemophagocytes diagnosing timely may benefit In addition, there some limitations these criteria. Abbreviations: aBMT: autologous bone marrow transplantation; CAR-T: chimeric antigen receptor-engineered T-cell; COVID-19: coronavirus disease 2019; CSS: syndrome; HLH: lymphohistiocytosis; MAS: CRS: CS: storm; MAHS: IAHS: fHLH/pHLH: sHLH: SARS-CoV-2: severe acute respiratory 2; TCR-T, T-cell T-cell.

Language: Английский

Citations

85
An Italian Survey on Dietary Habits and Changes during the COVID-19 Lockdown DOI Open Access
Luana Izzo,

Antonio Santonastaso,

Gaetano Cotticelli

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1197 - 1197

Published: April 5, 2021

The World Health Organization has declared the coronavirus outbreak a Public Emergency of International Concern; led to lockdowns in several parts world, and sudden changes people's lifestyles. This study explores impact first disease 2019 (COVID-19) pandemic period on dietary habits, lifestyle changes, adherence Mediterranean diet among Italian population, through an online questionnaire, conducted from April May 2020, involving 1519 participants. 14-point Diet Adherence Screener (MEDAS) highlighted medium 73.5% responders, which principally included younger aged 18-30 years (

Language: Английский

Citations

75