Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 816 - 816

Published: May 11, 2023

It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning knowledge that disease intimately tied to neurodegenerative disorders, affecting both central and peripheral nervous systems well leading dementia, seventh cause of death. New innovative therapeutic strategies address metabolism, apoptosis, autophagy, pyroptosis, mechanistic target rapamycin (mTOR), AMP activated protein kinase (AMPK), growth factor signaling with erythropoietin (EPO), risk factors apolipoprotein E (APOE-ε4) gene coronavirus 2019 (COVID-19) can offer valuable insights for clinical care treatment disorders impacted by disease. Critical insight into modulation these complex pathways are required since mTOR pathways, AMPK activation, improve memory retention in Alzheimer's (AD) DM, promote healthy aging, facilitate clearance β-amyloid (Aß) tau brain, control inflammation, but also may lead cognitive loss long-COVID syndrome through mechanisms include oxidative stress, mitochondrial cytokine release, APOE-ε4 if autophagy other programmed cell death left unchecked.

Language: Английский

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The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 8, 2023

Life expectancy is increasing throughout the world and coincides with a rise in non-communicable diseases (NCDs), especially for metabolic disease that includes diabetes mellitus (DM) neurodegenerative disorders. The debilitating effects of disorders influence entire body significantly affect nervous system impacting greater than one billion people disability peripheral as well cognitive loss, now seventh leading cause death worldwide. Metabolic disorders, such DM, neurologic remain significant challenge treatment care individuals since present therapies may limit symptoms but do not halt overall progression. These clinical challenges to address interplay between warrant innovative strategies can focus upon underlying mechanisms aging-related oxidative stress, cell senescence, death. Programmed pathways involve autophagy, apoptosis, ferroptosis, pyroptosis play critical role oversee processes include insulin resistance, β-cell function, mitochondrial integrity, reactive oxygen species release, inflammatory activation. silent mating type information regulation 2 homolog 1

Language: Английский

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The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease

Current Neurovascular Research, Journal Year: 2023, Volume and Issue: 20(3), P. 314 - 333

Published: July 25, 2023

Disorders of metabolism affect multiple systems throughout the body but may have greatest impact on both central and peripheral nervous systems. Currently available treatments behavior changes for disorders that include diabetes mellitus (DM) system diseases are limited cannot reverse disease burden. Greater access to healthcare a longer lifespan led an increased prevalence metabolic neurodegenerative disorders. In light these challenges, innovative studies into underlying pathways offer new treatment perspectives Alzheimer's Disease, Parkinson's Huntington's Disease. Metabolic intimately tied can lead debilitating outcomes, such as multi-nervous disease, susceptibility viral pathogens, long-term cognitive disability. Novel strategies robustly address involve careful consideration cellular metabolism, programmed cell death pathways, mechanistic target rapamycin (mTOR) its associated mTOR Complex 1 (mTORC1), 2 (mTORC2), AMP-activated protein kinase (AMPK), growth factor signaling, risk factors apolipoprotein E (APOE-ε4) gene. Yet, complex necessitate comprehensive understanding achieve clinical outcomes susceptibility, onset, progression.

Language: Английский

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Cognitive Impairment in Multiple Sclerosis

Bioengineering, Journal Year: 2023, Volume and Issue: 10(7), P. 871 - 871

Published: July 23, 2023

Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a demyelinating disease in nervous system with increased prevalence over last five decades, and is now being recognized as one significant etiology of cognitive loss dementia. Presently, modifying therapies can limit rate relapse potentially reduce brain volume patients MS, but unfortunately cannot prevent progression or onset disability. Innovative strategies are therefore required to address areas inflammation, immune cell activation, survival that involve novel pathways programmed death, mammalian forkhead transcription factors (FoxOs), mechanistic target rapamycin (mTOR), AMP activated protein kinase (AMPK), silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), associated apolipoprotein E (APOE-ε4) gene severe acute respiratory syndrome coronavirus (SARS-CoV-2). These intertwined at levels metabolic oversight cellular metabolism dependent upon nicotinamide adenine dinucleotide (NAD+). Insight into mechanisms these provide new avenues discovery for therapeutic treatment dementia cognition occurs during MS.

Language: Английский

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Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

Cells, Journal Year: 2023, Volume and Issue: 12(22), P. 2595 - 2595

Published: Nov. 9, 2023

Metabolic disorders and diabetes (DM) impact more than five hundred million individuals throughout the world are insidious in onset, chronic nature, yield significant disability death. Current therapies that address nutritional status, weight management, pharmacological options may delay but cannot alter disease course or functional organ loss, such as dementia degeneration of systemic bodily functions. Underlying these challenges onset aging associated with increased lifespan, telomere dysfunction, oxidative stress generation lead to multi-system dysfunction. These hurdles point urgent need underlying mechanisms innovative applications. New treatment strategies involve non-coding RNA pathways microRNAs (miRNAs) circular ribonucleic acids (circRNAs), Wnt signaling, Wnt1 inducible signaling pathway protein 1 (WISP1) dependent upon programmed cell death pathways, cellular metabolic AMP-activated kinase (AMPK) nicotinamide, growth factor Non-coding RNAs, AMPK cornerstone for overseeing complex offer avenues DM will necessitate continued appreciation ability each independently unison influence clinical outcome.

Language: Английский

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Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(15), P. 2853 - 2869

Published: July 22, 2024

Alzheimer's disease is characterized by a progressive deterioration of cognitive function and memory loss, it closely associated with the dysregulation cholinergic neurotransmission. Since acetylcholinesterase (AChE) critical enzyme in nervous system, responsible for breaking down neurotransmitter acetylcholine, its inhibition holds significant interest treatment various neurological disorders. Therefore, crucial to develop efficient AChE inhibitors capable increasing acetylcholine levels, ultimately leading improved The results reported here represent step forward development novel thiazoloindazole-based compounds that have potential serve as effective inhibitors. Molecular docking studies revealed certain evaluated nitroindazole-based outperformed donepezil, well-known inhibitor used treatment. Sustained these findings, two series were synthesized. One included triazole moiety (Tl45a–c), while other incorporated carbazole (Tl58a–c). These isolated yields ranging from 66 87% through nucleophilic substitution Cu(I)-catalyzed azide–alkyne 1,3-dipolar cycloaddition (CuAAC) reactions. Among synthesized compounds, 6b core derivatives emerged selective inhibitors, exhibiting remarkable IC50 values less than 1.0 μM. Notably, derivative Tl45b displays superior performance an inhibitor, boasting lowest (0.071 ± 0.014 μM). Structure–activity relationship (SAR) analysis indicated containing bis(trifluoromethyl)phenyl-triazolyl group demonstrated most promising activity against AChE, when compared more rigid substituents such carbazolyl moiety. combination molecular experimental synthesis provides suitable strategy new

Language: Английский

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A Bibliometric Insight into Immersive Technologies for Cultural Heritage Preservation

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

This study utilized bibliometric analysis to identify emerging trends and future directions in using immersive technologies for cultural heritage preservation. Its goal was key research developments gaps suggest directions. The uses a approach synthesize existing literature from the Web of Science database until December 31, 2023. Bibliographic coupling co-word were used evaluate these fields' current trends. revealed significant increase publications recent years, indicating interest progress identified five clusters focusing on technological applications tangible intangible In comparison, four related digital replication, public engagement, educational use experiences. emphasizes shift traditional preservation methods more dynamic, interactive approaches that improve visitor experiences education. is one first studies comprehensively map landscape It offers unique perspective how are transforming engagement

Language: Английский

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A bibliometric insight into immersive technologies for cultural heritage preservation

Published: April 30, 2025

Language: Английский

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Global research and research progress on climate change and their impact on plant phenology: 30 years of investigations through bibliometric analysis

Theoretical and Applied Climatology, Journal Year: 2024, Volume and Issue: 155(6), P. 4909 - 4923

Published: March 14, 2024

Language: Английский

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Innovative therapeutic strategies for cardiovascular disease.

PubMed, Journal Year: 2023, Volume and Issue: 22, P. 690 - 715

Published: Jan. 1, 2023

As a significant non-communicable disease, cardiovascular disease is the leading cause of death for both men and women, comprises almost twenty percent deaths in most racial ethnic groups, can affect greater than twenty-five million individuals worldwide over age twenty, impacts global economies with far-reaching financial challenges. Multiple factors onset that include high serum cholesterol levels, elevated blood pressure, tobacco consumption secondhand smoke exposure, poor nutrition, physical inactivity, obesity, concurrent diabetes mellitus. Yet, addressing any these cannot completely eliminate or progression disorders. Novel strategies are necessary to target underlying mechanisms. The silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), histone deacetylase, limit injury, assist stem cell development, oversee metabolic homeostasis through nicotinamide adenine dinucleotide (NAD+) pathways, foster trophic factor protection, control senescence modulation telomere function. Intimately tied SIRT1 pathways mammalian forkhead transcription (FoxOs) which modulate cardiac reduce oxidative stress, repair microcirculation disturbances, atherogenesis autophagy, apoptosis, ferroptosis. AMP activated protein kinase (AMPK) also critical among oversight cellular metabolism, insulin sensitivity, mitochondrial function, inflammation, susceptibility viral infections such as severe acute respiratory syndrome coronavirus impact disease. relationship intricate complex requires detailed insight successfully translate into clinical care

Language: Английский

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