2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Hypertension, Journal Year: 2017, Volume and Issue: 71(6)

Published: Nov. 13, 2017

Since 1980, the American College of Cardiology (ACC) and Heart Association (AHA) have translated scientific evidence into clinical practice guidelines (guidelines) with recommendations to improve cardiovascular health.In 2013, National Heart, Lung, Blood Institute (NHLBI) Advisory Council recommended that NHLBI focus specifically on reviewing highest-quality partner other organizations develop recommendations.P-1,P-2 Accordingly, ACC AHA collaborated stakeholder professional complete publish 4 (on assessment risk, lifestyle modifications reduce management blood cholesterol in adults, overweight obesity adults) make them available widest possible constituency.In 2014, AHA, partnership several societies, initiated a guideline prevention, detection, evaluation, high pressure (BP) adults.Under ACC/ Task Force, Prevention Subcommittee was appointed help guide development suite prevention disease (CVD).These guidelines, which are based systematic methods evaluate classify evidence, provide cornerstone for quality care.The sponsor publication without commercial support, members each organization volunteer their time writing review efforts.Guidelines official policy AHA. HypertensionJune 2018of practice.The Force may also invite societies related interests expertise participate as partners, collaborators, or endorsers. Relationships With Industry Other EntitiesThe rigorous policies ensure developed bias improper influence.The relationships industry entities (RWI) can be found online.Appendix 1 present document lists committee members' relevant RWI.For purposes full transparency, comprehensive disclosure information is online.Comprehensive online. Evidence Review CommitteesIn developing recommendations, uses evidence-based methodologies all data.P-6-P-9 Literature searches randomized controlled trials (RCTs) but include registries, nonrandomized comparative descriptive studies, case series, cohort reviews, expert opinion.Only key references cited.An independent (ERC) commissioned when there more questions deemed utmost importance merit formal review.The will determine patients most likely benefit from drug, device, treatment strategy what degree.Criteria commissioning an ERC include: a) absence current authoritative review, b) feasibility defining risk frame consistent guideline, c) relevance substantial number patients, d) likelihood findings actionable recommendations.ERC methodologists, epidemiologists, healthcare providers, biostatisticians.The by basis marked "SR." Guideline-Directed Management TherapyThe term guideline-directed therapy (GDMT) encompasses diagnostic testing, pharmacological procedural treatments.For these drug regimens, reader should confirm dosage product insert material regimen contraindications interactions.The limited drugs, devices, treatments approved use United States. Class Recommendation Level EvidenceThe (COR) indicates strength recommendation, encompassing estimated magnitude certainty proportion risk.The (LOE) rates supports intervention type, quantity, consistency data sources (Table 1).P-6-P-8

Language: Английский

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2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults

Journal of the American College of Cardiology, Journal Year: 2017, Volume and Issue: 71(19), P. e127 - e248

Published: Nov. 13, 2017

Language: Английский

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Proteobacteria: A Common Factor in Human Diseases

BioMed Research International, Journal Year: 2017, Volume and Issue: 2017, P. 1 - 7

Published: Jan. 1, 2017

Microbiota represents the entire microbial community present in gut host. It serves several functions establishing a mutualistic relation with Latest years have seen burst number of studies focusing on this topic, particular intestinal diseases. In scenario, Proteobacteria are one most abundant phyla, comprising known human pathogens. This review highlights latest findings role not only but also extraintestinal Indeed, an increasing amount data identifies as possible signature disease. Several demonstrate increased abundance members belonging to phylum such conditions. Major evidences currently involve metabolic disorders and inflammatory bowel However, more recent suggest lung diseases, asthma chronic obstructive pulmonary disease, still scant. Notably, all these conditions sustained by various degree inflammation, which thus core aspect Proteobacteria-related

Language: Английский

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2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

Circulation, Journal Year: 2018, Volume and Issue: 138(17)

Published: Oct. 22, 2018

Language: Английский

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Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Current Neurology and Neuroscience Reports, Journal Year: 2017, Volume and Issue: 17(12)

Published: Oct. 17, 2017

Language: Английский

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Gut microbiota and Covid-19- possible link and implications

Virus Research, Journal Year: 2020, Volume and Issue: 285, P. 198018 - 198018

Published: May 12, 2020

Language: Английский

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PPAR control of metabolism and cardiovascular functions

Nature Reviews Cardiology, Journal Year: 2021, Volume and Issue: 18(12), P. 809 - 823

Published: June 14, 2021

Language: Английский

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New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

Redox Biology, Journal Year: 2018, Volume and Issue: 20, P. 247 - 260

Published: Oct. 20, 2018

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis. Intracellular hyperglycemia promotes production mitochondrial reactive oxygen species (ROS), increased formation intracellular advanced glycation end-products, activation protein kinase C, polyol pathway flux. ROS directly increase expression inflammatory adhesion factors, oxidized-low density lipoprotein, insulin resistance. They activate ubiquitin pathway, inhibit AMP-protein adiponectin, decrease endothelial nitric oxide synthase activity, all which accelerate Changes composition gut microbiota changes microRNA that influence regulation target genes occur diabetes with to promote This review highlights consequences sustained acceleration atherosclerosis by diabetes. The potential contributions are discussed.

Language: Английский

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Pathophysiology of Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3346 - 3346

Published: March 20, 2022

Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which leading cause of mortality worldwide. initiated by endothelium activation and, followed a cascade events (accumulation lipids, fibrous elements, and calcification), triggers vessel narrowing inflammatory pathways. The resultant atheroma plaque, along with these processes, results in complications. This review focuses on different stages atherosclerosis development, ranging from endothelial dysfunction to plaque rupture. In addition, post-transcriptional regulation modulation microRNAs lncRNAs, role microbiota, importance sex as crucial are covered here order provide global view disease.

Language: Английский

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The Gut Microbiome Profile in Obesity: A Systematic Review

International Journal of Endocrinology, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 9

Published: Jan. 1, 2018

Gut microbiome has been identified in the past decade as an important factor involved obesity, but magnitude of its contribution to obesity and related comorbidities is still uncertain. Among vast quantity factors attributed environmental, dietary, lifestyle, genetic, others, aroused curiosity, scientific community published many original articles. Most studies have reported based on associations between microbiota in-depth study mechanisms studied mainly rodents exceptionally humans. Due diverse information published, need reviews mandatory recapitulate relevant achievements. In this systematic review, we provide overview current evidence association intestinal obesity. Additionally, analyze effects extreme weight loss intervention such bariatric surgery gut microbiota. The review divided into 2 sections: first, metabolic disorders with different profiles, including metagenomics studies, second, changes after surgery.

Language: Английский

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