OPA1 mediates cardiac function and metabolism: in silico and in vivo evidence DOI Creative Commons
Claire Fong-McMaster,

Serena M. Pulente,

Luke Kennedy

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 24, 2024

Abstract OPA1 is an inner mitochondrial membrane protein that mediates diverse signaling processes. important for cardiac function and protects against insults such as ischemia reperfusion injury. We sought to further assess in human mouse pathologies, hypothesizing may also a protective manner chronic heart failure. Bioinformatic analyses of histological transcript data from the GTEx database indicated expression levels vary heart, where elevated were correlated with fatty acid, branch chain amino acid contractile gene signatures. To experimentally these correlations, mice 1.5-fold whole body overexpression (OPA1-OE) subjected transverse aortic constriction surgery displayed improved 2D 4D functional parameters compared WT mice. OPA1-OE had no induction fibrotic markers sustained markers. Maximal oxidative capacity was both myofibers post-TAC. These results demonstrate role mediating highlight pathways.

Language: Английский

Mitochondrial function: A new direction for the targeted treatment of cardiovascular diseases with Chinese herbal medicine DOI Creative Commons
Lin Yang, Liang Wang, Baofeng Yang

et al.

Journal of Holistic Integrative Pharmacy, Journal Year: 2025, Volume and Issue: 6(1), P. 91 - 104

Published: March 1, 2025

Language: Английский

Citations

0
Editorial: Methods in cardiovascular biologics and regenerative medicine DOI Creative Commons
Narasimman Gurusamy, Olaf Bergmann, Clotilde Castaldo

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 13, 2024

Language: Английский

Citations

1
Estrogen receptors in mitochondrial metabolism: age-related changes and implications for pregnancy complications DOI
Antentor Hinton, Kit Neikirk,

Han Le

et al.

Aging advances., Journal Year: 2024, Volume and Issue: 1(2), P. 154 - 171

Published: Dec. 1, 2024

Estrogen hormones are primarily associated with their role as female sex responsible for primary and secondary sexual development. receptors known to undergo age-dependent decreases due age-related changes in hormone production. In the mitochondria, estrogen functions by reducing production of reactive oxygen species electron transport chain, inhibiting apoptosis, regulating mitochondrial DNA content. Moreover, may be key components maintaining membrane potential structure. Although plays a crucial development pregnancy, our understanding how change aging during pregnancy remains limited. During levels significantly elevated, corresponding upregulation receptors, which play various roles pregnancy. However, exact complications further investigated. The paper reviews regulation metabolism complications, special focus on effect function. We also address maintains function, including content, effects mitochondria-endoplasmic reticulum contacts have not been well studied. Based these emergent differential great relevance. emphasizes association between maternal health indicates need future research elucidate interdependence receptor-regulated function relationship gut microbiome. Overall, we summarize important highlight better understand complications. This only helps reveal mechanism underlying but has clinical implications new therapies targeting diseases

Language: Английский

Citations

1
Important Role of Mitochondrial Dysfunction in Immune Triggering and Inflammatory Response in Rheumatoid Arthritis DOI Creative Commons

P. Li,

Mengru Zhou,

Jia Wang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11631 - 11657

Published: Dec. 1, 2024

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, primarily characterized by chronic symmetric synovial inflammation and erosive bone destruction.Mitochondria, the primary site of cellular energy production, play a crucial role in metabolism possess homeostatic regulation capabilities. Mitochondrial function influences differentiation, activation, survival both immune non-immune cells involved RA pathogenesis. If organism experiences hypoxia, genetic predisposition, oxidative stress, it leads to mitochondrial dysfunction, which further affects cell metabolism, proliferation, apoptosis, signaling, causing onset progression RA; and, becoming increasingly important treatment RA.In this review, we examine structure mitochondria, analyze potential causes dysfunction RA, focus on mechanisms triggers disorders RA. We also explore effects osteoblasts, emphasizing its key response processes Furthermore, discuss biological that regulate homeostasis, are great importance for prevention

Language: Английский

Citations

1
OPA1 mediates cardiac function and metabolism: in silico and in vivo evidence DOI Creative Commons
Claire Fong-McMaster,

Serena M. Pulente,

Luke Kennedy

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 24, 2024

Abstract OPA1 is an inner mitochondrial membrane protein that mediates diverse signaling processes. important for cardiac function and protects against insults such as ischemia reperfusion injury. We sought to further assess in human mouse pathologies, hypothesizing may also a protective manner chronic heart failure. Bioinformatic analyses of histological transcript data from the GTEx database indicated expression levels vary heart, where elevated were correlated with fatty acid, branch chain amino acid contractile gene signatures. To experimentally these correlations, mice 1.5-fold whole body overexpression (OPA1-OE) subjected transverse aortic constriction surgery displayed improved 2D 4D functional parameters compared WT mice. OPA1-OE had no induction fibrotic markers sustained markers. Maximal oxidative capacity was both myofibers post-TAC. These results demonstrate role mediating highlight pathways.

Language: Английский

Citations

0