Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection DOI Creative Commons
Ming Lyu,

Chun-Lin Yan,

Haixin Liu

et al.

Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)

Published: Nov. 7, 2017

Although Danhong injection (DHI) is the most widely prescribed Chinese medicine for both stroke and coronary artery disease (CAD), its underlying common molecular mechanisms remain unclear. An integrated network pharmacology experimental verification approach was used to decipher pharmacological of DHI on CAD treatment. A compound-target-disease & function-pathway constructed analyzed, indicating that 37 ingredients derived from DH (Salvia miltiorrhiza Bge., Flos Carthami tinctorii DHI) modulated 68 targets shared by CAD. In-depth analysis results top diseases, functions, pathways upstream regulators implied a mechanism linking DHI's role in treatment inflammatory response process atherosclerosis. Experimentally, exerted comprehensive anti-inflammatory effects LPS, ox-LDL or cholesterol crystal-induced NF-κB, c-jun p38 activation, as well IL-1β, TNF-α, IL-10 secretion vascular endothelial cells. Ten 14 predicted were verified have significant activities LPS-induced inflammation. exerts efficacies through multi-ingredient, multi-target, multi-function multi-pathway mode. Anti-endothelial inflammation therapy serves mechanism. This study provides new understanding clinical application cardiovascular cerebrovascular diseases.

Language: Английский

Stroke–heart syndrome: clinical presentation and underlying mechanisms DOI
Jan F. Scheitz, Christian H. Nolte, Wolfram Doehner

et al.

The Lancet Neurology, Journal Year: 2018, Volume and Issue: 17(12), P. 1109 - 1120

Published: Oct. 26, 2018

Language: Английский

Citations

215
Systemic inflammation after stroke: implications for post‐stroke comorbidities DOI Creative Commons
Alba Simats, Arthur Liesz

EMBO Molecular Medicine, Journal Year: 2022, Volume and Issue: 14(9)

Published: Aug. 15, 2022

Language: Английский

Citations

127
The global prevalence of oropharyngeal dysphagia in different populations: a systematic review and meta-analysis DOI Creative Commons
Fatemeh Rajati, Nassim Ahmadi, Zahra Al-sadat Naghibzadeh

et al.

Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: April 11, 2022

Abstract Background Oropharyngeal dysphagia (OD) refers to any abnormality in the physiology of swallowing upper gastrointestinal tract, which leads related clinical complications, such as malnutrition, dehydration, and sever complication, aspiration pneumonia, suffocation, eventually, premature death. The previous studies indicated a various range prevalence OD. present systematic review meta-analysis aimed standardize global OD different populations. Methods A literature was conducted using Embase, Scopus, PubMed, Web Science (WoS) databases, Google Scholar motor engine MeSH/Emtree Free Text words, with no time limitation until November 2021. heterogeneity among quantified I 2 index random effects model used, due high results included meta-analysis. Results search retrieved 2092 studies. After excluding irrelevant studies, ultimately 27 articles sample size 9841 were combining overall estimate rate 43.8% (95% CI 33.3–54.9%) highest estimated Africa 64.2% 53.2–73.9%). Given subgroup analysis based on study population, Dementia 72.4% 26.7–95.0%). meta-regression that has an increasing trend enhancement year publication mean age. Conclusion revealed is populations its been recent years. Therefore, appropriate strategies should be applied reduce by finding causation monitoring at all levels, well providing feedback hospitals.

Language: Английский

Citations

90
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke DOI Creative Commons

Mingxu Duan,

Ya Xu,

Yuanshu Li

et al.

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 18, 2024

Abstract The notion that the central nervous system is an immunologically immune-exempt organ has changed over past two decades, with increasing evidence of strong links and interactions between peripheral immune system, both in healthy state after ischemic hemorrhagic stroke. Although primary injury stroke certainly important, limited therapeutic efficacy, poor neurological prognosis high mortality have led researchers to realize secondary damage may also play important roles influencing long-term neuroinflammatory process one most influences on disease progression. Here, we summarize stroke, particular, how activates recruits components, review recent advances corresponding approaches clinical studies, emphasizing importance role

Language: Английский

Citations

17
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence DOI
Natalie Gude,

Kathleen M. Broughton,

Fareheh Firouzi

et al.

Nature Reviews Cardiology, Journal Year: 2018, Volume and Issue: 15(9), P. 523 - 542

Published: July 27, 2018

Language: Английский

Citations

141
Systemic inflammation in hemorrhagic strokes – A novel neurological sign and therapeutic target? DOI Open Access
Aisha Rasool Saand, Fang Yu, Jun Chen

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2019, Volume and Issue: 39(6), P. 959 - 988

Published: April 8, 2019

Growing evidences suggest that stroke is a systemic disease affecting many organ systems beyond the brain. Stroke-related inflammatory response and immune dysregulations may play an important role in brain injury, recovery, outcome. The two main phenomena stroke-related peripheral are inflammation post-stroke immunosuppression. There emerging evidence suggesting spleen contracts following ischemic stroke, activates this further potentiate injury. Whether similar brain–immune crosstalk occurs hemorrhagic strokes such as intracerebral hemorrhage (ICH) subarachnoid (SAH) not established. In review, we systematically examined animal human to date on responses associated with strokes. Specifically, reviewed impact of clinical syndrome (SIRS), inflammation- immune-associated biomarkers, brain–spleen interaction, cellular mediators ICH SAH including regulatory T cells (Tregs). While there growing data dysregulation be injury pathogenesis outcome, details brain-immune system cross-talk remain insufficiently understood. This unmet scientific need lead novel therapeutic strategies highly morbid condition.

Language: Английский

Citations

141
Brain–heart interaction after acute ischemic stroke DOI Creative Commons
Denise Battaglini, Chiara Robba, Adriana Lopes da Silva

et al.

Critical Care, Journal Year: 2020, Volume and Issue: 24(1)

Published: April 21, 2020

Abstract Early detection of cardiovascular dysfunctions directly caused by acute ischemic stroke (AIS) has become paramount. Researchers now generally agree on the existence a bidirectional interaction between brain and heart. In support this theory, AIS patients are extremely vulnerable to severe cardiac complications. Sympathetic hyperactivity, hypothalamic–pituitary–adrenal axis, immune inflammatory responses, gut dysbiosis have been identified as main pathological mechanisms involved in brain–heart axis dysregulation after AIS. Moreover, evidence confirmed that causes mortality include heart attack, congestive failure, hemodynamic instability, left ventricular systolic dysfunction, diastolic arrhythmias, electrocardiographic anomalies, arrest, all which more or less associated with poor outcomes death. Therefore, intensive care unit admission continuous monitoring proposed standard for at high risk developing Recent trials also investigated possible therapies prevent secondary accidents Labetalol, nicardipine, nitroprusside recommended control hypertension during AIS, while beta blockers suggested both preventing chronic remodeling treating arrhythmias. Additionally, electrolytic imbalances should be considered, abnormal rhythms must treated. Nevertheless, therapeutic targets remain challenging, further investigations might essential complete complex multi-disciplinary puzzle. This review aims highlight pathophysiological implicated their clinical consequences patients, well provide specific recommendations management

Language: Английский

Citations

132
HealthGuard: A Machine Learning-Based Security Framework for Smart Healthcare Systems DOI

Akm Iqtidar Newaz,

Amit Kumar Sikder, Mohammad Ashiqur Rahman

et al.

Published: Oct. 1, 2019

The integration of Internet-of-Things and pervasive computing in medical devices have made the modern healthcare system "smart." Today, function is not limited to treat patients only. With help implantable wearables, Smart Healthcare System (SHS) can continuously monitor different vital signs a patient automatically detect prevent critical conditions. However, these increasing functionalities SHS raise several security concerns attackers exploit numerous ways: they impede normal SHS, inject false data change signs, tamper device outcome emergency. In this paper, we propose HealthGuard, novel machine learning-based framework malicious activities SHS. HealthGuard observes connected correlates vitals understand changes body functions distinguish benign activities. utilizes four detection techniques (Artificial Neural Network, Decision Tree, Random Forest, k-Nearest Neighbor) We trained with collected for eight smart twelve events including seven user five disease-affected events. Furthermore, evaluated performance against three threats. Our extensive evaluation shows that an effective accuracy 91 % F1 score 90 %.

Language: Английский

Citations

123
Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review DOI
Jinlin Zhang,

Jingjing Wu,

Fengguo Liu

et al.

European Journal of Pharmacology, Journal Year: 2019, Volume and Issue: 858, P. 172500 - 172500

Published: June 22, 2019

Language: Английский

Citations

112
Neuroimaging and deep learning for brain stroke detection - A review of recent advancements and future prospects DOI

R. Karthik,

R. Menaka,

Annie Johnson

et al.

Computer Methods and Programs in Biomedicine, Journal Year: 2020, Volume and Issue: 197, P. 105728 - 105728

Published: Aug. 26, 2020

Language: Английский

Citations

86