Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke

Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(8), P. 407 - 431

Published: July 3, 2023

Language: Английский

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Systemic inflammation after stroke: implications for post‐stroke comorbidities

EMBO Molecular Medicine, Journal Year: 2022, Volume and Issue: 14(9)

Published: Aug. 15, 2022

Language: Английский

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Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population: a cross-sectional analysis of the NHANES 1999-2018

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 4, 2023

Background Significant evidence suggests that asthma might originate from low-grade systemic inflammation. Previous studies have established a positive association between the immune-inflammation index (SII) and inflammation response (SIRI) levels risk of stroke. However, it remains unclear whether SII, SIRI prevalence stroke are related in individuals with asthma. Methods The present cross-sectional study used data National Health Nutrition Examination Survey (NHANES) conducted 1999 2018. SII was calculated using following formula: (platelet count × neutrophil count) / lymphocyte count. (neutrophil monocyte count)/lymphocyte Spearman rank correlation coefficient to determine any SIRI, baseline characteristics. Survey-weighted logistic regression employed calculate odds ratios (ORs) 95% confidence intervals (CIs) prevalence. predictive value for assessed through receiver operating characteristic (ROC) curve analysis, area under ROC (AUC) being indicative its value. Additionally, clinical models including coronary heart disease, hypertension, age, poverty income ratio were constructed evaluate their applicability. Results Between 2018, 5,907 NHANES participants identified, which 199 experienced stroke, while remaining 5,708 had not. analysis indicated neither nor exhibited significant characteristics (r<0.1). curves optimal cut-off values classify into low- high-level groups. Higher associated higher ORs 1.80 (95% CI, 1.18-2.76) 2.23 1.39-3.57), respectively. (AUC=0.618) superior (AUC=0.552). Furthermore, model demonstrated good (AUC=0.825), sensitivity 67.1% specificity 87.7%. Conclusion In asthmatics, significantly increased more pronounced coexisting obesity hyperlipidaemia. relatively stable novel inflammatory markers asthmatic population, having better than SII.

Language: Английский

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Interleukin-4 as a therapeutic target

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 242, P. 108348 - 108348

Published: Jan. 16, 2023

Language: Английский

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Innate immune memory after brain injury drives inflammatory cardiac dysfunction

Cell, Journal Year: 2024, Volume and Issue: 187(17), P. 4637 - 4655.e26

Published: July 22, 2024

The medical burden of stroke extends beyond the brain injury itself and is largely determined by chronic comorbidities that develop secondarily. We hypothesized these might share a common immunological cause, yet effects post-stroke on systemic immunity are underexplored. Here, we identify myeloid innate immune memory as cause remote organ dysfunction after stroke. Single-cell sequencing revealed persistent pro-inflammatory changes in monocytes/macrophages multiple organs up to 3 months injury, notably heart, leading cardiac fibrosis both mice patients. IL-1β was identified key driver epigenetic memory. These could be transplanted naive mice, inducing dysfunction. By neutralizing or blocking monocyte trafficking with CCR2/5 inhibitor, prevented Such immune-targeted therapies potentially prevent various IL-1β-mediated comorbidities, offering framework for secondary prevention immunotherapy.

Language: Английский

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DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

Nature, Journal Year: 2024, Volume and Issue: 633(8029), P. 433 - 441

Published: Aug. 7, 2024

The risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies1. Risk is particularly in patients with atherosclerosis, more than 10% experiencing events1,2. However, the enormous medical burden this clinical phenomenon, underlying mechanisms leading to increased vascular and are largely unknown. Here, using a novel mouse model stroke-induced ischaemia, we show that leads activation AIM2 inflammasome vulnerable atherosclerotic plaques via an increase circulating cell-free DNA. Enhanced plaque inflammation post-stroke results destabilization atherothrombosis, finally arterioarterial embolism within days index stroke. We confirm key steps also experimental myocardial infarction carotid artery samples from acute Rapid neutrophil NETosis was identified as main source DNA NET–DNA causative agent activation. Neutralization by DNase treatment or inhibition reduced rate recurrence Our findings present explanation for incident ischaemic atherosclerosis. detailed uncovered here provide clinically uncharted therapeutic targets which efficacy prevent events. Targeting DNA-mediated remote tissue injury represents promising avenue further development This study describes sensing mechanism ischemic

Language: Английский

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Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020)

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Background The systemic immunity-inflammation index(SII) is a new indicator of composite inflammatory response. Inflammatory response an important pathological process in stroke. Therefore, this study sought to investigate the association between SII and Methods We collected data on participants with stroke from 2015–2020 cycle National Health Nutrition Examination Survey (NHANES) for cross-sectional investigation. Multivariate linear regression models were used test Fitted smoothing curves threshold effect analysis applied describe nonlinear relationship. Results A total 13,287 included our study, including 611 (4.598%) In multivariate analysis, we found significant positive stroke, odds ratio (OR) [95% CI] associating prevalence was [1.02 (1.01, 1.04)] (P < 0.01). subgroup interaction experiments, that relationship not significantly correlated among different population settings such as age, gender, race, education level, smoking status, high blood pressure, diabetes coronary heart disease trend > 0.05). Moreover, inflection point 740 (1,000 cells /µl) by using two-segment model. Conclusions This implies increased levels are linked To confirm findings, more large-scale prospective investigations needed.

Language: Английский

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Exploring and validating associations between six systemic inflammatory indices and ischemic stroke in a middle-aged and old Chinese population

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 21, 2025

Abstract Background Inflammation and maladaptive immune mechanisms have been substantiated as integral components in the critical pathological processes of injury cascade ischemic stroke (IS). This study aimed to explore associations between six systemic inflammatory indices IS a Chinese population. Methods was case-control based on retrospective review electronic medical records from two hospitals Shandong Province, China. Systemic indices, including inflammation response index (SIRI), (SII), pan-immune-inflammation value (PIV), neutrophil lymphocyte ratio (NLR), platelet (PLR), monocyte (LMR), were calculated. Logistic regression models classification analyses employed evaluate discriminatory abilities. Results In total, 9392 participants aged 40–83 years old included discovery (3620 pairs IS-present cases healthy controls) validation (1076 IS-absent controls with mimics) datasets. After adjusting for potential confounding factors, found be associated all dataset, SIRI (odd [OR] 8.77, 95% confidence interval [CI] 7.48–10.33), SII (1.03, 1.01–1.04), PIV (1.01, 1.01–1.01), NLR (2.23, 2.08–2.39), PLR LMR (0.77, 0.75–0.78). Notably, only exhibited significant both datasets (0.88, 0.83–0.93), suggesting an independent protective role this index. SIRI, SII, PIV, NLR, showed good discriminative ability patients dataset (AUCs > 0.70). However, they performed poorly distinguishing mimics < 0.60). Conclusion provides valuable insights into IS, offering implications risk stratification. While these are indicators conditions, additional biomarkers may needed when differentiating other chronic conditions clinical practice.

Language: Английский

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Association between cardiometabolic index and depression in a stroke population: a cross-sectional study of NHANES

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 18, 2025

Stroke is a prevalent neurological disorder globally, often resulting in post-stroke depression (PSD). The cardiometabolic index (CMI) novel marker for assessing cardiovascular and metabolic health, but its association with PSD has not been adequately investigated. This study aims to explore the relationship between CMI PSD, providing basis clinical prevention treatment. We utilized data from 2007–2018 National Health Nutrition Examination Survey (NHANES) this cross-sectional analysis. Multivariable logistic regression restricted cubic spline (RCS) models were applied assess independent linear relationships PSD. To minimize confounding, propensity score matching (PSM) was employed. Subgroup analyses interaction tests also conducted further potential effect modifications. A total of 1082 participants included, 18.67% diagnosed Higher levels positively associated stroke patients. In fully adjusted model, remained significant (OR = 1.06; 95% CI 1.01–1.12). RCS analysis indicated (nonlinearity P 0.334). showed that persisted across different groups (all trend > 0.05). After covariate balance through PSM, positive supported. demonstrates may serve as useful tool evaluating risk depressive symptom patients, potentially aiding targeted interventions.

Language: Английский

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The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113611 - 113611

Published: Sept. 5, 2022

Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges worldwide due to their high morbidity and mortality limitations in clinical treatment strategies. Studies have shown that reactive oxygen species (ROS)-mediated inflammation, excitotoxicity, programmed cell death of each neurovascular unit during post-stroke hypoxia reperfusion play an important role the pathological cascade. Ferroptosis, a characterized by iron-regulated accumulation lipid peroxidation, is caused abnormal metabolism lipids, glutathione (GSH), iron, can accelerate acute central nervous system injury. Recent studies gradually uncovered process ferroptosis stroke. Some drugs iron chelators, ferrostatin-1 (Fer-1) liproxstatin-1 (Lip-1) protect nerves after injury stroke inhibiting ferroptosis. In addition, combined with our previous on mediated natural compounds this review summarized progress regulation mechanism chemical components herbal recent years, order provide reference information for future research lead development inhibitors.

Language: Английский

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