Nutrients,
Journal Year:
2023,
Volume and Issue:
15(3), P. 591 - 591
Published: Jan. 23, 2023
Iron
functions
as
an
essential
micronutrient
and
participates
in
normal
physiological
biochemical
processes
the
cardiovascular
system.
Ferroptosis
is
a
novel
type
of
iron-dependent
cell
death
driven
by
iron
accumulation
lipid
peroxidation,
characterized
depletion
glutathione
suppression
peroxidase
4
(GPX4).
Dysregulation
metabolism
ferroptosis
have
been
implicated
occurrence
development
diseases
(CVDs),
including
hypertension,
atherosclerosis,
pulmonary
myocardial
ischemia/reperfusion
injury,
cardiomyopathy,
heart
failure.
chelators
deferoxamine
dexrazoxane,
lipophilic
antioxidants
ferrostatin-1
liproxstatin-1
revealed
to
abolish
suppress
peroxidation
other
CVDs.
Notably,
inhibition
has
demonstrated
alleviate
cardiac
impairments,
fibrosis
pathological
remodeling
during
hypertension
potentiating
GPX4
signaling.
Administration
improved
injury
inhibiting
peroxidation.
Several
small
molecules
may
be
effective
treatment
ferroptosis-mediated
In
this
article,
we
summarize
regulatory
roles
underlying
mechanisms
dysregulation
Targeting
are
potential
therapeutic
strategies
prevention
Frontiers in Physiology,
Journal Year:
2019,
Volume and Issue:
10
Published: June 6, 2019
Age
is
a
primary
risk
factor
for
number
of
chronic
diseases
including
mobility
disability,
cardiovascular
disease
(CVD),
type
2
diabetes
(T2D),
and
cancer.
Most
physical
activity
guidelines
emphasize
the
performance
150
min
moderate-to-vigorous
or
75
minutes
vigorous
aerobic
exercise
training
(AET)
weekly
reduction
risk.
Nonetheless,
there
an
emerging
body
evidence
showing
that
resistance
(RET)
appears
to
be
as
effective
AET
in
reducing
several
diseases.
It
may
also
RET
more
than
some
regards;
converse
likely
true.
We
posit
perceived
divergent
mode-dependent
health
benefits
are
small
most
cases.
In
this
short
review,
our
aim
examine
associations
between
(mobility
T2D,
CVD,
cancer).
postulate
on
how
influencing
it
critical
component
healthy
aging.
Accumulating
points
potent
robust
preventive
strategy
against
traditionally
associated
with
AET,
but
favours
countermeasure
declines
mobility.
On
basis
review
we
propose
promotion
should
assume
prominent
position
particularly
older
persons.
Cardiovascular Diabetology,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: July 27, 2021
Abstract
Background
There
is
a
paucity
of
global
data
on
cardiovascular
disease
(CVD)
prevalence
in
people
with
type
2
diabetes
(T2D).
The
primary
objective
the
CAPTURE
study
was
to
estimate
established
CVD
and
its
management
adults
T2D
across
13
countries
from
five
continents.
Additional
objectives
were
further
characterize
sample
regarding
demographics,
clinical
parameters
medication
usage,
particular
reference
blood
glucose-lowering
agents
(GLAs:
glucagon-like
peptide-1
receptor
agonists
sodium-glucose
co-transporter-2
inhibitors)
demonstrated
benefit
randomized
intervention
trials.
Methods
Data
collected
managed
or
specialist
care
Australia,
China,
Japan,
Czech
Republic,
France,
Hungary,
Italy,
Argentina,
Brazil,
Mexico,
Israel,
Kingdom
Saudi
Arabia,
Turkey
2019,
using
standardized
methodology.
prevalence,
weighted
by
each
country,
estimated
for
overall
participating
countries.
Country-specific
odds
ratios
adjusted
relevant
demographic
parameters.
Results
included
9823
(n
=
4502
care;
n
5321
care).
had
median
(interquartile
range)
duration
10.7
years
(5.6–17.9
years)
glycated
hemoglobin
7.3%
(6.6–8.4%)
[56
mmol/mol
(49–68
mmol/mol)].
Overall
atherosclerotic
estimates
34.8%
(95%
confidence
interval
[CI]
32.7–36.8)
31.8%
CI
29.7–33.8%),
respectively.
Age,
gender,
accounted
some
between-country
variation
prevalence.
GLAs
used
21.9%
participants,
which
similar
participants
without
CVD:
21.5%
22.2%,
Conclusions
In
approximately
one
three
diagnosed
CVD.
low
use
even
suggested
that
most
not
according
contemporary
cardiology
guidelines.
Study
registration
NCT03786406
(registered
December
20,
2018),
NCT03811288
January
18,
2019).
npj Digital Medicine,
Journal Year:
2022,
Volume and Issue:
5(1)
Published: Aug. 26, 2022
Potential
benefits
of
precision
medicine
in
cardiovascular
disease
(CVD)
include
more
accurate
phenotyping
individual
patients
with
the
same
condition
or
presentation,
using
multiple
clinical,
imaging,
molecular
and
other
variables
to
guide
diagnosis
treatment.
An
approach
realising
this
potential
is
digital
twin
concept,
whereby
a
virtual
representation
patient
constructed
receives
real-time
updates
range
data
order
predict
optimise
treatment
selection
for
real-life
patient.
We
explored
term
twin,
its
defining
concepts,
challenges
as
an
emerging
field,
potentially
important
applications
CVD.
A
mapping
review
was
undertaken
systematic
search
peer-reviewed
literature.
Industry-based
participants
patent
were
identified
through
web-based
sources.
Searches
Compendex,
EMBASE,
Medline,
ProQuest
Scopus
databases
yielded
88
papers
related
conditions
(28%,
n
=
25),
non-cardiovascular
(41%,
36),
general
aspects
health
(31%,
27).
Fifteen
companies
commercial
interest
simulation
modelling
had
products
focused
on
The
18
from
11
applicants,
which
73%
27%
universities.
Three
applicants
cardiac-related
inventions.
For
CVD,
research
within
industry
academia
recent,
interdisciplinary,
established
globally.
Overall,
numerical
models,
although
precursor
models
exist
cyber-physical
system
characteristic
true
twin.
Implementation
ethical
constraints
clinical
barriers
adoption
decision
tools
derived
artificial
intelligence
systems.
Electronics,
Journal Year:
2022,
Volume and Issue:
11(15), P. 2292 - 2292
Published: July 22, 2022
The
Internet
of
Things
confers
seamless
connectivity
between
people
and
objects,
its
confluence
with
the
Cloud
improves
our
lives.
Predictive
analytics
in
medical
domain
can
help
turn
a
reactive
healthcare
strategy
into
proactive
one,
advanced
artificial
intelligence
machine
learning
approaches
permeating
industry.
As
subfield
ML,
deep
possesses
transformative
potential
for
accurately
analysing
vast
data
at
exceptional
speeds,
eliciting
intelligent
insights,
efficiently
solving
intricate
issues.
accurate
timely
prediction
diseases
is
crucial
ensuring
preventive
care
alongside
early
intervention
risk.
With
widespread
adoption
electronic
clinical
records,
creating
models
enhanced
accuracy
key
to
harnessing
recurrent
neural
network
variants
possessing
ability
manage
sequential
time-series
data.
proposed
system
acquires
from
IoT
devices,
stored
on
cloud
pertaining
patient
history
are
subjected
predictive
analytics.
smart
monitoring
predicting
heart
disease
risk
built
around
Bi-LSTM
(bidirectional
long
short-term
memory)
showcases
an
98.86%,
precision
98.9%,
sensitivity
98.8%,
specificity
98.89%,
F-measure
which
much
better
than
existing
systems.
Periodontology 2000,
Journal Year:
2021,
Volume and Issue:
87(1), P. 50 - 75
Published: Aug. 31, 2021
Abstract
Periodontitis
has
been
associated
with
many
systemic
diseases
and
conditions,
including
metabolic
syndrome.
Metabolic
syndrome
is
a
cluster
of
conditions
that
occur
concomitantly
together
they
increase
the
risk
cardiovascular
disease
double
type
2
diabetes.
In
this
review,
we
focus
on
association
between
periodontitis;
however,
also
include
information
diabetes
mellitus
disease,
since
these
two
are
significantly
intertwined
With
regard
to
periodontitis
syndrome,
date,
vast
majority
studies
point
an
demonstrate
can
contribute
development
of,
or
worsen,
Evaluating
effect
salivary
microbiome,
data
presented
herein
support
hypothesis
bacterial
profile
altered
in
patients
compared
healthy
patients.
Considering
three
human
animal
diabetes,
disease.
Moreover,
there
evidence
suggest
alter
oral
microbiome.
However,
more
needed
fully
understand
influence
have
each
other.
Progress in Cardiovascular Diseases,
Journal Year:
2021,
Volume and Issue:
70, P. 8 - 15
Published: Dec. 16, 2021
Cardiovascular
disease
(CVD)
is
the
leading
cause
of
death
globally.
Advancements
in
treatment
CVD
have
reduced
mortality
rates,
yet
global
burden
remains
high.
Considering
that
still
largely
a
preventable
disease,
prioritizing
preventative
measures
through
healthy
lifestyle
(HL)
behaviors
necessary
to
lessen
CVD.
HL
behaviors,
such
as
regular
exercise,
eating
habits,
adequate
sleep,
and
smoking
cessation,
can
influence
number
traditional
risk
factors
well
less
commonly
measured
factor,
cardiorespiratory
fitness
(CRF).
It
important
note
cardiac
rehabilitation
programs,
which
traditionally
focused
on
secondary
prevention,
also
emphasize
importance
making
comprehensive
behavior
changes.
This
review
discusses
reduce
an
increased
uptake
assessment
behaviors.
An
overview
CRF
factor
discussed
along
with
how
improve
other
interventions.
The
role
clinician
for
promoting
prevent
reviewed.
