Frontiers in Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Jan. 3, 2022
The
gut
microbiota,
often
viewed
as
a
"digestive
organ,"
can
influence
the
development
of
obesity
and
related
metabolic
disorders.
Diet
is
significantly
important
in
shaping
structure
modulating
function
microbiota.
Apigenin
(Api)
widely
exists
fruits
vegetables
naturally
occurring
flavonoid
has
anti-obesogenic,
anti-inflammatory,
anti-carcinogenic
properties.
Its
low
bioavailability
means
it
enough
time
to
interact
with
intestine
thus
becomes
potential
substrate
for
intestine;
thus,
contributing
health.
Here,
we
show
that
Api
reduces
whole-body
weight,
low-grade
inflammation,
insulin
resistance
high-fat
diet
(HFD)-induced
obese
mice.
Our
results
reflect
supplementation
substantially
improve
intestinal
dysbiosis
triggered
by
HFD
restores
barrier
damage
alleviating
endotoxemia.
Augmentation
Akkermansia
Incertae_Sedis
along
reduction
Faecalibaculum
Dubosiella
at
genus
level
potentially
mediated
protective
effects
on
syndrome.
Furthermore,
impact
body
weight
modification
microbiota
could
be
transferred
from
Api-administered
mice
HFD-feeding
via
horizontal
fecal
transplantation.
Taken
together,
our
data
highlight
prebiotic
role
its
contribution
restraint
deterioration
associated
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2021,
Volume and Issue:
11
Published: March 17, 2021
The
human
gut
microbiome
is
a
huge
microbial
community
that
plays
an
irreplaceable
role
in
life.
With
the
further
development
of
research,
influence
intestinal
flora
on
diseases
has
been
gradually
excavated.
Gut
microbiota
(GM)
dysbiosis
adverse
health
effects
body
will
lead
to
variety
chronic
diseases.
underlying
mechanisms
GM
are
incredibly
complicated.
This
review
focuses
regulation
and
mechanism
neurodegenerative
diseases,
cardiovascular
metabolic
gastrointestinal
thus
providing
potential
target
for
prevention
treatment
disease.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(2), P. 239 - 239
Published: Jan. 26, 2022
The
increased
consumption
of
fruits,
vegetables,
and
whole
grains
contributes
to
the
reduced
risk
many
diseases
related
metabolic
syndrome,
including
neurodegenerative
diseases,
cardiovascular
disease
(CVD),
diabetes,
cancer.
Citrus,
genus
Citrus
L.,
is
one
most
important
fruit
crops,
rich
in
carotenoids,
flavonoids,
terpenes,
limonoids,
other
bioactive
compounds
nutritional
nutraceutical
value.
Moreover,
polymethoxylated
flavones
(PMFs),
a
unique
class
abundantly
occur
citrus
fruits.
In
addition,
essential
oil,
limonoids
an
economically
product
due
its
potent
antioxidant,
antimicrobial,
flavoring
properties.
Mechanistic,
observational,
intervention
studies
have
demonstrated
health
benefits
bioactives
minimizing
syndrome.
This
review
provides
comprehensive
view
composition
fruits
their
associated
benefits.
Aging and Disease,
Journal Year:
2022,
Volume and Issue:
13(4), P. 1106 - 1106
Published: Jan. 1, 2022
Gut
microbiota,
a
collection
of
microorganisms
that
live
within
gastrointestinal
tract,
provides
crucial
signaling
metabolites
for
the
physiological
hosts.
In
healthy
state,
gut
microbiota
are
helpful
maintaining
basic
functions
hosts,
whereas
disturbed
production
these
can
lead
to
numerous
diseases
such
as
metabolic
diseases,
cardiovascular
neurodegenerative
and
cancer.
Although
there
many
reviews
about
specific
mechanisms
on
is
no
comprehensive
summarization
metabolites.
this
Opinion,
we
discuss
knowledge
including
types
their
ways
acting
targets.
addition,
summarize
pathologic
in
health
shaping
composition
nutrition.
This
paper
be
understanding
roles
thus
provide
guidance
developing
suitable
therapeutic
strategies
combat
microbial-driven
improve
health.
Microbiome,
Journal Year:
2021,
Volume and Issue:
9(1)
Published: July 20, 2021
Feelings
of
hunger
and
satiety
are
the
key
determinants
for
maintaining
life
humans
animals.
Disturbed
appetite
control
may
disrupt
metabolic
health
host
cause
various
disorders.
A
variety
factors
have
been
implicated
in
control,
including
gut
microbiota,
which
develop
intricate
interactions
to
manipulate
requirements
hedonic
feelings.
Gut
microbial
metabolites
components
act
as
appetite-related
signaling
molecules
regulate
hormone
secretion
immune
system,
or
directly
on
hypothalamic
neurons.
Herein,
we
summarize
effects
microbiota
consider
potential
molecular
mechanisms.
Furthermore,
propose
that
manipulation
represents
a
clinical
therapeutic
lessening
development
consequence
Video
abstract.
Gut,
Journal Year:
2021,
Volume and Issue:
71(1), P. 78 - 87
Published: Jan. 27, 2021
Objective
Effects
of
the
diet-induced
gut
microbiota
dysbiosis
reach
far
beyond
gut.
We
aim
to
uncover
direct
evidence
involving
gut–testis
axis
in
aetiology
impaired
spermatogenesis.
Design
An
excessive-energy
metabolic
syndrome
(MetS)
sheep
model
was
established.
The
testicular
samples,
host
metabolomes
and
microbiome
were
analysed.
Faecal
transplantation
(FMT)
confirmed
linkage
between
Results
demonstrated
that
number
arrested
spermatogonia
markedly
elevated
by
using
10×
single-cell
RNA-seq
MetS
model.
Furthermore,
through
metabolomics
profiling
16S
rDNA-seq,
we
discovered
absorption
vitamin
A
abolished
due
a
notable
reduction
bile
acid
levels,
which
significantly
associated
with
reduced
abundance
Ruminococcaceae_NK4A214_group
.
Notably,
abnormal
effects
transferable
cells
circulating
blood,
contributed
spermatogenesis,
as
FMT.
Conclusion
These
findings
define
starting
point
for
linking
function
regulation
via
will
be
potential
value
treatment
male
infertility
MetS.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 11, 2022
Type
2
diabetes
mellitus
(T2DM),
one
of
the
fastest
growing
metabolic
diseases,
has
been
characterized
by
disorders
including
hyperglycemia,
hyperlipidemia
and
insulin
resistance
(IR).
In
recent
years,
T2DM
become
disease
in
world.
Studies
have
indicated
that
patients
with
are
often
associated
intestinal
flora
dysfunction
involving
multiple
organs.
Metabolites
flora,
such
as
bile
acids
(BAs),
short-chain
fatty
(SCFAs)
amino
(AAs)may
influence
to
some
extent
decreased
sensitivity
regulate
well
immune
homeostasis.
this
paper,
we
review
changes
gut
mechanisms
which
microbiota
modulates
metabolites
affecting
T2DM,
may
provide
a
basis
for
early
identification
T2DM-susceptible
individuals
guide
targeted
interventions.
Finally,
also
highlight
microecological
therapeutic
strategies
focused
on
shaping
inform
improvement
progression.
Foods,
Journal Year:
2023,
Volume and Issue:
12(2), P. 320 - 320
Published: Jan. 9, 2023
In
recent
years,
research
on
the
interaction
between
flavonoids
and
intestinal
microbes
have
prompted
a
rash
of
food
science,
nutriology
biomedicine,
complying
with
future
trends.
The
gut
microbiota
plays
an
essential
role
in
maintenance
homeostasis
human
health,
but
once
flora
dysregulation
occurs,
it
may
contribute
to
various
diseases.
Flavonoids
shown
variety
physiological
activities,
are
metabolized
or
biotransformed
by
microbiota,
thereby
producing
new
metabolites
that
promote
health
modulating
composition
structure
flora.
Herein,
this
review
demonstrates
key
notion
as
well
dysbiosis,
aiming
provide
comprehensive
understanding
about
how
regulate
diseases
microbiota.
Emphasis
is
placed
microbiota-flavonoid
bidirectional
affects
metabolic
fate
their
metabolites,
influencing
mechanism,
biotransformation,
bioavailability
bioactivity.
Potentially
focusing
abundance
diversity
such
bile
acids,
we
discuss
influence
mechanism
protecting
barrier
function
immune
system.
Additionally,
crucial
regulating
We
explain
underlying
regulation
several
typical
including
gastrointestinal
diseases,
obesity,
diabetes
cancer,
theoretical
basis
guideline
for
promotion
treatment
