Treatment of stage I–III periodontitis—The EFP S3 level clinical practice guideline

Journal Of Clinical Periodontology, Journal Year: 2020, Volume and Issue: 47(S22), P. 4 - 60

Published: May 8, 2020

The recently introduced 2017 World Workshop on the classification of periodontitis, incorporating stages and grades disease, aims to link disease with approaches prevention treatment, as it describes not only severity extent but also degree complexity an individual's risk. There is, therefore, a need for evidence-based clinical guidelines providing recommendations treat periodontitis.

Language: Английский

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Periodontitis and cardiovascular diseases: Consensus report

Journal Of Clinical Periodontology, Journal Year: 2020, Volume and Issue: 47(3), P. 268 - 288

Published: Feb. 3, 2020

Abstract Background In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to failure) the major cause these CVD related deaths. Periodontitis also a chronic non‐communicable (NCD) with high prevalence, severe periodontitis, affecting 11.2% world's population, sixth most common human disease. Material and Methods There now significant body evidence support independent associations between periodontitis several NCDs, in particular CVD. 2012 joint workshop was held European Federation Periodontology (EFP) American Academy review literature relating systemic diseases, including last five years important new scientific information has emerged providing emerging Results Conclusions The present reports proceedings jointly organised by EFP World Heart (WHF), which updated existing epidemiological CVD, mechanistic links impact periodontal therapy on surrogate outcomes. This focused potential risk complications patients anti thrombotic made recommendations dentists, physicians visiting both dental medical practices.

Language: Английский

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Association between periodontitis and severity of COVID‐19 infection: A case–control study

Journal Of Clinical Periodontology, Journal Year: 2021, Volume and Issue: 48(4), P. 483 - 491

Published: Feb. 3, 2021

COVID-19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation also a main characteristic of periodontitis. Therefore, we investigated the association periodontitis complications.A case-control study was performed using national electronic health records State Qatar between February and July 2020. Cases were defined as patients who suffered complications (death, ICU admissions or assisted ventilation), controls discharged without major complications. Periodontal conditions assessed dental radiographs from same database. Associations COVID 19 analysed logistic regression models adjusted for demographic, medical behaviour factors.In total, 568 included. After adjusting potential confounders, complication including death (OR = 8.81, 95% CI 1.00-77.7), admission 3.54, 1.39-9.05) need ventilation 4.57, 1.19-17.4). Similarly, blood levels white cells, D-dimer C Reactive Protein significantly higher periodontitis.Periodontitis risk admission, patients, increased biomarkers linked to worse disease

Language: Английский

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Treatment of stage IV periodontitis: The EFP S3 level clinical practice guideline

Journal Of Clinical Periodontology, Journal Year: 2022, Volume and Issue: 49(S24), P. 4 - 71

Published: June 1, 2022

Abstract Background The recently published clinical practice guideline (CPG) for the treatment of periodontitis in stages I–III provided evidence‐based recommendations patients, defined according to 2018 classification. Stage IV shares severity and complexity characteristics stage III periodontitis, but includes anatomical functional sequelae tooth periodontal attachment loss (tooth flaring drifting, bite collapse, etc.), which require additional interventions following completion active therapy. Aim To develop an S3 Level CPG focusing on implementation inter‐disciplinary approaches required treat/rehabilitate patients associated loss. Materials Methods This was developed by European Federation Periodontology (EFP), methodological guidance from Association Scientific Medical Societies Germany Grading Recommendations Assessment, Development Evaluation (GRADE) process. A rigorous transparent process included synthesis relevant research 13 specifically commissioned systematic reviews, evaluation quality strength evidence, formulation specific a structured consensus with leading experts broad base stakeholders. Results culminated different interventions, including orthodontic movement, splinting, occlusal adjustment, tooth‐ or implant‐supported fixed removable dental prostheses supportive care. Prior planning, it is critically important undertake definitive comprehensive diagnosis case evaluation, obtain patient information, engage frequent re‐evaluations during after treatment. component therapy should follow I–III. Conclusions present informs practice, health systems, policymakers and, indirectly, public available most effective modalities treat maintain healthy dentition over lifetime, evidence at time publication.

Language: Английский

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Is the oral cavity relevant in SARS-CoV-2 pandemic?

Clinical Oral Investigations, Journal Year: 2020, Volume and Issue: 24(8), P. 2925 - 2930

Published: June 23, 2020

Recent scientific evidences suggest a relevant role of the oral cavity in transmission and pathogenicity SARS-CoV-2.A literature search was performed PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, cavity, antimicrobial agents.Oral viral load SARS-CoV-2 has been associated with severity thus, reduction could be decrease condition. Similarly, would diminish amount virus expelled reduce risk transmission, since (i) during first 10 days, mainly accumulates at nasal, oral, pharyngeal area; (ii) number angiotensin-converting enzyme (ACE2) receptor is greater salivary glands as compared lungs; (iii) droplets represent most route. To load, antiseptic agents may used, although evidence its efficacy indirect weak.Antiseptic mouth rinses, such those containing cetylpyridinium chloride or povidone-iodine, able COVID-19 by reducing infected subjects decreasing limiting droplets, generated normal life, aerosols, produced dental procedures. Well-designed clinical preclinical research must conducted support these hypotheses.Antiseptic rinses help transmission.

Language: Английский

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Periodontitis, Edentulism, and Risk of Mortality: A Systematic Review with Meta-analyses

Journal of Dental Research, Journal Year: 2020, Volume and Issue: 100(1), P. 37 - 49

Published: Aug. 31, 2020

Periodontitis has been independently associated with the chronic noncommunicable diseases that most frequently lead to death worldwide. The aim of present systematic review was study whether people periodontitis/edentulism are at increased risk all-cause and cause-specific mortality as compared those without periodontitis/edentulism. Cohort studies were included 1) evaluated periodontitis or edentulism exposures in relation an outcome 2) reported effect estimates hazard ratios, odds ratios 95% CIs crude numbers. Two authors searched for eligible studies, screened titles abstracts, did full-text analysis, extracted data from published reports, performed risk-of-bias assessment. In case disagreement, a third author consulted. Study results summarized through random effects meta-analyses. A total 57 included, involving 48 cohorts 5.71 million participants. (risk ratio, 1.46 [95% CI, 1.15 1.85]) due cardiovascular (1.47 [1.14 1.90]), cancer (1.38 [1.24 1.53]), coronary heart disease (2.58 [2.20 3.03]), cerebrovascular (3.11 [2.42 3.98]), but not pneumonia (0.98 [0.69 1.38]). Edentulism (all types) (1.66 [1.46 1.88]) (2.03 [1.50 2.74]), (1.55 1.94]), (1.72 [1.07 2.78]), (2.98 [2.43 3.65]), (3.18 [2.24 4.51]). its ultimate sequela (edentulism) (PROSPERO CRD42018100095).

Language: Английский

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Endpoints of active periodontal therapy

Journal Of Clinical Periodontology, Journal Year: 2020, Volume and Issue: 47(S22), P. 61 - 71

Published: Jan. 8, 2020

Abstract Aim Position paper on endpoints of active periodontal therapy for designing treatment guidelines. The question was as follows: How are, an individual patient, commonly applied probing measures—recorded after therapy—related to (a) stability clinical attachment level, (b) tooth survival, (c) need re‐treatment or (d) oral health‐related quality life. Methods A literature search conducted in Ovid MEDLINE(R) and Epub Ahead Print, In‐Process & Other Non‐Indexed Citations Daily <1946 07 June 2019>. Results total 94 papers were retrieved. From the search, it found that periodontitis patients with a low proportion deep residual pockets are more likely have level over follow‐up time ≥1 year. supporting confirms this finding additionally reports, at patient pocket depths ≥6 mm bleeding scores ≥30% risks loss. There is lack evidence measures completion tangible patient. Conclusions Based biological plausibility, reasonable state little inflammation levels less loss time. Guidelines should take into consideration long‐term outcomes, shallow (≤4 mm) without <30% sites best guarantee his/her attachment, heterogeneity changes immune response time, strategies include lifestyle Long‐term large population‐based practice‐based studies efficacy therapies including both patient‐reported outcomes (PROs) be initiated, which understanding complex disease variation inflammatory responses due environment, (epi)genetics, ageing. Involving people living co‐researchers design these would also help improve their relevance.

Language: Английский

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Pathophysiology of Cardiovascular Diseases: New Insights into Molecular Mechanisms of Atherosclerosis, Arterial Hypertension, and Coronary Artery Disease

Biomedicines, Journal Year: 2022, Volume and Issue: 10(8), P. 1938 - 1938

Published: Aug. 10, 2022

Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory system. Atherosclerosis is its major underlying cause. CVDs chronic can remain hidden for a long time. Moreover, leading cause of global morbidity mortality, thus creating public health concern. This review summarizes available information on pathophysiological implications CVDs, focusing coronary artery disease along atherosclerosis as arterial hypertension. We discuss endothelium dysfunction, inflammatory factors, oxidation atherosclerosis. Mechanisms such dysfunction inflammation, which have been identified critical pathways development disease, become easier to diagnose in recent years. Relatively recently, evidence has found indicating that interactions molecular cellular elements matrix metalloproteinases, immune system, oxidative stress involved pathophysiology Many studies revealed several important genetic risk factors CVDs. However, further investigation crucial improve our knowledge progression and, more importantly, accelerate basic research understanding mechanism pathophysiology.

Language: Английский

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ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 146, P. 37 - 48

Published: March 30, 2022

Language: Английский

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Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome

Periodontology 2000, Journal Year: 2021, Volume and Issue: 87(1), P. 50 - 75

Published: Aug. 31, 2021

Abstract Periodontitis has been associated with many systemic diseases and conditions, including metabolic syndrome. Metabolic syndrome is a cluster of conditions that occur concomitantly together they increase the risk cardiovascular disease double type 2 diabetes. In this review, we focus on association between periodontitis; however, also include information diabetes mellitus disease, since these two are significantly intertwined With regard to periodontitis syndrome, date, vast majority studies point an demonstrate can contribute development of, or worsen, Evaluating effect salivary microbiome, data presented herein support hypothesis bacterial profile altered in patients compared healthy patients. Considering three human animal diabetes, disease. Moreover, there evidence suggest alter oral microbiome. However, more needed fully understand influence have each other.

Language: Английский

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