Inflammation, Immunity, and Infection in Atherothrombosis

Journal of the American College of Cardiology, Journal Year: 2018, Volume and Issue: 72(17), P. 2071 - 2081

Published: Oct. 1, 2018

Language: Английский

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Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 10

Published: Jan. 21, 2020

Endothelial cells are important constituents of blood vessels that play critical roles in cardiovascular homeostasis by regulating fluidity and fibrinolysis, vascular tone, angiogenesis, monocyte/leukocyte adhesion, platelet aggregation. The normal endothelium is taken as a gatekeeper health, whereas abnormality major contributor to plethora ailments, such atherosclerosis, aging, hypertension, obesity, diabetes. dysfunction characterized imbalanced vasodilation vasoconstriction, elevated reactive oxygen species (ROS), proinflammatory factors, well deficiency nitric oxide (NO) bioavailability. occurrence endothelial disrupts the barrier permeability part inflammatory response development diseases. As such, abrogation cell activation/inflammation clinical relevance. Recently, hydrogen sulfide (H2S), an entry gasotransmitter, exerts diverse biological effects through acting on various targeted signaling pathways. Within system, formation H2S detected smooth muscle cells, cardiomyocytes. Disrupted bioavailability postulated be new indicator for inflammation its associated dysfunction. In this review, we will summarize recent advances about homeostasis, especially under pathological conditions, discuss putative therapeutic applications inflammation-associated disorders.

Language: Английский

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Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications

Advances in Nutrition, Journal Year: 2018, Volume and Issue: 10, P. S17 - S30

Published: Oct. 30, 2018

Language: Английский

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Intestinal Microbiota in Cardiovascular Health and Disease

Journal of the American College of Cardiology, Journal Year: 2019, Volume and Issue: 73(16), P. 2089 - 2105

Published: April 1, 2019

Language: Английский

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RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review

European Journal of Clinical Nutrition, Journal Year: 2021, Volume and Issue: 76(4), P. 489 - 501

Published: Sept. 28, 2021

Language: Английский

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Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota

The ISME Journal, Journal Year: 2018, Volume and Issue: 12(7), P. 1642 - 1657

Published: Feb. 6, 2018

Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, type 2 diabetes. We aimed to analyze systemic levels of succinate obesity, major risk factor CVD, its relationship with gut microbiome. explored association circulating specific metagenomic signatures cross-sectional prospective cohorts Caucasian Spanish subjects. Obesity was associated elevated concomitant impaired glucose metabolism. This increase changes related metabolism: higher relative abundance succinate-producing Prevotellaceae (P) Veillonellaceae (V), lower succinate-consuming Odoribacteraceae (O) Clostridaceae (C) obese individuals, (P + V/O C) ratio being main determinant plasma succinate. Weight loss intervention decreased coincident reduction In spontaneous evolution after good dietary advice, alterations were linked carbohydrate metabolism energy production independence body weight change. Our data support importance microbe-microbe interactions signature microbiome uncover as microbiota-derived CVD risk.

Language: Английский

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Human gut microbiota in health and disease: Unveiling the relationship

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 26, 2022

The human gut possesses millions of microbes that define a complex microbial community. microbiota has been characterized as vital organ forming its multidirectional connecting axis with other organs. This is responsible for host-microbe interactions and works by communicating the neural, endocrinal, humoral, immunological, metabolic pathways. microorganisms (mostly non-pathogenic) have symbiotic host relationships are usually associated host’s immunity to defend against pathogenic invasion. dysbiosis therefore linked various diseases, such anxiety, depression, hypertension, cardiovascular obesity, diabetes, inflammatory bowel disease, cancer. mechanism leading disease development crucial correlation microbiota, products, immune response in humans. understanding mechanisms over exerts positive or harmful impacts remains largely undefined. However, many recent clinical studies conducted worldwide demonstrating relation specific species eubiosis health disease. A comprehensive interactions, role updates on subject striking topics current review. We also addressed daunting challenges must be brought under control maintain treat diseases.

Language: Английский

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An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Science Translational Medicine, Journal Year: 2019, Volume and Issue: 11(475)

Published: Jan. 16, 2019

An engineered E. coli strain lowers blood ammonia, improves survival in models of hyperammonemia, and demonstrates safety healthy volunteers.

Language: Английский

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Gut microbiota and cardiovascular disease: opportunities and challenges

Microbiome, Journal Year: 2020, Volume and Issue: 8(1)

Published: March 14, 2020

Coronary artery disease (CAD) is the most common health problem worldwide and remains leading cause of morbidity mortality. Over past decade, it has become clear that inhabitants our gut, gut microbiota, play a vital role in human metabolism, immunity, reactions to diseases, including CAD. Although correlations have been shown between CAD demonstration potential causal relationships much more complex challenging. In this review, we will discuss direct indirect roots microbiota development via microbial metabolites interaction with immune system. Uncovering relationship can lead novel microbiome-based preventative therapeutic interventions. However, an interdisciplinary approach required shed light on bacterial-mediated mechanisms (e.g., using advanced nanomedicine technologies incorporation demographic factors such as age, sex, ethnicity) enable efficacious high-precision strategies for

Language: Английский

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Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism

Science Advances, Journal Year: 2020, Volume and Issue: 6(1)

Published: Jan. 3, 2020

Metabolic syndrome (MetS) is intricately linked to dysregulation of gut microbiota and host metabolomes. Here, we first find that a purified citrus polymethoxyflavone-rich extract (PMFE) potently ameliorates high-fat diet (HFD)-induced MetS, alleviates dysbiosis, regulates branched-chain amino acid (BCAA) metabolism using 16S rDNA amplicon sequencing metabolomic profiling. The metabolic protective effects PMFE are dependent, as demonstrated by antibiotic treatment fecal microbiome transplantation (FMT). modulation altered BCAA levels in the serum feces, which were significantly associated with features actively responsive therapeutic interventions PMFE. Notably, greatly enriched commensal bacterium Bacteroides ovatus, gavage B. ovatus reduced concentrations alleviated MetS HFD mice. may be used prebiotic agent attenuate target-specific microbial species have unique promise for diseases.

Language: Английский

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