Therapeutic peptides: current applications and future directions

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Feb. 14, 2022

Abstract Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced modified using both chemical biological methods, together with novel design delivery strategies, which helped overcome inherent drawbacks of peptides allowed continued advancement this field. A wide variety natural obtained studied, covering multiple therapeutic areas. This review summarizes efforts achievements peptide discovery, their current applications. We also discuss value challenges associated future developments peptides.

Language: Английский

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Periodontitis and cardiovascular diseases: Consensus report

Journal Of Clinical Periodontology, Journal Year: 2020, Volume and Issue: 47(3), P. 268 - 288

Published: Feb. 3, 2020

Abstract Background In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to failure) the major cause these CVD related deaths. Periodontitis also a chronic non‐communicable (NCD) with high prevalence, severe periodontitis, affecting 11.2% world's population, sixth most common human disease. Material and Methods There now significant body evidence support independent associations between periodontitis several NCDs, in particular CVD. 2012 joint workshop was held European Federation Periodontology (EFP) American Academy review literature relating systemic diseases, including last five years important new scientific information has emerged providing emerging Results Conclusions The present reports proceedings jointly organised by EFP World Heart (WHF), which updated existing epidemiological CVD, mechanistic links impact periodontal therapy on surrogate outcomes. This focused potential risk complications patients anti thrombotic made recommendations dentists, physicians visiting both dental medical practices.

Language: Английский

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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study

The Lancet, Journal Year: 2019, Volume and Issue: 395(10226), P. 785 - 794

Published: Sept. 3, 2019

Language: Английский

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Epidemiology and the Magnitude of Coronary Artery Disease and Acute Coronary Syndrome: A Narrative Review

Journal of Epidemiology and Global Health, Journal Year: 2021, Volume and Issue: 11(2), P. 169 - 169

Published: Jan. 1, 2021

Coronary Artery Disease (CAD) is the foremost single cause of mortality and loss Disability Adjusted Life Years (DALYs) globally. A large percentage this burden found in low middle income countries. This accounts for nearly 7 million deaths 129 DALYs annually a huge global economic burden.

Language: Английский

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The novel regulatory role of lncRNA‐miRNA‐mRNA axis in cardiovascular diseases

Journal of Cellular and Molecular Medicine, Journal Year: 2018, Volume and Issue: 22(12), P. 5768 - 5775

Published: Sept. 6, 2018

Long noncoding RNAs (lncRNAs) are longer than 200 nt in length that characterized by low levels of sequence conservation and expression; lncRNAs modulate various biological functions at epigenetic, transcriptional post-transcriptional levels, or directly regulate protein activity. As a family small evolutionarily conserved RNAs, microRNAs (miRNAs) capable regulating physiological pathological processes via inhibiting target mRNA translation promoting degradation. A number studies have confirmed both miRNAs closely associated with the development cardiovascular diseases (CVDs), such as cardiac remodelling, heart failure, myocardial injury arrhythmia, they act biomarkers, potential therapeutic targets strong indicators prognosis; however, underlying molecular mechanism has not been elucidated. Recently, emerging evidence showed novel regulatory crosstalk among lncRNAs, mRNAs plays pivotal role pathophysiological CVDs response to stress stimuli. In this review, I comprehensively summarized relationship highlighted important lncRNA-miRNA-mRNA axis CVDs.

Language: Английский

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Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality

New England Journal of Medicine, Journal Year: 2023, Volume and Issue: 389(14), P. 1273 - 1285

Published: Aug. 26, 2023

Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional sex-specific prevalence of their effect on these outcomes lacking. Download a PDF Research Summary. We pooled harmonized 112 cohort studies conducted in 34 countries 8 geographic regions participating Global Cardiovascular Risk Consortium. examined associations between (body-mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, diabetes) incident cause Cox regression analyses, stratified according region, age, sex. Population-attributable fractions were estimated for 10-year incidence all-cause mortality. Among 1,518,028 participants (54.1% whom women) median age 54.4 years, variations five noted. Incident occurred 80,596 during follow-up 7.3 years (maximum, 47.3), 177,369 died 8.7 47.6). For all combined, aggregate global population-attributable fraction was 57.2% (95% confidence interval [CI], 52.4 62.1) among women 52.6% CI, 49.0 56.1) men, corresponding values mortality 22.2% 16.8 27.5) 19.1% 14.6 23.6). Harmonized showed that cases respectively, deaths may be attributable factors. (Funded by German Center (DZHK); ClinicalTrials.gov number, NCT05466825.) QUICK TAKE VIDEO SUMMARYModifiable Factors, Disease, Mortality 02:13

Language: Английский

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An update on lipid oxidation and inflammation in cardiovascular diseases

Free Radical Biology and Medicine, Journal Year: 2019, Volume and Issue: 144, P. 266 - 278

Published: April 1, 2019

Language: Английский

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Effectiveness, acceptability and usefulness of mobile applications for cardiovascular disease self-management: Systematic review with meta-synthesis of quantitative and qualitative data

European Journal of Preventive Cardiology, Journal Year: 2018, Volume and Issue: 25(5), P. 505 - 521

Published: Jan. 9, 2018

Background Mobile technologies are innovative, scalable approaches to reducing risk of cardiovascular disease but evidence related effectiveness and acceptability remains limited. We aimed explore the effectiveness, usefulness mobile applications (apps) for self-management factor control. Design Systematic review with meta-synthesis quantitative qualitative data. Methods Comprehensive search multiple databases (Medline, Embase, CINAHL, SCOPUS Cochrane CENTRAL) grey literature. Studies were included if intervention was primarily an app at improving least two lifestyle behaviours in adults disease. Meta-synthesis data performed evaluate findings. Results Ten studies varying designs including 607 patients from five countries included. Interventions targeted hypertension, heart failure, stroke cardiac rehabilitation populations. Factors that improved among users rehospitalisation rates, disease-specific knowledge, quality life, psychosocial well-being, blood pressure, body mass index, waist circumference, cholesterol exercise capacity. Improved physical activity, medication adherence smoking cessation also characteristic users. Appealing features tracking healthy behaviours, self-monitoring, education personalised, customisable content. Small samples, short duration selection bias noted limitations across some studies, as relatively low overall scientific evidence. Conclusions Multiple factors appear modifiable shorter term use apps. Evidence requires larger, controlled longer duration, emphasis on process evaluation better understand important system- patient-level characteristics.

Language: Английский

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Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 159, P. 4 - 33

Published: Jan. 1, 2020

With cardiovascular disease being the leading cause of morbidity and mortality worldwide, effective cost-efficient therapies to reduce risk are highly needed. Lipids lipoprotein particles crucially contribute atherosclerosis as underlying pathology influence inflammatory processes well function leukocytes, vascular cardiac cells, thereby impacting on vessels heart. Statins form first-line therapy with aim block cholesterol synthesis, but additional lipid-lowering drugs sometimes needed achieve low-density (LDL) target values. Furthermore, beyond LDL cholesterol, also other lipid mediators risk. This review comprehensively discusses low- high-density (a), triglycerides fatty acids derivatives in context disease, providing mechanistic insights into their role pathological disease. Also, an overview applied emerging therapeutic strategies lipid-induced burden is provided.

Language: Английский

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Periodontitis and Cardiovascular Diseases. Consensus Report

Global Heart, Journal Year: 2020, Volume and Issue: 15(1), P. 1 - 1

Published: Feb. 3, 2020

Background: In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to failure) the major cause these CVD related deaths. Periodontitis also a chronic non‐communicable (NCD) with high prevalence, severe periodontitis, affecting 11.2% world’s population, sixth most common human disease. Material and Methods: There now significant body evidence support independent associations between periodontitis several NCDs, in particular CVD. 2012 joint workshop was held European Federation Periodontology (EFP) American Academy review literature relating systemic diseases, including last five years important new scientific information has emerged providing emerging associations. Results Conclusions: The present reports proceedings jointly organised by EFP World Heart (WHF), which updated existing epidemiological CVD, mechanistic links impact periodontal therapy on surrogate outcomes. This focused potential risk complications patients anti thrombotic made recommendations dentists, physicians visiting both dental medical practices.

Language: Английский

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